BIT (1,2-BENZISOTHIAZOLIN-3-ONE)

1,2-Benzisothiazolin-3-one (BIT) is a heterocyclic compound widely used as a preservative and antimicrobial agent in industrial and consumer products.
BIT (1,2-Benzisothiazolin-3-one) is valued for its strong biocidal activity against bacteria, fungi, and yeasts, making it a key ingredient in coatings, adhesives, and cleaning products.
BIT (1,2-Benzisothiazolin-3-one) is often preferred over other preservatives due to its thermal stability and broad-spectrum efficacy.

CAS Number: 2634-33-5
EC Number: 220-120-9
Molecular Formula: C7H5NOS
Molecular Weight: 151.19 g/mol

Synonyms: BIT, 1,2-Benzisothiazolin-3-one, Benzisothiazolinone, Benzisothiazoline, Proxel GXL, 1,2-Benzoisothiazolin-3-one, 1,2-Benzoisothiazol-3(2H)-one, Benzisothiazolin-3-one, 1,2-Benzisothiazolin-3-one Preservative, Benzisothiazolinone Biocide, BIT, 1,2‑Benzisothiazolin‑3‑one, Benzisothiazolinone, 1,2‑Benzothiazol‑3‑one, Benzisothiazolin-3-one, Benzisothiazolone, 1,2‑Benzisothiazolin‑3(2H)-one, BIT‑85, Benzisothiazolin‑one, Proxan, CAS 2634‑33‑5, EC 220‑120‑9, PubChem CID 17520, ChemSpider 16567, DuPont BIT, Isothiazolinone preservative, Biocide BIT, Fungicide BIT, Microbicide BIT, Antimicrobial BIT, Preservative BIT, Slimicide BIT, Broad‑spectrum biocide, Water‑based purifier BIT, Paint preservative BIT, Detergent preservative BIT, Adhesive preservative BIT, Ink preservative BIT, Cutting‑oil biocide BIT, Latex protector BIT, Leather preservative BIT, Textile biocide BIT, Drilling mud biocide BIT, Packer fluid biocide BIT, Industrial BIT, Consumer BIT, Household BIT, Tattoo ink preservative BIT, Cosmetic‑grade BIT, NOT cosmetic in EU BIT, Allowed in U.S. BIT, Allowed in Canada BIT, Respiratory allergen BIT, Skin sensitizer BIT

APPLICATIONS

BIT (1,2-Benzisothiazolin-3-one) is widely used in water-based paints and coatings to prevent microbial spoilage during storage and after application.
BIT (1,2-Benzisothiazolin-3-one) is incorporated into adhesives and sealants to prevent fungal and bacterial growth.
BIT (1,2-Benzisothiazolin-3-one) is included in polymer emulsions to improve shelf life and product stability.

BIT (1,2-Benzisothiazolin-3-one) is used in household cleaners and detergents as a preservative to prevent degradation over time.
BIT (1,2-Benzisothiazolin-3-one) is added to dishwashing liquids and surface disinfectants for antimicrobial efficacy.
BIT (1,2-Benzisothiazolin-3-one) enhances the microbial resistance of air fresheners and fabric softeners.

BIT (1,2-Benzisothiazolin-3-one) is employed in personal care products such as shampoos and lotions at very low concentrations.
BIT (1,2-Benzisothiazolin-3-one) helps to preserve skin care and cosmetic formulations from bacterial contamination.
BIT (1,2-Benzisothiazolin-3-one) is compatible with many surfactants and emulsifiers used in personal care.

BIT (1,2-Benzisothiazolin-3-one) is applied in leather treatment solutions and textile coatings for mold and mildew prevention.
BIT (1,2-Benzisothiazolin-3-one) is used in metalworking fluids to inhibit microbial growth in oil-water emulsions.
BIT (1,2-Benzisothiazolin-3-one) helps extend the functional life of industrial formulations exposed to moisture.

BIT (1,2-Benzisothiazolin-3-one) is found in inks, toners, and printing pastes to inhibit bacterial spoilage.
BIT (1,2-Benzisothiazolin-3-one) is used in paper coatings and size press solutions for long-term storage stability.
BIT (1,2-Benzisothiazolin-3-one) is an effective alternative to formaldehyde-releasing preservatives.

BIT (1,2-Benzisothiazolin-3-one) is incorporated into construction chemicals such as concrete additives and plasters.
BIT (1,2-Benzisothiazolin-3-one) is applied in marine and industrial coatings for microbial control in high-humidity environments.
BIT (1,2-Benzisothiazolin-3-one) is used in oilfield chemicals to control microbial corrosion and biofouling.

BIT (1,2-Benzisothiazolin-3-one) is used in fuel additives and lubricants to prevent microbial contamination during storage.
BIT (1,2-Benzisothiazolin-3-one) is compatible with glycol-based antifreeze and deicing fluids.
BIT (1,2-Benzisothiazolin-3-one) is employed in wastewater treatment systems to inhibit microbial slime formation.

BIT (1,2-Benzisothiazolin-3-one) is used in cosmetic raw materials during storage to prevent microbial degradation.
BIT (1,2-Benzisothiazolin-3-one) is often included in concentrate formulations to ensure product stability before dilution.
BIT (1,2-Benzisothiazolin-3-one) remains active under a wide pH range, making it suitable for varied applications.

BIT (1,2-Benzisothiazolin-3-one) is used as a preservative in water-based paints.
BIT (1,2-Benzisothiazolin-3-one) is incorporated into adhesives to prevent microbial degradation.

BIT (1,2-Benzisothiazolin-3-one) provides long-term protection in polymer emulsions.
BIT (1,2-Benzisothiazolin-3-one) is used in industrial coatings to inhibit bacterial growth.

BIT (1,2-Benzisothiazolin-3-one) prevents spoilage in construction materials like plasters and fillers.
BIT (1,2-Benzisothiazolin-3-one) is a common additive in sealants for antimicrobial resistance.

BIT (1,2-Benzisothiazolin-3-one) protects latex formulations from microbial contamination.
BIT (1,2-Benzisothiazolin-3-one) is used in cleaning agents to maintain shelf-life stability.

BIT (1,2-Benzisothiazolin-3-one) is used in water treatment formulations as a biocide.
BIT (1,2-Benzisothiazolin-3-one) is applied in inks and printing pastes to suppress microbial activity.

BIT (1,2-Benzisothiazolin-3-one) is used in household cleaners to inhibit mold and bacterial growth.
BIT (1,2-Benzisothiazolin-3-one) is a preservative in air freshener gels.

BIT (1,2-Benzisothiazolin-3-one) is used in car care products to prevent degradation.
BIT (1,2-Benzisothiazolin-3-one) is added to cutting fluids in the metalworking industry.
BIT (1,2-Benzisothiazolin-3-one) is compatible with surfactants in detergent formulations.

BIT (1,2-Benzisothiazolin-3-one) is used in oil-in-water emulsions for preservation.
BIT (1,2-Benzisothiazolin-3-one) helps prevent microbial growth in liquid detergents.

BIT (1,2-Benzisothiazolin-3-one) is applied in dishwashing liquids to enhance product longevity.
BIT (1,2-Benzisothiazolin-3-one) is used in water-based lubricants for microbial control.

BIT (1,2-Benzisothiazolin-3-one) is utilized in wet wipes for antimicrobial protection.
BIT (1,2-Benzisothiazolin-3-one) extends the shelf life of wax emulsions.

BIT (1,2-Benzisothiazolin-3-one) is used in textile auxiliaries to prevent fermentation.
BIT (1,2-Benzisothiazolin-3-one) is added to floor polishes as a protective preservative.
BIT (1,2-Benzisothiazolin-3-one) is suitable for preserving mineral slurries.

BIT (1,2-Benzisothiazolin-3-one) is used in printing inks to prevent microbial spoilage.
BIT (1,2-Benzisothiazolin-3-one) is effective in pigmented coatings for microbial stability.

BIT (1,2-Benzisothiazolin-3-one) is used in personal care raw materials as a preservative.
BIT (1,2-Benzisothiazolin-3-one) protects carpet shampoos from microbial spoilage.

BIT (1,2-Benzisothiazolin-3-one) is used in liquid air fresheners for stability.
BIT (1,2-Benzisothiazolin-3-one) is added to gypsum-based products to prevent microbial damage.
BIT (1,2-Benzisothiazolin-3-one) is found in waterborne varnishes for preservation.

BIT (1,2-Benzisothiazolin-3-one) maintains stability in industrial degreasers.
BIT (1,2-Benzisothiazolin-3-one) is incorporated in coating dispersions to maintain clarity and shelf life.

BIT (1,2-Benzisothiazolin-3-one) is suitable for use in alkyd emulsions.
BIT (1,2-Benzisothiazolin-3-one) is effective in inhibiting microbial growth in joint compounds.

BIT (1,2-Benzisothiazolin-3-one) is used in thickeners and binders to protect against contamination.
BIT (1,2-Benzisothiazolin-3-one) is added to defoamers to preserve their function.

BIT (1,2-Benzisothiazolin-3-one) is compatible with a wide range of surfactant systems.
BIT (1,2-Benzisothiazolin-3-one) provides antimicrobial protection in water-based waxes.

BIT (1,2-Benzisothiazolin-3-one) is used in ready-to-use tile adhesives.
BIT (1,2-Benzisothiazolin-3-one) is included in pigment dispersions for stability.

BIT (1,2-Benzisothiazolin-3-one) protects emulsion polymers during storage.
BIT (1,2-Benzisothiazolin-3-one) is suitable for use in chemical toilets as a biocide.

BIT (1,2-Benzisothiazolin-3-one) is added to grout mixtures to reduce microbial risks.
BIT (1,2-Benzisothiazolin-3-one) is used in wallpaper pastes to prevent spoilage.
BIT (1,2-Benzisothiazolin-3-one) maintains microbial stability in starch-based products.

BIT (1,2-Benzisothiazolin-3-one) is a preservative choice for cosmetic raw material storage.
BIT (1,2-Benzisothiazolin-3-one) is used in cooling water systems to control bacterial growth.

BIT (1,2-Benzisothiazolin-3-one) is added to emulsified oils for microbial resistance.
BIT (1,2-Benzisothiazolin-3-one) is applied in leather processing auxiliaries to ensure hygiene.

DESCRIPTION

BIT (1,2-Benzisothiazolin-3-one) is a white to off-white crystalline solid or pale yellow powder with a mild odor.
BIT (1,2-Benzisothiazolin-3-one) exhibits broad-spectrum antimicrobial properties at low concentrations.
BIT (1,2-Benzisothiazolin-3-one) is stable under elevated temperatures and varying pH conditions.

BIT (1,2-Benzisothiazolin-3-one) is soluble in polar solvents such as water and alcohols.
BIT (1,2-Benzisothiazolin-3-one) does not release formaldehyde and is considered a non-formaldehyde preservative.
BIT (1,2-Benzisothiazolin-3-one) is effective at concentrations as low as 0.01–0.1% depending on the formulation.

BIT (1,2-Benzisothiazolin-3-one) is a broad-spectrum antimicrobial preservative.
BIT (1,2-Benzisothiazolin-3-one) is effective against bacteria, yeast, and fungi in aqueous systems.
BIT (1,2-Benzisothiazolin-3-one) is often used in industrial and household formulations.

BIT (1,2-Benzisothiazolin-3-one) is a water-soluble, stable, and easy-to-use preservative.
BIT (1,2-Benzisothiazolin-3-one) is compatible with many surfactant and emulsifier systems.

BIT (1,2-Benzisothiazolin-3-one) remains stable under a broad pH range.
BIT (1,2-Benzisothiazolin-3-one) has low volatility and good shelf stability.
BIT (1,2-Benzisothiazolin-3-one) is a common alternative to formaldehyde-releasing preservatives.

BIT (1,2-Benzisothiazolin-3-one) offers strong protection in demanding storage conditions.
BIT (1,2-Benzisothiazolin-3-one) is not typically used in leave-on cosmetics due to sensitization concerns.

BIT (1,2-Benzisothiazolin-3-one) is non-volatile and exhibits good compatibility with emulsions and surfactant systems.
BIT (1,2-Benzisothiazolin-3-one) provides long-lasting protection against bacterial and fungal spoilage in aqueous systems.
BIT (1,2-Benzisothiazolin-3-one) is not effective against spores and must be used in conjunction with proper manufacturing hygiene.

BIT (1,2-Benzisothiazolin-3-one) can cause sensitization and must be handled with care in production environments.
BIT (1,2-Benzisothiazolin-3-one) is regulated in many countries with restrictions on use levels in certain applications.
BIT (1,2-Benzisothiazolin-3-one) is used globally in industry-standard preservative systems for water-based formulations.

PROPERTIES

Chemical Formula: C7H5NOS
Molecular Weight: 151.19 g/mol
Appearance: White to off-white crystalline powder
Odor: Mild to no odor
Solubility: Soluble in water, alcohols, and glycols
Melting Point: ~158–162°C
Boiling Point: Decomposes before boiling
Density: ~1.34 g/cm³
pH (1% solution): 6.0–8.0
Stability: Stable under normal storage conditions
Flash Point: >100°C
Reactivity: May react with strong acids and oxidizers
Storage Temperature: 5–25°C
Shelf Life: Typically 1–2 years if properly stored

FIRST AID

Inhalation:
Remove the affected person to fresh air.
Seek medical attention if symptoms like coughing or dizziness persist.

Skin Contact:
Immediately wash the area with soap and water.
Remove contaminated clothing.
Seek medical help if irritation develops.

Eye Contact:
Flush eyes with plenty of water for at least 15 minutes.
Seek medical assistance if irritation continues.

Ingestion:
Rinse mouth thoroughly.
Do not induce vomiting.
Seek immediate medical advice.

Note to Physicians:
Treat symptomatically and supportively.
There is no specific antidote.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves, goggles, and protective clothing.
Avoid breathing dust or vapors.
Handle in a well-ventilated area.
Prevent skin and eye contact.

Storage:
Store in a tightly closed container in a cool, dry, and well-ventilated area.
Avoid direct sunlight and moisture.
Keep away from incompatible substances like strong acids and oxidizing agents.

Spill and Leak Procedures:
Contain spillage and absorb with inert material.
Avoid discharge to drains.
Dispose of in accordance with local regulations.

Disposal:
Dispose of according to local environmental regulations.
Do not reuse empty containers.