PRODUCTS

BUTYLATED HYDROXY TOLUENE (BHT)

Butylated Hydroxy toluene (BHT) is used as an antioxidant or stabilizer.
Butylated Hydroxy Toluene (BHT) is used antiskinning agent in paints and inks.
Butylated Hydroxy Toluene (BHT) is commonly used rubber antioxidant, heat, oxygen aging have some protective effect, but also can inhibit copper harm.

CAS Number: 128-37-0
EC Number: 204-881-4
MDL number: MFCD00011644
Molecular Formula: C15H24O / [(CH3)3C]2C6H2(CH3)OH
Molecular Weight: 220.35 g/mol

SYNONYMS:
2,6-Bis(1,1-dimethylethyl)-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, DBPC, 2,6-Di-tert-butyl-4-methylphenol, Dibutylhydroxytoluene, Antioxidant 264, 2,6-Di-tert-butyl-4-methylphenol, Butylhydroxytoluene, Butylated hydroxytoluene, BHT, 2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC, 2,6-Di-tert-butyl-4-methylphenol (BHT), E321, Butylhydroxytoluenum, 2,6-Di-tert-butyl-4-methylphenol, 4-methyl-2,6-ditertbutylphenol, Butylhydroxytoluene, 2,6-Di-tert-butyl-p-cresol, 2,6-Di-t-butyl-4-methylphenol, 2,6-bis(1,1-dimethylethyl)-4-methylphenol, butylated hydroxytoluene, 2,6-di-tert-butyl-p-cresol (DBPC), 3,5-di-tert-butyl-4-hydroxytoluene, 1,3-di-tert-butyl-2-hydroxy-5-methyl benzene, di-tert-butyl-methylphenol, 2,6-DITERTIARY-BUTYL-p-CRESOL, 4-METHYL-2,6-DITERTIARY-BUTYL-PHENOL, Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, p-Cresol, 2,6-di-tert-butyl-, Dalpac, Deenax, Di-tert-butyl-p-cresol, Di-tert-butyl-p-methylphenol, Di-tert-butylcresol, Dibunol, Dibutylated hydroxytoluene, Ionol, Nonox TBC, Parabar 441, Stavox, Sumilizer BHT, Sustane BHT, Tenamene 3, Tenox BHT, Topanol, Vanlube PC, Vanlube PCX, Vianol, 2,6-Bis(1,1-dimethylethyl)-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, 2,6-Di-tert-butyl-p-methylphenol, 2,6-Di-tert-butyl-4-methylphenol, 3,5-Di-tert-butyl-4-hydroxytoluene, 4-Hydroxy-3,5-di-tert-butyltoluene, 4-Methyl-2,6-di-tert-butylphenol, 2,6-Di-t-butyl-4-methylphenol, 2,6-Di-tert-butyl-1-hydroxy-4-methyl benzene, 2,6-di-Butyl-para-cresol, 2,6-di-tert-Butyl-methylphenol, o-Di-tert-butyl-p-methylphenol, Butylated hydroxytoluol, DBMP, 1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene, 2,6-Di-terc.butyl-p-kresol, 2,6-Di-tert-butyl-4-cresol, 4-Methyl-2,6-di-terc. butylfenol, 4-Methyl-2,6-tert-butylphenol, Di-tert-Butylparamethylphenol, Di-tert-Butyl-4-methylphenol, 2,6-Di-t-butyl-p-cresol, Phenol, 2,6-di-tert-butyl-4-methyl-, 4-Methyl-2,6-di-t-butyl-phenol, BHT (butylated hydroxytoluene), 2,6-di-ter-butyl-4-methyl-phenol, 2,6-Di-tert-butyl-para-methylphenol, 2,6-di-tert-butyl-p-cresol (BHT), Butylated hydroxyl toluene (BHT), Dibutylhydroxytoluene, Dibutylcresol, 2,6-Bis(tert-butyl)-4-methylphenol, 2,6-Di(tert-butyl)hydroxytoluene, 2,6-di-ter-butul-4-methyl-phenol, 4-Methyl-2,6-di-tert.-butylphenol, Di-ter-butyl p-cresol, butylated OH tolueno, Dibutyl-p-cresol, Ergotamine, dihydro-, monomethanesulfonate (salt), 2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, 2,6-DI-tert-butyl-4-methylphenol, 3,5-Di-tert-butyl-4-hydroxytoluene, 2,6 ditertiary-butyl-4-methyl phenol, DBPC, BHT, E321, AO-29, Avox BHT, Antioxidant 264, Additin RC 7110, Dibutylated hydroxytoluene, 4-Methyl-2,6-di-tert-butyl phenol, 3,5-(Dimethylethyl)-4-hydroxytoluene, E321: Food additive code, Butylhydroxytoluene, BHT, 2,6-Di-t-butyl-4-methylphenol, 128-37-0, Antioxidant, Lonol (Antioxidant), Dibutylated Hydroxytoluene, 2,6-Di-tert-butyl-4-methylphenol, BHT, 2,6-Di-tert-butyl-4-methylphenol, Dibutylhydroxytoluene, Butylhydroxytoluene, Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, 2,6-di-t-butyl-p-cresol, Di-tert-butyl-p-cresol, 3,5-Di-tert-butyl-4-hydroxytoluene, 4-hydroxy-3,5-di-tert-butyltoluene, Ionol, Topanol O, Antioxidant DBPC, Sustane BHT, DBMP, BUKS, 2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC, Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, p-Cresol, 2,6-di-tert-butyl-, Advastab 401, Antioxidant DBPC, Antioxidant KB, Antioxidant 29, Antioxidant 30, Antioxidant 4K, AO 29, AO 4K, Butylhydroxytoluene, BHT, BUKS, Catalin Antioxydant 1, Catalin CAO-3, Chemanox 11, CAO 1, CAO 3, Dalpac, Deenax, Di-tert-butyl-p-cresol, Di-tert-butyl-p-methylphenol, Di-tert-butylcresol, Dibunol, Dibutylated hydroxytoluene, DBPC, Impruvol, Ionol, Ionol (Antioxidant), Ionol CP, Ionol 1, Ionole, Nonox TBC, P 21, Parabar 441, Stavox, Sumilizer BHT, Sustane BHT, Tenamene 3, Tenox BHT, Topanol, Topanol O, Topanol OC, Vanlube PC, Vanlube PCX, Vianol, 2,6-Bis(1,1-dimethylethyl)-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, 2,6-Di-tert-butyl-p-methylphenol, 2,6-Di-tert-butyl-4-methylphenol, 3,5-Di-tert-butyl-4-hydroxytoluene, 4-Hydroxy-3,5-di-tert-butyltoluene, 4-Methyl-2,6-di-tert-butylphenol, 2,6-Di-t-butyl-4-methylphenol, 2,6-Di-tert-butyl-1-hydroxy-4-methyl benzene, 2,6-di-Butyl-para-cresol, 2,6-di-tert-Butyl-methylphenol, o-Di-tert-butyl-p-methylphenol, Bht(food grade), Butylated hydroxytoluol, Dbpc(technical grade), DBMP, NCI-C03598, Paranox 441, 1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene, 2,6-Di-terc.butyl-p-kresol, 2,6-Di-tert-butyl-4-cresol, 4-Methyl-2,6-di-terc. butylfenol, 4-Methyl-2,6-tert-butylphenol, Di-tert-Butylparamethylphenol, Di-tert-Butyl-4-methylphenol, 2,6-Di-t-butyl-p-cresol, Phenol, 2,6-di-tert-butyl-4-methyl-, 4-Methyl-2,6-di-t-butyl-phenol, Annulex BHT, Antrancine 8, Lowinox BHT, Nipanox BHT, Ralox BHT, Sustane, Vulkanox KB, BHT (butylated hydroxytoluene), 2,6-di-ter-butyl-4-methyl-phenol, 2,6-Di-tert-butyl-para-methylphenol, 2,6-di-tert-butyl-p-cresol (BHT), Butylated hydroxyl toluene (BHT), Dibutylhydroxytoluene, Dibutylcresol, 2,6-Bis(tert-butyl)-4-methylphenol, 2,6-Di(tert-butyl)hydroxytoluene, Ionol BHT, BHT Swanox, Agidol, 2,6-di-ter-butul-4-methyl-phenol, 4-Methyl-2,6-di-tert.-butylphenol, Di-ter-butyl p-cresol, butylated OH tolueno, Dibutyl-p-cresol, Ergotamine, dihydro-, monomethanesulfonate (salt), Hydagen DEO (Salt/Mix), advastab 401, agidol, alkofen BP, annulex BHT, antioxidant 264, antioxidant 29, antioxidant 30, antioxidant 4, antioxidant DBPC, antioxidant KB, antioxidant MPJ, antioxidant T 501, antox QT, antracine 8, antrancine 8, B.H.T., BHT, BHT (butylated hydroxy toluene) tech grade, BHT FCC/NF, 2,6-bis(tert- butyl)-4-methylphenol, catalin antioxydant 1, catalin CAO-3, chemanox 11, (2,5- cyclohexadiene-1,4-diylidene)-dimalononitrile, dalpac, deenax, 2,6- di-(tert-butyl)-4-methylphenol, 2,6- di-t-butyl-4-methylphenol, 2,6- di-t-butyl-p-cresol, 2,6- di-tert-butyl-1-hydroxy-4-methylbenzene, 2,6- di-tert-butyl-4-cresol, 2,6- di-tert-butyl-4-hydroxytoluene, 2,6- di-tert-butyl-4-methyl phenol, 2,6- di-tert-butyl-4-methylhydroxybenzene, 2,6- di-tert-butyl-4-methylphenol, 2,6- di-tert-butyl-p-cresol, 2,6- di-tert-butyl-p-methylphenol, 2,6- di-tert-butyl-para-cresol, 2,6- di-tert-butylcresol, 2,6-bis(1,1- dimethylethyl)-4-methylphenol, embanox BHT, hydagen DEO, butylated hydroxy toluene, butylated hydroxy toluene (BHT) N.F. grade powder (40 mesh), 4- hydroxy-3,5-di-tert-butyltoluene, 1- hydroxy-4-methyl-2,6-di-tert-butylbenzene, butylated hydroxytoluene (BHT) N.F. grade powder (60 mesh), butylated hydroxytoluene (BHT) FCC grade, butylated hydroxytoluene (BHT) N.F. grade, butylated hydroxytoluene (BHT) NF & EP grade, butylated hydroxytoluene NF & EP grade powder (325 mesh), butylated hydroxytoluene NF & EP grade powder (60 mesh), butylated hydroxytoluene NF & EP grade powder (80 mesh), impruvol, ional, kerabit, 4- methyl-2,6-di-t-butyl-phenol, 4- methyl-2,6-ditertbutylphenol, 4- methyl-2,6-tert-butylphenol, nocrac 200, nonox TBC, parabar, paranox 441, tenox BHT food-grade antioxidant, vianol,

Butylated Hydroxy toluene (BHT) is a stabilizer that can also be found in cosmetics and moisturizers.
Butylated Hydroxy toluene (BHT) is a toluene-based ingredient used as a preservative in food and personal care products.
The antioxidant Butylated Hydroxy Toluene (BHT) is contained in food, adhesive glues, industrial oils and greases, including cutting fluids.

Butylated Hydroxy Toluene (BHT) is a white crystalline solid.
Butylated Hydroxy Toluene (BHT) is insoluble in water.
Butylated Hydroxy Toluene (BHT) is a synthetic antioxidant.

Butylated Hydroxy Toluene (BHT) scavenges peroxide, 2,2-diphenyl-1-picrylhydrazyl (DPPH; ), superoxide, and ABTS radicals in cell-free assays, as well as inhibits lipid peroxidation of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) in vitro when used at a concentration of 45 μg/ml.
Butylated Hydroxy Toluene (BHT) reduces freeze-thaw-induced malondialdehyde (MDA) production and increases sperm viability in boar spermatozoa preparations.

Formulations containing Butylated Hydroxy Toluene (BHT) have been used as antioxidant cosmetic and food additives.
Butylated Hydroxy Toluene (BHT) is not reported found naturally.
Butylated Hydroxy Toluene (BHT) is a member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.

Butylated Hydroxy Toluene (BHT) is a synthetic organic compound widely used as an antioxidant and preservative.
Chemically, Butylated Hydroxy toluene (BHT) belongs to the class of phenolic antioxidants, where bulky tert-butyl groups protect the phenolic OH group from oxidation.

Butylated Hydroxy toluene (BHT) slows or prevents the oxidation of fats and oils, helping extend shelf life in many products.
Butylated Hydroxy toluene (BHT) is listed by the NIH Hazardous Substances Data Bank under several categories in catalogues and databases, such as food additive, household product ingredient, industrial additive, personal care product/cosmetic ingredient, pesticide ingredient, plastic/rubber ingredient and medical/veterinary/research.

Butylated Hydroxy toluene (BHT) is an antioxidant shown to be chemopreventive against a variety of carcinogens.
As an antioxidant, Butylated Hydroxy toluene (BHT) acts as a free radical scavenger, binding to and neutralizing these highly reactive molecules in the body.

By doing so, Butylated Hydroxy toluene (BHT) helps protect cells from damage and reduces oxidative stress, which can otherwise lead to cell damage.
Butylated Hydroxy toluene (BHT) has been evaluated for safety by regulatory authorities and independent organizations in various countries and regions for its use in pharmaceuticals, foods, and cosmetics, and its safe levels of concentration have been specified.

Butylated Hydroxy Toluene (BHT) is a synthetic phenolic compound mainly used as an antioxidant and preservative in the food industry.
Butylated Hydroxy toluene (BHT) is a lab-made chemical that is added to foods as a preservative.

People also use Butylated Hydroxy toluene (BHT) as medicine.
Butylated Hydroxy toluene (BHT), butylhydroxytoluene, is a lipophilic organic compound derived from phenol.
Butylated Hydroxy toluene (BHT) is produced synthetically (through the alkylation of para-cresol with isobutylene) for use as a preservative.

USES and APPLICATIONS of BUTYLATED HYDROXY TOLUENE (BHT):
Because they prevent rancidity, antioxidants are of great interest to the food industry.
For example, Butylated Hydroxy Toluene (BHT), butylated hydroxyanisole (BHA), and EDTA are frequently used to preserve various foods, such as cheese or fried products.

Butylated Hydroxy Toluene (BHT) is a powerful inhibitor of lipid peroxidation, yet large doses of it can induce oxidative DNA damage and cancer development in the rat forestomach.
Uses of Butylated Hydroxy Toluene (BHT): Antioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, soaps.

Butylated Hydroxy Toluene (BHT) is used antiskinning agent in paints and inks.
Butylated Hydroxy Toluene (BHT) as general antioxidants is used widely in polymer materials, petroleum products and food processing industries.
Butylated Hydroxy Toluene (BHT) is commonly used rubber antioxidant, heat, oxygen aging have some protective effect, but also can inhibit copper harm.

Butylated Hydroxy Toluene (BHT) does not change color, not pollution.
Butylated Hydroxy Toluene (BHT) high solubility in oil, no precipitation, less volatile, non-toxic and non-corrosive.
Butylated Hydroxy Toluene (BHT) is also known as butylated hydroxy toluene.

Butylated Hydroxy Toluene (BHT) is an anti-oxidant that also has preservative and masking capabilities.
Butylated Hydroxy Toluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures.

Butylated Hydroxy Toluene (BHT) is also termed 2,6-di-tert-butyl-para-cresol.
Industrial & Commercial Uses: Butylated Hydroxy toluene (BHT)’s main function is as an antioxidant — it reacts with free radicals to inhibit oxidation.

Specific uses include: Food Additive (Preservative): Butylated Hydroxy toluene (BHT) helps prevent rancidity in fats and oils; recognized as GRAS (Generally Recognized As Safe) in regulated amounts in many countries (e.g., FDA in the USA).
Cosmetics & Personal Care: Butylated Hydroxy toluene (BHT) is used antioxidant ingredient in creams, lotions, and cosmetics.

Plastics & Rubber Industry: Butylated Hydroxy toluene (BHT) prevents oxidation during processing/storage.
Fuels & Oils: Butylated Hydroxy toluene (BHT) is added to petroleum products to stabilize against oxidative degradation.
Embalming Fluids & Pharmaceuticals: Butylated Hydroxy toluene (BHT) is used antioxidant in certain formulations.

Butylated Hydroxy toluene (BHT) acts as an antioxidant – we use it to help maintain the properties and performance of a product as it is exposed to air.
European and U.S. regulators have approved Butylated Hydroxy toluene (BHT) for use in food.

Some concerns have been raised over its use as a food additive, however our products containing Butylated Hydroxy toluene (BHT) are not intended for ingestion, so we feel that its use is acceptable.
Butylated Hydroxy toluene (BHT) is an antioxidant shown to be chemopreventive against a variety of carcinogens

Butylated Hydroxy toluene (BHT) is used as an antioxidant or stabilizer.
Butylated Hydroxy toluene (BHT) plays an important role in maintaining quality and performance of raw materials and products by preventing their deterioration due to the reaction with oxygen in the air (oxidation).

Butylated Hydroxy toluene (BHT) is used in a wide range of fields, including resins, rubber, textile processing, packaging materials, food additives, cosmetics, detergents, and pharmaceuticals.
Since Butylated Hydroxy toluene (BHT) is heat stable, it is useful to prevent oxidation of certain raw materials during manufacturing processes that involve heating.

Butylated Hydroxy toluene (BHT) is also used to protect oils, fats, and active ingredients such as vitamins that are susceptible to oxidation.
We use the minimum amount of Butylated Hydroxy toluene (BHT) in our products to ensure that they can be used safely until their expiration.
Butylated Hydroxy toluene (BHT) is an antioxidant and used as preservative in foods, animal feed, animal and vegetable oils, meat products

Butylated Hydroxy Toluene (BHT) is used to prevent the lipid oxidation in oils and fat-containing foods.
Butylated Hydroxy Toluene (BHT) is used in many near consumer products population wide exposure is expected.
Butylated Hydroxy Toluene (BHT) metabolites causing DNA strand breaks in cultured cells and DNA breaks between nucleosomes (a typical feature of apoptosis), which result in relieving inflammation.

Butylated Hydroxy Toluene (BHT) is used inhibiting secretion, aggregation, and protein phosphorylation caused by protein kinase C activators at the process of the pre-incubation of aspirin-treated platelets.
Butylated Hydroxy Toluene (BHT) is used inhibiting liver cancer formation induced by aflatoxin B1.

As Michael receptor, Butylated Hydroxy Toluene (BHT) can react with uninucleophiles and proteins.
Reaction of Butylated Hydroxy Toluene (BHT) with fluorine (II) - benzophenone dianion complex.
Butylated Hydroxy Toluene (BHT) can be used to prepare organoaluminum compound methylaluminum bis (2, 6-di-tert-butyl-4-alkylphenol oxide).

Butylated Hydroxy Toluene (BHT) has wide application, such as flavors, fragrances, biochemical reagents-other chemical reagents, chemical raw materials, organic chemical raw materials, biochemical, inorganic salts, antioxidants, food additives, feed additives, feed storage additives, aromatic hydrocarbons, bulk drugs and so on.

As a phenolic antioxidant, Butylated Hydroxy Toluene (BHT) can inhibit lipid peroxidation and exhibit electrophilic quinone methyl ether toxicity mediated by oxidative metabolism.
Butylated Hydroxy Toluene (BHT) has applications in various industries, including food and beverage, cosmetics and personal care, pharmaceuticals, plastics/rubbers, and petroleum products.

Butylated Hydroxy toluene (BHT) is used to treat genital herpes and acquired immunodeficiency syndrome (AIDS).
Some people apply Butylated Hydroxy toluene (BHT) directly to the skin for cold sores.
Use of Butylated Hydroxytoluene (Butylated Hydroxy toluene (BHT)) in Personal Care and Cosmetics

Many cosmetics contain fats and oils that are naturally susceptible to oxidative reactions that produce compounds with objectionable tastes and odors.
As one of the most popular preservatives, Butylated Hydroxy Toluene (BHT) reduces free-radical damage and spoilage, helping to maintain the properties and performance of products when exposed to air.

Butylated Hydroxy Toluene (BHT) is also used to prevent lipid oxidation in oils and fat-containing food products.
Lipid oxidation occurs in a complex series of chain reactions.

Butylated Hydroxy Toluene (BHT) acts to break the chain during processing, storage, and use of fat-containing products.
Butylated Hydroxy Toluene (BHT) can be easily incorporated into various personal care and cosmetic formulations.

-Antioxidant uses of Butylated Hydroxy toluene (BHT):
Cereals, chewing gum, potato chips, oils, etc.
Butylated Hydroxy toluene (BHT) retards rancidity in oils.

Butylated Hydroxy toluene (BHT) either increased or decreased the risk of cancer in various animal studies.
Residues of Butylated Hydroxy toluene (BHT) occur in human fat.
Butylated Hydroxy toluene (BHT) is unnecessary or is easily replaced by safe substitutes (see discussion of BHA).

-Pharmaceutical Applications of Butylated Hydroxy Toluene (BHT):
Butylated Hydroxy Toluene (BHT) is used as an antioxidant in cosmetics, foods, and pharmaceuticals.
Butylated Hydroxy Toluene (BHT) is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.

Butylated Hydroxy Toluene (BHT) is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
Butylated Hydroxy Toluene (BHT) has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.

-Food additive uses of Butylated Hydroxy toluene (BHT):
Butylated Hydroxy toluene (BHT) is primarily used as an antioxidant food additive.
Butylated Hydroxy toluene (BHT) is approved for use in the U.S. by the Food and Drug Administration.

For example, 21 CFR § 137.350(a)(4) allows Butylated Hydroxy toluene (BHT) up to 0.0033% by weight in enriched rice.
9 CFR § 381.147(f)(1) allows up to 0.01% in poultry by fat content.
Butylated Hydroxy toluene (BHT) is permitted in the European Union under E321.

Butylated Hydroxy toluene (BHT) is used as a preservative ingredient in some foods.
With this usage, Butylated Hydroxy toluene (BHT) maintains freshness or prevents spoilage.

Butylated Hydroxy toluene (BHT) may be used to decrease the rate at which the texture, color, or flavor of food changes.
Some food companies have voluntarily eliminated Butylated Hydroxy toluene (BHT) from their products or have announced that they were going to phase it out.

-Antioxidant uses of Butylated Hydroxy toluene (BHT):
Butylated Hydroxy toluene (BHT) is also used as an antioxidant in products such as metalworking fluids, cosmetics, pharmaceuticals, rubber, transformer oils, and embalming fluid.

In the petroleum industry, where Butylated Hydroxy toluene (BHT) is known as the fuel additive AO-29 (Innospec), it is used in hydraulic fluids, turbine and gear oils, and jet fuels.
Butylated Hydroxy toluene (BHT) is also used to prevent peroxide formation in organic ethers and other solvents and laboratory chemicals.

Butylated Hydroxy toluene (BHT) is added to certain monomers as a polymerisation inhibitor to facilitate their safe storage.
Some additive products contain Butylated Hydroxy toluene (BHT) as their primary ingredient, while others contain the chemical merely as a component of their formulation, sometimes alongside butylated hydroxyanisole (BHA).

-Cosmetics use of Butylated Hydroxy toluene (BHT):
The European Union restricts the use of Butylated Hydroxy toluene (BHT) in mouthwash to 0.001% concentration.
Butylated Hydroxy toluene (BHT) is restricted in toothpaste to 0.01% concentration.
Butylated Hydroxy toluene (BHT) is restricted to 0.8% in other cosmetics.

CHEMICAL CHARACTERISTICS of BUTYLATED HYDROXY TOLUENE (BHT):
Butylated Hydroxy toluene (BHT) is a phenolic antioxidant where the phenolic OH group intercepts free radicals and prevents propagation of oxidation chains in organic systems.
The ortho tert-butyl groups increase stability and reduce the rate of further oxidation.

BENEFITS & CHARACTERISTICS of BUTYLATED HYDROXY TOLUENE (BHT):
*Antioxidant Efficiency:
Butylated Hydroxy toluene (BHT) scavenges free radicals, extending shelf life of products containing fats/oils.

*Thermal Stability:
Relatively stable under typical processing temperatures.

*Lipophilic:
Effective in fatty environments due to high solubility in organic phases.

*Synergistic Effects:
Butylated Hydroxy toluene (BHT) is often used with other antioxidants like BHA for better protection.

PRODUCTION METHODS of BUTYLATED HYDROXY TOLUENE (BHT):
Prepared by the reaction of p-cresol with isobutene.

ALTERNATIVE PARENTS of BUTYLATED HYDROXY TOLUENE (BHT):
*Para cresols
*Toluenes
*Organooxygen compounds
*Hydrocarbon derivatives

SUBSTITUENTS of BUTYLATED HYDROXY TOLUENE (BHT):
*Phenylpropane
*P-cresol
*Toluene
*Phenol
*Organic oxygen compound
*Hydrocarbon derivative
*Organooxygen compound
*Aromatic homomonocyclic compound

PRODUCTION OF BUTYLATED HYDROXY TOLUENE (BHT):
The chemical synthesis of Butylated Hydroxy toluene (BHT) in industry has involved the reaction of p-cresol (4-methylphenol) with isobutylene (2-methylpropene), catalyzed by sulfuric acid:

CH3(C6H4)OH + 2 CH2=C(CH3)2 → ((CH3)3C)2CH3C6H2OH
Alternatively, Butylated Hydroxy toluene (BHT) has been prepared from 2,6-di-tert-butylphenol by hydroxymethylation or aminomethylation followed by hydrogenolysis.

REACTIONS OF BUTYLATED HYDROXY TOLUENE (BHT):
The species behaves as a synthetic analog of vitamin E, primarily acting as a terminating agent that suppresses autoxidation, a process whereby unsaturated (usually) organic compounds are attacked by atmospheric oxygen.

Butylated Hydroxy toluene (BHT) stops this autocatalytic reaction by converting peroxy radicals to hydroperoxides.
Butylated Hydroxy toluene (BHT) effects this function by donating a hydrogen atom:

RO2• + ArOH → ROOH + ArO•
RO2• + ArO• → nonradical products

where R is alkyl or aryl, and where ArOH is Butylated Hydroxy toluene (BHT) or related phenolic antioxidants.
Each Butylated Hydroxy toluene (BHT) consumes two peroxy radicals.

The electron-donating alkyl groups on the ortho and para positions of Butylated Hydroxy toluene (BHT) increase the electron density of the phenolic hydroxyl moiety through the inductive effect and the hyperconjugation effect, reduce the bond dissociation energy of the phenolic hydroxyl group, and enhance its reactivity to lipid free radicals.

Meanwhile, the phenoxy radical generated by Butylated Hydroxy toluene (BHT) is stabilized due to the delocalization of unpaired electrons around the aromatic ring and the steric hindrance effect of ortho tert-butyl groups.

Isobutene is one of the possible degradation products formed by Butylated Hydroxy toluene (BHT) oxidation with computational studies suggesting that there are two possible mechanisms that can lead to isobutene formation, with the OH addition pathways at the C2 site of Butylated Hydroxy toluene (BHT) more likely to result in isobutene formation than pathways of H abstracts from the t-butyl group.

WHAT IS BUTYLATED HYDROXY TOLUENE (BHT) USED FOR?
Butylated Hydroxy toluene (BHT) is mainly used as an antioxidant to prevent the spoilage of cosmetic formulations, particularly those that contain oil or fats in a water base.
Butylated Hydroxy toluene (BHT) is used in various cosmetic products that are aqueous in nature and contain active ingredients or plant extracts.

Butylated Hydroxy toluene (BHT) resists high temperatures and stabilizes the raw materials themselves and is also used in the manufacturing process of raw materials.
Butylated Hydroxy toluene (BHT) is often used at concentrations ranging from 0.0001% to 0.5%.

*Skin care:
Butylated Hydroxy toluene (BHT) enhances the shelf-life of skin care products by preventing oxidation.
Butylated Hydroxy toluene (BHT) also functions as a synthetic analog of vitamin E.
Similar to vitamin E, Butylated Hydroxy toluene (BHT) prevents autoxidation, where the unsaturated organic compounds in a cosmetic formulation may be attacked by oxygen changing their color, texture, or efficacy

ORIGIN of BUTYLATED HYDROXY TOLUENE (BHT):
Butylated Hydroxy toluene (BHT) is produced by the reaction of p-cresol with isobutylene and sulfuric acid.

WHAT DOES BUTYLATED HYDROXY TOLUENE (BHT) DO IN A FORMULATION?
ANTIOXIDANT
MASKING

SAFETY PROFILE of BUTYLATED HYDROXY TOLUENE (BHT):
Butylated Hydroxy toluene (BHT) has been considered as safe for use in cosmetics by the Cosmetic Ingredient Review (CIR) board.

ALTERNATIVES of BUTYLATED HYDROXY TOLUENE (BHT):
*TOCOPHEROL

FORMULATION CONSIDERATIONS of BUTYLATED HYDROXY TOLUENE (BHT):
Butylated Hydroxy Toluene (BHT) is stable but light-sensitive.
At a higher pH, Butylated Hydroxy Toluene (BHT) becomes unstable (</=9).
Butylated Hydroxy toluene (BHT) is incompatible with acid chlorides and acid anhydrides.

Butylated Hydroxy Toluene (BHT) is also incompatible with potent oxidizing agents such as peroxides and permanganates.
For this reason, Butylated Hydroxy toluene (BHT) shouldn’t be used in hair color, perming formulations, or other alkaline formulations.
Contact with oxidizing agents may cause spontaneous combustion.

The recommended maximum concentration range of Butylated Hydroxy toluene (BHT) is 0.1-1%.
Certain products have specific recommendations:
*0.001% in mouthwash
*0.1% in toothpaste
*0.8% for leave-on and rinse-off hair care products

Butylated Hydroxy toluene (BHT) is used between 0.0002 and 0.8% as an antioxidant in a wide spectrum of dermally applied or sprayable cosmetic product types.
In leave-on color cosmetics like Liquid foundation, eye-shadow, mascara, eye-liner, the concentration of Butylated Hydroxy Toluene (BHT) varies from 0.1 to maximum 0.8%.

CHEMICAL PROPERTIES of BUTYLATED HYDROXY TOLUENE (BHT):
BHA and Butylated Hydroxy Toluene (BHT) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming.

Butylated Hydroxy Toluene (BHT) has a very faint, musty, occasional cresylictype odor.
BHA and Butylated Hydroxy Toluene (BHT) are extensively used in foods as antioxidants.

Most fats, oils and fat-containing foods are naturally susceptible to rapid rancification and other oxidative reactions that produce compounds having objectionable taste and odor, making foods containing them unpalatable.

Lipid oxidation is autocatalytic and proceeds as a complex of chain reactions, the nature and speed of which vary with the substrate, temperature, light, availability of oxygen and presence or absence of oxidation catalysts.
Antioxidants like Butylated Hydroxy Toluene (BHT) act as “chain breaks” in the autooxidation processes under the usual conditions of processing, storage and use of fat-containing foods.

Butylated Hydroxy Toluene (BHT) is a white crystalline solid.
Butylated Hydroxy Toluene (BHT) is a white to pale yellow crystalline solid or powder.
Butylated Hydroxy Toluene (BHT) occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.

HOW DOES BUTYLATED HYDROXY TOLUENE (BHT) WORK ?
Butylated Hydroxy toluene (BHT) is an antioxidant.
Butylated Hydroxy toluene (BHT) may damage the protective outer layer of viral cells.
This may keep the viruses from multiplying and/or doing more damage.

CHEMICAL PROPERTIES of BUTYLATED HYDROXY TOLUENE (BHT):
Butylated Hydroxy Toluene (BHT) is white or light yellow crystal.
Butylated Hydroxy Toluene (BHT) has a melting point of 71°C, a boiling point of 265°C, a relative density of 1.048 (20/4°C), and a refractive index of 1.4859 (75°C).

Solubility of Butylated Hydroxy Toluene (BHT) at normal temperature: methanol 25, ethanol 25-26, isopropanol 30, mineral oil 30, acetone 40, petroleum ether 50, benzene 40, lard (40-50°C ) 40-50, corn oil and soybean oil 40-50.
Butylated Hydroxy Toluene (BHT) is insoluble in water, 10NaOH solution, glycerol, and propylene glycol.
Butylated Hydroxy Toluene (BHT) is odorless, odorless with good thermal stability.

PREPARATION of BUTYLATED HYDROXY TOLUENE (BHT):
Butylated Hydroxy toluene (BHT) is produced commercially by the alkylation of para-cresol with isobutylene.
Butylated Hydroxy toluene (BHT) is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.

REACTIVITY PROFILE of BUTYLATED HYDROXY TOLUENE (BHT):
Phenols, such as Butylated Hydroxy Toluene (BHT), do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure.

Instead, they react as weak organic acids.
Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]).

These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides.
Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas.

Heat is also generated by the acid-base reaction between phenols and bases.
Such heating may initiate polymerization of the organic compound.

Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature).
The reactions generate heat.

Phenols are also nitrated very rapidly, even by dilute nitric acid.
Nitrated phenols often explode when heated.

Many of them form metal salts that tend toward detonation by rather mild shock.
May react with oxidizing materials.

WHAT ARE BUTYLATED COMPOUNDS?
BHA is primarily used as an antioxidant and preservative in food, cosmetics, food packaging and animal feed.
It also serves as a preservative and antioxidant in pharmaceutical preparations and cosmetic formulations that contain oils and fats.

Dermal exposure to BHA occurs from its use as an antioxidant in commercial products, especially lipstick and eye shadow.
Butylated Hydroxy toluene (BHT) is a toluene-base ingredient that is used as a preservative in both food and personal care products.

Butylated Hydroxy toluene (BHT) is an antioxidant that acts as a stabilizer for personal care products and cosmetics that contain fats and oils.
Because fats and oils are highly susceptible to oxidation, emollients, heavy barrier creams, cosmetic oils, conditioning products, and cosmetics are prone to going rancid.

Butylated Hydroxy toluene (BHT) is an antioxidant that acts as a stabilizer for these products.
Butylated Hydroxy toluene (BHT) preserves a product’s color, odor, and texture, enabling the product to maintain its effectiveness when exposed to air and ensuring a positive customer experience.

Unlike some other preservatives, Butylated Hydroxy toluene (BHT) resists heat, making it popular for applications that require the use of high temperatures.
While Butylated Hydroxy toluene (BHT) has come under scrutiny due to its endocrine disruption in high doses, it’s considered safe for human health when used within recommended concentrations.

Butylated hydroxyanisole (BHA) and Butylated Hydroxy toluene (BHT)are used as preservatives in a variety of personal care products.
Both of these chemicals are also used as preservatives in foods.
These chemicals are linked to several health concerns including endocrine disruption and organ-system toxicity.

PHYSICAL and CHEMICAL PROPERTIES of BUTYLATED HYDROXY TOLUENE (BHT):
Appearance Form: Crystalline powder
Color: colorless
Odor: odorless
Odor Threshold: Not applicable
Molecular Weight: 220.35
Purity >99%
pH: No data available
Melting point/freezing point: Melting point/range: 69 - 73 °C - lit.
Initial boiling point and boiling range: 265 °C - lit

Flash point: No data available
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,00 hPa at 25 °C
Vapor density: No data available
Relative density: 1,03 g/cm3 at 20 °C -
Water solubility: 0,76 g/l at 20 °C
Partition coefficient n-octanol/water: log Pow: 5,1

Autoignition temperature: > 400 °C
Decomposition temperature: No data available
Viscosity: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Typical range of impurities: ≤ 10 ppm heavy metals and ≤3 ppm arsenic
Solubility:
0.4 mg/L in water at 20 °C
0.6 mg/L in water at 25 °C
1.5 mg/L at 30 ºC and 6 mg/L at 60 ºC

Freely soluble in toluene
55.9 wt% in n-heptane at 29.5 °C
34 wt% in ethanol at 28.7 °C
31.1 wt% in 1-octanol at 29.5 °C
0.5% w/w in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene,
Most hydrocarbon solvents, ethanol, petroleum ether,
liquid petrolatum (white oil), good solubility in linseed oil.
Insoluble in propylene glycol

Melting point: 70-71 °C
Boiling point: 265 °C at 760 mm Hg
Flash point: 127 °C
Vapour pressure: 0.01 mm Hg, 0.005 mm Hg at 25 °C, 0.39 Pa at 25 °C
Density: 0.899 (g/mL)
Viscosity:
3.47 centistokes at 0 °C
1.54 centistokes at 120 °C
pKa: 14, 12.2 at 20 °C
refractive index: 1.49 at 75 °C
topical polar surface area: 20.2 Å2

Appearance Form: powder, crystalline
Color: colorless
Odor: odorless
Odor Threshold: Not applicable
pH: No data available
Melting point/range: 69 - 73 °C - lit.
Initial boiling point and boiling range: 265 °C - lit.
Flash point: 127 °C
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits :No data available
Vapor pressure 0,00 hPa at 25 °C

Vapor density: No data available
Relative density: No data available
Water solubility 0,76 g/l at 20 °C
Partition coefficient: n-octanol/water log Pow: 5,1
Autoignition temperature: > 400 °C
Decomposition temperature: No data available
Viscosity:
*Viscosity, kinematic: No data available
*Viscosity, dynamic: No data available

Boiling point: 265 °C (1013 hPa)
Density:1.03 g/cm3 (20 °C)
Ignition temperature: 345 °C
Vapor pressure:0.39 Pa (298 K)
Bulk density: 450 kg/m3
Solubility: <0.001 g/l
Water Solubility: 0.015 g/L
logP: 5.25
logP: 5.27
logS: -4.2

pKa (Strongest Acidic): 11.6
pKa (Strongest Basic): -4.6
Physiological Charge: 0
Hydrogen Acceptor Count: 1
Hydrogen Donor Count: 1
Polar Surface Area: 20.23 Å²
Rotatable Bond Count: 2
Refractivity: 70.41 m³·mol⁻¹
Polarizability: 27.35 Å³
Number of Rings: 1

Bioavailability: Yes
Rule of Five: No
Ghose Filter: Yes
Veber's Rule: Yes
MDDR-like Rule: No
CAS number: 128-37-0
EC number: 204-881-4
Grade: E 321
Hill Formula: C₁₅H₂₄O
Molar Mass: 220.36 g/mol

HS Code: 2907 19 90
Chemical Formula: C₁₅H₂₄O
Molecular Weight: 220.35 g/mol
CAS Number: 128-37-0
Boiling point: 265 °C (1013 hPa)
Density: 1.03 g/cm3 (20 °C)
Flash point: 127 °C
Ignition temperature: 345 °C

Melting Point: 69.8 °C 1
Vapor pressure: 0.39 Pa (298 K)
Bulk density: 450 kg/m3
Solubility: <0.001 g/l
Appearance: White to yellowish crystalline powder
Solubility: Insoluble in water, but soluble in ethanol, methanol, and propylene glycol
Appearance: White crystalline powder or flake, odorless or with a characteristic faint aromatic odor
Other names: Butylhydroxytoluene, 2,6-ditertiary-butyl-p-cresol, 4-methyl-2,6-ditertiarybutylphenol 2
CAS number: 128-37-0

Chemical formula: C15H24O
Molecular weight: 220.36
Solubility: Insoluble in water, freely soluble in food fats and oils 3
Chemical formula: C15H24O
Molar mass: 220.356 g/mol
Appearance: White to yellow powder
Odor: Slight, phenolic
Density: 1.048 g/cm3
Melting point: 70 °C (158 °F; 343 K)
Boiling point: 265 °C (509 °F; 538 K)

Solubility in water: 1.1 mg/L (20 °C)
log P: 5.32
Vapor pressure: 0.01 mmHg (20 °C)
Product Name: BHT-Butyl Hydroxy Toluene (E 321)
Chemical Formula: C15H24O
Cas No: 128-37-0
EINESC No: 204-881-4
UN No: 3077
Physical Property: White Solid Crystal
Odor: Odorless
Molecular Weight: 220.4 g/mol

Density: 1.03 g/cm3
Solubility: Slightly soluble in water
Empirical Formula (Hill Notation): C15H24O
CAS Number: 128-37-0
Molecular Weight: 220.35
MDL number: MFCD00011644
UNSPSC Code: 12352104
E Number: E321
EC Index Number: 204-881-4
Physical state: crystalline

Color: white
Odor: odorless
Melting point/freezing point:
Melting point: 69,8 °C
Initial boiling point and boiling range:
265 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 127 °C - open cup
Autoignition temperature: > 400 °C

Decomposition temperature: No data available
pH: No data available
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0,76 g/l at 20 °C - slightly soluble
Partition coefficient: n-octanol/water:
log Pow: 5,1 - - Potential bioaccumulation, (ECHA)

Vapor pressure: 0,00 hPa at 25 °C
Density: 1,03 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information:
Bulk density: 450 kg/m3

Other(deleted CASRN):102962-45-8
ECHA EINECS - REACH Pre-Reg:204-881-4
FDA UNII:1P9D0Z171K
Nikkaji Web:J2.939D
Beilstein Number:1911640
MDL:MFCD00011644
XlogP3-AA:5.30 (est)
Molecular Weight:220.35548000
Formula:C15 H24 O

Appearance:White to light yellow crystalline solid/powder
Odor:Slight phenolic odor
Density:~1.048 g/cm³
Melting Point:~69-73 °C
Boiling Point:~265 °C
Flash Point:~127 °C (varies with test method)
Water Solubility:Very low (≈ 1.1 mg/L @ 20 °C)
Solubility:Soluble in organic solvents (methanol, ethanol, oils)

log P:~5.32 (lipophilic)
Vapor Pressure:Very low (~0.01 mmHg @ 20 °C)
Common Name:Butylated Hydroxy Toluene
Abbreviation:BHT
CAS Number:128-37-0
EC Number:204-881-4
Chemical Formula:C₁₅H₂₄O
Molar Mass:~220.36 g/mol
IUPAC Name:2,6-Di-tert-butyl-4-methylphenol

Appearance:colorless crystals (est)
Assay:95.00 to 100.00
Food Chemicals Codex Listed:Yes
Melting Point:70.00 to 73.00 °C. @ 760.00 mm Hg
Boiling Point:265.00 °C. @ 760.00 mm Hg
Vapor Pressure:15.000000 mmHg @ 141.00 °C.
Vapor Density:7.6 ( Air = 1 )
Flash Point:> 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w):5.100
Soluble in:alcohol;water, 0.6 mg/L @ 25 °C (exp)

FIRST AID MEASURES of BUTYLATED HYDROXY TOLUENE (BHT):
-If inhaled:
*After inhalation:
Fresh air.
-In case of skin contact:
Rinse skin with water/ shower.
-In case of eye contact:
*After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
-If swallowed:
*After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.

ACCIDENTAL RELEASE MEASURES of BUTYLATED HYDROXY TOLUENE (BHT):
-Environmental precautions
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.

FIRE FIGHTING MEASURES of BUTYLATED HYDROXY TOLUENE (BHT):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of BUTYLATED HYDROXY TOLUENE (BHT):
-Control parameters:
*Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of BUTYLATED HYDROXY TOLUENE (BHT):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Dry.
Tightly closed.
-Specific end use(s):
No other specific uses are stipulated

STABILITY and REACTIVITY of BUTYLATED HYDROXY TOLUENE (BHT):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).