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BISMUTH SUBNITRATE

EC / List no.: 215-136-8
CAS no.: 1304-85-4
Mol. formula: Bi5H9N4O22

Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent.
The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA.
Bismuth Subnitrate is a basic salt that contains the equivalent of not less than 79.0 percent of bismuth trioxide (Bi2O3),calculated on the dried basis.
Bismuth Subnitrate is both odorless and tasteless, and is used in bleaching and freckle creams, and hair dyes.
Bismuth subnitrate has been used to induce metallothionein in heart tissue and kidneys and to attenuate the toxicity of Adriamycin and cisplatin compounds, respectively.

Bismuth Subnitrate is a highly water soluble crystalline Bismuth source for uses compatible with nitrates and lower (acidic) pH.
All metallic nitrates are inorganic salts of a given metal cation and the nitrate anion.
The nitrate anion is a univalent (-1 charge) polyatomic ion composed of a single nitrogen atom ionically bound to three oxygen atoms (Formula: NO3) for a total formula weight of 62.05.
Nitrate compounds are generally soluble in water.
Nitrate materials are also oxidizing agents. When mixed with hydrocarbons, nitrate compounds can form a flammable mixture.
Nitrates are excellent precursors for production of ultra high purity compounds and certain catalyst and nanoscale (nanoparticles and nanopowders) materials.
Bismuth Nitrate is generally immediately available in most volumes.
High purity, submicron and nanopowder forms may be considered.
We also produce Bismuth Nitrate Solution. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.

Chemical Properties White, heavy, Slightly hygroscopic powder

Uses
manufacture of bismuth fluxes for enamels; in cosmetics.
Bismuth subnitrate (BiNO3) is used in the cosmetics industry and to make ceramic and enamel glazes.

About this substance
Helpful information
Bismuth Subnitrate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

Bismuth Subnitrate is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Widespread uses by professional workers
This substance is used in the following products: coating products, metal surface treatment products, inks and toners and laboratory chemicals.
ECHA has no public registered data on the types of manufacture using Bismuth Subnitrate. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Formulation or re-packing
Bismuth Subnitrate is used in the following products: coating products, metal surface treatment products, inks and toners, laboratory chemicals and pharmaceuticals.
Release to the environment of this substance can occur from industrial use: formulation in materials and formulation of mixtures.
Uses at industrial sites
Bismuth Subnitrate is used in the following products: coating products, metal surface treatment products, inks and toners, laboratory chemicals and pharmaceuticals.
Bismuth Subnitrate is used in the following areas: formulation of mixtures and/or re-packaging.
Bismuth Subnitrate is used for the manufacture of: mineral products (e.g. plasters, cement), electrical, electronic and optical equipment and plastic products.
Release to the environment of this substance can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites and of substances in closed systems with minimal release.
Manufacture
Release to the environment of Bismuth Subnitrate can occur from industrial use: manufacturing of the substance.

Pharmacodynamics
Bismuth subnitrate acts as an antacid that exert protective effects on the gastric mucosa.
In a double-blind endoscopically controlled study, bismuth substrate was demonstrated to be effective for symptomatic relief in duodenal ulcers.

Mechanism of action
Based on the findings of a clinical investigation in patients with duodenal ulcer disease and healthy volunteers receiving oral bismuth subnitrate tablets, the protective effects of bismuth subnitrate may be secondary to endogenous mucosal prostaglandin (PGE2) production, which is one of the deficient factors observed in peptic ulcer disease.

Antacid neutralizing activity of bismuth subnitrate was demonstrated to have a significant postprandial effect on gastric pH 2.

Absorption
Bismuth subnitrate may undergo minimal gastrointestinal absorption which may be potentiated with concomitant administration of sulfhydryl compounds 5 when dissolved in citrate buffer solution.
Approximately 0.2% of orally administered bismuth is absorbed systematically from the gastrointestinal tract with the peak plasma concentration typically occurring within 1 hour .

Volume of distribution
Bismuth has been shown to accumulate preferentially in the kidneys 1.

Protein binding
Upon accumulation in the kidneys, bismuth may bind to a bismuth-metal binding protein in the kidney 4.

Route of elimination
Bismuth may undergo both urinary and faecal excretion, however the exact proportion contributed by each route is still unknown.

Half-life
The distribution half-life of bismuth is approximately 1 to 4 hours, and the elimination half-life is 5 to 11 days

Absorption
Bismuth subnitrate may undergo minimal gastrointestinal absorption which may be potentiated with concomitant administration of sulfhydryl compounds when dissolved in citrate buffer solution.
Approximately 0.2% of orally administered bismuth is absorbed systematically from the gastrointestinal tract with the peak plasma concentration typically occurring within 1 hour.

Industry Uses
Paint additives and coating additives not described by other categories

Consumer Uses
Paints and coatings

Industry Processing Sectors
Paint and coating manufacturing

Pharmacological properties
Iodoform has a marked anaesthetic effect and antiseptic action due to the release of iodine.

Bismuth Subnitrate has both an astringent and absorbent action.

Pharmacokinetic properties
Pharmacokinetic particulars are not applicable since the active constituents are not systemically absorbed

Category
Metals, Inorganic Compounds
Description
Odorless, slightly hygroscopic solid; [Merck Index] White powder, insoluble;
Sources/Uses
Used to make enamel fluxes, cosmetics, antacids, and antiulceratives; [Merck Index] Used as an astringent, adsorbent, and protective; in topical lotions and ointments;

Product description
Bismuth Subnitrate is used as white pigment in beauty care. Used as a gentle disinfectant for wounds and in orally drugs as antacid.

The application of the Bismuth Subnitrate with purpose of hemostasy during tonsillectomy is a sanctioned practice

Description: Bismuth subnitrate has been used for its supposed antacid and mildly astringent action in various GI disorders.
Bismuth Subnitrate has also been used topically in the treatment of skin disorders, wounds, burns, haemorrhoids and other anorectal disorders.

Pharmacokinetics:
Absorption: Poor absorption in the GI tract.
Increased gastric pH may increase bismuth absorption.
Distribution: Distributed throughout the body tissues, including bone.
Excretion: Unabsorbed bismuth is excreted in the faeces. Plasma half-life: about 5 days.

White, heavy, slightly hygroscopic powder.
Bismuth subnitrate, also known as bismuth white, is used as a white pigment in cosmetics, ceramic glazes, surface coatings, and enamels

Bismuth Subnitrate has an approximate formula [Bi(OH)₂NO,] BIO(OH) and a basic bismuth nitrate.
On ignition at 105°C it gives not less than 79% of Bi₂Oy.

Preparation:
Bismuth Subnitrate is prepared by adding a solution of sodium hydroxide to a solution of bismuth nitrate at about 15°C with stirring till the pH is about 5.
The stirring is continued for some more time and the precipitate of bismuth subnitrate is collected by filtration washed with cold water and dried at about 50°C.

Properties:
Bismuth Subnitrate occurs as a white, slight hygroscopic powder.
Bismuth Subnitrate is practically insoluble in water and alcohol but dissolves readily in excess of hydrochloric or nitric acid.
As bismuth subnitrate slowly hydrolyses in water and liberates nitric acid, incompatibilities with carbonates, iodides, salts of organic acids, reducing agents are encountered.

Action and Uses:
Its main action is as an astringent, adsorbent, and protectant protection and is commonly used in the treatment of diarrhoeas and intestinal inflammation.
Bismuth Subnitrate is given in 2-5 g doses at 4 hours interval.
Bismuth Subnitrate is the main constituent of milk of bismuth.

Bismuth, a silver-white metal, atomic number 83, atomic weight 208.980, is the most metallic element in the group 15 in the periodic table.
Though the principal deposits are in ores, the primary source of bismuth is as a by-product in refining of copper and lead ores.
Of all the metals, bismuth is the most diamagnetic and has the lowest thermal conductivity except mercury.
Bismuth has a high electrical resistance and the highest Hall coefficient.
Elemental bismuth like antimony and water is the substances of which the liquid phase is denser than its solid phase.
The field of application of our bismuth-based chemicals is found in ceramic materials, pharmaceuticals, cosmetics, and automobile industry to reduce the levels of lead.
Bismuth telluride (Bi2Te3) and bismuth selenide (Bi2Se3) are used in thermoelectric equipment for refrigeration.
Bismuth phosphomolybdate (BiPMo12O40) is a highly effective catalyst for the preparation of acrylonitrile, which is the raw materials of acrylic fibres, plastics, and paints.
Bismuth chemicals are used in cosmetics for shiny look in eye shadow, nail varnish and lipstick due to metallic and pearlescent effect.
Salts of bismuth have astringent, antacid, and mildly germicidal properties and are used to treat diarrhea, nausea, indigestion, and other gastrointestinal conditions, They are used as a positive contrast agent in X-ray examination.
Bismuth Subnitrate is a white, almost odourless cryistalline powder, containing 71 - 75 % w/w of bismuth Bismuth Subnitrate is more astringent than other bismuth salts.
Bismuth Subnitrate is used pharmaceutically in wound dressing, ointment component and as an antiacid.
In cosmetics it is used as a cosmetic white pigment.

The Bismuth subnitrate, with the CAS registry number 1304-85-4, is also known as Bismuth nitrate basic.
It belongs to the product category of Inorganics.
Its EINECS number is 233-792-3. This chemical's molecular formula is Bi5H9N4O22 and molecular weight is 1461.99.
What's more, its systematic name is [(Dihydroxybismuthino)oxy](oxo)azane oxide - hydroxy(oxo)bismuthine.

Human Data; Pharmaceutic necessity. Antacid containing bismuth, sodium & magnesium carbonates, rutin, Khellin & Rhamnus bark powder.
This chemical should be sealed and stored in a cool and dry place.
Moreover, it should be ensured that the workshop is well ventilated or equipped with exhaust devices. It is used to prepared bismuth salt and bismuth salt.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to the eyes, respiratory system, and skin.
In case of contact with the eyes, you should rinse immediately with plenty of water and seek medical advice.
When using it, you need to wear suitable protective clothing, gloves, and eye/face protection.
When contact with combustible material, may cause a fire.
You should keep it away from combustible material.

Applications
It is used pharmaceutically in wound dressing, ointment component and as an antiacid.
In cosmetics it is used as a cosmetic white pigment.
Used in Ceramic glazes and enamel fluxes.

Bismuth Subnitrate Details
Chemical Name:Bismuth Subnitrate
CAS No.:1304-85-4
Molecular Fomula:Bi5H9N4O22
Chemical Structure:
Molecular weight: 1461.99
Appearance: White powder
Assay：79.0%min
Bismuth Subnitrate Typical Properties

Bismuth subnitrate uses and applications include: Absorbent, opacifier in cosmetics; ceramic glazes; enamel fluxes; adsorbent in antidiarrheal products; skin protectant for diaper rash and prickly heat; stain for light and electron microscopy
Suggested storage of Bismuth subnitrate: Hygroscopic

Bismuth Subnitrate Usage

1.Commonly used in the pharmaceutical industry, neutralizing stomach acid and astringent drugs
2.Used for the treatment of stomach and duodenal ulcers and diarrhea

IUPAC NAMES
Bismuth hydroxide nitrate oxide
bismuth hydroxide nitrate oxide
BISMUTH NITRATE BASIC
bismuth oxgen (2-) nitrate
Bismuth(III)subnitrate
pentabismuth(3+) nonahydroxide tetranitrate oxidandiide

SYNONYMS:
Bismuth hydroxide nitrate oxide, Bi2O3 79% min
Bismuth(III) hydroxide nitrate, extra pure, Ph Eur, USP
BisMuth Subnitrate (AS)
Bismuth Subnitrate (1.5 g) (AS)
BISMUTH(III) NITRATE BASIC FOR ANALYSIS
BROMOTHYMOL BLUE SODIUM SALT INDICATOR W
Bismuth(Ⅲ) subnitrate
BisMuth(Ⅲ) nitrate basic
BisMuth(Ⅲ) oxynitrate
Bismuth subnitratee
Bismuth(Ⅲ) Hydroxide Nitrate Oxide
Bismuth(III) nitrate alkaline for analysis EMSURE Reag. Ph Eur
Bismuth(Iii) Subnitrate, Meets analytical specification of USP
basicbismuthnitrate
bismuthhydroxidenitrateoxide(bi5(oh)9(no3)4o)
Bismuth subnitra
bismuthhydroxidenitrateoxide[bi5(oh)9(no3)4o]
bismuthhydroxidenitrateoxide[bi5o(oh)9(no3)4]
bismuthmagistery
bismuthoxide[bi2o3],compdwithnitrogenoxide(n2o5)(6:5),octahydrate
bismuthpaint
bismuthsubnitrateusp
bismuthsubnitricum
bismuthwhite
blancdefardac
c.i.77169
c.i.pigmentwhite17
cosmeticwhite
flakewhite
magisteryofbismuth
novismuth
paintwhite
snowcal5sw
spanishwhite
vicalin
vikaline
BISMUTHYL NITRATE
BISMUTH SUBNITRATE
BISMUTH NITRATE, BASIC
BISMUTH OXYNITRATE
BISMUTH OXYNITRATE CRYSTALLINE
BISMUTH OXYNITRATE HYDRATE
BISMUTH HYDROXIDE NITRATE OXIDE
BISMUTH(III) HYDROXIDE NITRATE
BISMUTH(III) HYDROXIDE NITRATE OXIDE
BISMUTH(III) NITRATE BASIC
BISMUTH(III) NITRATE OXIDE
BISMUTH(III) OXYNITRATE
BISMUTH(III) SUBNITRATE
BISMUTHSUBNITRATE(ULTRAMICRO)
BISMUTHSUBNITRATE,POWDER,USP
BISMUTHSUBNITRATE,PURIFIED
Bismuth hydroxide nitrate oxide, Bi2O3 79% min
Bismuth hydroxide nitrate oxide: (White paint)
Bismuth hydroxide nitrate oxide, BiO3 79% min
Bismuth hydroxide nitrate oxide, 98+%
Bismuth(III) nitrate basic, Bismuth(III) oxynitrate, Bismuth(III) subnitrate, Bismuthyl nitrate
Bismuth subnitrate