Quick Search
Ascorbyl glucoside helps neutralize free radicals that can damage skin cells.
Ascorbyl glucoside is a stable derivative of vitamin C (ascorbic acid) commonly used in cosmetic and dermatological formulations for its antioxidant and skin-brightening properties.
Ascorbyl glucoside is formed by combining ascorbic acid with a glucose molecule.
CAS Number: 129499-78-1
Molecular Formula: C12H18O11
Molecular Weight: 338.26
EINECS Number: 425-980-0
Synonyms: ascorbyl glucoside, 129499-78-1, L-Ascorbic acid 2-glucoside, AA2G, 2V52R0NHXW, DTXSID50926423, Brightening, skin whitening, RefChem:58140, GlyTouCan:G32886OM, OJW Hydrating Brightening spray, DTXCID801765786, G32886OM, Sandawha Vitamin C Brightening Essence, L-Ascorbic acid, 2-O-alpha-D-glucopyranosyl-, 603-337-7, 2-O-alpha-D-Glucopyranosyl-L-ascorbic acid, AA-2G, Ascorbic acid 2-O-glucoside, MFCD23701380, 2-o-a-d-glucopyranosyl-l-ascorbic acid, Ascorbic acid 2-glucoside, L-Ascorbic acid 2-O-alpha-glucoside, L-Ascorbic acid-2-glucoside, (R)-5-((S)-1,2-DIHYDROXYETHYL)-4-HYDROXY-3-(((2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL)OXY)FURAN-2(5H)-ONE, (2R)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2h-furan-5-one, 2-O-|A-D-Glucopyranosyl-L-ascorbic Acid, C12H18O11, Ascofresh, L-Ascorbicacid2-glucoside, UNII-2V52R0NHXW, 2-o--d-glucopyranosyl-l-ascorbic acid, SCHEMBL37903, orb1299155, orb3026044, SCHEMBL2388533, CHEMBL2011961, CHEBI:81685, HY-N6821R, MSK1604, L-ascorbic acid 2-O-|A-glucoside, EX-A2888, HY-N6821, s3215, AKOS015999708, DB11335, MG12858, DS-17832, SY056213, DB-365211, CS-0100234, NS00077720, ASCORBIC ACID 2-O-GLUCOSIDE [WHO-DD], C18339, F20404, 2-O-|A-D-Glucopyranosyl-L-ascorbic Acid (Standard), Q27155554, L-ASCORBIC ACID, 2-O-,.ALPHA.-D-GLUCOPYRANOSYL-, 2-O-a-D-Glucopyranosyl-L-ascorbic Acid, >=98% (HPLC), Ascorbyl Glucoside, Pharmaceutical Secondary Standard; Certified Reference Material, (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2H-furan-5-one, (5R)-5-[(1S)-1,2-Dihydroxyethyl]-4-hydroxy-3-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}furan-2(5H)-one, 154160-11-9, Pyrido(1,2-a)indol-6(7H)-one, 8,9-dihydro-7-(hydroxy(5-methyl-1H-imidazol-4-yl)methyl)-10-propyl-, (R*,S*), Ascofresh;L-Ascorbic acid, 2-O-.alpha.-D-glucopyranosyl-;AA-2G;ascorbic acid 2-O-glucoside;ASCORBYL GLUCOSIDE, ASCORBIC ACID-2- GLUCOSIDE;2-O-A-D-GLUCOPYRANOSYL-L-ASCORBIC ACID;L-Ascorbic acid 2-o-alpha-glucoside;Pyrido(1,2-A)indol-6(7H)-one, 8,9-dihydro-7-(hydroxy(5-methyl-1H-imidazol-4-yl)methyl)-10-propyl-, (R*,S*)-
Ascorbyl glucoside is a stable, water-soluble derivative of Vitamin C (L-ascorbic acid) combined with glucose.
Ascorbyl glucoside functions as an antioxidant to brighten skin, reduce hyperpigmentation, and boost collagen production.
Due to its gentle nature, Ascorbyl glucoside is ideal for sensitive skin and offers a comfortable texture in water-based serums.
Ascorbyl glucoside is a natural active substance containing Vitamin C structure, but it is stable. Ascorbyl glucoside can effectively inhibit formation of melanin, dilute the skin color, reduce age spots and freckles pigmentation.
Ascorbyl glucoside was originally developed as a quasi-drug cosmetic product in Japan to lighten the overall tone of the skin and reduce the pigmentation in age spots and freckles.
Further research has shown other dramatic benefits and today AA-2G is used all over the world-not only for whitening but also for brightening dull looking skin, reversing the effects of aging, and in sunscreen products for protection.
Chemically, ascorbyl glucoside is an ascorbic acid molecule linked to glucose via a glycosidic bond, typically at the 2-position.
This structure protects the vitamin C moiety from rapid oxidation.
In the skin, Ascorbyl glucoside can be enzymatically converted back to active ascorbic acid.
Physically, ascorbyl glucoside appears as a white to off-white crystalline powder.
It is highly soluble in water.
Ascorbyl glucoside is more stable than pure ascorbic acid in aqueous formulations.
Ascorbyl glucoside exhibits strong antioxidant properties.
This contributes to protection against oxidative stress.
This modification improves stability compared to pure vitamin C.
The compound is known for its skin-brightening and whitening effects.
Ascorbyl glucoside inhibits melanin production by affecting tyrosinase activity.
This helps reduce hyperpigmentation and uneven skin tone.
Ascorbyl glucoside is more stable under light, heat, and oxygen exposure compared to ascorbic acid.
This makes it suitable for long-lasting cosmetic formulations.
Ascorbyl glucoside maintains activity over extended storage periods.
In cosmetic formulations, it functions as a skin-conditioning, antioxidant, and brightening agent.
Ascorbyl glucoside is commonly used in serums, creams, and lotions.
It is suitable for daily skincare products.
Ascorbyl glucoside is best described as a stable, water-soluble vitamin C derivative that provides antioxidant and skin-brightening benefits in cosmetic formulations.
Ascorbyl glucoside is valued for its enhanced chemical stability compared to pure ascorbic acid.
The glucose moiety protects the molecule from rapid oxidation in the presence of air, light, and heat.
This allows longer shelf life in aqueous formulations.
Once applied to the skin, ascorbyl glucoside is enzymatically hydrolyzed by α-glucosidase.
This process slowly releases active ascorbic acid.
The gradual conversion provides sustained antioxidant activity.
The compound shows good compatibility with a wide range of cosmetic ingredients.
It can be formulated with other actives such as hyaluronic acid, niacinamide, and peptides.
This makes it suitable for multifunctional skincare products.
Ascorbyl glucoside is effective over a broader pH range than pure vitamin C.
It remains stable in mildly acidic to neutral formulations.
This flexibility simplifies formulation design.
It contributes to collagen synthesis support by providing a source of vitamin C.
Vitamin C plays a key role in collagen production in the skin.
This helps improve skin firmness and elasticity.
The compound also helps reduce oxidative damage caused by UV exposure and environmental stress.
Ascorbyl glucoside supports skin protection against free radicals.
This is beneficial in daily skincare routines.
Melting point 158-163℃
Boiling point 785.6±60.0 °C(Predicted)
Density 1.83±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 3.38±0.10(Predicted)
form Powder
color White to Off-white
Water Solubility Soluble in water. (879 g/L) at 25°C.
λmax 260nm(H2O)(lit.)
Cosmetics Ingredients Functions ANTIOXIDANT
Cosmetic Ingredient Review (CIR) Ascorbyl glucoside (129499-78-1)
InChI 1S/C12H18O11/c13-1-3(15)9-8(19)10(11(20)22-9)23-12-7(18)6(17)5(16)4(2-14)21-12/h3-7,9,12-19H,1-2H2/t3-,4+,5+,6-,7+,9+,12+/m0/s1
InChIKey MLSJBGYKDYSOAE-DCWMUDTNSA-N
SMILES OC([C@]([C@@H](O)CO)([H])O1)=C(C1=O)O[C@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO
LogP -2 at 20℃
Ascorbyl glucoside is generally considered milder and less irritating than pure ascorbic acid.
Ascorbyl glucoside is suitable for sensitive skin types.
This makes it popular in gentle skincare formulations.
Because it is water-soluble, it is easily incorporated into serums, gels, and lotions.
It does not require special solvents for dissolution.
This improves formulation efficiency.
Ascorbyl glucoside is a stable, water-soluble vitamin C derivative that provides gradual antioxidant release, skin brightening, and collagen-supporting benefits, making it highly suitable for modern cosmetic formulations.
Ascorbyl glucoside is a stable form of vitamin C combined with glucose.
When properly formulated and absorbed into skin, it breaks down to ascorbic acid (pure vitamin C).
Ascorbyl glucoside is a useful cosmetic gel and skin cleanser.
Once absorbed, its breakdown to vitamin C is gradual, creating what’s known as a reservoir effect within skin. This leads to longer-lasting benefits.
Ascorbyl glucoside is an ascorbic acid derivative that contains at least one glycosyl group.
Ascorbyl glucoside is commonly used in cosmetic products to administer vitamin C topically.
Ascorbyl glucoside exhibits superior stability and penetration ability compared to ascorbyl phosphate salts, but the rate of its in vivo conversion to ascorbic acid is not known.
Ascorbyl glucoside such as AA-2G, like many other derivatives of the ascorbic acid, show antiscorbutic effects.
It is also sometimes used in skin whitening products.[3]
Ascorbyl glucoside is known for its slow-release delivery system of vitamin C.
Unlike pure ascorbic acid, it does not act immediately but provides sustained activity over time.
This helps maintain longer-lasting antioxidant protection on the skin.
The molecule shows reduced sensitivity to oxidation during storage and use.
Ascorbyl glucoside does not easily degrade into inactive or irritating byproducts.
This stability improves product reliability and effectiveness.
Ascorbyl glucoside contributes to improved skin tone uniformity.
By gradually inhibiting melanin formation, it helps reduce dark spots and discoloration.
This results in a brighter and more even complexion.
Ascorbyl glucoside is often used in formulations targeting photoaging and environmental damage.
Its antioxidant activity helps protect against damage caused by UV radiation and pollution.
This supports long-term skin health.
The compound can enhance formulation clarity and aesthetic quality.
Ascorbyl glucoside does not significantly discolor formulations over time.
This is an advantage compared to unstable vitamin C forms.
Ascorbyl glucoside is compatible with both aqueous and emulsion-based systems.
It can be incorporated into a variety of product types.
This flexibility supports diverse cosmetic applications.
Ascorbyl glucoside is considered suitable for daily use formulations, including morning and evening skincare routines.
Its mild nature allows frequent application without strong irritation.
This increases consumer acceptance.
Because Ascorbyl glucoside converts into active vitamin C within the skin, it provides functional equivalence with improved stability.
Ascorbyl glucoside balances performance with formulation ease.
Ascorbyl glucoside is a next-generation vitamin C derivative offering stability, gradual activation, and multifunctional skin benefits, particularly in brightening and antioxidant skincare products.
Uses:
According to the manufacturer, Ascorbyl glucoside functions as a time-release version of vitamin C (ascorbic acid), and therefore is more stable than traditional ascorbic acid.
Ascorbyl glucoside is considered to have skin-lightening and anti-hyperpigmentation properties, thanks to an ability to suppress melanin production.
Its skinbrightening capacities are attributed to an apparent ability to reduce pre-existing melanin levels (as in the case of freckles or age spots).
Ascorbyl glucoside could also help promote collagen synthesis and help reduce skin inflammation.
Ascorbyl glucoside is found in antiaging, anti-wrinkle, and sun care products.
Ascorbyl glucoside reduce the free radicals that result from UV irradiation of the skin, and significantly reduce cell damage and photo-aging.
Ascorbyl glucoside also promotes collagen synthesis.
It can function as an antioxidant.
Ascorbyl glucoside is widely used in skin-brightening and whitening cosmetic products.
Ascorbyl glucoside helps reduce hyperpigmentation and dark spots by inhibiting melanin production.
This improves overall skin tone and radiance.
In facial serums and creams, it functions as an antioxidant and skin-conditioning agent.
Ascorbyl glucoside protects the skin from oxidative stress caused by environmental factors.
This supports healthier and more youthful-looking skin.
Ascorbyl glucoside is used in anti-aging formulations to support collagen synthesis.
It helps improve skin firmness and elasticity.
This reduces the appearance of fine lines and wrinkles.
In daily skincare products, including moisturizers and lotions, it provides gentle vitamin C benefits.
Its stability allows consistent performance over time.
This makes it suitable for long-term use.
Ascorbyl glucoside is applied in sun-care and after-sun products.
It helps protect the skin from UV-induced oxidative damage.
This supports skin recovery and protection.
In eye creams and sensitive-skin formulations, it is used because of its mild nature.
It delivers antioxidant benefits without strong irritation.
This makes it suitable for delicate skin areas.
Ascorbyl glucoside is used in sheet masks and treatment products to deliver concentrated skin benefits.
It helps brighten and hydrate the skin.
This enhances overall skin appearance.
In cosmetic emulsions and gels, it improves formulation stability while providing active benefits.
Ascorbyl glucoside is easy to incorporate into water-based systems.
This supports efficient product formulation.
Ascorbyl glucoside is also used in pharmaceutical and dermatological topical formulations for antioxidant and skin-protective effects.
It helps reduce oxidative damage and supports skin repair.
Ascorbyl glucoside is used wherever stable vitamin C activity, skin brightening, antioxidant protection, and anti-aging benefits are required in cosmetic and dermatological products.
Safety Profile:
Ascorbyl glucoside is generally considered to have low hazard potential and is widely regarded as safe for use in cosmetic and dermatological formulations.
Ascorbyl glucoside is a stabilized derivative of vitamin C and is typically well tolerated.
However, standard precautions should be followed when handling the raw material.
Skin contact is usually well tolerated, but in rare cases mild irritation may occur, especially at high concentrations.
Symptoms may include slight redness or sensitivity.
Ascorbyl glucoside is generally suitable for sensitive skin.
Eye contact may cause mild irritation or discomfort.
Exposure can lead to temporary redness or watering.
Eyes should be rinsed with water if contact occurs.
Inhalation risk is low, as the material is typically handled as a solid powder or dissolved in formulations.
However, dust may cause slight respiratory irritation in industrial settings.
Proper ventilation should be maintained during handling.
Ingestion is considered low toxicity, as it is related to vitamin C.
However, large amounts may cause mild gastrointestinal discomfort.
Ascorbyl glucoside is not intended for oral use unless specifically approved.
Ascorbyl glucoside is not flammable under normal conditions.
Thermal decomposition at high temperatures may produce carbon oxides and other organic fumes.
Standard fire safety precautions should be followed.
