Quick Search
Basic methacrylate copolymer, which dissolve at higher pH values, basic methacrylate copolymers are generally permeable and swell more readily in acidic environments.
Basic methacrylate copolymer improves flexibility in oral drug delivery design.
Basic methacrylate copolymer contains amine-functional methacrylate units distributed along the polymer chain.
CAS Number: 24938-16-7
Molecular Formula: C21H37NO6
Molecular Weight: 399.52158
EINECS Number: 209-927-7
Synonyms: 2-Propenoic acid, 2-methyl-, butyl ester, polymer with 2-(dimethylamino)ethyl 2-methyl-2-propenoate and methyl 2-methyl-2-propenoate;Eudragit-E;N,N-Dimethylaminoethylmethacrylat, Butylmethacrylat, Methylmethacrylat-Copolymer;Amino Methacrylate Copolymer (1.5 g);Polyacrylic resin Ⅳ;2-Methyl-2-propenoic acid butyl ester polymer with 2-(dimethylamino)ethyl 2-methyl-2-propenoate and methyl 2-methyl-2-propenoate;Basic butylated methacrylate copolyme;Allyl Diglycol Carbonate Eudragit Ⅳ
Basic methacrylate copolymer is a synthetic cationic (positively charged) copolymer produced from methacrylate and methacrylic acid ester monomers containing tertiary amino groups.
These amino groups can accept protons in acidic environments, giving the polymer a positive charge and unique pH-dependent properties.
Basic methacrylate copolymer is widely used in the pharmaceutical industry as a film-coating material, taste-masking agent, controlled-release polymer, and drug delivery excipient.
Basic methacrylate copolymer amine groups provide cationic character and influence permeability, adhesion, and interactions with active pharmaceutical ingredients.
Basic methacrylate copolymer improves formulation functionality and tunability.
Physically, it usually appears as a white to slightly yellow powder, granule, or aqueous dispersion capable of forming transparent, flexible films.
These films are mechanically strong and can be tailored for different release profiles.
Basic methacrylate copolymer improves coating quality and durability.
Functionally, Basic methacrylate copolymer acts as a film former, permeability modifier, taste-masking material, binder, and controlled-release coating polymer.
Its ability to respond to environmental pH makes it particularly valuable in oral dosage forms.
Basic methacrylate copolymer improves therapeutic performance and patient acceptability.
Basic methacrylate copolymer is best described as a cationic methacrylate-based pharmaceutical polymer used to control drug release, improve coating performance, and mask unpleasant tastes through pH-dependent permeability and film-forming properties.
Basic methacrylate copolymer are a group of polymeric compounds used as food additives.
The E numbers are E1205, E1206, and E1207, depending on whether the substance is basic, neutral, or anionic, respectively.
Basic methacrylate copolymer (often known under the trade name Eudragit E or E1205 in food additives) is a synthetic cationic polymer.
Composed of dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate, it is primarily used in pharmaceuticals and food supplements for taste masking, moisture protection, and targeted gastric release.
Basic methacrylate copolymer is particularly valuable because it combines cationic charge, film-forming ability, and controllable permeability within a single material.
This allows formulators to regulate how quickly water enters a dosage form and how rapidly a drug is released.
Basic methacrylate copolymer improves precision in controlled-release design.
At the molecular level, the polymer contains tertiary amine groups that become protonated under acidic conditions.
As protonation increases, the polymer becomes more hydrophilic and allows greater water penetration.
Basic methacrylate copolymer improves pH-responsive permeability.
Unlike enteric polymers, which remain intact in the stomach and dissolve in the intestine, basic methacrylate copolymers usually function as permeable diffusion membranes.
Drug release occurs mainly through diffusion rather than complete polymer dissolution.
Basic methacrylate copolymer improves sustained and predictable release behavior.
In film-coating technology, the polymer forms clear, smooth, and flexible coatings with good mechanical strength.
These coatings can withstand handling, packaging, and transportation without cracking.
Basic methacrylate copolymer improves product durability and appearance.
In multiparticulate dosage forms, it is commonly used to coat thousands of small pellets individually.
Each pellet acts as a miniature drug delivery system with its own controlled-release coating.
This improves dose uniformity and reduces release variability.
In coating permeability engineering, formulators can adjust release rates by changing coating thickness, polymer grade, or the amount of plasticizer used.
This allows a wide range of release profiles to be achieved.
Basic methacrylate copolymer improves formulation flexibility.
In combination polymer systems, basic methacrylate copolymers are often blended with neutral methacrylate copolymers to fine-tune permeability and mechanical properties.
The resulting films can provide more precise release control than either polymer alone.
Basic methacrylate copolymer improves coating optimization.
Flash point: >250℃
storage temp.: 2-8°C
Appearance: Light yellow to yellow Solid
Major Application: pharmaceutical (small molecule)
InChI: InChI=1S/C8H15NO2.C8H14O2.C5H8O2/c1-7(2)8(10)11-6-5-9(3)4;1-4-5-6-10-8(9)7(2)3;1-4(2)5(6)7-3/h1,5-6H2,2-4H3;2,4-6H2,1,3H3;1H2,2-3H3
InChIKey: NEDGUIRITORSKL-UHFFFAOYSA-N
SMILES: C(=O)(OC)C(=C)C.C(=O)(C(=C)C)OCCCC.O(CCN(C)C)C(=O)C(=C)C
Basic methacrylate copolymers are among the most important cationic pharmaceutical coating polymers because they combine good film formation with controlled permeability.
Unlike enteric polymers, they generally do not completely block release in the stomach.
Instead, they regulate the diffusion of fluids and active ingredients through the coating.
Basic methacrylate copolymer improves controlled-release design flexibility.
The polymer's performance depends heavily on the content of tertiary amino groups.
When exposed to acidic conditions, these groups become protonated, increasing the polymer's hydrophilicity and permeability.
Basic methacrylate copolymer improves responsiveness to gastric conditions.
In taste-masking applications, the polymer forms a protective film around bitter active ingredients.
Because the coating does not dissolve rapidly in saliva, unpleasant tastes are minimized before swallowing.
Basic methacrylate copolymer improves patient compliance, especially in pediatric formulations.
In sustained-release technologies, the polymer acts as a semi-permeable membrane that controls water penetration and drug diffusion rates.
The release profile can be modified by adjusting coating thickness and formulation composition.
Basic methacrylate copolymer improves dosing consistency and therapeutic effectiveness.
In pellet coating systems, it is commonly applied to small drug-loaded pellets using fluid-bed coating processes.
The resulting coated pellets can be filled into capsules or compressed into tablets.
Basic methacrylate copolymer improves manufacturing flexibility and release uniformity.
In drug–polymer interaction studies, the cationic amino groups may interact with negatively charged drug molecules.
These interactions can affect stability, dissolution, and release characteristics.
Basic methacrylate copolymer improves formulation optimization opportunities.
In multi-layer coating systems, basic methacrylate copolymers are often combined with neutral or anionic polymers to achieve complex release patterns.
Basic methacrylate copolymer allows formulators to design highly customized oral dosage forms.
This improves advanced drug delivery capabilities.
In pharmaceutical process engineering, the polymer is compatible with aqueous coating systems, reducing the need for large quantities of organic solvents.
Basic methacrylate copolymer improves manufacturing safety and environmental performance.
In modified-release capsule technologies, it can be used to create coatings that gradually become permeable after ingestion.
This provides smoother release profiles than immediate-release systems.
Basic methacrylate copolymer improves therapeutic control.
In modern drug delivery research, basic methacrylate copolymers are being investigated for applications involving poorly soluble drugs, multiparticulate delivery systems, and personalized medicine approaches.
Basic methacrylate copolymer improves future formulation possibilities.
In stability enhancement applications, the polymer coating helps protect active ingredients from moisture, oxygen, and mechanical damage during storage and handling.
Basic methacrylate copolymer improves shelf life and product quality.
In orally disintegrating and chewable formulations, it is frequently used for taste masking because it can significantly reduce contact between bitter drugs and taste receptors.
This improves patient acceptance and compliance.
In fluid-bed coating processes, the polymer exhibits excellent coating performance and uniform film formation.
Basic methacrylate copolymer makes it suitable for large-scale pharmaceutical manufacturing.
Basic methacrylate copolymer improves production efficiency and reproducibility.
In advanced drug delivery research, basic methacrylate copolymers are studied for use in targeted release systems, nanoparticle coatings, and novel oral delivery platforms.
Their cationic nature offers unique opportunities for interacting with biological surfaces and active ingredients.
Basic methacrylate copolymer improves future pharmaceutical innovation.
Uses:
Basic methacrylate copolymer is used in preparation of Isosorbide and heat-melted substances containing solid pharmaceutical formulation for suppressing unpleasant organoleptic properties.
Basic methacrylate copolymer is used as a glazing agent in solid food supplements and in solid foods for special medical purposes (FSMPs).
The neutral form is used as a glazing agent in solid food supplements and solid FSMPs.
The anionic form is used as a glazing agent in solid food supplements and solid FSMPs. Sodium lauryl sulfate, a non-authorised ingredient, was found to be present in some samples.
Basic methacrylate copolymer is mainly used as a film-forming agent, taste-masking polymer, controlled-release coating material, permeability modifier, and protective coating polymer because of its cationic and pH-responsive properties.
In taste-masked tablets, granules, and chewable formulations, it is used to reduce the perception of bitter drugs.
Basic methacrylate copolymer improves patient compliance and product acceptability.
In controlled-release formulations, it is used to regulate water penetration and drug diffusion.
Basic methacrylate copolymer improves therapeutic consistency and dosing control.
In tablet film coatings, it is used to create durable and functional protective layers.
Basic methacrylate copolymer improves stability, appearance, and handling characteristics.
In pellet and multiparticulate systems, it is used to produce uniform release-controlling coatings.
Basic methacrylate copolymer improves dose uniformity and formulation flexibility.
In modified-release capsules, it is used to achieve gradual drug release through semi-permeable coatings.
Basic methacrylate copolymer improves release predictability.
In moisture-protective coatings, it is used to shield sensitive active ingredients from environmental humidity.
Basic methacrylate copolymer improves storage stability.
In industrial pharmaceutical coating processes, it is used in fluid-bed coating, spray coating, and pan coating operations.
Basic methacrylate copolymer improves manufacturing scalability and consistency.
Basic methacrylate copolymer is mainly used as a film-forming polymer, taste-masking agent, controlled-release coating material, permeability modifier, and protective coating polymer because its cationic structure provides adjustable permeability and strong film-forming properties.
In taste-masking coatings, Basic methacrylate copolymer is used to coat bitter active pharmaceutical ingredients and prevent their rapid dissolution in saliva.
Basic methacrylate copolymer improves patient acceptance and compliance.
In controlled-release tablets and capsules, it is used as a semi-permeable coating that regulates water penetration and drug diffusion.
Basic methacrylate copolymer improves dosing consistency and therapeutic performance.
In sustained-release pellet systems, it is used to coat drug-loaded pellets with uniform release-controlling films.
Basic methacrylate copolymer improves dose uniformity and release predictability.
In tablet film coatings, Basic methacrylate copolymer is used to form smooth, flexible, and durable protective layers.
Basic methacrylate copolymer improves mechanical protection, appearance, and handling characteristics.
In multiparticulate dosage forms, it is used to create individual coated particles that can be combined into capsules or tablets.
Basic methacrylate copolymer improves formulation flexibility and manufacturing control.
In moisture-protective coatings, it is used to reduce exposure of sensitive drugs to environmental humidity.
Basic methacrylate copolymer improves stability and shelf life.
In drug diffusion control systems, it is used as a permeability-regulating membrane that controls the movement of water and active ingredients.
Basic methacrylate copolymer improves release-rate control.
In combination polymer coatings, it is blended with neutral or anionic methacrylate polymers to obtain customized release profiles.
Basic methacrylate copolymer improves formulation optimization and versatility.
In fluid-bed, pan-coating, and spray-coating processes, it is used as an industrial pharmaceutical coating material.
Basic methacrylate copolymer improves large-scale manufacturing efficiency and coating uniformity.
In advanced oral drug delivery systems, it is used in modified-release and taste-masked formulations for improved therapeutic outcomes and patient convenience.
Basic methacrylate copolymer improves pharmaceutical performance and user experience.
Safety Profile:
Basic methacrylate copolymer is generally considered a low-toxicity and low-hazard pharmaceutical excipient, with most risks arising from handling the dry polymer rather than from significant chemical toxicity.
The primary hazard is dust generation during processing and handling.
Airborne polymer particles may cause temporary irritation of the eyes, nose, throat, and respiratory tract.
Basic methacrylate copolymer improves workplace safety awareness.
Inhalation of high concentrations of dust may result in coughing, throat irritation, or temporary respiratory discomfort, particularly in poorly ventilated manufacturing areas.
Basic methacrylate copolymer improves occupational exposure control.
Eye contact with powder may cause mechanical irritation, redness, watering, or discomfort due to the presence of fine particles.
Flushing with water is generally sufficient.
This improves basic first-aid preparedness.
Skin contact is usually low risk, although prolonged or repeated exposure to large amounts of powder may cause mild dryness or irritation in sensitive individuals.
Basic methacrylate copolymer improves handling safety awareness.
The polymer is generally considered non-corrosive and non-reactive under normal conditions of use.
It does not typically present significant chemical burn or sensitization hazards.
Basic methacrylate copolymer improves operational safety.
From a toxicological perspective, basic methacrylate copolymers exhibit low acute toxicity and are widely used in approved pharmaceutical formulations.
They are generally not associated with significant systemic toxicity when used as intended.
This improves confidence in regulated applications.
The material is chemically stable under normal storage conditions, but excessive heat may cause thermal decomposition.
During decomposition, organic vapors and fumes such as carbon oxides and nitrogen-containing compounds may be generated.
Basic methacrylate copolymer improves storage and fire-safety awareness.
