PRODUCTS

BHT (BUTYLATED HYDROXYTOLUENE)

BHT (Butylated hydroxytoluene) is an organic chemical composed of 4-methylphenol modified with tert-butyl groups at positions 2 and 6.
BHT (Butylated hydroxytoluene) inhibits autoxidation of unsaturated organic compounds.
BHT (Butylated hydroxytoluene) is used in food, cosmetics and industrial fluids to prevent oxidation and free radical formation.

CAS Number: 128-37-0
EC Number: 204-881-4
IUPAC Name: 2,6-Di-tert-butyl-4-methylphenol
Chemical Formula: C15H24O

Other names: 2,6-Di-tert-butyl-4-methylphenol, 128-37-0, Butylated hydroxytoluene, Butylhydroxytoluene, 2,6-Di-tert-butyl-p-cresol, 2,6-Di-t-butyl-4-methylphenol, Ionol, DBPC, BHT, Dibunol, Stavox, Ionol CP, Impruvol, Topanol, Dalpac, Deenax, Ionole, Vianol, Antioxidant KB, 3,5-Di-tert-butyl-4-hydroxytoluene, Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, 2,6-ditert-butyl-4-methylphenol, Antioxidant 4K, Sumilizer BHT, Topanol O, Topanol OC, Vanlube PC, Antioxidant DBPC, Sustane BHT, Tenamene 3, Vanlube PCX, Antioxidant 29, Antioxidant 30, Nonox TBC, Tenox BHT, Di-tert-butyl-p-cresol, Chemanox 11, Ionol 1, Agidol, Catalin CAO-3, Kerabit, Advastab 401, Ionol (antioxidant), BUKS, Parabar 441, Paranox 441, 2,6-Di-tert-butyl-4-cresol, Catalin antioxydant 1, Antrancine 8, Butylated hydroxytoluol, Vulkanox KB, Dibutylated hydroxytoluene, Ional, 2,6-Bis(1,1-dimethylethyl)-4-methylphenol, AO 4K, CAO 1, CAO 3, Di-tert-butyl-p-methylphenol, o-Di-tert-butyl-p-methylphenol, 4-Methyl-2,6-tert-butylphenol, 2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene, 2,6-Di-tert-butyl-p-methylphenol, AO 29, NCI-C03598, 2,6-ditert-butyl-4-methyl-phenol, 2,6-DI-T-BUTYL-P-CRESOL, 4-Methyl-2,6-di-tert-butylphenol, Butyl hydroxy toluene, 2,6-Di-terc.butyl-p-kresol, 4-Hydroxy-3,5-di-tert-butyltoluene, FEMA No. 2184, P 21, Bht(food grade), 4-Methyl-2,6-di-terc. butylfenol, 2,6-Di-tert-butyl-4-methyl-phenol, Butylhydroxytoluenum, 1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene, MFCD00011644, Di-tert-butylcresol, UNII-1P9D0Z171K, Butylated hydroxytoluene (bht), Dbpc(technical grade), E321, p-Cresol, 2,6-di-tert-butyl-, CHEMBL146, CHEBI:34247, 1P9D0Z171K, NSC-6347, 2,6-di-tert-butyl-4-methyl phenol, NCGC00091761-03, Tonarol, DSSTox_CID_216, Antioxidant MPJ, Antioxidant 4, Toxolan P, Alkofen BP, Swanox BHT, Tenamen 3, Antox QT, Antioxidant 264, DSSTox_RID_75440, Agidol 1, DSSTox_GSID_20216, Bht (food grade), Antioxidant T 501, Nocrac 200, Caswell No. 291A, Dbpc (technical grade), Annulex BHT, AOX 4K, AOX 4, CAS-128-37-0, Butylohydroksytoluenu, CCRIS 103, Butylohydroksytoluenu [Polish], Ionol CP-antioxidant, Di-tert-butyl-p-cresol (VAN), HSDB 1147, BHT 264, NSC 6347, EINECS 204-881-4, 2,6-Di-terc.butyl-p-kresol [Czech], EPA Pesticide Chemical Code 022105, 2,6-Di-tert-butyl-4-methylhydroxybenzene, Popol, AI3-19683, 4-Methyl-2,6-di-terc. butylfenol [Czech], Lowinox BHT, Nipanox BHT, BHT Swanox, BHT, food grade, 4-Methyl-2,6-di-t-butyl-phenol, Ionol BHT, Ralox BHT, 2, food grade, Butylated hydroxytoluene [BAN:NF], 3IM, Dibutyl-para-cresol, 2,6-bis(tert-butyl)-4-methylphenol, butylated-hydroxytoluene, Spectrum_001790, BHT FCC/NF, SpecPlus_000768, Methyldi-tert-butylphenol, Spectrum3_001849, Spectrum5_001612, Hydagen DEO (Salt/Mix), EC 204-881-4, 2,6-di-Butyl-para-cresol, 2.6-di-t-butyl-p-cresol, SCHEMBL3950, 2,6-ditert-butyl-p-cresol, p-Cresol,6-di-tert-butyl-, Di-tert-Butylparamethylphenol, BSPBio_003238, KBioSS_002281, 2,6-di-tert.butyl-p-cresol, Di-tert-Butyl-4-methylphenol, MLS000069425, BIDD:ER0031, Butylated hydroxytoluene (NF), DivK1c_006864, SPECTRUM1600716, 2,6-bis-tert-butyl-p-cresol, 2,6-di-tert-butyl-paracresol, BHT (butylated hydroxytoluene), 2,6-di-tert. butyl-p-cresol, 2,6-di-tert.-butyl-p-cresol, 2,6-ditertiary-butyl-p-cresol, INS NO.321, 2,6-di-tert-butyl-para-cresol, 2,6-di-tert-Butyl-methylphenol, 2,6-ditertbutyl-4-methylphenol, 128-37-0, 2,6-Di-tert-butyl-4-methylphenol, Butylated hydroxytoluene, Butylhydroxytoluene, 2,6-Di-tert-butyl-p-cresol, 2,6-Di-t-butyl-4-methylphenol, Ionol, DBPC, BHT, Dibunol, Stavox, Ionol CP, Impruvol, Topanol, Dalpac, Deenax, Ionole, Vianol, Antioxidant KB, 3,5-Di-tert-butyl-4-hydroxytoluene, Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, 2,6-ditert-butyl-4-methylphenol, Antioxidant 4K, Sumilizer BHT, Topanol O, Topanol OC, Vanlube PC, Antioxidant DBPC, Sustane BHT, Tenamene 3, Vanlube PCX, Antioxidant 29, Antioxidant 30, Nonox TBC, Tenox BHT, Di-tert-butyl-p-cresol, Chemanox 11, Ionol 1, Agidol, Catalin CAO-3, Kerabit, Advastab 401, Ionol (antioxidant), BUKS, Parabar 441, Paranox 441, 2,6-Di-tert-butyl-4-cresol, Catalin antioxydant 1, Antrancine 8, Butylated hydroxytoluol, Vulkanox KB, Dibutylated hydroxytoluene, Ional, 2,6-Bis(1,1-dimethylethyl)-4-methylphenol, AO 4K, CAO 1, CAO 3, Di-tert-butyl-p-methylphenol, o-Di-tert-butyl-p-methylphenol, 4-Methyl-2,6-tert-butylphenol, 2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene, 2,6-Di-tert-butyl-p-methylphenol, AO 29, NCI-C03598, 2,6-ditert-butyl-4-methyl-phenol, 2,6-DI-T-BUTYL-P-CRESOL, 4-Methyl-2,6-di-tert-butylphenol, Butyl hydroxy toluene, 2,6-Di-terc.butyl-p-kresol, 4-Hydroxy-3,5-di-tert-butyltoluene, FEMA No. 2184, P 21, Bht(food grade), 4-Methyl-2,6-di-terc. butylfenol, 2,6-Di-tert-butyl-4-methyl-phenol, Butylhydroxytoluenum, 1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene, MFCD00011644, Di-tert-butylcresol, UNII-1P9D0Z171K, Butylated hydroxytoluene (bht), Dbpc(technical grade), E321, p-Cresol, 2,6-di-tert-butyl-, CHEMBL146, CHEBI:34247, 1P9D0Z171K, NSC-6347, 2,6-di-tert-butyl-4-methyl phenol, NCGC00091761-03, Tonarol, DSSTox_CID_216, Antioxidant MPJ, Antioxidant 4, Toxolan P, Alkofen BP, Swanox BHT, Tenamen 3, Antox QT, Antioxidant 264, DSSTox_RID_75440, Agidol 1, DSSTox_GSID_20216, Bht (food grade), Antioxidant T 501, Nocrac 200, Caswell No. 291A, Dbpc (technical grade), Annulex BHT, AOX 4K, AOX 4, CAS-128-37-0, Butylohydroksytoluenu, CCRIS 103, Butylohydroksytoluenu [Polish], Ionol CP-antioxidant, Di-tert-butyl-p-cresol (VAN), HSDB 1147, BHT 264, NSC 6347, EINECS 204-881-4, 2,6-Di-terc.butyl-p-kresol [Czech], EPA Pesticide Chemical Code 022105, 2,6-Di-tert-butyl-4-methylhydroxybenzene, Popol, AI3-19683, 4-Methyl-2,6-di-terc. butylfenol [Czech], Lowinox BHT, Nipanox BHT, BHT Swanox, BHT, food grade, 4-Methyl-2,6-di-t-butyl-phenol, Ionol BHT, Ralox BHT, 2, food grade, Butylated hydroxytoluene [BAN:NF], 3IM, Dibutyl-para-cresol, 2,6-bis(tert-butyl)-4-methylphenol, butylated-hydroxytoluene, Spectrum_001790, BHT FCC/NF, SpecPlus_000768, Methyldi-tert-butylphenol, Spectrum3_001849, Spectrum5_001612, Hydagen DEO (Salt/Mix), EC 204-881-4, 2,6-di-Butyl-para-cresol, 2.6-di-t-butyl-p-cresol, SCHEMBL3950, 2,6-ditert-butyl-p-cresol, p-Cresol,6-di-tert-butyl-, Di-tert-Butylparamethylphenol, BSPBio_003238, KBioSS_002281, 2,6-di-tert.butyl-p-cresol, Di-tert-Butyl-4-methylphenol, MLS000069425, BIDD:ER0031, Butylated hydroxytoluene (NF), DivK1c_006864, SPECTRUM1600716, 2,6-bis-tert-butyl-p-cresol, 2,6-di-tert-butyl-paracresol, BHT (butylated hydroxytoluene), 2,6-di-tert. butyl-p-cresol, 2,6-di-tert.-butyl-p-cresol, 2,6-ditertiary-butyl-p-cresol, INS NO.321, 2,6-di-tert-butyl-para-cresol, 2,6-di-tert-Butyl-methylphenol, 2,6-ditertbutyl-4-methylphenol, DTXSID2020216, 2,6-di-t butyl-4-methylphenol, 2.6-di-t-butyl-4-methylphenol, FEMA 2184, KBio1_001808, KBio2_002280, KBio2_004848, KBio2_007416, KBio3_002738, 2,6-di-tert-butyl-4-methylenol, 2,6-di-tert-butyl-4methylphenol, 2,6-di-tert-butyl4-methylphenol, 2,6-di-tertbutyl-4-methylphenol, 2,6-ditert.butyl-4-methylphenol, Butylated hydroxyl toluene (BHT), INS-321, NSC6347, 2,6-Di(tert-butyl)hydroxytoluene, 2,6-di(t-butyl)-4-methylphenol, 2,6-di-t- butyl-4-methylphenol, 2,6-di-t-butyl 4-methyl phenol, 2,6-di-t-butyl-4-methyl phenol, 2,6-di-t-butyl-4-methyl-phenol, 3,5-di-t-butyl-4-hydroxytoluene, Butylated hydroxytoluene (e 321), HMS2091E21, HMS2231M22, HMS3369G17, HMS3750M21, Pharmakon1600-01600716, 2,1-dimethylethyl)-4-methylphenol, 2,6-di-tert-butyl 4-methylphenol, 2,6-di-tert-butyl-4 methylphenol, 2,6-di-tert-butyl4-methyl phenol, 2,6-di-tert.butyl-4-methylphenol, 2,6-ditert.-butyl-4-methylphenol, 2.6-di-tert-butyl-4-methylphenol, 4-methyl-2,6-di-tert.butylphenol, 2,6-di-ter-butyl-4-methyl-phenol, 2,6-Di-tert.-Butyl4-methylphenol, 2,6-ditertiarybutyl-4-methylphenol, 2.6-di- t-butyl- 4-methylphenol, AMY40200, HY-Y0172, STR04334, ZINC1481993, 2,6 -di-tert-butyl-4-methylphenol, 2,6-di(tert-butyl)-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, 8CI, 2,6-di-tert.-butyl-4-methylphenol, Tox21_113537, Tox21_201093, Tox21_303408, 2,6-di-tert-butyl-p-cresol (BHT), 2,6-Di-tert-butyl-para-methylphenol, BDBM50079507, NSC759563, s6202, STL277184, 2,6-di-tert-butyl-4-methylphenol

BHT (Butylated hydroxytoluene) is a white crystalline solid.
BHT (Butylated hydroxytoluene) is a natural product found in Thymus longicaulis, Teucrium leucocladum, and other organisms with data available.

Use and Manufacturing of Butylated Hydroxytoluene
Used as an anti-oxidant in gasoline, oils, waxes, rubbers, paints, and plastics; purified forms are used as anti-oxidants in foods; [ACGIH] Used as an anti-skinning agent in paints and inks;
BHT (Butylated hydroxytoluene) is a preservative and anti-oxidant used in food, cosmetics, and medications. Industrial applications include: animal feeds, jet fuels, rubber, plastics, paints, and glues.
Antioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, soaps. Antiiskinning agent in paints and inks.

BHT (Butylated hydroxytoluene) is used as an antioxidant which finds many applications in a wide variety of industries.
BHT (Butylated hydroxytoluene) is used in ground vehicle and aviation gasolines; lubricating, turbine, and insulation oils; waxes, synthetic and natural rubbers, paints, plastics, and elastomers.
BHT (Butylated hydroxytoluene) protects these materials from oxidation during prolonged storage.

Highly purified grades are suitable for use in foods to retard oxidation of animal fats, vegetable oils, and oil-soluble vitamins.
BHT (Butylated hydroxytoluene) is also used in cosmetics and food packaging materials such as waxed paper, paper board, and polyethylene.
BHT (Butylated hydroxytoluene) is important in delaying the onset of rancidity of oils and fats in animal feeds, and in preserving the essential nutrients and pigment-forming compounds of these foods.

Industry Uses of Butylated Hydroxytoluene
Adhesives and sealant chemicals
Anti-oxidant
Antioxidant
Antioxidant/Preservative/Stabilizer
Chemical Distribution
Fuels and fuel additives
Intermediates
Laboratory chemicals

Lubricants and lubricant additives
Odor agents
Oxidizing/reducing agents
Paint additives and coating additives not described by other categories
Photosensitive chemicals
Pigments
Plasticizers
Polymer Additive

Polymer Manufacturing
Process regulators
Processing aids, not otherwise listed
Processing aids, specific to petroleum production
Surface active agents
printing inks, lithographs

Consumer Uses of Butylated Hydroxytoluene
Adhesives and sealants
Air care products
Building/construction materials not covered elsewhere
Cleaning and furnishing care products
Fabric, textile, and leather products not covered elsewhere
Fuels and related products
Ink, toner, and colorant products

Laundry and dishwashing products
Lubricants and greases
Non-TSCA use
Paints and coatings
Paper products
Photographic supplies, film, and photo chemicals
Plastic and rubber products not covered elsewhere
printing inks, lithographs

Household Products of Butylated Hydroxytoluene
Household & Commercial/Institutional Products
Information on 482 consumer products that contain 2,6-Di-t-butyl-p-cresol (BHT (Butylated hydroxytoluene)) in the following categories is provided:
Auto Products
Commercial / Institutional
Hobby/Craft
Home Maintenance
Home Office
Inside the Home
Personal Care
Pet Care

Methods of Manufacturing of Butylated Hydroxytoluene
The production of the important antioxidant 2,6-di-tert-butyl-4-methylphenol from 4-cresol and isobutene is carried out at 70 °C using H2SO4 as the catalyst.
BHT (Butylated hydroxytoluene) is produced commercially by the alkylation of para-cresol with isobutylene.

BHT (Butylated hydroxytoluene), also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for its antioxidant properties.
BHT (Butylated hydroxytoluene) is widely used to prevent free radical-mediated oxidation in fluids (e.g. fuels, oils) and other materials, and the regulations overseen by the U.S. F.D.A.—which considers BHT (Butylated hydroxytoluene) to be "generally recognized as safe"—allow small amounts to be added to foods.
Despite this, and the earlier determination by the National Cancer Institute that BHT (Butylated hydroxytoluene) was noncarcinogenic in an animal model, societal concerns over its broad use have been expressed.
BHT (Butylated hydroxytoluene) has also been postulated as an antiviral drug, but as of March 2020, use of BHT (Butylated hydroxytoluene) as a drug is not supported by the scientific literature and it has not been approved by any drug regulatory agency for use as an antiviral.

Phytoplankton, including the green algae Botryococcus braunii, as well as three different cyanobacteria (Cylindrospermopsis raciborskii, Microcystis aeruginosa and Oscillatoria sp.) are capable of producing BHT (Butylated hydroxytoluene) as a natural product.
The fruit lychee also produces BHT (Butylated hydroxytoluene) in its pericarp.[9] Several fungi (for example Aspergillus conicus) living in olives produce BHT (Butylated hydroxytoluene).

Production of Butylated hydroxytoluene
Industrial production
The chemical synthesis of BHT (Butylated hydroxytoluene) in industry has involved the reaction of p-cresol (4-methylphenol) with isobutylene (2-methylpropene), catalyzed by sulfuric acid:
CH3(C6H4)OH + 2 CH2=C(CH3)2 → ((CH3)3C)2CH3C6H2OH
Alternatively, BHT (Butylated hydroxytoluene) has been prepared from 2,6-di-tert-butylphenol by hydroxymethylation or aminomethylation followed by hydrogenolysis.

Reactions
The species behaves as a synthetic analog of vitamin E, primarily acting as a terminating agent that suppresses autoxidation, a process whereby unsaturated (usually) organic compounds are attacked by atmospheric oxygen.
BHT (Butylated hydroxytoluene) stops this autocatalytic reaction by converting peroxy radicals to hydroperoxides.
It effects this function by donating a hydrogen atom:
RO2+ ArOH → ROOH + ArO-
RO2+ ArO→ nonradical products
where R is alkyl or aryl, and where ArOH is BHT (Butylated hydroxytoluene) or related phenolic antioxidants.
Each BHT (Butylated hydroxytoluene) consumes two peroxy radicals.

Applications of Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is listed by the NIH Hazardous Substances Data Bank under several categories in catalogues and databases, such as food additive, household product ingredient, industrial additive, personal care product/cosmetic ingredient, pesticide ingredient, plastic/rubber ingredient and medical/veterinary/research.

Food additive of Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is primarily used as an antioxidant food additive.
In the United States, it is classified as generally recognized as safe (GRAS) based on a National Cancer Institute study from 1979 in rats and mice.
It is approved for use in the U.S. by the Food and Drug Administration: For example, 21 CFR § 137.350(a)(4) allows BHT (Butylated hydroxytoluene) up to 0.0033% by weight in "enriched rice",while 9 CFR § 381.147](f)(1) allows up to 0.01% in poultry "by fat content".
It is permitted in the European Union under E321.

BHT (Butylated hydroxytoluene) is used as a preservative ingredient in some foods.
With this usage BHT (Butylated hydroxytoluene) maintains freshness or prevents spoilage; it may be used to decrease the rate at which the texture, color, or flavor of food changes.
Some food companies have voluntarily eliminated BHT (Butylated hydroxytoluene) from their products or have announced that they were going to phase it out.

Antioxidant of Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is also used as an antioxidant in products such as metalworking fluids, cosmetics, pharmaceuticals, rubber, transformer oils, and embalming fluid.
In the petroleum industry, where BHT (Butylated hydroxytoluene) is known as the fuel additive AO-29, it is used in hydraulic fluids, turbine and gear oils, and jet fuels.
BHT (Butylated hydroxytoluene) is also used to prevent peroxide formation in organic ethers and other solvents and laboratory chemicals.
It is added to certain monomers as a polymerisation inhibitor to facilitate their safe storage.
Some additive products contain BHT (Butylated hydroxytoluene) as their primary ingredient, while others contain the chemical merely as a component of their formulation, sometimes alongside butylated hydroxyanisole (BHA).

Health effects of Butylated hydroxytoluene
Like many closely related phenol antioxidants, BHT (Butylated hydroxytoluene) has low acute toxicity(e.g., the desmethyl analog of BHT (Butylated hydroxytoluene), 2,6-di-tert-butylphenol, has an LD50 of >9 g/kg).
The US Food and Drug Administration classifies BHT (Butylated hydroxytoluene) as generally recognized as safe (GRAS) as a food preservative when used according in an approved manner.
In 1979, the National Cancer Institute determined that BHT (Butylated hydroxytoluene) was noncarcinogenic in a mouse model.

Nevertheless, the World Health Organization discussed a possible link between BHT (Butylated hydroxytoluene) and cancer risk in 1986, and some primary research studies in the 1970s–1990s reported both potential for increased risk and potential for decreased risk in the area of oncology.
Because of this uncertainty, the Center for Science in the Public Interest puts BHT (Butylated hydroxytoluene) in its "caution" column and recommends avoiding it.

Based on various, disparate primary research reports, BHT (Butylated hydroxytoluene) has been suggested to have anti-viral activity,and the reports divide into various study types.
First, there are studies that describe virus inactivation—where treatment with the chemical results in disrupted or otherwise inactivated virus particles.
The action of BHT (Butylated hydroxytoluene) in these is akin to the action of many other organic compounds, e.g., quaternary ammonium compounds, phenolics, and detergents, which disrupt viruses by insertion of the chemical into the virus membrane, coat, or other structure, which are established methods of viral disinfection secondary to methods of chemical oxidation and UV irradiation.

In addition, there is a report of BHT (Butylated hydroxytoluene) use, topically against genital herpes lesions, a report of inhibitory activity in vitro against pseudorabies (in cell culture), and two studies, in veterinary contexts, of use of BHT (Butylated hydroxytoluene) to attempt to protect against virus exposure (pseudorabies in mouse and swine, and Newcastle in chickens).
The relevance of other reports, regarding influenza in mice, is not easily discerned.
Notably, this series of primary research reports does not support a general conclusion of independent confirmation of the original research results, nor are there critical reviews appearing thereafter, in secondary sources, for the various host-virus systems studied with BHT (Butylated hydroxytoluene).

Hence, at present, the results do not present a scientific consensus in favour of the conclusion of the general antiviral potential of BHT (Butylated hydroxytoluene) when dosed in humans.
Moreover, as of March 2020, no guidance from any of the internationally recognized associations of infectious disease specialists had advocated use of BHT (Butylated hydroxytoluene) products as an antiviral therapy or prophylactic.

BHT (Butylated hydroxytoluene) is a lab-made chemical that is added to foods as a preservative.
People also use it as medicine.
BHT (Butylated hydroxytoluene) is used to treat genital herpes and acquired immunodeficiency syndrome (AIDS).
Some people apply BHT (Butylated hydroxytoluene) directly to the skin for cold sores.

BHT (Butylated hydroxytoluene) is an antioxidant.
BHT (Butylated hydroxytoluene) may damage the protective outer layer of viral cells.
This may keep the viruses from multiplying and/or doing more damage.

Butylated Hydroxy Toluene, butylhydroxytoluene, or BHT (Butylated hydroxytoluene) is a fat-soluble organic compound in a white powder form that is primarily used as an antioxidant food additive and cosmetics and, pharmaceuticals.
Technical applications include additives in jet fuels, rubber, petroleum products, electrical transformer oil, and embalming fluid.
BHA (butylated hydroxyanisole) and BHT (Butylated hydroxytoluene) are closely related synthetic antioxidants used as preservatives in lipsticks and moisturizers, among other cosmetics.
They are also widely used as food preservatives.

Reactivity Profile of Butylated hydroxytoluene
BUTYLATED HYDROXYTOLUENE, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure.
Instead, they react as weak organic acids.
Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88).
These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides.
Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas.

Heat is also generated by the acid-base reaction between phenols and bases.
Such heating may initiate polymerization of the organic compound.
Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature).
The reactions generate heat.

Phenols are also nitrated very rapidly, even by dilute nitric acid.
Nitrated phenols often explode when heated.
Many of them form metal salts that tend toward detonation by rather mild shock.
May react with oxidizing materials.

Butylated hydroxytoluene, commonly known as BHT (Butylated hydroxytoluene), is an organic compound that is used in the food, cosmetic, and pharmaceutical industry as an antioxidant.
BHT (Butylated hydroxytoluene) is a substituted derivative of phenol.
BHT (Butylated hydroxytoluene) helps to prevent the formation of free radicals and oxidation.
When used in food products, it delays oxidative rancidity of fats and oils, and prevents loss of activity of oil-soluble vitamins.
It may be found in pharmaceutical gels, creams and liquid or gelatin capsules, tablets and other pharmaceutical dosage forms.

The ability of oral BHT (Butylated hydroxytoluene) to lead to cancer is a controversial topic, but most food industries have replaced it with butylated hydroxyanisole (BHA).
BHT (Butylated hydroxytoluene) was first used as an antioxidant food additive in 1954.
BHT (Butylated hydroxytoluene) does have other commercial uses, as in animal feeds and in the manufacture of synthetic rubber and plastics, where it also acts as an antioxidant.
The U.S. Food and Drug Administration has deemed that BHT (Butylated hydroxytoluene) is safe enough when used in limited concentrations.
BHT (Butylated hydroxytoluene) currently permits its use in concentrations of about 0.01% to 0.02% in most foods.
As an emulsion stabilizer in shortening, it may be used in a somewhat higher concentration, 200 parts per million.

BHT (Butylated hydroxytoluene) is commonly used as a food and cosmetics additive; it exhibits antioxidative and anti-inflammatory activities.
BHT (Butylated hydroxytoluene) may also display neuroprotective benefit, decreasing ethanol-induced brain damage and neurodegeneration and suppressing activation of NF-κB activation and COX-2 expression in vivo.

BHT (Butylated hydroxytoluene) is an antioxidant used in a variety of products.
Intended uses include products like food, animal feed, cosmetics, packaging materials, pharmaceuticals, polymers and paints.
BHT (Butylated hydroxytoluene) toxicity is generally considered as being low.
Since BHT (Butylated hydroxytoluene) is used in many near consumer products population wide exposure is expected.

BHT (Butylated hydroxytoluene) or BHT (Butylated hydroxytoluene) is a stabiliser that can be found in cosmetic products.
It acts as an antioxidant that helps maintain the properties and performance of a product as it is exposed to air (to avoid a change in odor, in color, in texture...).
To identify BHT (Butylated hydroxytoluene) in our products, take a look at the ingredients list on packaging.
It can be found under the acronym BHT (Butylated hydroxytoluene).

BHT (Butylated hydroxytoluene) is used in various cosmetic products, including certain formulas containing fats or in aqueous emulsions containing certain active ingredients or plant extracts.
BHT (Butylated hydroxytoluene) is an antioxidant used in certain products to stabilise and protect the raw materials themselves, and less as an ingredient in and of itself.
BHT (Butylated hydroxytoluene) can resist high temperatures (unlike some natural antioxidants): it is therefore very useful in certain raw material manufacturing processes.
We only use it as an ingredient for its antioxidant properties, helping to protect the products from oxidation and ensure the quality and stability of formulas.

Aceto's BHT (Butylated hydroxytoluene) multi-compendial is an excipient which meets USP-NF, EP and BP monographs.
BHT (Butylated hydroxytoluene) multi-compendial is described as a white or pale yellow crystalline solid or powder.
It has antioxidant properties and is used in pharmaceutical gels, creams, liquids, gelatin capsules and tablets.
It is used as a preservative for fats and oils.
Aceto's BHT (Butylated hydroxytoluene) USP-NF is an excipient which meets the USP-NF monograph.

BHT (Butylated hydroxytoluene) USP-NF is described as a white or pale yellow crystalline solid or powder.
It has antioxidant properties and is used in pharmaceutical gels, creams, liquids, gelatin capsules and tablets.
It is used as a preservative for fats and oils.
BHT (Butylated hydroxytoluene) is a commonly also used excipient as an antioxidant.

BHT (Butylated hydroxytoluene) N.F. Grade Powder (60 Mesh) is a colorless powder food additive with a mild phenolic, camphor odor.
BHT (Butylated hydroxytoluene) is used to add preservatives and antioxidants to enriched rice, margarine, gums, chewing gum bases, and other food preservatives.
BHT (Butylated hydroxytoluene) is a phenolic antioxidant used in the preservation of a wide variety of products, including shelf-stable baked goods.
BHT (Butylated hydroxytoluene) is an antioxidant for preventing spoilage of fats and oils in baked goods.

BHT (Butylated hydroxytoluene) is used in foods that contain oil and fat. It functions as an antioxidant for preventing spoilage of fats and oils in baked goods by binding oxygen molecules.
Oxygen molecules react preferentially with BHT (Butylated hydroxytoluene) rather than oxidizing the fats or oils.
In addition, this action preserves food aroma, color, and flavor.

First Aid of Butylated hydroxytoluene
EYES:
First check the victim for contact lenses and remove if present.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN:
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.
Gently wash all affected skin areas thoroughly with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown atmosphere.
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION:
DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center.
Be prepared to transport the victim to a hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.
DO NOT INDUCE VOMITING.
IMMEDIATELY transport the victim to a hospital.

Hazard classification & labelling of Butylated hydroxytoluene
Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is very toxic to aquatic life with long lasting effects and is very toxic to aquatic life.

About Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
BHT (Butylated hydroxytoluene) is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses of Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is used in the following products: washing & cleaning products, lubricants and greases, plant protection products, adhesives and sealants, polishes and waxes, coating products and fertilisers.
Other release to the environment of BHT (Butylated hydroxytoluene) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Article service life of Butylated hydroxytoluene
Release to the environment of BHT (Butylated hydroxytoluene) can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and industrial abrasion processing with high release rate (e.g. sanding operations or paint stripping by shot-blasting).
Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

BHT (Butylated hydroxytoluene) can be found in complex articles, with no release intended: vehicles. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), metal (e.g. cutlery, pots, toys, jewellery), wood (e.g. floors, furniture, toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys).

Widespread uses by professional workers of Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is used in the following products: washing & cleaning products, polishes and waxes and plant protection products.
BHT (Butylated hydroxytoluene) is used in the following areas: printing and recorded media reproduction and building & construction work.
BHT (Butylated hydroxytoluene) is used for the manufacture of: textile, leather or fur, furniture and machinery and vehicles.
Other release to the environment of BHT (Butylated hydroxytoluene) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

Formulation or re-packing of Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is used in the following products: lubricants and greases, textile treatment products and dyes, polymers, inks and toners, coating products, cosmetics and personal care products, fertilisers and leather treatment products.
Release to the environment of BHT (Butylated hydroxytoluene) can occur from industrial use: formulation of mixtures and formulation in materials.

Uses at industrial sites of Butylated hydroxytoluene
BHT (Butylated hydroxytoluene) is used in the following products: washing & cleaning products, metal surface treatment products, textile treatment products and dyes, polymers, pH regulators and water treatment products, leather treatment products and lubricants and greases.
BHT (Butylated hydroxytoluene) is used in the following areas: printing and recorded media reproduction and formulation of mixtures and/or re-packaging.

BHT (Butylated hydroxytoluene) is used for the manufacture of: plastic products, rubber products, pulp, paper and paper products, textile, leather or fur and wood and wood products.
Release to the environment of BHT (Butylated hydroxytoluene) can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Manufacture of Butylated hydroxytoluene
Release to the environment of BHT (Butylated hydroxytoluene) can occur from industrial use: manufacturing of the substance.