PRODUCTS

BISMUTH CITRATE

Bismuth Citrate = Bismuth (III) Citrate = Citric Acid Bismuth Salt = Monobismuthyl Citric Acid

CAS Number: 813-93-4
Molecular Weight: 398.08
EC Number: 212-390-1
MDL number: MFCD00050817
NACRES: NA.22
MF: C6H5BiO7
EINECS: 201-337-8

Properties of Bismuth Citrate:
IUPAC Name: 5-hydroxy-2,8,9-trioxa-1-bismabicyclo[3.3.2]decane-3,7,10-trione
Physical Form: Solid
Molecular Weight: 398.08
Melting Point: 300 °C
Boiling Point: N/A
Density: 0.94 g/mL at 25 °C (lit.)
Solubility in H2O: N/A
Exact Mass: 397.983926
Odor: Odorless
Sensitivity: Light sensitive
Monoisotopic Mass: 397.983926
Appearance:White powder
Quality Level: 100
Assay: 99.99% trace metals basis
Reaction Suitability: bismuth is core and reagent type is catalyst
Particle Size: −325 mesh
SMILES string: OC12CC(=O)O[Bi](OC(=O)C1)OC2=O
InChI: 1S/C6H8O7.Bi/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3
InChI key: ANERHPOLUMFRDC-UHFFFAOYSA-K

Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 7

Rotatable Bond Count: 2
Exact Mass: 397.98393
Monoisotopic Mass: 397.98393
Topological Polar Surface Area: 141 Å²
Heavy Atom Count: 14
Formal Charge: 0
Complexity: 211
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Description:
Bismuth citrate is the bismuth salt of citric acid.
Bismuth is a brittle metal with a pinkish hue.
Bismuth citrate occurs naturally in the Earth's crust and is about twice as abundant as gold.
Bismuth citrate is a colour additive.
Bismuth citrate is one of numerous organo-metallic compounds.
Bismuth citrate for uses requiring non-aqueous solubility such as recent solar energy and water treatment applications.
Bismuth citrate is generally immediately available in most volumes, including bulk quantities.
The color additive bismuth citrate is the synthetically prepared crystalline salt of bismuth and citric acid, consisting principally of BiC6H5O7.
Bismuth citrate helps to impart a color to hair.

Bismuth (III) citrate can be obtained by adding the nitrate solution of bismuth (III) into the solution of ammonium citrate.
Bismuth citrate can be obtained by adding the solution of citric acid to bismuth nitrate solution within pH range 0.10.7 at the process temperature of (60±5) °C.
Bismuth citrate can be obtained by adding the solution of citric acid to bismuth-containing lactic-acetic or glycerol-containing solutions.
Bismuth citrate can be obtained by boiling freshly precipitated bismuth hydroxide or basic carbonate with the solution of citric acid.
Bismuth citrate-based compounds have been clinically used worldwide to treat peptic ulcers and exhibit promising antiviral activities.
The structures of bismuth citrate-based complexes are complicated due to their tendency to polymerize.

Solubility of Bismuth Citrate:
Bismuth citrate is insoluble in water, alcohol, ether.
Bismuth citrate is soluble in ammonia solution and in solution of alkali citrates.
Typical tap density of bismuth citrate is 0;50g/cm3.

Production of Bismuth Citrate:
The formation of bismuth citrate of the type BiC6H5O7 occurs in the temperature range 50-70degC at pH 0.5-0.7.
Bismuth citrate is characterized by the methods of chemical analysis, X-ray powder diffraction, IR spectroscopy and differentional thermal analysis.
The method of synthesis of bismuth citrate by the solid-liquid reaction is compared with the precipitate method from nitric acid solutions.

Use of Bismuth Citrate:
Bismuth (III) citrate is used to prepare efficient anti ulcerants (De-Nol, Tribimol, Gastronorm, Pilorid),nutrient media for the production of bacterial preparations.
Bismuth citrate is used in the synthesis of bismuth containing high-temperature superconducting materials.
Bismuth citrate has been used as a sorbent in spin columns to develop a novel stationary phase for the selective and efficient isolation of phenolic compounds from natural sources.
Bismuth citrate can be used to synthesize bismuth subcarbonate ((BiO)2CO3) nanotubes that are reported to show antibacterial property against Helicobacter pylori.
Bismuth citrate is used as intermediate for stomachache and anti-ulcer drug.
Bismuth citrate is used for treating gastric ulcer, duodenal ulcer, compound ulcer and stoma ulcer as well chronic superficial gastritis with infection of helicobacter pylori.
The amount of bismuth citrate in the cosmetic shall not be in excess of 2.0 percent (w/v).
Bismuth citrate is used in the formulation of hair coloring products used on the scalp In cosmetics and personal care products.
Bismuth citrate is used in washing & cleaning products, in cosmetics and personal care products and also in laboratory chemicals.
Bismuth citrate can be found also in paper-based product; for example: books, magazines and wallpapers.
Bismuth citrate is for uses requiring non-aqueous solubility such as recent solar energy and water treatment applications.
Bismuth citrate is generally immediately available in most volumes, including bulk quantities.

Application of Bismuth Citrate:
Bismuth citrate has been used as a sorbent in spin columns to develop a novel stationary phase for the selective and efficient isolation of phenolic compounds from natural sources via solid phase extraction.
Bismuth citrate can be used to synthesize bismuth subcarbonate ((BiO)2CO3) nanotubes that are reported to show antibacterial property against Helicobacter pylori.

What Is Ranitidine Bismuth Citrate?
Ranitidine bismuth citrate was withdrawn from the U.S. market in 1998.
Ranitidine is in a class of drugs called histamine receptor antagonists and, works by decreasing the amount of acid your stomach produces.
Bismuth is a mild antibiotic.
Citrate is a form of salt.
Ranitidine bismuth citrate is used to decrease the amount of acid in the stomach and to treat Helicobacter pylori, a bacterial infection involved in causing stomach ulcers.
Ranitidine bismuth citrate is most commonly used with clarithromycin (Biaxin), an antibiotic, to treat this infection.
Ranitidine bismuth citrate may also be used for conditions other than those listed in this medication guide.

Ranitidine bismuth citrate (RBC), a novel complex of rani-tidine, bismuth and citrate, which was developed specifically forthe purpose of eradicating H pylori.
Dual therapy with RBC incombination with clarithromycin for 14 days yields eradicationrates of 76%.
Triple therapy bid for one week with a proton pumpinhibitor, clarithromycin and either amoxicillin or a nitroimida-zole is advocated as the treatment of choice for H pylori eradication.
Analogous regimens with RBC in place of proton pump inhibitors show effective eradication rates incomparative studies and with pooled data.
RBC, used alone or incombination with other antibiotics, appears to be a safe and effective drug for the treatment of H pylori infection.
Bismuth levels donot appear to rise to toxic levels.

Bismuth Citrate Storage:
Bismuth citrate should be placed in cool and dry.

Safety Information of Bismuth Storage:
The Food and Drug Administration (FDA) lists Bismuth citrate as a color additive exempt from certification and it may be safely used for coloring hair on the scalp at concentrations not to exceed 0.5% of the final product.

Color Additive Status of Bismuth Citrate
Bismuth citrate - Color additives exempt from certification and permanently listed for cosmetic use.
Status: For cosmetics intended to color hair on scalp only (Not for coloring eyelashes or eyebrows or other body hair) - ≤ 2.0% (wt/v) - 73.2110

Pharmacology and Biochemistry of Bismuth Citrate
-Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
-Antacids: Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT. (See all compounds classified as Antacids.)
-Anti-Ulcer Agents: Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract.
This has included antibiotics to treat Helicobacter infections, histamine H2 antagonists to reduce gastric acid secretion and antacids for symptomatic relief.

Bismuth Citrate May Help Control NE:
Bismuth citrate, a citric acid salt, may help control necrotic enteritis in broilers, indicates preliminary research conducted by researchers at Texas A&M University.
The first study was designed to determine a dose response to bismuth citrate in broilers challenged with isolates of C. perfringens obtained from active field cases in Virginia, North Carolina and Georgia.
When 100 or 200 ppm bismuth citrate was fed, broilers had reduced intestinal C. perfringens colonization and lesion development compared to birds not fed bismuth citrate.
Bismuth citrate fed at 50 ppm also reduced intestinal lesions but did not reduce colonization.In the second study, the investigators also fed the acidifiers lactose or citric acid to determine if they would enhance the effects of bismuth citrate.
Considering whether the effects of bismuth citrate will increase, the second study was evaluated by C. perfringens colonization and pH levels and, no significant interactions were found.
However, the addition of lactose along with bismuth citrate did significantly reduce intestinal pH when compared only to negative controls.
A third study further evaluated the effect of lactose and bismuth citrate on C. perfringens colonization and lesions.
Birds challenged with C. perfringens had significantly reduced NE lesions compared to birds receiving control diets, the researchers say in the November 2009 issue of Poultry Science.
Bismuth citrate has been shown to reduce cecal colonization by other pathogens.
Bismuth citrate treatments of 100 ppm and 200 ppm significantly reduced C. perfringens colonization and intestinal lesion development, the investigators say.

Synonyms:

813-93-4

Bismuth (III) citrate

UNII-N04867Y76N

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, bismuth(3+) salt (1:1)

N04867Y76N

Bismuth citrate [USP:USP]

Bi-citrate

EINECS 212-390-1

Bismuth citrate (USP)

C6H5BiO7

EC 212-390-1

SCHEMBL41916

Bismuth, (citrato(3-))-citric acid bismuth(III) salt

DTXSID6074330

CHEBI:157700

AKOS015839589

K447

D08875

134873-EP2275420A1

134873-EP2292612A2

bismuth(3+) 2-hydroxypropane-1,2,3-tricarboxylate

2-hydroxy-1,2,3-propanetricarboxylic acid bismuth salt

Bismuth(3+) 2-hydroxy-1, 2, 3-propanetricarboxylate

Citric acid bismuth salt