PRODUCTS

BENZALKONIUM CHLORIDE (BKC), 50 %

Benzalkonium Chloride (BKC), 50 % also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, is a type of cationic surfactant.
Benzalkonium Chloride (BKC), 50 % is an organic salt classified as a quaternary ammonium compound.
Benzalkonium Chloride (BKC), 50 % have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent.

CAS Number : 68391-01-5
EC Number : 269-919-4
Molecular Formula : C23H42ClN
Molecular Weight : 368.0 g/mol

Solubility and physical properties of Benzalkonium Chloride (BKC), 50 %
Depending on purity, Benzalkonium Chloride (BKC), 50 % ranges from colourless to a pale yellow (impure).
Benzalkonium Chloride (BKC), 50 % is readily soluble in ethanol and acetone.
Dissolution in water is ready, upon agitation.
Aqueous solutions should be neutral to slightly alkaline.
Solutions foam when shaken.
Concentrated solutions have a bitter taste and a faint almond-like odour.

Standard concentrates are manufactured as 50% and 80% w/w solutions, and sold under trade names such as BC50, BC80, BAC50, BAC80, etc.
The 50% solution is purely aqueous, while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) to prevent increases in viscosity or gel formation under low temperature conditions.

Cationic surfactant of Benzalkonium Chloride (BKC), 50 %
Benzalkonium Chloride (BKC), 50 % also possesses surfactant properties, dissolving the lipid phase of the tear film and increasing drug penetration, making it a useful excipient, but at the risk of causing damage to the surface of the eye.

Laundry detergents and treatments.
Softeners for textiles.

Bioactive agents of Benzalkonium Chloride (BKC), 50 %
Especially for its antimicrobial activity, Benzalkonium Chloride (BKC), 50 % is an active ingredient in many consumer products:

Pharmaceutical products such as eye, ear and nasal drops or sprays, as a preservative.
Personal care products such as hand sanitizers, wet wipes, shampoos, soaps, deodorants and cosmetics.
Skin antiseptics and wound wash sprays, such as Bactine.
Throat lozenges and mouthwashes, as a biocide
Spermicidal creams.
Cleaners for floor and hard surfaces as a disinfectant, such as Lysol and Dettol antibacterial spray and wipes.
Algaecides for clearing of algae, moss, lichens from paths, roof tiles, swimming pools, masonry, etc.

Benzalkonium Chloride (BKC), 50 % is also used in many non-consumer processes and products, including as an active ingredient in surgical disinfection.
A comprehensive list of uses includes industrial applications.

During the course of the COVID-19 pandemic, from time to time there have been shortages of hand cleaner containing ethanol or isopropanol as active ingredients.
The FDA has stated that Benzalkonium Chloride (BKC), 50 % is eligible as an alternative for use in the formulation of healthcare personnel hand rubs.
However, in reference to the FDA rule, the CDC states that it does not have a recommended alternative to ethanol or isopropanol as active ingredients, and adds that "available evidence indicates benzalkonium chloride has less reliable activity against certain bacteria and viruses than either of the alcohols." In November 2020 The Journal of Hospital Infection published a study on benzalkonium chloride formulations; it was found that laboratory and commercial disinfectants with as little as 0.13% Benzalkonium Chloride (BKC), 50 % inactivated the SARS-CoV-2 virus within 15 seconds of contact, even in the presence of a soil or hard water.

This resulted in a growing consensus that BZK sanitizers are just as effective as alcohol-based sanitizers despite the CDC guidelines.
As a hand sanitizer, use of BZK may be advantageous over ethanol in some situations because it has significantly more residual antibacterial action on the skin after initial application.
Benzalkonium Chloride (BKC), 50 % has demonstrated persistent antimicrobial activity for up to four hours after contact whereas ethanol-based sanitizer demonstrate skin protection for only 10 minutes post-application.

Medicine
Benzalkonium Chloride (BKC), 50 % is a frequently used preservative in eye drops; typical concentrations range from 0.004% to 0.01%.
Stronger concentrations can be caustic and cause irreversible damage to the corneal endothelium.
Avoiding the use of Benzalkonium Chloride (BKC), 50 % solutions while contact lenses are in place is discussed in the literature.

Due to its antimicrobial activity when applied to skin, some topical medications for acne vulgaris have benzalkonium chloride added to increase the products’ efficiency or shelf-life.
Benzalkonium Chloride (BKC), 50 % is scientifically proven to be a successful spermicide.
In Russia and China, Benzalkonium Chloride (BKC), 50 % is used as a contraceptive.
Tablets are inserted vaginally, or a gel is applied, resulting in local spermicidal contraception.
Benzalkonium Chloride (BKC), 50 % is not a wholly reliable method, and can cause irritation.

Use and Manufacturing of Benzalkonium Chloride (BKC), 50 %
Used as a surfactant, detergent, deodorizer, and germicide/biocide (food products and services, industrial plants, hospitals, farms, swimming pools, and cooling towers); Also used as a medication; [HSDB] Also used as a wood preservative

Used as an antimicrobial/insecticide/fungicide for agricultural, food handling, medical equipment; Has been used in swimming pools and industrial water systems (recirculating cooling water, pulp and paper, drilling muds, oil well injection, and saltwater disposal): Also used as a wood preservative and on ornamental plants

Industry Uses of Benzalkonium Chloride (BKC), 50 %

Cleaning agent
Corrosion inhibitor
Cleaning agent
Corrosion inhibitor
Processing aids not otherwise specified
Processing aids, specific to petroleum production
Surface active agents
Surfactant (surface active agent)
Corrosion inhibitor
Demulsifier
Emulsifier
Intermediate
Not Known or Reasonably Ascertainable
Other (specify)
Processing aids, specific to petroleum production
Surface active agents
Surfactant (surface active agent)

Consumer Uses of Benzalkonium Chloride (BKC), 50 %
Cleaning agent
Surface active agents
Surfactant (surface active agent)
Corrosion inhibitor
Emulsifier
Preservative
Surface active agents
Surfactant (surface active agent)

Household Products of Benzalkonium Chloride (BKC), 50 %

Household & Commercial/Institutional Products
Information on 215 consumer products that contain Alkyl(C12-16)dimethylbenzylammonium chloride in the following categories is provided:

• Auto Products
• Commercial / Institutional
• Home Maintenance
• Inside the Home
• Personal Care

General Manufacturing Information
Industry Processing Sectors
All Other Chemical Product and Preparation Manufacturing
Oil and Gas Drilling, Extraction, and Support activities

Industry Processing Sectors
All Other Basic Organic Chemical Manufacturing
All Other Chemical Product and Preparation Manufacturing
Food, beverage, and tobacco product manufacturing
Not Known or Reasonably Ascertainable
Oil and Gas Drilling, Extraction, and Support activities
Paper Manufacturing
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Petroleum Refineries
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Wholesale and Retail Trade

Industry Processing Sectors
All Other Chemical Product and Preparation Manufacturing
Construction
Food, beverage, and tobacco product manufacturing
Not Known or Reasonably Ascertainable
Oil and Gas Drilling, Extraction, and Support activities
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Wholesale and Retail Trade

Benzalkonium Chloride (BKC), 50 % is the most widely used preservative in ophthalmology.
Benzalkonium Chloride (BKC), 50 % is a quaternary ammonium compound that acts as an antimicrobial agent by denaturing proteins and disrupting cytoplasmic membranes.

Application of Benzalkonium Chloride (BKC), 50 %:

Benzalkonium Chloride (BKC), 50 % is used in pharmaceuticals such as leave-on skin antiseptics
Benzalkonium Chloride (BKC), 50 % is used as antiseptic in Bactine to safely treat childhood scrapes and cuts
Benzalkonium Chloride (BKC), 50 % is used in advanced, next generation hand sanitizers
Benzalkonium Chloride (BKC), 50 % is used in hygienic towelettes and wet wipes
Benzalkonium Chloride (BKC), 50 % is used in cosmetics such as eye and nasal drops, as a preservative
Benzalkonium Chloride (BKC), 50 % is used in cleaners for floor and hard surfaces as a disinfectant
Benzalkonium Chloride (BKC), 50 % is used in high-level surgical instrument sterilizing and disinfection solutions
Benzalkonium Chloride (BKC), 50 % is used in air and surface sprayable disinfectants

Substance identity

EC / List no.: 269-919-4
CAS no.: 68391-01-5

Hazard classification & labelling of Benzalkonium Chloride (BKC), 50 %
Danger! According to the classification provided by companies to ECHA in CLP notifications this substance causes severe skin burns and eye damage, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed, causes serious eye damage, is harmful in contact with skin and causes skin irritation.

Biocidal Uses of Benzalkonium Chloride (BKC), 50 %
Benzalkonium Chloride (BKC), 50 % is being reviewed for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, veterinary hygiene, food and animals feeds, preservation for construction materials, preservation for liquid systems, controlling slimes, embalming or taxidermy.

Benzalkonium Chloride (BKC), 50 % indicated, in 2009, as being intended to be registered by at least one company in the EEA.
Benzalkonium Chloride (BKC), 50 % indicated for which classification and labeling data have been submitted to ECHA in a registration under REACH or notified by manufacturers or importers under CLP.
Such notifications are required for hazardous substances, as such or in mixtures, as well as for all substances subject to registration, regardless of their hazard.
Benzalkonium Chloride (BKC), 50 % indicated approved or for which approval is sought as Biocidal active substances.
Benzalkonium Chloride (BKC), 50 % listed in the EINECS, ELINCS, or NLP inventories.

Synonyms:
(C12-C18) Alkyldimethylbenzyl ammonium chloride
N-Alkyl dimethyl benzyl ammonium chloride (C12-C18)
(C12-C18)Alkylbenzyldimethylammonium chloride
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides
Alkyl (C12-18) dimethylbenzyl ammonium chloride (ADBAC (C12-18))
Alkyl(C12-C18)benzyldimethylammonium chloride
Alkil (C12-18) chlorku dimetylobenzyloamonu (ADBAC (C12-18)) (pl)
Alkil (C12-18) dimetilbenzil amonijev klorid (ADBAC (C12-18) (hr)
Alkil (C12-18) dimetilbenzil amonio chloridas (ADBAC (C12-18)) (lt)
Alkil (C12-18) dimetilbenzilamonija hlorīds (ADBAC (C12-18)) (lv)
Alkil (C12–16) dimetil-benzil-ammónium-klorid (ADBAC [C12–18]) (hu)
Alkil (C12–18) dimetilbenzil amonijev klorid (ADBAC (C12–18)) (sl)
Alkyl (C12-18) dimethylbenzyl ammonium chloride (ADBAC (C12-18)) (mt)
Alkyl (C12-18) dimethylbenzyl ammonium chloride (ADBAC (C12-18)) (no)
alkyl(C12-18)benzyldimetylamónium-chlorid [ADBAC (C12-18)] (sk)
alkyl(C12-18)dimethylbenzylammoniumchlorid (ADBAC (C12-18)) (cs)
alkyl(C12-18)dimethylbenzylammoniumchlorid (ADBAC (C12-18)) (da)
Alkyl(C12-18)dimethylbenzylammoniumchlorid (ADBAC (C12-18)) (de)
Alkyl(C12-18)dimethylbenzylammoniumchloride (ADBAC (C12-18)) (nl)
Chlorure d'alkyl(C12-C18)diméthylbenzylammonium [ADBAC (C12-18)] (fr)
Cloreto de alquil(C12-18)dimetilbenzilamónio (ADBAC C12-18) (pt)
Cloruro de C12-18-alquildimetilbencilamonio (ADBAC (C12-18)) (es)
Clorură de alchil (C12-18) dimetilbenzil amoniu [ADBAC (C12-18)] (ro)
Composti di ammonio quaternario, benzil- C12-18 -alchildimetil, cloruri (ADBAC (C12-18) (it)
ALKYL DIMETHYL BENZYL AMMONIUM CHLORIDE
Alkyl Dimethyl Benzyl Ammonium Chloride
Alkyldimethylbenzyl ammonium chloride
Benzalkonium Chloride
Benzalkonium chloride
benzyl-dimethyl-tetradecylazanium chloride
C12-C18 alkyl benzyl dimethyl ammonium chloride
N-benzyl-N,N-dimethyl-C12-18-(evennumbered)-alkyl-1-aminium chloride
N-benzyl-N,N-dimethyltetradecan-1-aminium chloride
Not available
Quaternary ammonium compounds, benzyl-C12-18-alkyldimethyl, chlorides
56939-83-4
68391-01-5
68424-86-2
959428-18-3
139-08-2
Benzyldimethyltetradecylammonium chloride
Myristalkonium chloride
n-benzyl-n,n-dimethyltetradecan-1-aminium chloride
Tetradecyldimethylbenzylammonium Chloride
68391-01-5
Miristalkonium chloride
Zephiramine
68424-85-1
Dibactol
Faringets
Quaternario 14B
Sanibond 200lg
Zephiramine chloride
Barquat MB 50
Quarton 14 BCL
Benzenemethanaminium, N,N-dimethyl-N-tetradecyl-, chloride
Barquat MS 100
Hyamine 3500
Myristyldimethylbenzylammonium chloride
Arquad DM14B-90
Cloruro de miristalkonio
Chlorur de miristalkonium
benzyl-dimethyl-tetradecylazanium;chloride
Nissan cation M2-100
Protek Q
Rolquat cdm/BC
Black alg aetrine
Benzyldimethylmyristylammonium chloride
Catigene T80
Dimethylbenzylmyristylammonium chloride
Bioquat 80
Cyncal 80
Dimethylbenzyltetradecylammonium chloride
Barquat MB 80
Bioquat 501
Gardiquat 1250AF
Myristyl dimethyl benzyl ammonium chloride
Miristalkonii chloridum
Tetradecyl-dimethyl-benzylammonium chloride
HSDB 5627
N,N-Dimethyl-N-tetradecylbenzenemethanaminium chloride
Tetradecyl dimethyl benzyl ammonium chloride
Maquat MC 1412
Tret-O-lite WF 88
Ammonium, benzyldimethyltetradecyl-, chloride
Miristalkonium chloride [INN:BAN]
BTC 824P100
EINECS 205-352-0
Miristalkonii chloridum [INN-Latin]
Tret-O-lite WF 828
UNII-9U1Q4T4ZYS
Chlorur de miristalkonium [INN-French]
Cloruro de miristalkonio [INN-Spanish]
Myristyl-benzalkonium chloride
UNII-0W255OL75T
Trimethyl tetradecylphenyl ammonium chloride
N-Benzyl-N-tetradecyldimethylammonium chloride
TETRADECYLBENZYLDIMETHYLAMMONIUM CHLORIDE
BTC 835
0W255OL75T
EINECS 269-919-4
EINECS 270-325-2
SDA 16-052-00
DSSTox_CID_8460
EC 270-325-2
Miristalkonium chloride (INN)
MIRISTALKONIUM CHLORIDE [INN]
Quaternary ammoniumcompounds, benzyl-C12-16-alkyldimethyl, chlorides
BENZYLDIMETHYLTETRADECYLAMMONIUM CHLORIDE HYDRATE
Zephiran chloride
Alpagelle (TN)
ADBAC
benzyl-dimethyl-tetradecyl-ammonium chloride
9U1Q4T4ZYS
DSSTox_RID_78652
DSSTox_GSID_28460
DSSTox_GSID_28492
SCHEMBL60915
Benzyldimethyltetradecylammonium chloride, anhydrous
CHEMBL421049
DTXSID6036384
Miristalkonium chloride [BAN:INN]
Tox21_202570
Tox21_303955
MIRISTALKONIUM CHLORIDE [HSDB]
MYRISTALKONIUM CHLORIDE [INCI]
AKOS015890487
CS-W011803
HY-W011087
MIRISTALKONIUM CHLORIDE [MART.]
MIRISTALKONIUM CHLORIDE [WHO-DD]
NCGC00260119-01
NCGC00357189-01
tetradecyldimethylbenzyl ammonium chloride
BS-23861
LS-16820
CAS-68391-01-5
CAS-68424-85-1
A0208
FT-0621977
FT-0657918
FT-0778233
D08223
D78371
n-benzyl-n,n-dimethyltetradecan-1-aminiumchloride
A807480
Benzenemethanaminium,N,N-dimethyl-N-tetradecyl-,ch
N-Benzyl-N,N-dimethyl-1-tetradecanaminium chloride
W-109496
Q27231176
Benzenemethanaminium, N,N-dimethyl-N-tetradecyl-, chloride (1:1)
Compuestos de amonio cuaternario, bencil-c12-16-alquildimetil, cloruros
Compuestos de amonio cuatornario, bencil-c12-18-alquildimetil, cloruros
200-300-3 [EINECS]
56-93-9 [RN]
Benzenemethanaminium, N,N,N-trimethyl-, chloride (1:1) [ACD/Index Name]
BENZYL TRIMETHYL AMMONIUM CHLORIDE
Benzyltrimethylammonium chloride
benzyltrimethylazanium chloride
Chlorure de N,N,N-triméthyl(phényl)méthanaminium [French] [ACD/IUPAC Name]
MFCD00011782 [MDL number]
N,N,N-Trimethyl(phenyl)methanaminium chloride [ACD/IUPAC Name]
N,N,N-Trimethyl(phenyl)methanaminiumchlorid [German] [ACD/IUPAC Name]
[56-93-9] [RN]
14800-24-9 [RN]
200-300-3MFCD00011782
8001-54-5 [RN]
Ammonium, benzyltrimethyl-, chloride
Benzalkonium chloride [Wiki]
Benzenemethanaminium, N,N,N-trimethyl-, chloride
Benzyl trimethylammonium chloride
BENZYLTRIMETHYL AMMONIUM CHLORIDE
Benzyltrimethyl ammoniumchloride
benzyltrimethylammonium
benzyl-trimethylammonium chloride
benzyl-trimethyl-ammonium chloride
Benzyltrimethylammonium chloridemissing
benzyltrimethylammoniumchloride
benzyl-trimethylazanium chloride
benzyl-trimethyl-azanium chloride
BTM
EINECS 200-300-3
missing
N,N,N-Trimethyl-1-phenylmethanaminium chloride
N,N,N-Trimethylbenzenemethanaminium chloride
N,N,N-Trimethylbenzenemethanammoniumchloride
N-benzyl-N,N,N-trimethyl-ammonium chloride
T5315006
Tmbac
trimethyl-(phenylmethyl)azanium chloride
Trimethylbenzyl ammonium chloride
trimethylbenzylamine, chloride
Trimethylbenzylammonium chloride
VNK45Y7BA1 [DBID]
13970_FLUKA [DBID]
13980_ALDRICH [DBID]
228982_ALDRICH [DBID]
CCRIS 4587 [DBID]
HSDB 4196 [DBID]
MLS000069800 [DBID]
NCGC00090720-01 [DBID]
SMR000059199 [DBID]
UNII:VNK45Y7BA1 [DBID]
UNII-VNK45Y7BA1 [DBID]