PRODUCTS

AZELAIC ACID

Azelaic Acid is used as a thickening agent in polymer industries.
Azelaic Acid is also used in the inhibition of microbial cellular protein synthesis.
Azelaic acid applications span numerous industries, as the chemical is highly favored for its status as a dicarboxylic acid.

CAS Number: 123-99-9
EC Number: 204-669-1
MDL number: MFCD00004432
Linear Formula: HO2C(CH2)7CO2H
Molecular Formula: C9H16O4

SYNONYMS:
Azelaic Acid, Nonanedioic Acid, 1,7-Heptanedicarboxylic Acid, Lepargylic Acid, Azelaic Acid Powder, 1,9-Nonanedioic Acid, Heptylcarboxylic Acid, Azelainic Acid, azelaic acid, finacea, anchoic acid, azelex, lepargylic acid, skinoren, 1,7-heptanedicarboxylic acid, heptanedicarboxylic acid, 1,9-nonanedioic acid, emerox 1110, Nonanedioic acid, Anchoic acid, Emerox 1144, Lepargylic acid, 1,7-Heptanedicarboxylic acid, Heptanedicarboxylic acid, Azelainic acid, Azelaic acid, technical grade, Emerox 1110, 1,9-Nonanedioic acid, 1,7-Dicarboxyheptane, n-Nonanedioic acid, Emery's L-110, Skinoren, ZK-62498, Finacea, NSC 19493
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Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Azelaic Acid is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin.
Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.

Azelaic Acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Azelaic Acid is an alpha,omega-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.

Azelaic Acid has a role as an antibacterial agent, an antineoplastic agent, a dermatologic drug and a plant metabolite.
Azelaic Acid is a dicarboxylic fatty acid and an alpha,omega-dicarboxylic acid.
Azelaic Acid is a conjugate acid of an azelaate(2-) and an azelaate.

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Azelaic Acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.

Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Azelaic acid is a metabolite found in or produced by Escherichia coli.
The physiologic effect of azelaic acid is by means of Decreased Protein Synthesis, and Decreased Sebaceous Gland Activity.

Azelaic acid has been reported in Tuber indicum, Streptomyces nigra, and other organisms with data available.
Azelaic Acid is a naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products.
Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins.
Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers.

Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical.
This drug is used topically to reduce inflammation associated with acne and rosacea.
Azelaic Acid is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 1995 and has 3 approved and 3 investigational indications.

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Azelaic Acid is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Azelaic Acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.

Azelaic Acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Azelaic acid is a dicarboxylic acid molecule with anti-inflammatory and antioxidant properties, effective in the treatment of acne vulgaris and papulopustular rosacea, among other cutaneous conditions.

Azelaic acid is a naturally occurring by-product of the metabolism of the yeast Malassezia furfur (also known as Pityrosporum ovale).
Azelaic acid is a dicarboxylic acid derived from grains like wheat and barley.
Azelaic Acid’s both an acid and an antioxidant!

Azelaic Acid inhibits the growth of acne-causing bacteria and is a natural exfoliator that reduces the buildup of dead skin cells.
In addition to all of this, azelaic acid has excellent anti-inflammatory properties and targets pigments that create hyperpigmentation.
Azelaic acid (AzA) is an organic compound with the formula HOOC(CH2)7COOH.

This saturated dicarboxylic acid, Azelaic Acid, exists as a white powder.
Azelaic Acid is found in wheat, rye, and barley.
Azelaic Acid is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners.

Azelaic Acid inhibits tyrosinase.
Azelaic acid was once one of the best kept secrets in skin care, mostly known in medical and professional settings.
Now Azelaic Acid’s one of the more highly sought-after ingredients thanks to undeniable research demonstrating how it significantly diminishes the appearance of skin blemishes, helps fade post-acne marks and other discolorations, refines skin’s surface and even reduces sensitivity.

In short, azelaic acid is an ingredient you need to know about.
Azelaic Acid is a type of acid that's found in some grains like rye, wheat, and barley.
Azelaic Acid's naturally produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast found on healthy skin.

Azelaic acid is a potent skin care ingredient because it can help treat common issues such as acne and rosacea.
Azelaic acid is a skin-friendly dicarboxylic acid with unique properties that works by inhibiting misbehaving elements on and within skin's uppermost layers.

Left unchecked, these troublemakers lead to persistent, visible skin imperfections (like brown patches and post-blemish marks), dull skin tone and signs of sensitivities.
Essentially, azelaic acid has a radar-like ability to interrupt or inhibit what's causing skin to act up.

Skin "hears" the message azelaic acid sends and responds favorably, which leads to skin that looks better, no matter your age, skin type, or concerns.
Azelaic acid can be derived from grains like barley, wheat, and rye.
However, the lab-engineered form is typically used in skin care formulas because of Azelaic Acid's greater stability and effectiveness.

Azelaic acid is a naturally occurring acid found in grains such as barley, wheat, and rye.
Azelaic Acid has antimicrobial and anti-inflammatory properties, which make it effective in the treatment of skin conditions like acne and rosacea.
Azelaic Acid can prevent future outbreaks and clean bacteria from your pores that causes acne.

Azelaic acid is applied to your skin and is available in gel, foam, and cream form.
Because it takes some time to take effect, azelaic acid by itself isn’t typically a dermatologist’s first choice for treating acne.
Azelaic Acid also has some side effects, such as skin burning, dryness, and peeling.

Keep reading to find out everything you need to know about using azelaic acid for acne.
Azelaic acid (AZA) is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH).
Azelaic Acid possesses a variety of biological actions both in vitro and in vivo.

Interest in the biological activity of Azelaic Acid arose originally out of studies of skin surface lipids and the pathogenesis of hypochromia in pityriasis versicolor infection.
Later, Azelaic Acid was shown that Pityrosporum can oxidize unsaturated fatty acids to C8-C12 dicarboxylic acids that are cornpetitive inhibitors of tyrosinase in vitro.

Azelaic acid was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: it possesses a middle-range of antityrosinase activity, is inexpensive, and more soluble to be incorporated into a base cream than other dicarboxylic acids.
Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris.

Azelaic Acid offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl peroxide and with less irritation than tretinoin.
Azelaic acid is less expensive than certain other prescription acne preparations, but it is much more expensive than nonprescription benzoyl peroxide preparations.

Whether Azelaic Acid is safe and effective when used in combination with other agents is not known
Azelaic acid is a highly effective and versatile ingredient found in many skincare products.
Azelaic Acid is naturally found in the plant environment and can be produced on the surface of healthy skin by Malassezia furfur.

When used topically, azelaic acid has been shown to be beneficial in treating a wide range of skin concerns, including acne, rosacea and post-inflammatory hyperpigmentation.
Azelaic Acid belongs to the class of organic compounds known as medium-chain fatty acids.

These are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms.
Azelaic acid, alternatively called nonanedioic acid and available through Acme-Hardesty under the name Matrilox LA001M, is a saturated dicarboxylic acid with a chemical structure of (CH2)7(CO2H)2.

Azelaic Acid, sold as a fine white powder, is derived primarily from wheat, rye and barley.
Acme-Hardesty is an authorized azelaic acid distributor, providing a product that is made from environmentally friendly, sustainable sources.
Azelaic acid is a naturally occurring compound produced by a yeast called Malassezia furfur.

For industrial applications, purified azelaic acid is made by the ozonolysis of oleic acid.
Acme-Hardesty’s product is fully European in origin and derived from oils obtained from sustainably produced vegetable crops.
As a result, Azelaic Acid is fully vegetarian and both GMO- and BSE/TSE-free.

Azelaic Acid is also free of common allergens such as tree nuts, peanuts, dairy and gluten.
Azelaic acid (nonanedioic acid) is a dicarboxylic acid occurring as a white crystalline powder, available in varying degrees of purity depending on the final application.

Azelaic acid is a nine-carbon dicarboxylic acid.
Azelaic Acid comes as white to light yellow monocline rhombus crystals or needle like crystals or powder.
Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.

USES and APPLICATIONS of AZELAIC ACID:
Azelaic Acid is used as a thickening agent in polymer industries.
In the medical industry, Azelaic Acid is used to cure mild to moderate acne and skin pigmentation.
Azelaic Acid is also used in the inhibition of microbial cellular protein synthesis.

Azelaic Acid treats rosacea.
Azelaic Acid works by decreasing inflammation and killing or preventing the growth of bacteria on your skin.
Azelaic acid applications span numerous industries, as the chemical is highly favored for its status as a dicarboxylic acid.

Some of the most common applications of azelaic acid include the following:
Cosmetics: Azelaic Acid is used in skincare products for acne, rosacea, and hyperpigmentation treatment due to its antimicrobial and anti-inflammatory effects.

Pharmaceuticals uses of Azelaic Acid: Active ingredient in topical creams for skin conditions.
Industrial Applications uses of Azelaic Acid: Component in the production of polyesters and nylons.
Azelaic Acid is used plasticizer in polymers.

Azelaic Acid is used intermediate in lubricants and corrosion inhibitors.
Food Industry: Azelaic Acid is rarely used as an antibacterial preservative.
Azelaic acid gel and foam is used to clear the bumps, lesions, and swelling caused by rosacea (a skin disease that causes redness, flushing, and pimples on the face).

Azelaic acid cream is used to treat the pimples and swelling caused by acne.
Azelaic acid is in a class of medications called dicarboxylic acids.
Azelaic Acid works to treat rosacea by decreasing the swelling and redness of the skin.

Azelaic Acid works to treat acne by killing the bacteria that infect pores and by decreasing production of keratin, a natural substance that can lead to the development of acne.
Azelaic acid, extracted from grains such as wheat, rye and barley, is a versatile ingredient used in skin care to treat inflammatory lesions related to acne and rosacea, post-hyperpigmentation inflammatory and hyperkeratosis.

Azelaic Acid's anti-inflammatory properties make it a valuable ally for skin with acne or rosacea, it reduces the number of lesions and reduces redness.
Azelaic Acid is effective in treating hyperpigmentation by acting on melanin production and is therefore used to reduce post-inflammatory lesions
Azelaic acid topical cream is used to treat mildly to moderately inflamed acne.

The topical foam and gel are used to treat mild to moderate rosacea.
For acne, Azelaic Acid works by killing the bacteria that cause acne and by keeping the skin pores clean.
Azelaic Acid is available in the following dosage forms: Cream, Foam, and Gel/Jelly.

Cosmetics uses of Azelaic Acid: Treatment of acne, rosacea, and hyperpigmentation due to its antimicrobial and anti-inflammatory properties
Pharmaceuticals uses of Azelaic Acid: Active ingredient in topical skin treatments and creams
Industrial: Azelaic Acid is used in the production of lubricants, plasticizers, and polymers

Food Industry uses of Azelaic Acid: Occasionally employed as a preservative due to its mild antibacterial activity
Other uses for Azelaic acid is also used for other skin conditions, such as hyperpigmentation, rosacea, and skin lightening.
The innovative production process makes Azelaic Acid possible to obtain azelaic acid with very high purity and low monocarboxylic content.

These characteristics are fundamental for Azelaic Acid's use as an intermediate in polymerization processes, typically as an alternative to sebacic and adipic acids.
Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals.

Azelaic Acid is used as a raw material for the production of plasticizer dioctyl nonanediate and perfume, lubricating oil, oil agent, polyamide resin
Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis.

-Azelaic acid for acne scars:
Some people use azelaic to treat acne scarring in addition to active outbreaks.
Azelaic acid encourages cell turnover, which is a way to reduce how severe scarring appears.

Azelaic Acid also prevents what’s known as melanin synthesis, the ability of your skin to produce pigments that can vary your skin’s tone.
If you’ve tried other topical medications to help with scarring or blemishes that’re slow to heal, azelaic acid might help.
More research is needed to understand who this treatment works best for and how effective it can be.

-Azelaic acid for hyperpigmentation:
After a breakout, inflammation can result in hyperpigmentation on some areas of your skin.
Azelaic acid stops discolored skin cells from populating.

A pilot study from 2011 showed azelaic acid can treat acne while evening out hyperpigmentation triggered by acne.
Further research on skin of color has also shown that azelaic acid is safe and beneficial for this use.

-Azelaic acid for skin lightening:
The same property that makes azelaic acid effective for the treatment of inflammatory hyperpigmentation also enables it to lighten skin that’s discolored by melanin.
Using azelaic acid for skin lightening in patchy or blotchy areas of your skin due to melanin has been found effective, according to an older study.

-Azelaic acid for rosacea:
Azelaic acid can reduce inflammation, making it an effective treatment for symptoms of rosacea.
Clinical studies demonstrate that azelaic acid gel can continually improve the appearance of swelling and visible blood vessels caused by rosacea.

Azelaic acid is a multifunctional skincare ingredient derived from grains that gently helps clear acne and rosacea prone skin while also reducing redness and brown spots for a flawless complexion.

-Medical use sof Azelaic Acid:
Azelaic acid is an active ingredient in many topical creams and other prescription treatments for light-to-moderate acne.
Like other dicarboxylic acids, Azelaic Acid is effective at killing acne-causing bacteria and decreasing keratin production.

Azelaic Acid’s also effective at reducing inflammation, making it a good treatment for rosacea and other inflammatory skin conditions.
Products containing azelaic acid are also used to treat rosacea, melasma and other skin pigmentation problems.

-Azelaic acid is a multifunctional biochemical agent role in inhibiting tyrosinase, an enzyme critical to melanin synthesis.
This inhibition is competitive, meaning azelaic acid can effectively reduce melanin production by competing with substrates for the enzyme′s active site.
Beyond its interaction with tyrosinase, azelaic acid displays significant antimicrobial activity, particularly against Propionibacterium acnes, a key bacterium in acne development.

Azelaic Acid achieves this through a dual mechanism: firstly, by disrupting the synthesis of vital nucleic acids such as DNA and RNA within the bacterial cells, thereby halting their proliferation; and secondly, by attenuating the pathogenicity of these organisms at a molecular level.
Azelaic acid impacts cellular processes related to inflammation and keratinization.

Azelaic Acid suppresses the release of pro-inflammatory cytokines like interleukin-8 and modulates the process of keratin production, which when excessive, contributes to the obstructive pathology of acne lesions.

-Polymers uses of Azelaic Acid:
Azelaic acid esters are used as a basic component of renewable and degradable plastics.
Because Azelaic Acid is derived entirely from plant sources, it is better for the environment than plastics produced wholly from fossil fuels.
Azelaic acid is also used to prepare PVC plasticizers.

-Lubricants and Corrosion Inhibitors:
Azelaic acid is a component of synthetic lubricants and corrosion inhibitors, and is frequently used as a thickening agent in lithium complex greases.
Within these applications, pelargonic acid poses mild hazards to human health and safety — Azelaic Acid can cause skin irritation and is an eye irritant.

In rare cases, Azelaic Acid can cause an allergic reaction, and consistent contact with the skin can result in lightening of skin color.
Azelaic Acid should not be ingested or inhaled.
Azelaic Acid should also be avoided during pregnancy, as there are some studies that link azelaic acid with developmental disorders.

-Uses of azelaic acid for acne
Azelaic acid works by:
*clearing your pores of bacteria that may be causing irritation or breakouts
*reducing inflammation so acne becomes less visible, less red, and less irritated
*gently encouraging cell turnover so your skin heals more quickly and scarring is minimized

-To use of Azelaic Acid the gel, foam, or cream, follow these steps:
Wash the affected skin with water and a mild soap or soapless cleansing lotion and pat dry with a soft towel.
Ask your doctor to recommend a cleanser, and avoid alcoholic cleansers, tinctures, abrasives, astringents, and peeling agents, especially if you have rosacea.

Shake the azelaic acid foam well before use.
Apply a thin layer of gel, or cream to the affected skin.
Gently and thoroughly massage it into the skin.

Apply a thin layer of foam to the entire face including cheeks, chin, forehead, and nose.
Do not cover the affected area with any bandages, dressings, or wrappings.

You may apply make-up to your face after the medication is dry.
Wash your hands with soap and water after you finish handling the medication.

-Azelaic acid can be used in gel, foam, or cream form.
All forms have the same basic instructions for use:
*Wash the affected area thoroughly with warm water and pat dry.
*Use a cleanser or mild soap to make sure the area is clean.

*Wash your hands before applying the medication.
*Apply a small amount of medication to the affected area, rub it in, and let it dry completely.
*Once the medication has dried, you can apply cosmetics. *There’s no need to cover or bandage your skin.

*Keep in mind that you should avoid using astringents or “deep-cleansing” cleansers while you use azelaic acid.
*Some people will need to apply the medication twice per day, but this will vary according to a doctor’s instructions.

-Azelaic acid uses for skin:
Azelaic acid’s many benefits lend themselves to a myriad of uses for skin.
The ingredient is often touted as the perfect way to tackle an uneven tone or dark spots but this glosses over azelaic acid’s penchant for calming redness and smoothing skin.

Beyond the different skin concerns that this multitasking ingredient works on, azelaic acid can also be delivered through both prescription and OTC (over-the-counter) products, depending on the percentage included in the product, as we’ve mentioned above.

-Dark Spots uses of Azelaic Acid:
Reducing the appearance of dark spots and an uneven tone is azelaic acid’s top claim to fame and why it’s often compared to vitamin C.

Azelaic acid conquers this concern by helping to interrupt an enzyme (tyrosinase) in skin's uppermost layers that would otherwise lead to uneven skin tone and dark spots.
Azelaic acid also helps reduce the appearance of dark spots that are incurred from previous inflammation, life changes, environmental damage and injury to skin.

-Whitening agent uses of Azelaic Acid:
Azelaic acid is used for treatment of skin pigmentation, including melasma and postinflammatory hyperpigmentation, particularly in those with darker skin types.

Azelaic Acid has been recommended as an alternative to hydroquinone.
As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin.
According to one report in 1988, azelaic acid in combination with zinc sulfate in vitro was found to be a potent (90% inhibition) 5α-reductase inhibitor, similar to the hair loss drugs finasteride and dutasteride.

In vitro research during mid-1980s evaluating azelaic acid's depigmenting (whitening) capability concluded it is effective (cytotoxic to melanocytes) at only high concentrations.

A 1996 review claimed 20% Azelaic Acid is as potent as 4% hydroquinone after a period of application of three months without the latter's adverse effects and even more effective if applied along with tretinoin for the same period of time.

-Redness uses of Azelaic Acid:
Although it’s billed as a dark spot buster, azelaic acid is also routinely used to help soothe and calm the redness that’s often associated with irritation and sensitivity as well as being suitable for rosacea- and eczema-prone skin.
Although more research needs to be done to examine exactly how this acid does so, studies have already shown azelaic acid assists in the decrease of visible redness on skin, and is even suitable for rosacea-prone skin

-Skin texture uses of Azelaic Acid:
As a dicarboxylic acid, azelaic acid also has mild exfoliating properties.
Through the usage of its keratolytic abilities, that is, the way that azelaic acid can break down the dead, dull outer layers of skin, it refines skin texture.
Consistent usage of azelaic acid can result in fewer clogged pores and bumps as well as a radiant, healthy look.

-Polymers and related materials use sof Azelaic Acid:
Esters of this dicarboxylic acid find applications in lubrication and plasticizers. In lubricant industries it is used as a thickening agent in lithium complex grease. With hexamethylenediamine, azelaic acid forms Nylon-6,9, which finds specialized uses as a plastic.[4]

-Medical uses of Azelaic Acid:
Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne.
Azelaic Acid belongs to a class of chemicals called dicarboxylic acids.

Azelaic Acid works by killing acne bacteria that infect skin pores.
Azelaic Acid also decreases the production of keratin, which is a natural substance that promotes the growth[clarification needed] of acne bacteria.

Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation.
Azelaic Acid clears the bumps and swelling caused by rosacea.

In topical pharmaceutical preparations and scientific research Azelaic Acid is typically used in concentrations between 15% and 20% but some research demonstrates that in certain vehicle formulations the pharmaceutical effects of 10% Azelaic acid has the potential to be fully comparable to that of some 20% creams

-Acne treatment uses of Azelaic Acid:
Azelaic acid is effective for mild to moderate acne when applied topically at a 15%-20% concentration.
In patients with moderate acne, twice daily application over 3 months of 20% Azelaic Acid significantly reduced the number of comedones, papules, and pustules; at this strength, it’s considered to be as effective as benzoyl peroxide 5%, tretinoin 0.05%, erythromycin 2%, and oral tetracycline at 500 mg-1000 mg.

In a comparative review of effects of topical Azelaic Acid, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid, AzA had more high-quality evidence of effectiveness than the rest.

Results can be expected after 4 weeks of twice-daily treatment.
The effectiveness of long term use is unclear, but it’s been recommended that Azelaic Acid be used for at least 6 months continuously for maintenance.

HOW SHOULD AZELAIC ACID BE USED?
Azelaic acid comes as a gel, foam, and a cream to apply to the skin.
Azelaic Acid is usually applied twice a day, in the morning and the evening.

To help you remember to use azelaic acid, use it at around the same times every day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Use azelaic acid exactly as directed.
Do not use more or less of it or use Azelaic Acid more often than prescribed by your doctor.

Be careful not to get azelaic acid in your eyes or mouth.
If you do get azelaic acid in your eyes, wash with plenty of water and call your doctor if your eyes are irritated.

BENEFITS OF AZELAIC ACID:
Some of the research on azelaic acid has looked at prescription-only topical products with concentrations between 15% and 20%, but there are incredible skin benefits to be seen even at lower concentrations.

*Mild exfoliating action that helps unclog pores and refine skin's surface
*Skin tone-evening properties to help fade post-acne marks and other discolorations
*Significant skin-calming factors to reduce sensitivity and bumps
*Antioxidant power that contributes to healthier-looking skin

The research on the unique way azelaic acid improves skin led us to formulate our 10% Azelaic Acid Booster.
The azelaic acid within targets a wide range of skin imperfections and is formulated with 0.5% salicylic acid for a bit of a pore-refining nudge.

The 10% Azelaic Acid Booster also contains a soothing complex of brightening plant extracts plus skin-restoring adenosine, an energizing ingredient that visibly reduces signs of aging.

PROPERTIES OF AZELAIC ACID:
*Azelaic Acid exhibits antimicrobial activity against Propionibacterium acnes
*Azelaic Acid inhibits the production of melanin, aiding in skin brightening
*Non-comedogenic and suitable for sensitive skin

BENEFITS OF AZELAIC ACID:
*Effective for reducing acne, redness, and post-inflammatory hyperpigmentation
*Gentle and well-tolerated alternative to harsher treatments like benzoyl peroxide or retinoids
*Derived from renewable sources (e.g., plant oils), making it eco-friendly

HOW TO USE AZELAIC ACID:
Azelaic acid products “play” well with others, meaning you can layer it into your routine without worrying that the azelaic acid will overpower or deactivate other ingredients.

If Azelaic Acid’s an over-the-counter product, apply once or twice daily.
If Azelaic Acid’s prescription strength, follow the advice of your prescriber.

In the case of 10% Azelaic Acid Booster, we recommend applying it after your normal cleansing, toning and exfoliating steps.
Azelaic Acid can be applied on its own or mixed into your favorite serum or non-SPF moisturizer.

It's fine to apply Azelaic Acid to the entire face, or you can target blemished areas as needed.
During the day, finish with a broad-spectrum sunscreen rated SPF 30 or greater.

FORMULA OF AZELAIC ACID:
Azelaic acid is an organic compound with a saturated dicarboxylic acid which is found in wheat, barley and rye.
Azelaic Acid is also known as nonanedioic acid.

Azelaic Acid can be obtained by the ozonolysis of oleic acid at an industry level and naturally, it can be produced by a yeast that is found on the skin called Malassezia furfur.

The property value of hydrogen bond acceptor and hydrogen bond donor are 2 and 4 respectively.
The rotatable bond count is 8.

ALTERNATIVE PARENTS OF AZELAIC ACID:
*Dicarboxylic acids and derivatives
*Carboxylic acids
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds

SUBSTITUENTS OF AZELAIC ACID:
*Medium-chain fatty acid
*Dicarboxylic acid or derivatives
*Carboxylic acid
*Carboxylic acid derivative
*Organic oxygen compound
*Organic oxide
*Hydrocarbon derivative
*Organooxygen compound
*Carbonyl group
*Aliphatic acyclic compound

PHYSICAL AND CHEMICAL PROPERTIES OF AZELAIC ACID:
Melting point 98-103°C
boiling point 286 ° C (100 mmHg)
flash point 215°C
water-soluble 2.4g/L (20°C)

AZELAIC ACID CAN BE USED IN COMBINATION WITH:
Azelaic Acid can be used in combination with other active ingredients such as Niacinamide (Niacinamide), Arbutin, and Superoxide Dismutase (SOD) to enhance its effectiveness.
When used in combination with these ingredients, Azelaic Acid can help to reduce the appearance of acne, rosacea, and PIH, while also brightening the skin and improving its overall texture and tone.

HOW OFTEN CAN YOU USE AZELAIC ACID:
Azelaic Acid should be used as part of the skincare regime.
Azelaic Acid’s most often used once a day in the evening and can be used in the morning or evening.

DO NOT USE AZELAIC ACID IF:
Azelaic acid should be used with care on thin, supersensitive, reactive, or irritated skin.
Azelaic Acid may be better to do a patch test on a small skin area in the elbow grease, before committing to azelaic acid.

Azelaic acid is not effective on freckles and age spots.
Universkin does not recommend layering azelaic acid with Alpha or Beta Hydroxy Acids as it will increase the risk of dryness and irritation.
In pregnant and breastfeeding women, it is recommended to consult a gynecologist before use.

ORIGINS OF AZELAIC ACID:
Azelaic acid is found in the plant environment, in wheat, rye, and barley for example, where it forms part of the defense system against certain pathogens.
Some fungi in the normal skin flora of the genus Pityrosporum (Malassezia furfur, also known as Pityrosporum ovale), are capable of synthesizing azelaic acid.
Universkin has selected a pure grade of synthetic azelaic acid.

CHEMICAL COMPOSITION OF AZELAIC ACID:
The name azelaic acid comes from the fact that it was originally produced by the oxidation of oleic acid with nitric acid.
Azelaic acid is a naturally occurring saturated dicarboxylic acid chemically known as 1,7-heptane dicarboxylic acid.
Azelaic acid is a white crystalline powder.

MECHANISM OF ACTION OF AZELAIC ACID:
Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

Azelaic Acid works by reducing the formation of acne by reducing the production of sebum and inhibiting the growth of Propionibacterium acnes (P. acnes), the bacteria that is responsible for causing acne and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins.

Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radicals, helping to reduce redness and irritation associated with acne and rosacea.

Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers.

Azelaic Acid exfoliates gently, removes dead cells, and avoids clogged pores and dull skin.
Azelaic Acid has proven depigmenting activity and is effective on post-inflammatory hyperpigmentation from acne breakouts and in darker skin.

BENEFITS OF AZELAIC ACID:
Azelaic acid is a multi-functional ingredient that provides numerous benefits for the skin.
Azelaic Acid is a highly effective ingredient against pimples and blemishes in acne-prone skin, as it has antibacterial properties that help to eliminate the bacteria that cause these conditions.

Azelaic Acid also helps to reduce redness and inflammation associated with cutaneous eruptions and is known to be particularly effective in reducing hyperpigmentation.
In addition to its antibacterial properties, azelaic acid has been shown to regulate the production of sebum and gently exfoliate the skin, making it a great choice for those with oily and dull skin.

STABILITY OF AZELAIC ACID:
Azelaic acid is a highly stable ingredient that is resistant to oxidation and degradation, making it a reliable and long-lasting ingredient for use in skincare products.
Azelaic Acid is poorly soluble in water and can be supplied in suspension.

In conclusion, azelaic acid is a highly effective and versatile ingredient that offers numerous benefits for the skin.
Whether you're looking to address acne or rosacea, improve the appearance of hyperpigmented skin, or enhance your skin's natural protective barrier, azelaic acid is a valuable addition to your skincare routine.

HANDLING AND STORAGE INFORMATION ABOUT AZELAIC ACID:
Azelaic Acid should be kept in a tightly closed container away from sources of heat, light and flames.
Exposure to any of these factors can cause degradation and damage to the material, as well as other hazards.
Long-term storage should be at temperatures between 16-40°C, in a dry and well-ventilated place.

As it is a powder, Azelaic Acid poses an explosive risk and should be handled with appropriate care.
Azelaic acid is a mild irritant.
Appropriate first aid procedures should be followed in the event of contact with the skin or eyes.

Wear protective clothing, safety glasses and a dust respirator at all times when handling azelaic acid powder.
Discard unused or spoiled product in accordance with local regulations and handle spills promptly.

PROPERTIES OF AZELAIC ACID:
*Azelaic Acid exhibits antimicrobial properties, particularly effective against acne-causing bacteria
*Azelaic Acid inhibits tyrosinase, which helps lighten hyperpigmented skin
*Stable under standard conditions

BENEFITS OF AZELAIC ACID:
*Safe for sensitive skin and non-comedogenic
*Azelaic Acid helps improve skin tone and texture
*Versatile applications in industrial and cosmetic fields
*Eco-friendly, as it can be derived from renewable resources like vegetable oils

CONCENTRATION OF AZELAIC ACID:
The concentration of Azelaic Acid in cosmetics typically ranges from around 10% while higher strengths are generally used in prescription topical products.

WHO SHOULD USE AZELAIC ACID:
Azelaic Acid is right for practically everyone, great for oily and combination skins.
Azelaic Acid may be a good alternative for anyone whose skin is not compatible with stronger actives against acne, rosacea, or post-inflammatory hyperpigmentation.

Azelaic acid should be applied with care on sensitive skin, on the eye contour, and around the lips.
Topical azelaic acid is well tolerated in comparison with standard topical anti-acne agents.

Azelaic Acid can be used by pregnant or breastfeeding women, but Universkin recommends checking with an obstetrician-gynecologist before incorporating azelaic acid into a skincare regimen.

Unlike other anti-acne actives, azelaic acid does not bleach clothing or towels.
Unlike other acids, azelaic acid does not make the skin sensitive to the sun.

WHAT IS AZELAIC ACID USED FOR?
Azelaic acid is predominantly used as a topical treatment for mild to moderate acne, and may be combined with oral antibiotics or hormonal therapy.
Azelaic Acid is useful for both comedonal and inflammatory acne vulgaris.
Azelaic acid, a tyrosine inhibitor, also helps reduce pigmentation, therefore is particularly useful for darker skinned patients whose acne spots leave persistent brown marks (postinflammatory pigmentation) or who have melasma.

HOW LONG DOES AZELAIC ACID TAKE TO WORK?
Like other bioactive ingredients, you’ll see results from the first application of an azelaic acid product.
A visible soothing of sensitivity is one of the benefits you’ll notice immediately.

A more robust picture of azelaic acid’s benefits, like the visible reduction of dark spots and uneven tone, appear after one to three months of consistent usage.
This assumes you’re also protecting your skin from UV light exposure by applying a broad-spectrum sunscreen rated SPF 30 or greater every day.

WHO COULD BENEFIT FROM AZELAIC ACID?
Azelaic acid is particularly beneficial for those with blemished skin and/or those with uneven tone and bumpy texture due to the ingredient’s ability to help visibly reduce the appearance of dark spots and rough texture.

Those prone to redness and the discomfort of eczema can also reap the benefits of azelaic acid, since it can also be used to calm sensitivity.
It’s even suitable for those struggling with rosacea.

WHO SHOULD STAY AWAY FROM AZELAIC ACID?
Adverse reactions and side effects to azelaic acid are not common, but as with any skin care ingredient, if you experience signs of irritation, stop use or experiment with applying less often (once every other day, for example).

WHO SHOULD USE AZELAIC ACID AND WHO SHOULD NOT?
Azelaic acid is a safe skin care ingredient that has widespread compatibility with all skin types and is typically well-tolerated, even by those with sensitive skin.
Its multitasking abilities mean Azelaic Acid’s sought after by those with varying skin concerns as well.

BENEFITS OF AZELAIC ACID:
Here's how azelaic acid can help your skin:
*Azelaic Acid kills bacteria that cause acne.
Experts aren’t exactly sure how this happens, but using a cream with 15%-20% azelaic acid has been found to be effective.

*Azelaic Acid protects your skin.
Free radicals can damage cells, leading to skin inflammation and acne.
Because azelaic acid is an antioxidant, it can defend your body against the harmful effects of these toxins.

*Azelaic Acid keeps your pores from getting clogged.
Acne is caused by a buildup of dead skin cells and sebum (oil).
Azelaic acid can help keep your pores open, making your skin less inflamed and new pimples less likely to form.

*Azelaic Acid can prevent dark patches.
Certain skin cells make pigment when you expose your skin to sunlight.

That pigment may show up as dark patches, called hyperpigmentation, on your skin.
Azelaic acid can block this process.

*Azelaic Acid can reduce redness.
Azelaic acid can also help prevent the widening of your blood vessels, thereby minimizing the redness of your skin.

Most research focuses on prescription-strength azelaic acid. You can find over-the-counter products and creams with 10% or less azelaic acid, but it’s still a good idea to check with your doctor before using these products.

PRODUCTION OF AZELAIC ACID:
Azelaic acid is industrially produced by the ozonolysis of oleic acid.
The side product is nonanoic acid.
Azelaic Acid is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
The bacterial degradation of nonanoic acid gives azelaic acid.

BIOLOGICAL FUNCTION OF AZELAIC ACID:
*Plants biology
In plants, azelaic acid serves as a "distress flare" involved in defense responses after infection.
Azelaic Acid serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.

*Human biology
The mechanism of action in humans is thought to be through the inhibition of hyperactive protease activity that converts cathelicidin into the antimicrobial skin peptide LL-37.

AZELAIC ACID AND ROSACEA:
Rosacea is a common skin condition. In the early stages, your face may flush.
Over time, you can start to have more symptoms, and your skin can get very sensitive.
For instance, it could burn or sting when you use a skin care product, or you could get acne-like breakouts.

Rosacea can also start to affect your eyes.
Researchers haven't yet found the exact cause of rosacea, but several factors are likely involved, including an overactive immune system and an issue with your nerves and blood vessels.

You can get rosacea no matter what your skin tone is.
Once you have it, there's no cure.
Instead, you'll need to take steps to prevent flare-ups of your symptoms.

Azelaic acid cream, gel, foam, or lotion can help with the red bumps and pimples that are caused by rosacea.
This treatment doesn't start working right away.
Some people don't see results for weeks.

But multiple studies have shown that about 70%-80% of people see their rosacea symptoms improve.
To help improve your skin, your doctor might also prescribe another medicine at the same time.

AZELAIC ACID VS. SALICYLIC ACID:
Azelaic acid vs. salicylic acid
Many skin care products contain salicylic acid, which is a different type of acid.
Salicylic acid softens a protein in your skin called keratin. This can help keep your pores from getting clogged, reducing the occurrence of pimples.

Azelaic acid not only unclogs pores but also helps kill acne-causing bacteria on your skin.
Azelaic Acid can also even out your skin tone by getting rid of free radicals, toxins that can damage your cells.
Generally speaking, salicylic acid works deep inside your pores, while azelaic acid largely works on the surface of your skin.

FORMS OF AZELAIC ACID:
Azelaic acid can be prescribed in a few different forms.

*Azelaic acid cream:
Your doctor might suggest this type to help clear up your acne.
You'll probably be told to wash and gently dry your skin, then apply a thin layer to the affected area, twice a day.
Kids younger than 12 will get different instructions.

*Azelaic acid gel:
A gel or jelly form of Azelaic Acid is typically prescribed to improve rosacea.
Like the cream, Azelaic Acid's often also applied twice a day, and children under 12 usually need a smaller, safer dose.

*Azelaic acid serum:
You can find azelaic acid in some skin care products, such as face serums.
These are designed to be used before moisturizers.
They contain high amounts of azelaic acid and can sink into your skin quickly.

OTHER FORMS OF AZELAIC ACID:
You could also find azelaic acid in some soaps or get it prescribed as a foam.
The foam is often used to treat rosacea.
Because Azelaic Acid's flammable, you'll need to avoid smoking and open flames after you apply it.
Prescription products usually have 15%-20% azelaic acid, while over-the-counter versions have less.

PHYSICAL and CHEMICAL PROPERTIES of AZELAIC ACID:
CAS: 123-99-9
EINECS: 204-669-1
InChI: InChI=1/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)/p-2
InChIKey: BDJRBEYXGGNYIS-UHFFFAOYSA-N
Molecular Formula: C9H16O4
Molar Mass: 188.22
Density: 1.029 g/cm3
Melting Point: 98 °C
Boiling Point: 286°C 100mm Hg (lit.)
Flash Point: 215 °C

Water Solubility: 2.4 g/L (20 ºC)
Solubility: Soluble in boiling water and ethanol,
soluble in organic solvents,
slightly soluble in benzene
Vapor Pressure: <1 mm Hg (20 °C)
Vapor Density: 6.5 (vs air)
Appearance: White flakes
Color: White to slightly yellow
Merck: 14,905
BRN: 1101094

pKa: 4.53, 5.33 (at 25℃)
pH: 3.5 (1g/l, H2O)
Storage Condition: Store below +30°C
Stability: Stable.
Incompatible with bases, strong oxidizing agents.
Readily biodegrades in soil and water with >70% DOC reduction after 28 days
Sensitive: Easily absorbing moisture
Refractive Index: 1.4303
MDL: MFCD00004432
Density: 1.029 g/mL

Molar Volume: 182.9 mL/mol
Refractive Index: 1.428
Molecular Refractive Power: 47.06 mL/mol
Dipole Moment: 2.35 D
Melting Point: 106 °C
Boiling Point: 357 °C
MeSH: Antineoplastic Agents
CAS RN: [123-99-9]
Formula: C9H16O4; 188.22 g/mol

InChiKey: BDJRBEYXGGNYIS-UHFFFAOYSA-N
SMILES: OC(=O)CCCCCCCC(O)=O
IUPAC Name: Nonanedioic acid
Molecular Formula: C9H16O4
Molecular Weight: 188.223 g/mol
Melting Point: 109 to 111℃
Boiling Point: 286℃
Density: 1.443 g/mL
Solubility in Water: 2.14 g/L
Appearance: White solid
Refractive Index: 1.4303 at 111℃

Chemical Name: Nonanedioic Acid
Molecular Formula: C9H16O4
Molecular Weight: 188.22 g/mol
EC Number: 204-669-1
CAS Number: 123-99-9
Appearance: White crystalline powder
Density: ~1.29 g/cm³
Melting Point: 106-109°C
Boiling Point: Decomposes before boiling
Flash Point: >200°C (closed cup)
Solubility: Slightly soluble in water, soluble in alcohols and organic solvents
Odor: Odorless
Chemical Name: Azelaic Acid

Molecular Formula: C9H16O4
Molecular Weight: 188.22 g/mol
EC Number: 204-669-1
CAS Number: 123-99-9
Appearance: White crystalline powder
Density: ~1.29 g/cm³
Melting Point: 106-109°C
Boiling Point: Decomposes before boiling
Flash Point: >200°C (closed cup)
Solubility: Slightly soluble in water, soluble in ethanol and acetone
Odor: Odorless
Chemical Formula: C9H16O4

Molar Mass: 188.22 g/mol
Appearance: White solid
Density: 1.443 g/mL
Melting Point: 109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling Point: 286 °C (547 °F; 559 K) at 100 mmHg
Solubility in Water: 2.14 g/L
Acidity (pKa): 4.550, 5.498
Molecular Weight: 188.22 g/mol
XLogP3: 1.6
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4

Rotatable Bond Count: 8
Exact Mass: 188.10485899 g/mol
Monoisotopic Mass: 188.10485899 g/mol
Topological Polar Surface Area: 74.6 Å²
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 147
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Linear Formula: HO2C(CH2)7CO2H
CAS Number: 123-99-9
Molecular Weight: 188.22
Beilstein: 1101094
EC Number: 204-669-1
MDL Number: MFCD00004432
UNSPSC Code: 12162002
PubChem Substance ID: 24278221

CAS Index Name: Nonanedioic acid
Molecular Formula: C9H16O4
Molecular Weight: 188.22
Lipid Number: C9:0
SMILES: O=C(O)CCCCCCCC(=O)O
Isomeric SMILES: C(CC(O)=O)CCCCCC(O)=O
InChI: InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChIKey: InChIKey=BDJRBEYXGGNYIS-UHFFFAOYSA-N
CAS Number: 123-99-9
EC Number: 204-669-1

Hill Formula: C₉H₁₆O₄
Chemical Formula: HOOC(CH₂)₇COOH
Molar Mass: 188.22 g/mol
HS Code: 2917 13 90
Boiling Point: 237 °C (20 hPa)
Density: 1.029 g/cm³ (20 °C)
Flash Point: 215 °C
Melting Point: 107 °C
pH Value: 3.5 (1 g/l, H₂O)
Vapor Pressure: <1 hPa (20 °C)
Solubility: 2.4 g/l
Chemical Formula: C9H16O4

Average Molecular Weight: 188.2209
Monoisotopic Molecular Weight: 188.104859
IUPAC Name: Nonanedioic acid
Traditional Name: Azelaic acid
CAS Registry Number: 123-99-9
SMILES: OC(=O)CCCCCCCC(O)=O
InChI Identifier: InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI Key: BDJRBEYXGGNYIS-UHFFFAOYSA-N
IUPAC: AZELAICACID
CAS Number: 123-99-9
Molecular Weight: 188.223

Formula: C9H16O4
SMILES: OC(=O)CCCCCCCC(O)=O
Preferred IUPAC Name: Nonanedioic acid
InChIKey: InChIKey=BDJRBEYXGGNYIS-UHFFFAOYSA-N
Purity: ≥98%
Storage: Powder: -20 °C, 3 years; 4 °C, 2 years. In solvent: -80 °C, 2 years; -20 °C, 1 year
Molecular Weight: 188.22
Molecular Formula: C9H16O4
CAS No.: 123-99-9
Appearance: Solid
Solubility: Soluble in DMSO and H2O

CAS 123-99-9
Color: White
Assay Percent Range: 85 to 90%
Molecular Formula: C9H16O4
Linear Formula: HOOC(CH2)7COOH
InChI Key: BDJRBEYXGGNYIS-UHFFFAOYSA-N
SMILES: C(CCCC(=O)O)CCCC(=O)O
IUPAC Name: Nonanedioic acid
Molecular Weight (g/mol): 188.223
PubChem CID: 2266
ChEBI: CHEBI:48131

Formula Weight: 188.22
Percent Purity: ≥85%
Grade: Technical
Infrared Spectrum: Authentic
Packaging: Plastic bottle
Physical Form: Flakes
Chemical Name or Material: Azelaic acid, tech., 85-90%
Molecular formula: C9H16O4
Molecular weight: 188.22
Lipid number: C9:0
Smiles: O=C(O)CCCCCCCC(=O)O

Isomeric Smiles: C(CC(O)=O)CCCCCC(O)=O
InChI: InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChIKey: InChIKey=BDJRBEYXGGNYIS-UHFFFAOYSA-N
CAS number: 123-99-9
EC number: 204-669-1
Hill Formula: C₉H₁₆O₄
Chemical formula: HOOC(CH₂)₇COOH
Molar Mass: 188.22 g/mol
HS Code: 2917 13 90
Boiling point: 237 °C (20 hPa)
Density: 1.029 g/cm3 (20 °C)
Flash point: 215 °C

Melting Point: 107 °C
pH value: 3.5 (1 g/l, H₂O)
Vapor pressure: <1 hPa (20 °C)
Solubility: 2.4 g/l
Chemical Formula: C9H16O4
Average Molecular Weight: 188.2209
Monoisotopic Molecular Weight: 188.104859
IUPAC Name: nonanedioic acid
Traditional Name: azelaic acid
CAS Registry Number: 123-99-9

SMILES: OC(=O)CCCCCCCC(O)=O
InChI Identifier: InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChI Key: BDJRBEYXGGNYIS-UHFFFAOYSA-N
IUPAC: AZELAICACID
CAS Number: 123-99-9
Molecular Weight: 188.223
Formula: C9H16O4
SMILES: OC(=O)CCCCCCCC(O)=O
Preferred IUPAC Name: NONANEDIOIC ACID
InChIKey: InChIKey=BDJRBEYXGGNYIS-UHFFFAOYSA-N
Purity: ≥98%

Storage: Powder: -20 °C, 3 years; 4 °C, 2 years.
In solvent: -80 °C, 2 years; -20 °C, 1 year
Molecular Weight: 188.22
Molecular Formula: C9H16O4
CAS No.: 123-99-9
Appearance: Solid
Solubility: Soluble in DMSO and H2O
CAS: 123-99-9
Color: White
Assay Percent Range: 85 to 90%
Molecular Formula: C9H16O4
Linear Formula: HOOC(CH2)7COOH

InChI Key: BDJRBEYXGGNYIS-UHFFFAOYSA-N
SMILES: C(CCCC(=O)O)CCCC(=O)O
IUPAC Name: nonanedioic acid
Molecular Weight (g/mol): 188.223
PubChem CID: 2266
ChEBI: CHEBI:48131
Formula Weight: 188.22
Percent Purity: ≥85%
Grade: Technical
Quantity: 25 g
Infrared Spectrum: Authentic
Packaging: Plastic bottle
Physical Form: Flakes
Chemical Name or Material: Azelaic acid, tech., 85-90%

FIRST AID MEASURES of AZELAIC ACID:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of AZELAIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of AZELAIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of AZELAIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of AZELAIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of AZELAIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available