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Bakuchiol oil is a potent antioxidant and anti-aging ingredient used in a wide variety of cosmetics and skin care products.
Bakuchiol oil has the unique ability to treat skin discoloration caused by environmental exposure.
Further, Bakuchiol oil fights the visible signs of aging such as wrinkles, and gives a youthful glow to the skin.
CAS: 10309-37-2
MF: C18H24O
MW: 256.38
EINECS: 685-515-4
Synonyms
BAKUCHIOL;P-(3,7-DIMETHYL-3-VINYLOCTA-TRANS-1,6-DIMETHYL) PHENOL;7-dimethyl-1,6-octadienyl)-4-(3-ethenyl-(s-(e))-pheno;BACTRIS GASIPAES FRUIT JUICE;(S)-Bakuchiol;4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadienyl]phenol;4-[(1E,3S)-3-Vinyl-3,7-dimethyl-1,6-octadienyl]phenol;4-[(S,E)-3-Ethenyl-3,7-dimethyl-1,6-octadienyl]phenol
Bakuchiol oil is better than retinol as it does not cause any side effects even though it may produce slower results.
Additionally, Bakuchiol oil is great for sensitive skin types and can be used by pregnant women without worries.
The Indian name of Bakuchiol oil is bakuchi or babchi.
Bakuchi Oil is extracted from the seeds of the Psoralea Corylifolia plant and is commonly used in lotions, hair care, anti-ageing products and emulsions.
Bakuchiol oil is fast growing in the skincare industry, as it is believed to act as a natural retinol alternative.
Bakuchiol oil is much gentler on the skin and doesn’t cause dryness and irritation that is commonly found with retinol use.
Because Bakuchiol oil is plant-based, it is also a clean and natural vegan alternative.
In addition to this, Bakuchiol oil's also reported to possess antibacterial, antioxidant, anti-inflammatory and antifungal activities.
Bakuchiol oil is obtained from the Bakuchi plant which is native to South Asia.
Bakuchiol oil is pressed directly from the leaves and has been used in Chinese medicine for generations.
In recent years Bakuchiol oil has been tested and used in Western medicine and cosmetics due to its skin improving qualities.
Bakuchiol oil is a natural terpenoid antioxidant.
Bakuchiol oil has the follow effects:
1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.
2.Protects against acute lung injury.
3.Displays neuroprotective and anti-inflammatory effects.
Bakuchiol oil is a phytoestrogen that can be obtained from psoralen seeds.
Bakuchiol oil has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2), with IC50s values of 40.9 μM and 7.28 μM, respectively.
Bakuchiol oil exhibits significant research and application potential in areas such as anti-inflammatory, antibacterial, antitumor therapies, as well as drug metabolism regulation.
Bakuchiol oil is a natural compound extracted from the seeds and leaves of the plant Psoralea corylifolia, commonly known as babchi.
Bakuchiol oil is a meroterpenoid, which means it has a partial terpenoid structure.
Bakuchiol oil has gained significant attention in recent years due to its broad range of biological and pharmacological properties, including antioxidant, anti-inflammatory, and anti-aging effects.
Bakuchiol oil is a phenolic substance extracted from the herb psoralen.
Bakuchiol oil is the main component of the commonly used traditional Chinese medicine psoralen volatile oil, accounting for more than 60%.
Bakuchiol oil is an isoprenylphenol terpenoid compound.
Bakuchiol oil Chemical Properties
Boiling point: 391℃
Density: 0.963
Vapor pressure: 0Pa at 25℃
Refractive index: 1.4500 (estimate)
Fp: 177℃
Storage temp.: Inert atmosphere,Store in freezer, under -20°C
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Form: Liquid
pka: 10.10±0.26(Predicted)
Color: Oil
Optical activity: [α]/D +24.0 to +30.0°, c = 0.1 in chloroform
BRN: 3611720
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey: LFYJSSARVMHQJB-WYMLVPIESA-N
LogP: 5.09 at 20℃ and pH6.31
Surface tension: 43.92mN/m at 1g/L and 20℃
Uses
Bakuchiol oil is widely used in the cosmetic industry for its anti-aging, antioxidant, and anti-inflammatory properties.
Bakuchiol oil serves as a gentle alternative to retinol, offering similar benefits without the associated irritation.
Bakuchiol oil promotes collagen production, reducing the appearance of fine lines and wrinkles, and improves skin elasticity.
Bakuchiol oil also helps to even out skin tone, reduce hyperpigmentation, and combat acne by inhibiting bacterial growth.
Additionally, Bakuchiol oil's antioxidant properties protect the skin from environmental stressors and oxidative damage, making it a valuable ingredient in various skincare products such as serums, creams, and moisturizers.
Bakuchiol oil works to soothe and help heal your skin and has the ability to reduce fine lines and wrinkles.
Bakuchiol oil can also even the skin tone, improving the skins texture.
Bakuchiol oil aids in reducing dark spots, brightening the face, and treating hyperpigmentation.
Known to improve hair conditioning and shine, Bakuchiol oil is rich in omega 6, 7 and 9 fatty acids.
Bakuchiol oil is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa.
An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects.
Studies have shown that Bakuchiol oil is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.
1.Regulate retinoic acid receptors and related downstream genes.
2.Promote collagen production
3.Oil control and anti-acne effects: down-regulate 5α-reductase, inhibit matrix metalloproteinases, inhibit lipid peroxidation; inhibit acne bacteria, staphylococcus aureus, etc., inhibit NFKD pro-inflammatory factors, and soothe inflammatory reactions.
4.Regulate the expression of aquaporin
5.Anti-aging and anti-wrinkle effects: Inhibits matrix metalloproteinases, eliminates free radicals, accelerates cell renewal, promotes the growth of collagen, and reduces wrinkles.
Biological Activity
Bakuchiol oil has various pharmacological effects such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, antidiabetic, cardioprotective, and estrogen-like effects.
Bakuchiol oil exhibits antimicrobial activity against oral microorganisms such as Streptococcus mutans.
Bakuchiol oil is also a DNA polymerase inhibitor and showed anti-tumour activity in human lung adenocarcinoma A549 cells.
Bakuchiol oil showed hepatoprotective activity in vitro and in vivo against liver injury in rats.
Bakuchiol oil is a phytoestrogens from psoralea seeds that have anti-tumor and other effects.
Mode of action
The research found that Bakuchiol oil upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI.
Bakuchiol oil promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis.
In addition, Bakuchiol oil exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN).
BAK (60mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions.
