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Ascorbyl Isostearate is a highly stable, oil-soluble Vitamin C derivative used in cosmetics as a skin-conditioning agent and antioxidant.
Ascorbyl Isostearate penetrates the skin efficiently, converting into pure L-ascorbic acid to boost collagen production, brighten skin by inhibiting tyrosinase, and reduce wrinkles.
Ascorbyl Isostearate is known for its superior solubility in oily formulations and high resistance to oxidation compared to pure Vitamin C.
CAS Number: 33425-76-2
Molecular Formula: C24H42O7
Molecular Weight: 442.58608
Synonyms: ascorbyl isostearate, ORISTAR AIS, 0833RLV6F6, OLI-2192 ASCORBYL ISOSTEARATE, RefChem:199636 ASCORBYL ISOSTEARATE [INCI], SCHEMBL17542168, Q27236355, L-Ascorbic acid, 6-tetradecanoate;6-tetradecanoate;Ascorbyl monomyristate;Ascorbyl myristate
Ascorbyl isostearate is a lipophilic derivative of vitamin C (ascorbic acid) used in cosmetic and personal-care formulations for its antioxidant and skin-conditioning properties.
Ascorbyl Isostearate is formed by esterifying ascorbic acid with isostearic acid.
This modification improves oil solubility and stability.
Chemically, ascorbyl isostearate consists of an ascorbic acid molecule esterified with isostearic acid, a branched fatty acid.
This structure makes the molecule more hydrophobic than pure vitamin C.
Ascorbyl Isostearate is designed to function in oil-based or emulsion systems.
Physically, ascorbyl isostearate appears as a waxy or oily substance, typically light yellow to off-white.
Ascorbyl Isostearate is soluble in oils and lipids but poorly soluble in water.
It can be incorporated into oil phases of formulations.
Ascorbyl isostearate exhibits antioxidant activity, helping to neutralize free radicals.
Ascorbyl Isostearate protects both the skin and formulation components from oxidative damage.
This contributes to improved product stability.
The compound provides skin-conditioning and emollient properties.
It helps soften and smooth the skin surface.
This enhances the sensory feel of cosmetic products.
Compared to ascorbic acid, ascorbyl isostearate is more stable in formulations, especially in the presence of oxygen and light.
Its lipophilic nature reduces rapid degradation.
This allows longer shelf life in oil-based systems.
In cosmetic formulations, it functions as a lipid-soluble antioxidant and conditioning agent.
Ascorbyl Isostearate is commonly used in creams, lotions, and oil-based products.
It is especially useful in formulations requiring fat-soluble actives.
Ascorbyl Isostearate is best described as a fat-soluble vitamin C derivative that provides antioxidant protection and skin-conditioning benefits in oil-based cosmetic formulations.
Ascorbyl isostearate belongs to a group of fatty acid esters of ascorbic acid, which are designed to improve formulation versatility.
These derivatives allow vitamin C activity in systems where water-soluble forms are not suitable.
This expands its application range in cosmetic chemistry.
The branched structure of isostearic acid contributes to improved spreadability and texture.
Ascorbyl Isostearate gives formulations a smooth, non-greasy feel.
This enhances the sensory profile of creams and oils.
Ascorbyl isostearate can act as a co-antioxidant in lipid systems, working together with other antioxidants.
It helps interrupt oxidative chain reactions in oils.
This supports long-term formulation stability.
The compound is particularly useful in emulsion systems where oil-phase protection is required.
It stabilizes lipophilic ingredients against oxidation.
This helps maintain product efficacy and appearance.
Because of its lipophilic nature, ascorbyl isostearate tends to remain in the stratum corneum (outer skin layer).
This allows localized antioxidant protection at the skin surface.
Ascorbyl Isostearate contributes to barrier protection and skin conditioning.
Melting point: 110.5-111.5 °C
Boiling point: 488.9±45.0 °C(Predicted)
Density: 1.181±0.06 g/cm3(Predicted)
pka: 3.96±0.10(Predicted)
Ascorbyl Isostearate is the oil soluble derivative of the vitamin C.
After the absorption by the skins and through the action of enzyme, VC Isostearate is regenerated into vitamin C in the body, so as to improve the defect of vitamin C which may easily be oxidized and discolored.
Ascorbyl Isostearate is the oil resoluble derivative of the vitamin C.
Inhibits the generation of melanin as well as blocks up the oxidizing chain in the course of melanin generation and thus reduces the melanin.
Ascorbyl Isostearate accelerates the synthesis of collagen and scavenges the free oxygen radicals.
Ascorbyl Isostearate inhibits the oxidation of lipid, and has the function of anti-aging. Possesses good resistance to acid and heat.
Ascorbyl Isostearate can be dissolved in various oily compounds.
Ascorbyl stearate (C24H42O7) is an ester formed from ascorbic acid and stearic acid.
In addition to its use as a source of vitamin C, it is used as an antioxidant food additive in margarine (E number E305).
The USDA limits its use to 0.02% individually or in conjunction with other antioxidants.
Ascorbyl isostearate is designed to provide enhanced compatibility with lipid phases in cosmetic formulations.
Its hydrophobic structure allows it to dissolve easily in oils, waxes, and esters.
This makes it suitable for oil-rich systems where water-soluble vitamin C cannot be used.
The esterification with isostearic acid improves resistance to oxidation and degradation.
This increases the shelf stability of formulations containing the ingredient.
It also helps maintain product color and performance over time.
Ascorbyl isostearate acts as a protective antioxidant for oils and lipids within formulations.
It helps prevent rancidity and oxidative deterioration of sensitive ingredients.
This is particularly important in formulations containing unsaturated oils.
The compound can contribute to improved skin barrier support.
Its lipophilic nature allows better interaction with the skin’s lipid matrix.
This helps enhance skin smoothness and softness.
Compared to water-soluble vitamin C derivatives, ascorbyl isostearate provides localized antioxidant effects within the lipid phase.
This allows protection of oil-soluble components.
It complements water-soluble antioxidants in dual-phase systems.
Ascorbyl isostearate may show slower release of active vitamin C compared to more hydrophilic derivatives.
This results in more gradual activity on the skin.
It supports sustained antioxidant performance.
The ingredient is often used in formulations requiring low water activity or anhydrous systems.
Examples include balms, oils, and sticks.
Its solubility profile makes it ideal for such products.
It is generally compatible with other oil-soluble actives, such as tocopherols (vitamin E) and coenzyme Q10.
These combinations can enhance antioxidant performance.
This supports multifunctional cosmetic formulations.
Ascorbyl Isostearate is a lipophilic vitamin C derivative that enhances oxidative stability, supports skin conditioning, and performs effectively in oil-based and anhydrous cosmetic systems.
Ascorbyl Isostearate is often used in formulations aiming for enhanced product stability without strong acidity.
Unlike pure ascorbic acid, it does not significantly lower pH.
This allows easier formulation with pH-sensitive ingredients.
Ascorbyl isostearate is suitable for anhydrous or low-water formulations, including oils, balms, and sticks.
It maintains stability even in the absence of water.
This makes it valuable in specialized cosmetic products.
The ingredient is generally considered mild and non-irritating, especially compared to acidic vitamin C forms.
Ascorbyl Isostearate is suitable for sensitive or dry skin formulations.
This increases its usability in gentle skincare products.
Ascorbyl Isostearate is a fat-soluble, stable vitamin C derivative that enhances lipid-phase antioxidant protection, improves formulation texture, and supports skin conditioning in oil-based systems.
Uses:
Ascorbyl Isostearate is a bioactive compound with notable chemical properties.
Ascorbyl isostearate is widely used in oil-based cosmetic formulations as a lipid-soluble antioxidant.
It helps protect oils and other lipophilic ingredients from oxidation.
This improves product stability and shelf life.
In creams and lotions, it functions as a conditioning agent and antioxidant within the oil phase.
It supports smooth skin feel and helps prevent oxidative degradation of formulation components.
This enhances both performance and texture.
Ascorbyl isostearate is used in anhydrous products such as balms, ointments, and sticks.
Its oil solubility makes it ideal for formulations without water.
Ascorbyl Isostearate provides antioxidant protection in these systems.
In anti-aging skincare products, it helps protect the skin from oxidative stress.
It contributes to maintaining skin health and appearance.
This supports formulations targeting aging concerns.
Ascorbyl Isostearate is applied in sun-care and after-sun products to protect lipids from UV-induced oxidation.
It works alongside other antioxidants to improve product performance.
Ascorbyl isostearate is used in lip care products, including lip balms and lipsticks.
It helps stabilize oils and waxes while providing conditioning benefits.
This improves product durability and feel.
In hair-care formulations, it acts as an antioxidant to protect oils and conditioning agents.
Ascorbyl Isostearate helps maintain formulation quality over time.
This supports stable hair-care products.
It is used in cosmetic oils and serums to prevent rancidity and oxidation of active ingredients.
This ensures long-term product effectiveness.
It also enhances sensory performance.
Ascorbyl isostearate is applied in makeup formulations, such as foundations and creams, to stabilize lipid components.
Ascorbyl Isostearate helps maintain color and texture stability.
This contributes to consistent product quality.
Ascorbyl Isostearate is used wherever lipid-phase antioxidant protection, formulation stability, and skin-conditioning effects are required, especially in oil-based and anhydrous cosmetic products.
Ascorbyl isostearate is used in facial oils and treatment serums to protect delicate plant oils from oxidation.
It helps extend product shelf life and maintain efficacy.
This is especially important in formulations rich in unsaturated lipids.
In night creams and repair formulations, it provides antioxidant support during skin recovery phases.
It helps protect skin lipids from oxidative stress.
This supports skin barrier maintenance overnight.
Ascorbyl isostearate is applied in sensitive-skin formulations as a mild alternative to acidic vitamin C.
It delivers antioxidant benefits with lower irritation potential.
This makes it suitable for delicate or reactive skin types.
In water-in-oil emulsions, it stabilizes the oil phase and protects active ingredients.
Ascorbyl Isostearate helps maintain emulsion integrity over time.
It is used in solid cosmetic products, such as sticks and bars.
Its wax-compatible nature allows easy incorporation.
This supports stable and uniform formulations.
Ascorbyl isostearate is included in dermatological topical formulations to provide localized antioxidant protection.
It helps reduce oxidative damage on the skin surface.
This contributes to therapeutic skincare applications.
In color cosmetics, such as lipsticks and cream-based products, it helps prevent oxidation of pigments and oils.
Ascorbyl Isostearate maintains color stability and product consistency.
This improves product appearance over time.
Ascorbyl Isostearate is also used in premium and luxury skincare formulations where long-term stability and mildness are required.
It supports high-performance antioxidant systems.
This enhances overall formulation quality.
Safety Profile:
Ascorbyl isostearate is generally considered to have low hazard potential when used in cosmetic and personal-care formulations.
Ascorbyl Isostearate is a fatty acid ester of vitamin C and is typically well tolerated.
However, standard handling precautions should be followed for the raw material.
Skin contact is usually well tolerated, but prolonged exposure to concentrated material may cause mild irritation in sensitive individuals.
Symptoms may include slight redness or discomfort.
Protective gloves are recommended during bulk handling.
Eye contact may cause mild irritation.
Exposure can result in temporary redness or watering.
Eyes should be rinsed thoroughly with water if contact occurs.
Inhalation risk is low, as the material is typically handled as an oily or waxy substance.
However, mists or aerosols in industrial settings may cause slight respiratory irritation.
Adequate ventilation should be maintained.
Ingestion is considered low toxicity, but large amounts may cause gastrointestinal discomfort.
Ascorbyl Isostearate is not intended for oral consumption unless specifically approved.
Medical advice should be sought if significant ingestion occurs.
Ascorbyl isostearate is not highly flammable, but it can burn if exposed to strong heat or open flame.
Thermal decomposition may produce carbon oxides and other organic fumes.
Standard fire safety precautions should be followed.
