BISABOLOL

Bisabolol is used in cosmetic formulations as a skin conditioning agent.
Bisabolol has anti-inflammatory and antibacterial properties and is widely used in the cosmetic and pharmaceutical industries, particularly in skin care products . 
Bisabolol is used in cosmetics for its soothing properties, but is also known as an anti-inflammatory and healing agent.

CAS Number: 515-69-5 
EC Number: 208-295-9
Molecular Formula: C15H26O
Molecular Weight: 222.37 g/mol

SYNONYMS:
Bisabolol, α-Bisabolol, (−)-α-Bisabolol, Levomenol, α-4-Dimethyl-α-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol, Camilol, Dragosantol, dl-α-Bisabolol (racemic mixture), (2S)-6-Methyl-2-[(1S)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol, Levomenol, Bisabolol, 515-69-5, 36HQN158VC, DTXSID5045964, DTXCID3025964, 5-HEPTEN-2-OL, 6-METHYL-2-(4-METHYL-3-CYCLOHEXEN-1-YL)-, 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-penten-1-yl)-, (alphaR,1R)-rel-, 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (alphaR,1R)-rel-, 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (R*,R*)-, GZE Skincare Oil, Bisabolol 0.5%, RefChem:917307, 208-205-9, alpha-Bisabolol, (+)-alpha-Bisabolol, 23178-88-3, (2R)-6-methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol, D-alpha-Bisabolol, MFCD03846910, (+)-(1'R,2R)-alpha-Bisabolol, Dragosantol, Camilol, (AlphaR,1R)-Alpha-Bisabolol, CHEMBL1171719, Hydagen B, 105S6I733Z, (2R)-6-Methyl-2-(4-methyl-3-cyclohexenyl)-5-heptene-2-ol, (R)-6-Methyl-2-((R)-4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol, (+/-)-alpha-Bisabolol, alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol, rel-(R)-6-Methyl-2-((R)-4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol, 3-Cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (R*,R*)-, dl-.alpha.-Bisabolol, 6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, BISABOLOL, ALPHA, CAS-515-69-5, BISABOLOL, .ALPHA., RACEMIC ALFA-BISABOLOL, alpha-Bisabolol, (+)-, UNII-36HQN158VC, BISABOLA-1,12-DIEN-8-OL, UNII-105S6I733Z, alpha-Bisabolol (+)-form [MI], NCGC00095252-01, (+)-a-Bisabolol, EINECS 208-205-9, EINECS 246-973-7, (+/-)alpha-Bisabolol, (aR,1R)-a-Bisabolol, (+)-.alpha.-Bisabolol, BISABOLOL [WHO-DD], 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-penten-1-yl)-, (alphaR,1R)-, D-.ALPHA.-BISABOLOL, SCHEMBL24988, (+)-6R,7R-alpha-Bisabolol, .alpha.,4-Dimethyl-.alpha.-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol, .ALPHA.-BISABOLOL [MI], BISABOLOL, (+/-), SCHEMBL31157846, (R*,R*)-.alpha.,4-Dimethyl-.alpha.-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol, (R*,R*)-.alpha.,4-Dimethyl-.alpha.-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol, CHEBI:192031, ALPHA-BISABOLOL, (+-), 3-Cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-penten-1-yl)-, (.alpha.R,1R)-rel-, (+/-)-.ALPHA.-BISABOLOL, .ALPHA.-BISABOLOL, (+)-, Tox21_111490, BDBM50284328, MSK158680, s6136, AKOS015969722, Tox21_111490_1, .ALPHA.-BISABOLOL, (+/-), (R*,R*)-alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol, NCGC00095252-05, 25428-43-7, (inverted exclamation markA)-|A-Bisabolol, .ALPHA.-BISABOLOL (+)-FORM [MI], HY-121222, (+)-(1'R,2R)-.ALPHA.-BISABOLOL, CS-0081254, 515B695, 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (R*,R*)-(1)-alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol, alpha,4-Dimethyl-alpha-(4-methyl-3-penten-1-yl)-(alphaR,1R)-3-Cyclohexene-1-methanol, 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL-3-PENTEN-1-YL)-, (.ALPHA.R,1R)-REL-, 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL- 3-PENTENYL)-, (.THETA.,.THETA.)-(+/-)-, 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL- 3-PENTENYL)-, (R*,R*)-, 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL-3-PENTEN-1-YL)-, (.ALPHA.R,1R)-, 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (theta,theta)-(+/-)-, Bisabolol; 3-Cyclohexene-1-methanol, α,4-dimethyl-α-(4-methyl-3-pentenyl)-, (R*,R*)-; 5-Hepten-2-ol, 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-; α,4-Dimethyl-α-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol; 6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; (R*,R*)-α,4-Dimethyl-α-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol; (R*,R*)-α,4-Dimethyl-α-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol; 3-Cyclohexene-1-methanol, α,4-dimethyl-α-(4-methyl-3-penten-1-yl)-, (αR,1R)-rel-; 3-Cyclohexene-1-methanol, α,4-dimethyl-α-(4-methyl-3-pentenyl)-, (αR,1R)-rel-; Camilol; Dragosantol; Hydagen B; dl-α-Bisabolol; α-bisabolool; α-Bisabalol, (-)-alpha-Bisabolol, (−)-6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, Levomenol, bisabola-1,12-dien-8-ol, bisabolol, dextro,laevo-alpha-bisabolol, DL-alpha-bisabolol, bisabolol alpha racemic synthetic, alpha-bisabolol ex lemon natural, alpha-bisabolol nat., alpha-bisabolol natural, alpha-bisabolol rac., 3-cyclohexene-1-methanol, a,4-dimethyl-a-(4-methyl-3-penten-1-yl)-, (aR,1R)-, 3-cyclohexene-1-methanol, a,4-dimethyl-a-(4-methyl-3-pentenyl)-, (aR,1R)-rel-, (R*,R*)-6-dethyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, (R*,R*)-(1)-alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl) cyclohex-3-ene-1-methanol, (R*,R*)-alpha,4-dimethyl-alpha

Bisabolol, or more formally α-(−)-bisabolol or also known as levomenol, is a natural monocyclic sesquiterpene alcohol.
Bisabolol is a colorless viscous oil that is the primary constituent of the essential oil from German chamomile (Matricaria recutita) and Myoporum crassifolium.

High concentrations of bisabolol can also be found in certain medicinal cannabis cultivars.
It is poorly soluble in water and glycerine, but soluble in ethanol.
The enantiomer, α-(+)-bisabolol, is also found naturally but is rare.

Synthetic bisabolol is usually a racemic mixture of the two, α-(±)-bisabolol.
Bisabolol is the terpenoid responsible for the distinctive aroma of chamomile flowers, and when isolated, its scent has also been likened to apples, sugar and honey.

Bisabolol has a weak, sweet floral aroma and is used in various fragrances.
Bisabolol has also been used for hundreds of years in cosmetics because of its skin healing properties including reducing wrinkles, skin toughness and repairing sun-damaged skin, and more recently it has been compounded with tretinoin as a topical treatment for acne.

Bisabolol is known to have anti-irritant, anti-inflammatory, and anti-microbial properties.
Bisabolol is also demonstrated to enhance the percutaneous absorption of certain molecules and has found use as a penetration enhancer: an agent used in topical formulations, increasing the substances propensity for absorption beneath the skin.

The structurally related compound, β-bisabolol (15352-77-9 ), differs in the positioning of the tertiary alcohol functional group.
Bisabolol is the main component of chamomile essential oil.
Bisabolol helps reduce redness thanks to its soothing and regenerating properties.

Bisabolol also has the remarkable additional benefit of increasing the effectiveness of other active ingredients.
Bisabolol is a sesquiterpenoid.
Bisabolol can be found naturally in chamomile or synthetically produced. 

Bisabolol is a chosen selection of products used in skin care due to its soothing, moisturizing, and anti-aging effects.
Bisabolol has been reported in Lasiolaena morii, Microbiota decussata, and other organisms with data available.
Bisabolol is a scent ingredient naturally occurring in camomile.

It's one of the active parts of Chamomile that contains about 30% of bisabolol.
Bisabolol's a clear oily fluid that is used in skincare as a nice anti-inflammatory and soothing ingredient.
Bisabolol, more formally αlpha-bisabolol or also known as levomenol, is a natural monocyclic sesquiterpene alcohol.

Bisabolol is a colorless to light yellow, oily liquid, that is the primary constituent of the essential oil from German chamomile (Matricaria recutita) and Myoporum crassifolium.
In terms of their chemical structure, there are two different forms of bisabolol: α-bisabolol and β-bisabolol

Bisabolol is obtained directly from the essential oil of chamomile.
The advantage of Bisabolol is its very high efficacy.
There is also a synthetic mix of alpha-bisabolol and beta-bisabolol.

Although this reduces the effect of bisabolol somewhat, it increases skin tolerance.
Bisabolol should be noted here that purely natural extracts always have an increased allergenic potential compared to synthetically produced ingredients.

Bisabolol is a monocyclic sesquiterpene alcohol found primarily in chamomile (Matricaria chamomilla) and the bark of the candeia tree (Vanillosmopsis erythropappa).

Bisabolol [(-)-alpha-bisabolol)], also known as Alpha Bisabolol or levomenol, is the primary constituent of German Chamomile (Matricaria chamomilla or Matricaria recutita), and is also found naturally in the bark of the Candeia (Vanillosmopsis erythropappa) tree of Brazil, which accounts for most of the world's production of this ingredient.

Bisabolol is a terpene and is classed as an alcohol.
Bisabolol is produced from the bark of the Candeia tree which is harvested in a sustainable manner.
Bisabolol is a well-known skin soothing agent.

Bisabolol comes in two different structural forms: alpha-bisabolol, derived from chamomile and other plants (although it can also be lab-created) vs. beta-bisabolol which is found in cotton and corn.
Bisabolol is the one used in skin care products.

Because bisabolol is typically derived from chamomile, and chamomile is a member of the ragweed family, it may be best to avoid it if you have a confirmed allergy to ragweed.
As a raw material, bisabolol is a colourless to light yellow, oily liquid.

In 2017, the Cosmetic Ingredient Review council concluded that bisabolol is safe used up to 1% concentration in leave-on formulations.
Bisabolol is naturally present in German Chamomile (Matricaria chamomilla or Matricaria recutita) or the wood of the Brazilian candela tree.
Bisabolol is an ingredient present in chamomile flowers.

The anti-inflammatory effect of chamomile flowers mainly comes from α-bisabolol.
Bisabolol, also known as Levomenol, may be obtained from the direct distillation of the oil from the tropical shrub candeia.
This shrub, Linnean name Vanillosmopsis erythropappa, which is of the Asteraceae family, grows in the southeast and midwest regions of Brazil.

This tree yields a white, hard, resinous wood and its leaves, flowers and oil have medicinal properties.
Bisabolol is also a major constituent of German Chamomile [Chamomilla Recutita (Matricaria) Flower Oil], which has been used in the traditional medicines of Europe for hundreds of years.

The essential oil of chamomile contains up to 50% 1-alpha-bisabolol.
RTD Alpha-Bisabolol Natural is an optically active viscous colorless to somewhat yellow liquid with slight characteristic floral wood odor.
Bisabolol contains at least 95% (-)-1-alpha-bisabolol, a monocyclic unsaturated sesquiterpene alcohol.

Bisabolol, which is nontoxic and nonirritating to the skin, has been shown to possess anti-inflammatory and wound healing properties, as well as antimycotic and antibacterial effects.
Specifically, Bisabolol is a potent inhibitor of fungi, Candida albicans and gram-positive bacteria.

Bisabolol is suitable for use in skin care products where the formulator wishes to take advantage of its anti-inflammatory, bactericidal and antimycotic properties, which make it a preferred active ingredient for protection of skin against stresses including cleansing, shaving, depilation, and sun exposure.

When Bisabolol is used at low levels (0.1 - 1.0% is recommended), it is active, safe, and skin compatible.
Bisabolol, also known as Levomenol, is obtained by distillation of certain essential oils, including wild camomile (Matricaria Recutita).
Bisabolol is in the form of a slightly fragrant oily liquid.

Bisabolol (or α-bisabolol) is a cosmetic ingredient commonly used in cosmetics and skincare products.
Bisabolol is a colorless, viscous oil that is a major component of German chamomile.

Bisabolol is frequently found in essential oils.
Bisabolol can also be synthetically produced.

USES and APPLICATIONS of BISABOLOL:
Bisabolol is used in cosmetic formulations as a skin conditioning agent.
Bisabolol has a weak sweet floral aroma and is used in various fragrances.

Bisabolol has anti-inflammatory and antibacterial properties and is widely used in the cosmetic and pharmaceutical industries, particularly in skin care products . 
Bisabolol is a naturally occurring active ingredient that accelerates the healing process of skin and protects it from the effects of daily stress.

Known to have anti-irritant and anti-inflammatory properties, bisabolol has been shown to reduce UV-induced erythema in-vivo.
Bisabolol has also been demonstrated in studies to enhance the dermal penetration of other ingredients, making it a truly versatile active ingredient for skin care products, especially those containing other active ingredients and cosmeceuticals.

Bisabolol also has natural anti-bacterial as well as anti-mycotic properties.
Cosmetic Applications of Bisabolol: Products for sensitive skin, Baby care products, After-shave preparations, After-sun formulations, and Cosmeceuticals.

Bisabolol is commonly found in many personal care products, including moisturisers, cleansers, and serums.
Bisabolol often plays a bio-active skin-calming role thanks to its anti-inflammatory properties and shows up in many products designed for sensitive skin.

Beyond its soothing properties, research indicates bisabolol may offer some discoloration-fading capabilities.
The naturally sweet, slightly floral scent of bisabolol means it is sometimes used in higher amounts to impart fragrance to a formula.
However, in lower amounts Bisabolol doesn’t impart much, if any, scent and its soothing compounds easily outweigh any risk of irritation.

Bisabolol is used in cosmetics for its soothing properties, but is also known as an anti-inflammatory and healing agent.
Bisabolol is also for these functions (anti-irritant) that it is found in some toothpastes.

WHAT DOES BISABOLOL DO FOR THE SKIN?
Bisabolol has several key benefits for the skin, including both soothing and anti-aging effects.
Its antioxidant properties mean that it can visibly help reduce the signs of aging, meaning that bisabolol helps keep skin firm and youthful in appearance.

BISABOLOL BENEFITS FOR SKIN: 
*Soothes the skin:
Bisabolol helps to improve the condition of the skin.

*Antioxidant:
Bisabolol is thought to be a potent antioxidant.
Antioxidants work by neutralizing surface free radicals, the unstable molecules that contribute to premature wrinkles and fine lines on the skin.

Surface free radicals are generated in the skin by factors such as smoking and diet.
The topical use of products such as bisabolol may help address this.

*Improves skin pigmentation:
Bisabolol may help reduce the appearance of dark spots on the skin and may even out and brighten skin tone.

*It’s good for treating dry skin:
Bisabolol has moisturizing properties, which make it beneficial for dry skin.
Bisabolol is commonly used to reduce the appearance of fine lines while smoothing and hydrating skin.

USES, BENEFITS & FUNCTIONAL CHARACTERISTICS of BISABOLOL:
Cosmetic / topical uses of Bisabolol:
*Skin conditioning / soothing: 
Bisabolol is widely used in skincare, cosmetics, personal care products (creams, lotions, serums, cleansers) for its anti-irritant, soothing, and skin conditioning properties.

*Fragrance / aroma additive: 
Bisabolol's mild floral aroma is used in perfumes, essential oil blends, and scented products.

*Anti-inflammatory / anti-irritant action: 
Many studies (and the CIR safety assessment) cite that bisabolol exhibits anti-inflammatory activity, helps reduce irritation, and supports skin repair.

*Penetration enhancement: 
Bisabolol can enhance the dermal absorption of certain actives in a formulation (i.e. it can increase permeation of other molecules) — formulators sometimes use it in small amounts to help other actives penetrate deeper.

*Other skin benefits / ancillary claims of Bisabolol: 
Some smaller studies suggest possible antimicrobial, antioxidant, or wound-healing supportive effects (these are more specialty / adjunct claims).

TYPICAL USAGE CONCENTRATIONS of BISABOLOL:
In cosmetic formulations, bisabolol is often used at 0.01% to 1.0% depending on product type (leave-on vs rinse-off) and the desired effect.
The CIR safety review notes that reported maximum use concentration is about 1% in leave-on products.
Bisabolol is generally used in fairly low concentrations because of its potency and cost.

WHAT IS BISABOLOL USED FOR?
Bisabolol is a safe ingredient used in a wide array of formulations.
Bisabolol is safely used up to 1% concentration in leave-on formulations.

***Skin care: 
Bisabolol has skin healing properties including reducing wrinkles and skin roughness, and repairing sun-damaged skin, and more recently it has been compounded with tretinoin as a topical treatment for acne.

Because of its anti-oxidant qualities, bisabolol can help keep skin firm and youthful-looking by visibly reducing the signs of aging.
Due to its anti-inflammatory qualities, Bisabolol frequently plays a bioactive skin-calming role and is found in many products made for sensitive skin.

In addition to its calming effects, research suggests bisabolol may have some ability to lighten discoloration.
Bisabolol provides moisturization and relieves dry and itchy, flaky skin.

***Hair care: 
Because of its high panthenol concentration, Bisabolol can effectively stimulate and promote the skin's healing process and encourage healthy hair growth.

ORIGIN of BISABOLOL:
German chamomile (Matricaria chamomilla or Matricaria recutita) plants or the Brazilian candeia tree (Vanillosmopsis erythropappa) bark are the two sources used to extract bisabolol.

Similar steps are taken in the extraction process as in the distillation of essential oils.
Following the extraction of the raw oil, it is refined to separate the desired bisabolol from the other ingredients.

Bisabolol can also be created synthetically using molecular engineering.
The procedure entails using human enzymes and organisms like yeast or bacteria to produce the nature-identical molecule, typically through fermentation.

Because no trees need to be cut down, this has exciting implications for sustainability.
Synthetic bisabolol can also be produced using chemicals.
However, since petroleum is a common source of carbon, the resulting bisabolol is of lower purity levels.

WHAT DOES BISABOLOL DO IN A FORMULATION?
*MASKING
*SKIN CONDITIONING
*SOOTHING

The Food and Drug Administration (FDA) includes German chamomile as Generally Recognized as Safe (GRAS).
The flowers of this plant are on the list of GRAS essential oils, oleoresins, and natural extractives.

The safety of Bisabolol has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel.
The CIR Expert Panel evaluated scientific data and concluded that Bisabolol was safe as used in cosmetics and personal care products.

ALTERNATIVES OF BISABOLOL:
*ALLANTOIN
*PANTHENOL
*CENTELLA ASIATICA EXTRACT

WHAT IS IT?
Bisabolol is a colorless, thick oily liquid that is the main component of the essential oil made from the German chamomile plant.
In cosmetics and personal care products, Bisabolol is used in the formulation of a wide variety of products including facial makeup, skin care and hair care products.

WHY IS IT USED?
Bisabolol enhances the appearance of dry or damaged skin by reducing flaking and restoring suppleness.
Bisabolol may also be used as a fragrance ingredient in cosmetics and personal care products.

SCIENTIFIC FACTS:
Bisabolol exists in two structural forms: beta and alpha.
beta-Bisabolol is found in corn and cotton.
alpha-Bisabolol is used in cosmetics and personal care products and is found in various plants, including the herbal tea, chamomile.

BISABOLOL FOR BLEMISH-PRONE SKIN OR ACNE?
Certainly by now, it will become clear how underestimated bisabolol really is.
Bisabolol is suitable for sensitive skin to dry skin, but also for blemish-prone skin – for a variety of reasons.

Thanks to its anti-inflammatory properties, Bisabolol can help to prevent the development of blemishes or inflammatory responses.
Bisabolol can also combat harmful bacteria, which prevents the formation of pimples on the skin.
Accelerated skin renewal improves wound-healting and the soothing effect of bisabolol helps to reduce irritation.

FUNCTIONS (INCI) of BISABOLOL:
*Masking : 
Bisabolol reduces or inhibits the odor or basic taste of the product

*Skin conditioning : 
Bisabolol maintains skin in good condition

*Soothing : 
Bisabolol helps to reduce the skin or scalp discomfort

BISABOLOL IS PRESENT IN:
Bisabolol is present in 2.49% of cosmetics.
*After shave balm (31.22%)
*After sun (22.4%)
*Aftershave lotion (16.62%)
*Diaper cream (15.81%)
*Moist toilet tissue (14.2%)

FACTS OF BISABOLOL AT A GLANCE:
The most important beneficial properties of Bisabolol:
*Anti-inflammatory
*Antibacterial
*Soothing
*Stimulates skin renewal
*For irritated, blemish-prone and sensitive skin

FUNCTION(S) OF BISABOLOL IN COSMETIC PRODUCTS
*FRAGRANCE
Bisabolol enhances the smell of a product and / or perfumes the skin

*SKIN CONDITIONING
Bisabolol maintains the skin in good condition

*SOOTHING
Bisabolol relieves discomfort on the skin and the scalp (eg itching)

CHEMISTRY OF BISABOLOL:
Bisabolol is a colorless, oily liquid with the molecular formula C₁₅H₂₆O.
Bisabolol's structure is characterized by a hydroxylated monocyclic terpene chain , which is believed to be responsible for its bioactive properties. 

MECHANISM OF ACTION OF BISABOLOL:
The effects of bisabolol are not fully understood.
Bisabolol is thought to act through several mechanisms at the cellular level, although most effects have only been demonstrated in vitro .
Bisabolol modulates the activity of cytokines and the production of nitric oxide , thus thought to influence the inflammatory process .
Bisabolol is also believed to have antioxidant properties, which are thought to protect the skin from the damaging effects of oxidative stress . 

THE SOOTHING POWER OF CHAMOMILE OIL:
Bisabolol is a colorless extract of chamomile oil.
Chamomile has been known for its healing and anti-inflammatory properties for thousands of years.
In cosmetics, bisabolol offers countless benefits: It has anti-inflammatory, anti-bacterial and skin-calming properties and also promotes skin renewal.

Another point that should definitely be on the pro side: 
Bisabolol is very gentle and non-irritating.

Bisabolol has the same effect as “real chamomile“, but with a much lower allergy rate.
That is why Bisabolol is often included in products for sensitive or irritated skin.
Bisabolol is an ingredient in some acne products that support medical treatment and in personal care products for blemish-prone skin.

PHARMACOKINETICS OF BISABOLOL:
Bisabolol is well absorbed through the skin because of its high penetration rate into the dermis
Bisabolol is also known as alpha-Bisabolol or levomenol and is the primary component in the essential oil of the German chamomile (Matricaria chamomilla and Matricaria recutita).

Bisabolol belongs to the terpene family and has scientifically proven therapeutic and beneficial effects on the skin.
Bisabolol has a high panthenol concentration so it can effectively stimulate and promote the skin's healing process and encourage healthy hair growth.

People have used Bisabolol for centuries for medicinal practices, because of its anti-irritant, anti-inflammatory, and anti-microbial properties.

Bisabolol is best known for its anti-inflammatory and anti-irritant properties.
In addition to those, Bisabolol promotes wound healing and anti-microbial action on the skin.
Studies have shown that bisabolol regenerates well from UV rays damaged skin (after sunbathing).

Studies have shown that bisabolol can infiltrate the skin deeply and acts as a penetrator, which means that it also helps other drugs to penetrate deeper, which can be particularly useful when feeding the skin with antioxidants.
In cosmetics, Bisabolol is used as an active ingredient in sensitive skin products, sunscreen creams, etc.

BENEFITS OF BISABOLOL:
Bisabolol has the following benefits:
*anti-inflammatory
*skin soothing and repair
*antioxidant and anti-irritant
*after-sun and sunburn
*reduces skin redness
*Clear, colorless, oil-soluble liquid
*Very low odor
*Dermatologically and toxicologically safe
*IL-1a - TNFa and LTB4 inhibition
*Hyaluronic Acid stimulator

BISABOLOL AT A GLANCE:
*Famous skin-soothing ingredient
*Often included as a calming agent in bio-active formulas or products designed for sensitive skin
*May offer some discoloration-fading properties
*Commonly derived from chamomile but can also be created synthetically
*Bisabolol is a colourless to light yellow, oily liquid

NATURAL VS. SYNTHETIC BISABOLOL:
As previously noted, the essential oils of both chamomile and candeia are good botanical sources for preparing 95+% pure (-) alpha-Bisabolol.
Bisabolol can also be made by chemical synthesis.

The substance thus obtained, however, is only about 85% pure Bisabolol and, further, is a racemic mixture of both levorotary and dextrorotary isomers.
So Bisabolol contains only about 42% of active (-) isomer.

When considering the cost effectiveness of natural vs. synthetic material, remember that 1 kg natural Bisabolol contains a minimum of 950 g active (-) Alpha-Bisabolol, while 1 kg synthetic Alpha-Bisabolol contains only about 425 g active (-) Alpha-Bisabolol.
So on an “actives" basis, Bisabolol Natural is about 2.24 times more potent than synthetic material.

PHYSICAL and CHEMICAL PROPERTIES of BISABOLOL:
IUPAC / systematic name: (2S)-6-Methyl-2-[(1S)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol (for the natural (−)-α-bisabolol enantiomer)
CAS number(s): – 515-69-5 (for α-bisabolol) – Also 23089-26-1 is used in some registration / ECHA dossiers for Levomenol (α form)
EC / EINECS number: 245-423-3
Molecular formula: C₁₅H₂₆O
Molar mass (molecular weight): approximately 222.366 g/mol
InChI / InChIKey / SMILES (for α-bisabolol): InChI = InChI=1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m1/s1
Chemical formula: C15H26O
Molar mass: 222.372 g·mol−1

Density: 0.92 g cm−3
Boiling point: 153 °C (307 °F; 426 K) at 12 mmHg
InChIKey: RGZSQWQPBWRIAQ-CABCVRRESA-N
Natural occurrence / sources: Bisabolol (especially α-bisabolol) is a major constituent of chamomile essential oil (e.g. Matricaria recutita) and some other plants.
General description: Bisabolol is a monocyclic sesquiterpene alcohol (a terpene-derived alcohol), 
with a mild floral aroma, often used in cosmetics for its soothing, anti-inflammatory, and skin conditioning properties.

Appearance / physical state: A pale yellow (or nearly colorless) viscous liquid / oil for the α-bisabolol form
Density / specific gravity: ~0.92–0.93 g/cm³ (at ~25 °C)
Refractive index: ~1.4930 to 1.4990 @ 20 °C (typical reported range in supplier / data listings)
Boiling point / vapor pressure: Boiling point ~314 °C at 760 mm Hg (for pure α-bisabolol)
Also a lower-pressure boiling data: ~151–152 °C at 12 mm Hg reported in some data tables
Solubility / miscibility: Very poorly soluble in water (water solubility is extremely low, e.g. ~1.7 mg/L at 25 °C estimated)
Boiling Point: 314-315°C
Solubility: Insoluble in water, Slightly soluble in ethanol, 

Soluble in ethanol, organic solvents, oils, and miscible with many cosmetic vehicle solvents
Log P (octanol/water partition coefficient): Estimated ~4.59 (i.e. lipophilic)
Flash point: ~112.78 °C (est) in one supplier data listing The Good Scents Company
Viscosity / flow: As a viscous oil, it is higher in viscosity than lighter solvents 
(not usually quoted in basic public sources)
Stability / chemical behavior: Fairly stable under normal conditions; 
may oxidize or degrade under extreme heat, light, or in presence of strong oxidizers. 
As a terpene alcohol, care in formulation and storage is required. 
It can act as a penetration enhancer (i.e. increase dermal absorption of other molecules) in formulations.

Molecular Weight: 222.37 g/mol
XLogP3-AA: 3.8
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 4
Exact Mass: 222.198365449 Da
Monoisotopic Mass: 222.198365449 Da
Topological Polar Surface Area: 20.2 Ų
Heavy Atom Count: 16

Formal Charge: 0
Complexity: 284
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Empirical Formula (Hill Notation): C15H26O

CAS Number: 23089-26-1
Molecular Weight: 222.37
EC Number: 208-205-9
MDL number: MFCD03412455
UNSPSC Code: 12352100
PubChem Substance ID: 57647161
NACRES: NA.22
Physical state: liquid
Color: colourless
Odor: No data available

Melting point/freezing point: Melting point/ range: -20 °C
Initial boiling point and boiling range: 300.2 °C at 1.013 hPa 
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 143 °C - closed cup - ISO 3679
Autoignition temperature: 245 °C at 1.012 - 1.020 hPa - DIN 51794
Decomposition temperature: No data available
pH: No data available

Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0.022 g/l at 20 °C - OECD Test Guideline 105 - partly soluble
Partition coefficient: n-octanol/water log Pow: 5.5 at 25 °C 
Vapor pressure: <0.1 hPa at 20 °C - OECD Test Guideline 104
Density: 0.93 g/cm3 at 20 °C - OECD Test Guideline 109
Relative density: No data available
Relative vapour density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive

Oxidizing properties: none
Other safety information: Surface tension 57.3 mN/m at 20 °C
Appearance: colorless clear viscous liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 314.00 to 315.00 °C @ 760.00 mm Hg
Vapor Pressure: 0.000040 mmHg @ 25.00 °C (est)
Flash Point: 275.00 °F TCC (135.00 °C)
logP (o/w): 5.070 (est)
Soluble in: alcohol water, 1.688 mg/L @ 25 °C (est)
Insoluble in: water

FIRST AID MEASURES of BISABOLOL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of BISABOLOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of BISABOLOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of BISABOLOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of BISABOLOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of BISABOLOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available