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Bakuchiol Oil is photochemically and hydrolytically stable and can be used during the day.
Bakuchiol Oil is an effective vitiligo treatment and also treats related skin diseases and conditions.
Bakuchiol Oil works as an anti-inflammatory and an antioxidant so those who suffer from dry, sensitive skin and can't tolerate a retinol can use it in all cosmetics.
CAS Number: 10309-37-2
EC Number: 685-515-4
Molecular formula: C₁₈H₂₄O
Molar mass (average): ~ 256.38 g/mol
SYNONYMS:
4-[(1E,3S)-3-Ethenyl-3,7-dimethylocta-1,6-dien-1-yl]phenol, (+)-Bakuchiol, Bakuchiol, (S)-(+)-Bakuchiol, Backuchiol, Drupanol, (S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol, UP 256, Psoralenolum
Bakuchiol Oil is a plant-derived skincare ingredient to help you take on the signs of ageing.
From Bakuchiol Oil’s skin benefits to how to incorporate it into your routine, find out everything you need to know about this natural ingredient.
Bakuchiol Oil, a meroterpene, is the first natural alternative to retinol without having any of the negatives associated with retinol.
Bakuchiol Oil modulates retinoid-binding and metabolizing genes.
Bakuchiol Oil is a vegan skincare ingredient found in the leaves and seeds of the Psoralea corylifolia plant.
Bakuchiol Oil is a potent antioxidant, visibly reduces skin discolourations from environmental exposure, and has a pronounced soothing effect on skin.
Bakuchiol Oil can also reduce the appearance of fine lines and wrinkles, which is why you’re seeing it in more skincare products.
Bakuchiol Oil has its roots in Chinese Medicine, and the latest research shows topical application has unique benefits for all skin types.
Bakuchiol Oil is a potent antioxidant and anti-aging ingredient used in a wide variety of cosmetics and skin care products.
The Indian name of Bakuchiol Oil is bakuchi or babchi.
Bakuchiol Oil is a chemical compound that most often comes from the seeds of the babchi plant, or Psoralea corylifolia.
Practitioners of ayurveda as well as traditional Chinese and Korean medicine use this purple-flowered plant for Bakuchiol Oil's medicinal properties.
Bakuchiol Oil's a popular addition to skin-care products because it could help promote healthy skin aging.
Bakuchiol Oil, pronounced “buh-koo-chee-all”, is a retinol alternative derived from the babchi plant.
Scientifically speaking, Bakuchiol Oil’s a meroterpene isolated from the seeds of the babchi plant, also known as Psoralea corylifolia.
The babchi plant has been used for centuries in Ayurvedic and Traditional Chinese medicine for its numerous benefits.
However, the seeds are of most interest as they contain significant medicinal properties.
Bakuchiol Oil is a cosmetic ingredient that’s considered a true natural retinol alternative, without the irritation, photosensitivity or common concerns associated with traditional retinol products.
Generally speaking, Bakuchiol Oil can be found in skincare products like a Bakuchiol Oil serum — however this is not always the case.
Bakuchiol oil may seem like some new, trendy oil on the skincare block, but it has been around the block for a while.
Discovered in 1966, Bakuchiol Oil (pronounced bah-koo-chee-all) is a unique compound that’s derived from the seeds and leaves of the bakuchi plant, hence the name “bakuchiol.”
While it’s been found in a few other sources like vegetables and animal liver, Bakuchiol Oil’s key source is bakuchi plant, making it both vegan and all-natural.
As one of nature’s great skin gifts, bakuchiol oil is great for herbal remedies due to its anti-inflammatory properties.
Bakuchiol Oil has been cultivated and used in Indian Ayurvedic and Chinese medicine for centuries.
The best qualities of these plants can be found in India and China.
Bakuchiol Oil has recently garnered a lot of popularity due to its being a natural and vegan alternative to retinol.
Bakuchiol Oil is often referred to as a “retinol-alternative;” and with all the potential side effects that retinol is known for, this makes it a welcome staple in many skincare routines.
Some of the most common side effects of retinol include dryness, the potential to cause discomfort, and irritation, which are worsened for sensitive and reactive skin types.
As a result, there was a massive oil hunt from beyond the skincare block to find a safe, effective, plant-based alternative that could provide the benefits of retinol without its undesirable effects and instability.
Since Bakuchiol Oil’s initial discovery, our team at 100% PURE has been hard at work to make this plant-based all-star ingredient the ultimate addition to your beauty regimen.
Bakuchiol Oil is a meroterpenoid (a chemical compound having a partial terpenoid structure) in the class terpenophenol.
It was first isolated in 1966 by Mehta et al. from Psoralea corylifolia seed and was called Bakuchiol Oil based on the Sanskrit name of the plant, Bakuchi.
Bakuchiol Oil is a meroterpene phenol abundant in and mainly obtained from the seeds of the Psoralea corylifolia plant, which is widely used in Indian Ayurveda to treat a variety of diseases.
Bakuchiol Oil has also been isolated from other plants, such as P. grandulosa, P. drupaceae, Ulmus davidiana, Otholobium pubescens, Piper longum and Aerva sangulnolenta Blum.
Even though the first complete synthesis of Bakuchiol Oil was described in 1973, its first commercial use in topical applications did not occur until 2007 when it was introduced to the market under the trade name Sytenol A by Sytheon Ltd.
It has been reported to have anticancer activity in preclinical models, possibly due to its structural similarity with resveratrol.
One study in rats suggested that Bakuchiol Oil and ethanol extracts of the Chinese medicinal plant Psoralea corylifolia could protect against bone loss.
Bakuchiol Oil possesses antioxidant, anti-inflammatory, and in vitro antibacterial properties.
Bakuchiol Oil isolated from P. corylifolia has shown activity against numerous Gram-positive and Gram-negative oral pathogens.
Bakuchiol Oil was able to inhibit the growth of Streptococcus mutans under a range of sucrose concentrations, pH values and in the presence of organic acids in a temperature-dependent manner and also inhibited the growth of cells adhered to a glass surface.
Despite having no structural resemblance to retinol, Bakuchiol Oil was found to have retinol functionality through retinol-like regulation of gene expression.
In 2018, a randomized, double-blind, 12-week clinical study with 44 volunteers demonstrated that Bakuchiol Oil is comparable with retinol in its ability to improve photoaging (wrinkles, hyperpigmentation) but has a better skin tolerance.
Bakuchiol Oil has been found to possess antiandrogenic activity in prostate cancer cells, which inhibited cell proliferation.
Bakuchiol Oil is an extract from the seeds of Psoralea corylifolia (nicknamed "babchi"), a plant grown in India that’s been a staple of traditional Indian Ayurvedic and Chinese medicine for many years.
Similar to retinoids, Bakuchiol Oil appears to stimulate collagen producing receptors in the skin.
It’s sold in serums and creams, many of which combine Bakuchiol Oil with other botanicals, like rosehip and seaweed.
Bakuchiol Oil is primarily known as a cosmetic / dermal active ingredient with reported beneficial properties.
Bakuchiol Oil is spoken about as a natural anti-aging active ingredient that is as powerful as Retinol, yet gentler on skin.
Derived from the seeds of the Babchi plant, also called the Psoralea Corylifolia.
At first glance, you could think that Bakuchiol Oil is your average plant extract.
Bakuchiol Oil is derived from the seeds of Psoralea Corylifolia, aka Babchi, a plant important in Indian and Chinese medicine.
The molecule was first isolated in 1973 and several anti-something properties are known about it: Bakuchiol Oil has anti-inflammatory, antioxidant, anti-tumor, anti-bacterial and hepatoprotective magical abilities like plenty of other Ayurvedic plant extracts.
What makes Bakuchiol Oil a special snowflake is the recent discovery that it behaves on the skin in a way very similar to well-known skincare superstar, retinol.
While chemically, it has nothing to do with the vitamin-A family, aka retinoids, comparative gene expression profiling (a fancy way of saying that they compared how retinol and Bakuchiol Oil modify the way skin cells behave and produce important skin proteins such as collagen) shows that retinol and Bakuchiol Oil regulate skin cell behavior in a similar way.
To be more specific, both Bakuchiol Oil and retinol upregulate collagen I, III and IV production and downregulate MMP, the evil collagen attacking enzyme in our skin.
This means more collagen stays in our skin and we all know that more collagen equals firmer, more wrinkle-free skin.
A 12-week clinical study using a 0.5% Bakuchiol Oil formula with 17 people using it twice a day confirmed a significant improvement in lines and wrinkles, elasticity, firmness and an overall reduction in photo-damage.
Also, the test formula was very well tolerated, without any retinol-like side effects.
What's more, a 2018 double-blind study with 44 people compared 0.5% Bakuchiol Oil with 0.5% retinol cream and found that "Bakuchiol Oil is comparable to retinol in its ability to improve photoaging and is better tolerated than retinol".
If you are not a daredevil-type who doesn't want to stop using a super well-proven retinol for a newbie like Bakuchiol Oil, we have good news.
The two also work very nicely together and Bakuchiol Oil can actually help to stabilize the otherwise unstable and hard to formulate retinol.
And we are still not done, as Bakuchiol Oil shows not only anti-aging properties but also nice anti-acne effects.
1% Bakuchiol Oil seems to be very effective in itself (57% reduction in acne after 6 weeks treatment) and even better when combined with 2% salicylic acid (67% reduction in acne after 6 weeks).
We like that Bakuchiol Oil is such a good team player!
The molecule works against acne in multiple ways: Bakuchiol Oil downregulates 5α-reductase (a sebum-controlling enzyme), it is antibacterial (including P. acnes), anti-inflammatory and it inhibits lipid-peroxidation, an evil oxidative process that is recently thought to be a very early trigger in the acne process.
Overall, we think Bakuchiol Oil is an awesome molecule with lots of promise both for anti-aging and anti-acne.
But the proof compared to the well-established superstars is far from solid, so in a skincare routine, we would rather add Bakuchiol Oil next to retinol than straight up replace it.
Unless you are a gimme-the-newest-shiny-thing-under-the-sun-type.
USES and APPLICATIONS of BAKUCHIOL OIL:
Bakuchiol Oil significantly improves multiple dermal and dermo-epidermal junction genes/proteins.
Bakuchiol Oil stimulates Collagen I, III and IV and is clinically proven to reduce multiple signs of aging, including roughness and dryness, fine lines and wrinkles and improvement in skin tone, elasticity and firmness, increasing radiance and brightness.
Bakuchiol Oil is photochemically and hydrolytically stable and can be used during the day.
Bakuchiol Oil is an effective vitiligo treatment and also treats related skin diseases and conditions.
Bakuchiol Oil shrinks white spots on skin and reduces pigmentation.
Bakuchiol Oil works as an anti-inflammatory and an antioxidant so those who suffer from dry, sensitive skin and can't tolerate a retinol can use it in all cosmetics.
The antibacterial properties of Bakuchiol Oil also mean that it's great for those with acne and oily skin.
Bakuchiol Oil has been shown to activate a number of chemical pathways in skin cells that ultimately lead to improved collagen production, decreased collagen breakdown and reduction of melanin (pigment) synthesis.
The overall net effect seems to be an improvement in fine lines, wrinkles and pigmentation which are commonly associated with the natural ageing process of the skin.
Bakuchiol Oil is likely the only agent after retinoic acid shown to be effective against multiple pathophysiologic features of acne.
Bakuchiol Oil may also have a suppressive effect on melanin-producing cells in skin, which may make it a beneficial ingredient to lighten dark spots or improve uneven skin tone due to sun damage.
Bakuchiol Oil also has antifungal activity, particularly against the type of fungi that cause athlete's foot (medically, Tinea pedis).
Bakuchiol Oil has an excellent safety profile and was shown to be nonirritating and non-sensitizing based on human repeat insult patch testing, has no photo- or hydrolytic stability issues, and thus can be used throughout the day.
Applications of Bakuchiol Oil: Anti-aging skin care products, Hair care, and Anti-inflammatory and Antioxidant
Bakuchiol Oil has the unique ability to treat skin discoloration caused by environmental exposure.
Further, Bakuchiol Oil fights the visible signs of aging such as wrinkles, and gives a youthful glow to the skin.
Bakuchiol Oil is better than retinol as it does not cause any side effects even though it may produce slower results.
Additionally, Bakuchiol Oil is great for sensitive skin types and can be used by pregnant women without worries.
Bakuchiol Oil has the potential to increase Collagen production* and stimulate cell renewal, helping to minimise signs of aging.
Bakuchiol Oil has traditionally been used in Indian and Chinese medicines, but it's rapidly increasing in popularity as people opt for more plant-based ingredients in their skincare routines.
The rise in popularity can also be linked to that of Retinol, as Bakuchiol Oil offers many of the same advantages without the potential irritation - making it more suitable for use on sensitive skin.
Bakuchiol Oil is often integrated into both morning and evening anti-age skincare routines, usually paired with hydrating or plumping ingredients such as Hyaluronic Acid.
8 BENEFITS OF BAKUCHIOL OIL FOR SKIN:
Bakuchiol Oil’s benefits are mainly anti-aging.
The following are several of the key benefits of Bakuchiol Oil for the face and skin:
***Boosts Collagen Production:
Dependent on formulations, Bakuchiol Oil has the potential to boost the production of Collagen Type I and VII.
***Stimulates Cell Renewal:
Bakuchiol Oil helps to increase cell turnover and renewal, promoting a more radiant complexion.
***Reduces Fine Lines and Wrinkles:
Regular use of Bakuchiol Oil can help to reduce signs of aging including fine lines and wrinkles - even deep ones, helping skin to appear younger.
***Improves Skin Elasticity and Firmness:
As we age skin naturally loses Bakuchiol Oil's ability to snap back into place and can begin to sag.
Products containing Bakuchiol Oil can help to stimulate Collagen, therefore potentially increasing firmness and redefining contours.
***Counteracts Photo-Aging and Redness:
Photoaging is the process of skin prematurely aging due to exposure to the sun.
Bakuchiol Oil’s structure helps to reduce the impact of photoaging and can also help to soothe redness.
***Reduces Dark Spots and Smoothes Skin Tone:
Some studies have shown that Bakuchiol Oil may have the ability to fade dark spots and improve skin tone.
***Antioxidant Properties:
Thanks to its antioxidant action, Bakuchiol Oil can help neutralise free radicals, unstable compounds that can damage skin cells and accentuate the signs of premature ageing.
***Potentially Reduces Blemishes on Acne-Prone Skin:
Limited studies have shown that Bakuchiol Oil oil's antioxidant, antibacterial and anti-redness properties can reduce and soothe certain symptoms of mild acne, such as pimples.
THE BENEFITS OF BAKUCHIOL OIL:
As mentioned previously, Bakuchiol Oil is pretty much considered a safer alternative to retinol and one that’s just as effective.
Numerous scientific studies have explored the positive effects of Bakuchiol Oil on the skin, highlighting its potential as a beneficial skincare ingredient.
Here are some key findings from research and the most amazing Bakuchiol Oil benefits:
***Anti-aging properties:
Bakuchiol Oil has been shown to stimulate collagen production, a crucial protein responsible for maintaining skin elasticity and reducing the appearance of wrinkles.
A study published in the International Journal of Cosmetic Science found that Bakuchiol Oil increased type I collagen synthesis in human skin cells, demonstrating its ability to promote a more youthful complexion.
***Comparable effects to retinol:
Research published in the British Journal of Dermatology compared the effects of Bakuchiol Oil and retinol on photoaged skin.
The study revealed that both ingredients significantly improved various signs of aging, including wrinkles, pigmentation, and elasticity.
Bakuchiol Oil was found to be comparable to retinol in its efficacy but without the associated side effects.
WHAT IS BAKUCHIOL OIL USED FOR?
Bakuchiol Oil is widely used in the cosmetic industry for its anti-aging, antioxidant, and anti-inflammatory properties.
Bakuchiol Oil serves as a gentle alternative to retinol, offering similar benefits without the associated irritation.
Bakuchiol Oil promotes collagen production, reducing the appearance of fine lines and wrinkles, and improves skin elasticity.
Bakuchiol Oil also helps to even out skin tone, reduce hyperpigmentation, and combat acne by inhibiting bacterial growth.
Additionally, Bakuchiol Oil's antioxidant properties protect the skin from environmental stressors and oxidative damage, making it a valuable ingredient in various skincare products such as serums, creams, and moisturizers.
ORIGIN of BAKUCHIOL OIL:
Bakuchiol Oil is extracted from the seeds and leaves of the Psoralea corylifolia plant.
The extraction process involves using solvents like ethanol or supercritical CO2 to obtain the raw material, which is then purified through processes such as distillation or chromatography.
The chemical formula of Bakuchiol Oil is C18H24O.
WHAT DOES BAKUCHIOL OIL DO IN A FORMULATION?
*ANTIMICROBAL
*ANTIOXIDANT
*SKIN PROTECTING
Bakuchiol Oil is considered safe for use in cosmetics, boasting a favorable safety profile.
Bakuchiol Oil is non-irritating and suitable for sensitive skin, causing minimal to no redness, peeling, or dryness.
Studies have shown Bakuchiol Oil to be non-toxic and non-sensitizing, with a low risk of adverse reactions.
Its natural origin and gentle action make Bakuchiol Oil a preferred choice for individuals seeking effective anti-aging benefits without the harsh side effects commonly associated with retinoids.
Bakuchiol Oil is vegan.
ALTERNATIVES of BAKUCHIOL OIL
*RETINOL
*NIACINAMIDE
*ASCORBIC ACID
POTENTIAL BENEFITS OF BAKUCHIOL OIL:
The evidence for Bakuchiol Oil so far seems promising, but as one research review notes, more high-quality research is necessary to prove its efficacy and determine appropriate usage guidelines, particularly in people with skin conditions.
It's difficult to quantify the exact benefits on skin because studies have either been performed in vitro, meaning not on human skin but in a lab, or have been performed without perfect study design, which makes drawing firm conclusions difficult.
Because the skin-care industry has funded much of the current research on Bakuchiol Oil, there's also a risk of bias in this research, he adds.
***Slows Aging
Most people use products with Bakuchiol Oil to minimize the appearance of wrinkles and fine lines.
Oxidative stress and inflammation are two significant factors in skin aging, and industry-sponsored research showed that Bakuchiol Oil has both antioxidant and anti-inflammatory properties, suggesting that it may be an effective anti-aging treatment.
One research review found that Bakuchiol Oil works in several ways — it showed antioxidant, anti-inflammatory, and pro-collagen effects in studies on skin cells in a lab and on human subjects — that could support its use as an effective anti-aging ingredient.
The review cites preliminary industry-sponsored clinical trials showing that Bakuchiol Oil reduces wrinkles, improves skin elasticity, and stimulates collagen growth.
However, additional high-quality, independent trials on larger, more diverse groups of people are needed to confirm these results.
***Reduces Signs of Sun Damage
A key source of oxidative stress on skin is sun exposure, which can lead to collagen breakdown and increased signs of aging like hyperpigmentation.
A research review found that Bakuchiol Oil had similar effectiveness as retinol when it came to reducing the effects of sun damage.
The review's author notes, however, that the current research is limited, and that much of the research funding came from companies manufacturing products with Bakuchiol Oil.
***Soothes Acne
In one company-sponsored study, a topical 0.5 percent Bakuchiol Oil cream decreased the number of inflammatory lesions and lessened discoloration from healed acne spots, leading researchers to conclude that Bakuchiol Oil may be effective for mild to moderate acne, especially in skin of color.
It's important to point out that this study was done on only 13 people over a period of 12 weeks, so more research is needed to fully understand how effective Bakuchiol Oil is in treating acne and how it compares with retinoids, which are commonly prescribed to treat mild to moderate acne.
***Fights Infection
Bakuchiol Oil may have the potential to fight bacteria and fungi linked to skin infections, rashes, and acne.
For instance, one study found that Bakuchiol Oil was effective against the infection-causing bacteria Staphylococcus aureus, which is resistant to multiple antibiotics.
Another lab-based study suggested that Bakuchiol Oil could help fight fungal infections caused by Candida albicans when used alongside garlic, though researchers note that studies in humans are needed to confirm efficacy and determine the therapeutic dosage.
TYPES OF SKIN-CARE PRODUCTS THAT CONTAIN BAKUCHIOL OIL
You can find Bakuchiol Oil in a wide variety of skin-care products, from serums to toners.
Popular options include these formulations:
**Serum
This lighter, typically water-based product delivers a fast-absorbing, higher concentration of Bakuchiol Oil to your skin.
Moisturizer
Bakuchiol Oil and skin hydration may be a winning combo, since both can help minimize fine lines — you'll usually apply a moisturizer as one of the last steps in your skin-care routine.
**Oil
Bakuchiol Oil is similar to serum in that it's more highly concentrated, but it's a heavier, more moisturizing product.
Eye Cream
Eye cream with Bakuchiol Oil delivers moisture and fine line reduction specifically to this delicate skin.
**Toner
Toner is a water-based primer that help prep your skin to better absorb any serums or moisturizers.
In addition to Bakuchiol Oil, a toner might contain hyaluronic acid, lactic acid, witch hazel, or salicylic acid to smoothen and hydrate your skin.
WHAT IS THE DIFFERENCE BETWEEN BAKUCHIOL OIL AND RETINOL?
Bakuchiol Oil and Retinol are commonly seen as substitutes to one another due to their similar benefits, these include:
*Reducing fine lines and wrinkles
*The potential to help with acne, although more studies are needed in this area
*Smoothing of uneven skin tones
*Stimulating Collagen production
The differences between Bakuchiol Oil and Retinol are namely:
***Vegan Friendliness:
Although both can come from non-animal sources, Retinol may occasionally be derived from egg yolk or fish liver oil - making Bakuchiol Oil unsuitable for vegan use.
As Bakuchiol Oil is plant-based, product formulations containing it may be suitable for vegans (provided all other ingredients and production method is vegan as well).
***Use During Pregnancy:
Bakuchiol Oil is advised to avoid Retinol and any other Retinoid use during pregnancy due to the potential impact on the baby’s development.
At present, the risk of using Bakuchiol Oil during pregnancy is considered negligible.
However please consult with your doctor if you plan to use Bakuchiol Oil during pregnancy.
***Better Tolerated by Sensitive Skin:
Retinol is known to potentially irritate skin - causing dryness or redness.
Bakuchiol Oil’s soothing properties reduce these risks of irritation, making it more suitable than Retinol for sensitive skin.
However, no ingredient is ever completely without risk of any irritation.
IS BAKUCHIOL OIL BETTER THAN RETINOL?
If you’re looking for a gentle and/or natural alternative to retinol, then the short answer is yes.
Bakuchiol Oil offers similar skin benefits without the negative side-effects of retinol.
WHAT IS THE DIFFERENCE BETWEEN BAKUCHIOL OIL AND RETINOL?
Bakuchiol Oil is derived from the Babchi plant and has a different chemical structure than retinol.
Though structurally different, Bakuchiol Oil is considered a true retinol alternative because clinical studies show that it functions similarly to retinol when applied to the skin.
The upside is that Bakuchiol Oil does not cause the same negative side-effects as retinol.
Some of retinol’s most common side-effects include redness, irritation, dryness, sun-sensitivity and peeling.
SOURCES / ORIGIN of BAKUCHIOL OIL:
Bakuchiol Oil is a naturally occurring meroterpenoid (a phenolic terpene derivative) found in seeds and leaves of Psoralea corylifolia (babchi / “bakuchi” plant) in Ayurvedic / traditional medicine.
Bakuchiol Oil has also been isolated from other botanical sources such as Ulmus davidiana, Otholobium pubescens, Piper longum, and others.
Bakuchiol Oil was first isolated in 1966; its total synthesis was later described in 1973.
COSMETIC / DERMATOLOGIC / BIOACTIVE PROPERTIES & BENEFITS of BAKUCHIOL OIL:
Bakuchiol Oil’s popularity stems from several reported or studied bioactivities.
Some of these are better supported than others, so caution is needed in interpretation:
ACTIVITY / BENEFIT OF BAKUCHIOL OIL:
Mechanistic / experimental support / notes
**Antioxidant
Bakuchiol Oil is able to scavenge reactive oxygen species (ROS) and reduce oxidative stress in cellular or in vitro studies.
**Anti-inflammatory
Reported to reduce inflammatory mediators in experimental models; Bakuchiol Oil is used in skin inflammation contexts.
**Antimicrobial / antibacterial
Activity has been shown in vitro against Gram-positive and Gram-negative bacteria (e.g. Streptococcus mutans) in some studies.
**Anti-aging / retinol-like effects
Although structurally different from retinol, Bakuchiol Oil has been reported to regulate gene expression in skin cells in a retinol-like way (stimulating collagen, reducing fine lines, improving appearance of photoaging) with generally improved skin tolerance (less irritation).
**Depigmenting / pigment control
Some reports suggest that Bakuchiol Oil might help even skin tone or reduce hyperpigmentation (by modulating melanogenesis pathways), though clinical evidence is still limited.
**Anticancer / chemopreventive
In various in vitro and preclinical models, Bakuchiol Oil has shown inhibition of proliferation in certain cancer cell lines (e.g. skin cancer lines) possibly via modulation of MAPK / kinase pathways (Hck, Blk, p38) and induction of apoptosis.
**Antiandrogenic / hormonal effects
Some studies have suggested an antiandrogenic effect in prostate cancer cell models, impacting cell proliferation.
Because many of these are from early-stage research (in vitro, animal, small clinical), real-world efficacy and safety, especially in humans over long use, still warrant careful evaluation.
In cosmetic formulations, Bakuchiol Oil is used as a “retinol alternative / retinol-like active” in serums, creams, oils, face treatments, anti-aging products.
THE SCIENCE BEHIND BAKUCHIOL OIL:
Let’s talk about Bakuchiol Oil, the new “IT” ingredient in the beauty community.
Bakuchiol Oil is the latest anti-aging ingredient that many are calling a safer alternative to retinol.
Before we dive into its mind-blowing benefits, let's look at the science that backs the effectiveness of bakuchiol oil
Bakuchiol Oil doesn’t appear to bring on the same side effects as retinol, as some of the research below indicates.
Bakuchiol Oil is generally observed to be less irritating and may carry a lower risk of side effects like redness or flaking.
Bakuchiol Oil, unlike retinol which can aggravate some skin conditions, possesses anti-inflammatory and anti-bacterial properties that may lead to improvements in acne and psoriasis.
Due to the gentle nature of bakuchiol oil, it’s also tolerated and effective for sensitive skin types.
While bakuchiol has not been as extensively studied as ingredients like retinol, there has been other studies and evidence indicating the amazing benefits of bakuchiol oil:
**Safe & Gentle:
Since Bakuchiol Oil is known for being gentle on the skin, just about anyone can safely use it.
**Even skin tone:
Bakuchiol Oil is known to deeply penetrate the outer layer of the skin, which helps lessen the appearance of dark spots or areas of hyperpigmentation.
This retinol alternative can help lessen the signs of photoaging.
**Help with acne and marks:
Due to Bakuchiol Oil’s anti-inflammatory and anti-bacterial properties, it can offer benefits to acne-prone skin in several ways, and it gets better: it may even help with acne scars.
In the case of superficial acne, scars tend to fade away evenly.
But in the case of cystic acne, ruptured cysts have a higher chance of damaging the follicle wall, which can make inflammation worse.
Some research has shown that the application of Bakuchiol Oil on the skin can reduce lesions while improving post-inflammatory hyperpigmentation (PIH).
This means clearer, smoother skin in a shorter period.
**Reduce signs of aging:
Bakuchiol Oil sends signals to your cells to regenerate and produce more collagen, promoting plumpness in your skin and reducing the look of lines and wrinkles.
Despite having fairly new research, the results examining Bakuchiol Oil for aging concerns are promising.
In one study in the British Journal of Dermatology, it was found that Bakuchiol Oil is just as effective at lessening the appearance of fine lines and wrinkles as well as improving skin tone as retinol, but with fewer of the side effects associated with retinol, like peeling and burning.
In a twelve-week trial evaluating a blend of Bakuchiol Oil, melatonin, and the vitamin C derivative ascorbyl tetraisopalmitate and its effects, researchers observed fewer wrinkles, stronger firmness, and an overall improvement in complexion among the trial participants.
Meanwhile, in one systematic review examining the uses of Bakuchiol Oil in six pre-clinical studies, seven clinical studies, three commentaries, two narrative reviews, and one report on adverse events, it was concluded that bakuchiol is a retinol alternative with anti-aging, antibacterial, and anti-inflammatory properties.
DOES BAKUCHIOL OIL WORK?
Whether Bakuchiol Oil fights skin aging as well as the long-studied retinol is the question.
And the answer is based on very limited evidence.
A small study in the British Journal of Dermatology found Bakuchiol Oil to be just as effective at erasing fine lines and improving skin color as retinol, but with less peeling and burning.
The challenge in interpreting these results as a win for Bakuchiol Oil was the study’s small size — just 44 participants (seven of whom dropped out).
In a different study, a Bakuchiol Oil-containing cleanser and moisturizer improved skin smoothness and signs of aging in 60 older women with sensitive skin.
Another trial evaluated a product that combined Bakuchiol Oil with melatonin and the vitamin C derivative, ascorbyl tetraisopalmitate in a three-in-one anti-aging cream.
After 12 weeks of once-daily use, the researchers noted fewer wrinkles, increased skin firmness, and an overall improvement in skin quality among the participants.
HOW DOES BAKUCHIOL OIL WORK?
Bakuchiol Oil has soothing properties which help to comfort skin and minimise issues associated with sensitivity and reactivity.
Bakuchiol Oil is also a potent antioxidant and helps fight signs of ageing, such as fine lines and loss of firmness by targeting free radicals.
Antioxidants also help to protect the skin from pollution and environmental stressors which can cause damage.
You may have seen Bakuchiol Oil acne skincare products.
The soothing and calming properties of Bakuchiol Oil could help those with acne-prone skin in addition to skin that is beginning to show signs of ageing.
WHAT DOES BAKUCHIOL OIL DO?
Research has shown that Bakuchiol Oil has a range of anti-ageing benefits for skin.
Bakuchiol Oil can reduce the appearance of fine lines and wrinkles, help restore firmness, refine skin texture and even out skin tone.
Bakuchiol Oil helps to calm skin making it a good option for those whose skin shows signs of sensitivity.
When paired with retinol, Bakuchiol Oil can help stabilise it and keep it effective for longer.
Another benefit of using products that contain both Bakuchiol Oil and retinol is that Bakuchiol Oil’s calming ability may enable skin to tolerate retinol in higher amounts.
HOW TO USE BAKUCHIOL OIL?
Skincare products containing Bakuchiol Oil extract should be applied to cleansed face and neck.
Apply your products in the order of thinnest to thickest, so if your Bakuchiol Oil product is a lightweight serum it should be applied before your moisturiser.
If using Bakuchiol Oil in the morning follow with a broad-spectrum SPF rated 30 or greater.
SHOULD YOU USE A BAKUCHIOL SERUM OR BAKUCHIOL OIL?
Since an increasing number of skincare products contain Bakuchiol Oil, you’ll be relieved to know that the product texture doesn’t impact efficacy.
What counts is the concentration of Bakuchiol Oil; research has shown that amounts between 0.5-2% are ideal to get visible benefits.
Choose a Bakuchiol Oil serum or lotion-like treatment if you want a lightweight formula that layers easily with other leave-on products in your routine.
A bakuchiol oil is great for dry, dehydrated skin.
If using a heavier oil-based formula, Bakuchiol Oil should generally be applied at night, as the last step in your routine.
HOW TO ADD BAKUCHIOL TO YOUR SKINCARE ROUTINE:
Adding a Bakuchiol Oil to your skincare routine is easy: apply once or twice daily after cleansing, toning, and using a leave-on AHA or BHA exfoliant.
If Bakuchiol Oil is a bakuchiol serum, apply before your moisturiser.
If it’s a moisturiser with Bakuchiol Oil, apply after your serum.
As mentioned above, a bakuchiol oil is best applied at night (or mix a drop or two into one of your favourite non-SPF skincare products each morning).
IS BAKUCHIOL OIL A NATURAL ALTERNATIVE TO RETINOL?
Bakuchiol Oil is often said to be a natural alternative to retinol.
This Bakuchiol Oil-retinol alternative connection is because Bakuchiol Oil follows some of the same skin-improving pathways; however, it doesn’t work exactly like this vitamin A ingredient.
Retinol and Bakuchiol Oil can reduce fine lines, wrinkles, and other signs of ageing, and it’s perfectly OK to use a product that contains both.
HOW TO DO THAT?
Usage would be the same as mentioned above for a leave-on product with Bakuchiol Oil.
Combining retinol and Bakuchiol Oil delivers the overlapping and unique benefits of each, plus Bakuchiol Oil has a natural stabilising effect on vitamin A, not to mention its soothing properties can improve skin’s tolerance to various strengths of retinol.
During the day, finish with a broad-spectrum sunscreen rated SPF 30 or greater.
Bakuchiol Oil is stable in sunlight and isn’t known to make skin more sun-sensitive but, as with any anti-ageing ingredient, daily UV protection is essential to getting (and keeping) the best results.
PHYSICAL and CHEMICAL PROPERTIES of BAKUCHIOL OIL:
CAS number: 10309-37-2
EC number (EINECS / list number): 685-515-4
Molecular formula: C₁₈H₂₄O
Molar mass (average): ~256.38 g/mol
ChemSpider ID: 4579217
Stereochemistry / Enantiomers: The naturally occurring form is (S)-(+)-bakuchiol; there is also an (R) enantiomer.
Appearance / physical state: Bakuchiol is typically a viscous, clear to yellowish oil / liquid in its pure form.
Boiling point / vapor: The CAS Common Chemistry page reports a boiling point of 145-147 °C at 0.7 Torr (i.e. under reduced pressure)
Because of its relatively high boiling point and oil nature, it is not highly volatile under ambient conditions.
Density: Some literature / database sources (e.g. German Wikipedia’s bakuchiol page) list a density of ~0.96 g/cm³ (i.e. ~0.96 g/mL) for the liquid form.
Solubility: Insoluble or very low solubility in water (practically hydrophobic) Soluble in organic solvents such as ethanol, DMSO, DMF, chloroform, dichloromethane, acetone, ethyl acetate, etc.
Some sources give specific solubility figures, e.g. in DMSO up to ~30 mg/mL or in ethanol likewise ~30 mg/mL under certain conditions.
Stability / storage: Should be stored protected from light, in airtight containers, in a cool place (−20 °C is often used for stock / long-term).
Solutions (in organic solvent) tend to have shorter shelf life and may degrade / oxidize over time if exposed to air, light, moisture.
Chemical reactivity: The phenolic (hydroxyl) group can engage in hydrogen bonding, oxidation, or other phenol-type chemistry.
The long aliphatic conjugated double-bond chain (prenyl / terpene portion) can undergo oxidation or isomerization under harsh conditions (light, heat, reactive oxygen).
Because it is relatively nonpolar and stable, its reactivity is modest compared to small reactive molecules; however, oxidative degradation is a concern in formulations.
Other computed / derived values: ChemSpider gives average mass and monoisotopic mass (256.182715 u) PubChem lists various identifiers, structure, and classification details. solubility in water of ~1 g/L at 20 °C (i.e. very low)
FIRST AID MEASURES of BAKUCHIOL OIL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of BAKUCHIOL OIL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of BAKUCHIOL OIL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of BAKUCHIOL OIL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of BAKUCHIOL OIL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of BAKUCHIOL OIL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
