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CAS:131-57-7
Benzophenone-3 (BP-3) is a naturally occurring chemical found in some flowering plants. BP-3 absorbs and scatters the sun’s harmful ultraviolet (UV) rays. For this reason, it is produced for use as sunscreen in lotions, conditioners, and cosmetics. BP-3 also is used in plastic products to block and prevent UV rays from altering the plastic and the contents inside.
Synonyms:
(2-Hydroxy-4-methoxyphenyl)phenylmethanone; 2-Hydroxy-4-methoxybenzophenone; 4-Methoxy-2-hydroxybenzophenone; Advastab 45; Anuvex; Benzophenone, 2-hydroxy-4-methoxy-; Benzophenone-3; Chimassorb 90; Cyasorb UV 9; Cyasorb UV 9 Light Absorber; Escalol 567; HMBP; MOB; MOD; Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-; Ongrostab HMB; Oxibenzona; 2-Benzoyl-5-methoxyphenol; 2'-HYDROXY-4'-METHOXY BENZOPHENONE; 2-HYDROXY-4-METHOXYBENZOPHENONE; 3-BENZOPHENONE; 4-methoxy; 2-hydroxybenzophenone; BENZOPHENONE-3; EUSOLEX(R) 4360; HMB; NEO HELIOPAN BB; OXYBENZONE; PROSORB UV 200; UV-ABSORBER BAYER 325; (2-hydroxy-4-methoxyphenyl)phenyl-methanon; (2-Hydroxy-4-methoxyphenyl)phenylmethanone; (2-hydroxy-4-methoxyphenyl)phenyl-Methanone; 2-hydroxy-4-methoxy-benzophenon; 4-Methoxy-2-hydroxybenzophenone butyric acid; Advastab 45; advastab45; Anuvex; oxybenzone; 131-57-7; 2-HYDROXY-4-METHOXYBENZOPHENONE; Benzophenone-3; (2-hydroxy-4-methoxyphenyl)(phenyl)methanone; 4-Methoxy-2-hydroxybenzophenone; Oxybenzon; 2-Benzoyl-5-methoxyphenol; Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-; Anuvex; Benzophenone 3; Escalol 567; Chimassorb 90; Uvinul 9; Advastab 45; Cyasorb UV 9; Oxibenzona; Oxybenzonum; Sunscreen UV-15; Syntase 62; Uvistat 24; Usaf cy-9; Uvinul M40; Spectra-sorb UV 9; Ongrostab HMB; Oxybenzonum [INN-Latin]; Oxibenzona [INN-Spanish]; Cyasorb UV 9 Light Absorber; (2-Hydroxy-4-methoxyphenyl)phenylmethanone; NSC-7778; Benzophenone, 2-hydroxy-4-methoxy-; (2-hydroxy-4-methoxyphenyl)-phenylmethanone; NCI-C60957; UNII-95OOS7VE0Y; Uvinul M 40; CHEBI:34283; 2-hydroxy-4-methoxy benzophenone; MFCD00008387; 95OOS7VE0Y; CHEMBL1625; MOB; (2-hydroxy-4-methoxy-phenyl)-phenyl-methanone; 2-hydroxy-4-methoxy-benzophenone; NSC7778; 2-Hydroxy-4-methoxybenzophenone, 98%; NCGC00016394-07; CAS-131-57-7; DSSTox_CID_2405; DSSTox_RID_76576; DSSTox_GSID_22405; 2-HYDROXY-4-METHOXYBENZOPHENONE (OXYBENZONE); 2-hydroxy-4-methoxyphenyl phenyl ketone; SMR000035344; CCRIS 1078; HSDB 4503; KAHSCREEN BZ-3; SR-01000610567; NSC 7778; EINECS 205-031-5; BRN 1913145; Oxybenzone [USAN:USP:INN]; AI3-23644; Neo heliopan BB; Kopben-3; PubChem3274; Solaquin (Salt/Mix); Spectrum_001049; DuraScreen (Salt/Mix); ACMC-1BVPH; PreSun 15 (Salt/Mix); Epitope ID:131795; WLN: 1OR CQ DVR; EC 205-031-5; Oprea1_174131; SCHEMBL15551; DivK1c_000184; SPECTRUM1500451; SPBio_001135; SPBio_002893; Oxybenzone, analytical standard; BPBio1_000742; DTXSID3022405; HMS500J06; KBio1_000184; HMS2424P09; HMS3714B16; Pharmakon1600-01500451; ZINC136138; ALBB-021277; BCP25880; HY-A0067; ANW-19363; BBL003220; BDBM50253134; CCG-40226; NSC757260; s4691; SBB056669; STK057962; AKOS000120532; Tox21_110418_1; CS-3186; DB01428; MCULE-2222013605; NSC-757260; IDI1_000184; I956; ST029243; SBI-0051470.P003; AB00052063; FT-0612546; H2437; (2-hydroxy-4-methoxyphenyl)(phenyl) methanone; C14285; D05309; AB00052063_13; AE-848/01549044; Q518114; Q-200287; component of Caraloe snow & sun lip balm (Salt/Mix); Benzophenone 3;Eusolex-4360;2-Hydroxy-4-methoxybenzone; Z1945708085; 2-Hydroxy-4-methoxybenzophenone 10 microg/mL in Cyclohexane; Oxybenzone, United States Pharmacopeia (USP) Reference Standard; 2-Hydroxy-4-methoxybenzophenone, certified reference material, TraceCERT(R); Oxybenzone, Pharmaceutical Secondary Standard; Certified Reference Material; 1-(cyclopropylcarbonyl)-N-(4-ethoxyphenyl)-3,3-dimethylindoline-5-sulfonamide
A chemical sunscreen agent that absorbs UVB and short UVA rays (280-350nm) with its peak protection at 288 nm. Unlike many other chemical sunscreens, it is highly stable but its UV absorbing abilities are weak so it always has to be combined with other sunscreen agents for proper protection. More often than not, it's used as a photostabilizer rather than a proper sunscreen agent as it can protect formulas nicely from UV damage.
First, its molecules are small (228 Da) and very lipophilic (oil loving) and these properties result in very good absorption.
In fact, a 2004 follow-up study to examine the estrogenic effect of sunscreens when used topically on the whole body found that "the endogenous levels of reproductive hormones were unaffected"
On the up side, sunscreens are pretty well regulated in several parts of the world, and BP-3 is considered "safe as used" and is an allowed sunscreen agent everywhere. It can be used in concentrations of up to 10% in the EU and up to 6% in the US.
Submission I on the UV-filter Oxybenzone (the INN name), also known as Benzophenone-3 or 2-hydroxy-4-methoxybenzone, has been submitted by COLIPA1 . Benzophenone-3 is proposed to be continued for use in sunscreen products at a maximum concentration at 10% weight/weight. The substance is currently regulated in the cosmetics directive in annex VII, part 1 list of permitted UV filters which cosmetic product may contain. The regulation demands a warning on the label "contains oxybenzone". According to the preamble to annex VII the authorised UV-filters “may be added to other cosmetic products within the limits and under the conditions laid down in this annex.”
Although it is acknowledged that Benzophenone-3 has been used for many years in several types of applications and that the chemical and physical specifications have been extensively studied in the past, it is the opinion of the SCCP that characterization and determination of purity should be based upon raw data instead of simple mentions in material technical/safety data sheets. At least the solubility in water, partition coefficient and the chemical characterisation, including the UV-spectrum, should be given for a recently tested batch.
Benzophenone-3 is used as a broad-band UV filter in concentrations of up to 10% in sunscreen products alone or in combination with other UV filters. Beside the usage in sunscreens, Benzophenone-3 is incorporated in other types of cosmetic products at concentrations ranging between 0.05 - 0.5% for product protection (photoprotection).
Oxybenzone or benzophenone-3 or BP-3 (trade names Milestab 9, Eusolex 4360, Escalol 567, KAHSCREEN BZ-3) is an organic compound. It is a pale-yellow solid that is readily soluble in most organic solvents. Oxybenzone belongs to the class of aromatic ketones known as benzophenones. It is a naturally occurring[4] chemical found in various flowering plants[5] as well as being an organic component of many sunscreen lotions. It is also in widespread use in things like plastics, toys, furniture finishes, and more to limit UV degradation.
Being a conjugated molecule, oxybenzone absorbs light at lower energies than many aromatic molecules.[7] As in related compounds, the hydroxyl group is hydrogen bonded to the ketone.[8] This interaction contributes to oxybenzone's light-absorption properties. At low temperatures, however, it is possible to observe both the phosphorescence and the triplet-triplet absorption spectrum. At 175 K the triplet lifetime is 24 ns. The short lifetime has been attributed to a fast intramolecular hydrogen transfer between the oxygen of the C=O and the OH.
Oxybenzone is used in plastics as an ultraviolet light absorber and stabilizer.] It is used, along with other benzophenones, in sunscreens, hair sprays, and cosmetics because they help prevent potential damage from sunlight exposure. It is also found, in concentrations up to 1%, in nail polishes. Oxybenzone can also be used as a photostabilizer for synthetic resins. Benzophenones can leach from food packaging, and are widely used as photo-initiators to activate a chemical that dries ink faster.
As a sunscreen, it provides broad-spectrum ultraviolet coverage, including UVB and short-wave UVA rays. As a photoprotective agent, it has an absorption profile spanning from 270 to 350 nm with absorption peaks at 288 and 350 nm. It is one of the most widely used organic UVA filters in sunscreens today. It is also found in nail polish, fragrances, hairspray, and cosmetics as a photostabilizer. Despite its photoprotective qualities, much controversy surrounds oxybenzone because of its possible hormonal and photoallergenic effects, leading many countries to regulate its use.
Oxybenzone was approved for use in the US by the FDA in the early 1980s. Revised as of April 1, 2013, the FDA allows oxybenzone in OTC sunscreen products up to 6%.
Water-insoluble, soluble in alcohol & oil. Potent UVA & UVB absorber (primarily UVB but also UVA), enhances UVB protection of other sunscreens (e.g. homosalate, octyl salicylate, OM-cinnamate)
INCI Name: Benzophenone-3
Other Names: Oxybenzone
Cosmetic Applications: Sun care products , color cosmetics with sun protection, various cosmetics & fragrances for product protection.
Appearance: Yellowish crystalline powder
Solubility: Soluble in oils
Oxybenzone is an organic compound used in sunscreens. Oxybenzone is used as an ingredient in sunscreen and other cosmetics because it absorbs UVB and short-wave UVA (ultraviolet) rays. Oxybenzone was one of the first compounds incorporated into sunscreen formulations to offer enhanced UVA protection because its absorption spectrum extends to less than 350 nm.
Sunscreen. UV stabilizer
ultraviolet screen
Ultraviolet light absorber and stabilizer, especially in plastics and paints.
A hydroxybenzophenone that is benzophenone which is substituted at the 2and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.
White to off-white or light yellow powder.
Insoluble in water.
UV-9 is a light yellow or white crystalline powder, also known as sunscreen 2, BP-3, suitable for polyvinyl chloride, polyvinylidene chloride, polymethyl methacrylate , unsaturated polyester, ABS resin and cellulose resin and other plastics, the maximum absorption wavelength range of 280-340 nm, the general amount of 0.1-1.5%, good thermal stability, does not decompose at 200 ℃. This product hardly absorb visible light, it applies to light-colored transparent products. This product can also be used for paints and synthetic rubber. For the broad-spectrum UV absorbers, with high absorption rate, non-toxic, non-teratogenic effect, light, thermal stability. UV-9 can absorb UV-A and UV-B together, is the US FDA approved Class I sunscreen and being used with a higher frequency in the US and European countries. UV-9 is widely used in sunscreen cream, cream, honey, lotion, oil and other sunscreen cosmetics, but also as a product from the photosensitive and discoloration of the anti-discoloration agent. In addition, it is usually used for PVC and unsaturated polyester and many other fields, because UV-9 has good compatibility with many kinds of plastics and resins.
Consumer Uses
This substance is used in the following products: cosmetics and personal care products, coating products, fillers, putties, plasters, modelling clay and finger paints.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.
Article service life
Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).
Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). This substance can be found in complex articles, with no release intended: vehicles and Vehicles (e.g. personal vehicles, delivery vans, boats, trains, metro or planes)). This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), rubber used for large surface area articles (e.g. construction and building materials for flooring), plastic used for large surface area articles (e.g. construction and building materials for flooring, insulation), plastic used for packaging (excluding food packaging), plastic used for articles intended for food contact (e.g. plastic dinner ware, food storage) and plastic used for furniture & furnishings, including furniture coverings.
Widespread uses by professional workers
This substance is used in the following products: coating products, cosmetics and personal care products, adhesives and sealants, fillers, putties, plasters, modelling clay and finger paints.
This substance is used in the following areas: building & construction work.
This substance is used for the manufacture of: wood and wood products and machinery and vehicles.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Formulation or re-packing
This substance is used in the following products: cosmetics and personal care products, polymers, adhesives and sealants and coating products.
Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites
This substance is used in the following products: polymers, coating products, adhesives and sealants, photo-chemicals and cosmetics and personal care products.
This substance is used in the following areas: formulation of mixtures and/or re-packaging.
This substance is used for the manufacture of: plastic products and machinery and vehicles.
Release to the environment of this substance can occur from industrial use: in the production of articles and in processing aids at industrial sites.
IDENTIFICATION: 2-Hydroxy-4-methoxybenzophenone, also known as benzophenone-3, is a yellowish-white, cream-colored powder. It has a very weak odor. It has low solubility in water. It occurs naturally in some plants. USE: Benzophenone-3 is used as an ingredient in sunscreen products, cosmetics and as a UV stabilizer in paints and plastics.
Benzophenone-3 (BZ-3) is one of the UV-absorbing agents that has been used in industry and medicine for more than 30 years.
Millions of consumers are exposed to benzophenones on a daily basis owing to the widespread use of these compounds in many of the products on the market, such as lipsticks, hair sprays, hair dyes, shampoo and detergent bars and sunscreen lotions.
Used in cosmetics and sunscreen products at a maximum concentration at 10% weight/weight. Used as a broad-band UV filter in concentrations of up to 10% in sunscreen products alone or in combination with other UV filters. Beside the usage in sunscreens, it is incorporated in other types of cosmetic products at concentrations ranging between 0.05 - 0.5% for product protection (photoprotection).
Benzophenones-2, -3, -4, -6, -8, and, -9 are used in suntan lotions and hair sprays because they protect the skin and hair from the harmful effects of the sun. These ingredients also photostabilize cosmetic dyes, creams, and lotions. ...Benzophenones-1, -3, and -6 are ... frequently found in nail polishes (in concentrations up to 1%).
Industry Uses
Oxidizing/reducing agents
Stabilizer
2-Hydroxy-4-methoxybenzophenone is used as a broad-band filter in sunscreens cosmetic products in order to protect the skin from the deleterious effects of the sun. It acts as a reagent in the gravimetric determination of copper(II). Further, it is used in the preparation of poly[(2-hydroxy-4-methoxybenzophenone) propylene], which is a polymeric ligand useful for the synthesis of metal/ligand polychelates.
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.
Oxybenzone is a hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively. It has a role as a dermatologic drug, a protective agent, an ultraviolet filter, a xenobiotic and an environmental contaminant. It is a hydroxybenzophenone and a monomethoxybenzene.
Benzophenone-3 (BZ-3) is a category 1 (over-the-counter) product approved by the US Food and Drug Administration (FDA) for use as a sunscreen agent in medicine, cosmetics, industry, and agriculture. This is due to its ability to absorb and dissipate ultraviolet light in a harmless manner, thus protecting human skin and products from UV irradiation.
Sunscreen agents are indicated for the prevention of sunburn. In addition to limiting the skin's exposure to the sun, using sunscreen agents regularly when in the sun may help reduce long-term sun damage such as premature aging of the skin and skin cancer. /Sunscreen agents, topical; Included in US product labeling
The photoprotective effect after incorporation of the molecular sunscreen 2-hydroxy-4-methoxybenzophenone (Eusolex 4360) into the solid lipid nanoparticle (SLN) dispersion was observed to be increased threefold compared to a reference emulsion. Further, film formation on the skin was investigated by scanning electron microscopy, showing particle fusion due to water evaporation and formation of a dense film.
Oxybenzone is a chemical compound which is the active ingredient in most over the counter sunscreens, personal care and other skincare products. This is a UV- ray blocker which is highly effective and decelerates the absorption of harmful UVA and UVB rays from human skin. Exposure to solar UV radiation leads to skin cancer. This is the reason Oxybenzone are designed to help prevent life-threatening skin cancers.
Sunscreen lotions are used to protect the skin from the harmful effects of the sun. They help in preventing sunburn and premature ageing i.e. wrinkles and leathery skin. Oxybenzone helps in decreasing the risk of skin cancer and also sunburn reactions caused by various medications.
The active ingredients in sunscreen work as absorbing ultraviolet radiation and prevent it from reaching the deeper layers of the skin.
Sunscreens are used on the skin only. Follow all the directions mentioned on the package. Apply sunscreen to the exposed area before 30mins of sun exposure 30 grams is enoughto cover the entire body. If you are staying outside for a longer time apply the lotion for every 2 hours.
Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
Sunscreens are used to protect the skin from the harmful effects of the sun. They help to prevent sunburn and premature aging (such as wrinkles, leathery skin). Sunscreens also help to decrease the risk of skin cancer and also of sunburn-like skin reactions (sun sensitivity) caused by some medications (including tetracyclines, sulfa drugs, phenothiazines such as chlorpromazine).The active ingredients in sunscreens work either by absorbing the sun's ultraviolet (UV) radiation, preventing it from reaching the deeper layers of the skin, or by reflecting the radiation.Wearing sunscreen does not mean that you can stay out longer in the sun. Sunscreens cannot protect against all of the sun's radiation.There are various types of sunscreens available in many forms (e.g., cream, lotion, gel, stick, spray, lip balm). See the Notes section for information about selecting a sunscreen.
Used as an ultraviolet light absorber and stabilizer (especially in plastics), photostabilizer for synthetic resins, and topical sunscreen agent;
"This sector of the composites industry is characterized by the use of expensive, high-performance resin systems and high-strength, high-stiffness fiber reinforcement. The aerospace industry, including military and commercial aircraft of all types, is the major customer for advanced composites. These materials have also been adopted for use by the sporting goods suppliers who sell high-performance equipment to the golf, tennis, fishing, and archery markets."
Many hazardous chemicals and materials may be handled in the production of polymer-matrix composites such as 1) resin manufacturing; 2) resin formulation; 3) prepregging; and 4) open molding. The most commonly used fibers are carbon/graphite, Kevlar, and glass fibers. Commonly used chemicals include: solvents, isocyanates, epoxy resins, anhydrides, amino- and phenol-formaldehyde resins, and various amines used as catalysts or hardeners. Allergic contact dermatitis and asthma are the occupational diseases most likely to be encountered in this "industry."
Oxybenzone — also called benzophenone-3 and sometimes Milestab 9, Eusolex 4360, Escalol 567, or KAHSCREEN BZ-3 — is a chemical compound that is the active ingredient in most over-the-counter sunscreens and other personal care and skincare products. It’s a UV-ray blocker that is highly effective in slowing the absorption of harmful UVA and UVB rays by human skin.
Oxybenzone is a common ingredient found in 70% of all sunscreens and personal care products. It is an ultraviolet light absorber and filter
This ingredient is also a penetration enhancer that helps other ingredients penetrate the skin more readilyOxybenzone is in hundreds of personal care products like facial moisturizers, lip balm, lipstick, anti-aging creams, hair conditioners, and fragrances, it is most commonly found in sunscreen
IUPAC
(2-hydroxy-4-methoxyphenyl)(phenyl)methanone
(2-Hydroxy-4-methoxyphenyl)-phenylmethanone
(2-hydroxy-4-methoxyphenyl)-phenylmethanone
(2-Hydroxy-4-methoxyphenyl)phenylmethanone
2-benzoyl-5-methoxyphenol
2-Hydroxy-4-methoxy benzophenone
2-HYDROXY-4-METHOXYBENZOPHENONE
2-Hydroxy-4-Methoxybenzophenone
2-Hydroxy-4-methoxybenzophenone
Benzophenone, 2-hydroxy-4-methoxy-
Benzophenone-3
Eversorb 11
Oxybenzone
oxybenzone
Oxybenzone
oxybenzone
Speedblock UV-9
unknown
TRADE
Benzophenone-3(BP3)
Escalol 567
Eversorb 11
Oxybenzone
Speedblock UV-9
UVINOL M40
