BUTYLATED HYDROXYTOLUENE

BUTYLATED HYDROXYTOLUENE = 2,6-ditert-butyl-4-methylphenol = Dibunol

CAS Number: 128-37-0
EC Number: 204-881-4
MDL number: MFCD00011644
Molecular Formula : C15H24O

BUTYLATED HYDROXYTOLUENE is an organic chemical composed of 4-methylphenol modified with tert-butyl groups at positions 2 and 6. 
BUTYLATED HYDROXYTOLUENE (BHT) inhibits autoxidation of unsaturated organic compounds. 
Butylated hydroxytoluene is a white crystalline solid. 
2,6-di-tert-butyl-4-methylphenol is a member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6. 
BUTYLATED HYDROXYTOLUENE has a role as an antioxidant, a food additive, a ferroptosis inhibitor and a geroprotector. 

BUTYLATED HYDROXYTOLUENE derives from a phenol.
White, crystalline or flaked solid, odourless or having a characteristic faint aromatic odour.
Butylated hydroxytoluene (BHT), also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for Butylated hydroxytoluenes antioxidant properties.
BUTYLATED HYDROXYTOLUENE is a lab-made chemical that is added to foods as a preservative. 
BUTYLATED HYDROXYTOLUENE is an antioxidant. 
BUTYLATED HYDROXYTOLUENE, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. 

Butylated hydroxytoluene is colorless, white or quasi-white crystalline or crystalline powder. 
Butylated hydroxytoluene is easily dissolved in acetone, soluble in ethanol and insoluble in water and propylene glycol.
Butylated hydroxytoluene belongs to phenol and has phenol-like reaction characteristics. 
Butylated hydroxytoluene will change color and lose activity with iron salt, and  Butylated hydroxytoluene will rapidly decompose with acid.
Chemically, BHT is 2, 6 ditertiarybutyl-4-methyl phenol; commonly referred to as butylated hydroxytoluene (BHT). 
Butylated hydroxytoluene (BHT), also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for Butylated hydroxytoluenes antioxidant properties.

Butylated hydroxytoluene (BHT) is commonly used as a food and cosmetics additive; Butylated hydroxytoluene exhibits antioxidative and anti-inflammatory activities.
BHT is not thermally stable. 
Butylated hydroxytoluene evaporates at a temperature below 100°C, and evaporates/decomposes completely at 250°C.
Butylated hydroxytoluene has the least thermal resistance among synthetic antioxidants like PG (propyl gallate), BHA (butylated hydroxyanisole) and TBHQ (tertiary-butyl hydroquinone).
Butylated hydroxytoluene (BHT) is a white, crystalline solid which is odorless or has a faint aromatic odor. 

Butylated hydroxytoluene is insoluble in water, and freely soluble in ethanol and fatty oils. 
Butylated hydroxytoluene has a melting point of 70 °C and an octanol/water partition coefficient of 5.1. 
Butylated hydroxytoluene (BHT) is prepared in a multistep process by the reaction of p-cresol (4-methylphenol) with high purity isobutylene (2-methylpropene) using an acid catalyst. 
Upon neutralization by addition of sodium carbonate, crystallization with isopropanol, filtration and washing with isopropanol, the substance is dried and sieved to obtain the final product.
Butylated hydroxytoluene is produced by the reaction of p-cresol with isobutylene and sulfuric acid.

The key function of Butylated hydroxytoluene is that of a stabilizer. 
Butylated hydroxytoluene inhibits the degradation of fats and oils through Butylated hydroxytoluenes antioxidant action and prevents rancidity. 
Butylated hydroxytoluene (BHT) is a lipophilic chemical compound derived from phenol. 
Butylated hydroxytoluene or Hydroxy toluene butylate or BHT or Toluene hydroxylated butylate, is an antioxidant of the additives, generally foodstuffs, of pharmaceutical products.
Butylated Hydroxytoluene (BHT) or di-butylhydroxytoluene, is an organic compound that is chemically derived from carbolic acid also known as phenol.

BHT is prepared in the lab and has powerful antioxidants that are used to terminate free radicals and bacterias from the products. 
Butylated hydroxytoluene is also used as a preservative in a variety of products because Butylated hydroxytoluene prevents oxidation in different materials.
Appearance of Butylated Hydroxytoluene varies from white to yellowish in color. 
Butylated hydroxytoluene can easily be dissolved partly in ethyl alcohol, isopropyl alcohol, and some other oils because of Butylated hydroxytoluenes stable and non-reactive nature. 
Butylated hydroxytoluene has a very slightly acidic odor. 

Butylated hydroxytoluene is lipophilic but does not get dissolved in water. 
BHT is of practical importance in preserving polyunsaturated lipids. 
Butylated hydroxytoluene also mutilates the protective outer layer of viral cells.
Butylated hydroxytoluene is a lipophilic or fat-soluble ingredient that is generally synthetically produced. 
While BHT is produced naturally by phytoplankton, green algae, and three different types of cyanobacteria, Butylated hydroxytoluene is more sustainable and cost-effective to synthetically produce the ingredient. 

USES and APPLICATIONS OF BUTYLATED HYDROXYTOLUENE:
-Butylated hydroxytoluene is mainly used as a food additive that exploits Butylated hydroxytoluenes antioxidant properties, known as BHT Food Grade and BHT Feed Grade. 
-BHT is widely used as an antioxidant for industrial use, called BHT Technical Grade, for plastics, elastomers and waxes, oil for electric transformers, hydraulic fluids; Butylated hydroxytoluene is also used as a fuel additive with the name AO-29. 
-Butylated hydroxytoluene is also used to prevent the formation of peroxide in diethyl ether and other laboratory chemicals. 
-Some additives contain BHT as their main ingredient, while others contain the chemical merely as part of their formulation.
-BHT is used in food, cosmetics and industrial fluids to prevent oxidation and free radical formation.

-BHT is used to treat genital herpes and acquired immunodeficiency syndrome (AIDS).
-Some people apply BHT directly to the skin for cold sores.
-BHT (butylated hydroxytoluene) is closely related synthetic antioxidants used as preservatives in lipsticks and moisturizers, among other cosmetics. 
-Butylated hydroxytoluene is also widely used as food preservatives.
-Butylated hydroxytoluene (BHT) is an antioxidant added to plastics such as polyethylene and polypropylene films and polybags to prevent aging.

-As antioxidant in pharmaceuticals, cosmetics and  oil& fat in food.
-Delay or prevent oxidative rancidity of oil and fat and loss of fat-soluble vitamins.
-Butylated hydroxytoluene can be used alone or in combination with synergists such as citric acid and phosphoric acid.
-Butylated hydroxytoluene has antiviral activity and can be used for treatment of lip surface simple cell rash.
-Butylated hydroxytoluene (BHT) is an antioxidant used in a variety of products. 
Intended uses include products like food, animal feed, cosmetics, packaging materials, pharmaceuticals, polymers and paints.

-Butylated hydroxytoluene (BHT) is a man-made chemical commonly used as a preservative in processed foods. 
Similar to the synthetic preservative butylated hydroxyanisole (BHA) with which Butylated hydroxytoluene is often used, BHT is an antioxidant that is soluble in oils and animal fats (Butylated hydroxytoluene actually has greater solubility than does BHA). 
Both BHA and BHT are used to extend shelf life of processed foods by reducing the occurrence of oxidation and rancidity. 
Instead of being added directly to the food itself, BHT is usually added to the packaging material from where Butylated hydroxytoluene vaporizes into the food during storage. 
-Processed foods most likely to contain BHT include chewing gum, active dry yeast, frozen convenience foods, prepared cereal products, prepared snacks, dried and processed meat, potato flakes, enriched rice products and shortening. 

-BHT is also a chemical preservative used in animal feeds and drugs; therefore eatomg non-organic meats and dairy products may be another way in which exposure occurs. 
-Butylated hydroxytoluene has outstanding solubility in fats and oils and provides carry through effectiveness in baked foods. 
-Butylated hydroxytoluene is used singly antioxidants, BHT imparts stability to cereals, fats, oils, and packaging materials.
-Beverage ingredients
-Food ingredients
-Food preservatives
-Personal care ingredients
-Skin care ingredients

-Butylated hydroxytoluene, commonly known as BHT, is an organic compound that is used in the food, cosmetic, and pharmaceutical industry as an antioxidant. 
-BHT is a substituted derivative of phenol. 
-BHT helps to prevent the formation of free radicals and oxidation. 
-When Butylated hydroxytoluene is used in food products, Butylated hydroxytoluene delays oxidative rancidity of fats and oils, and prevents loss of activity of oil-soluble vitamins. 
-Butylated hydroxytoluene may be found in pharmaceutical gels, creams and liquid or gelatin capsules, tablets and other pharmaceutical dosage forms. 

-Butylated hydroxytoluene (BHT) is widely used as a food preservative for its antioxidizing property. 
-Butylated hydroxytoluene has been found to be a potent inactivator of lipid-containing mammalian and bacterial viruses.
-BHT is widely used to prevent free radical-mediated oxidation in fluids (e.g. fuels, oils) and other materials.
-BHT may also display neuroprotective benefit, decreasing ethanol-induced brain damage and neurodegeneration and suppressing activation of NF-κB activation and COX-2 expression in vivo.
-BHT is a phenolic antioxidant used in the preservation of a wide variety of products, including shelf-stable baked goods.

-BHT, Butylated Hydroxytoluene, is an effective stabilizer and antioxidant for synthetic oils and fluids such as cutting, spindle, hydraulic and slushing oils, transformer oils, transmission fluids, and brake fluids.
-Butylated hydroxyanisole (BHA) and the related compound butylated hydroxytoluene (BHT) are phenolic compounds that are often added to foods to preserve fats and oils and keep them from becoming rancid. 
-Butylated Hydroxytoluene is added to food, cosmetics, and packing of products that contain fats to maintain nutrient levels, color, flavor, and odor. 
-BHT is also sold as a dietary supplement for use as an antioxidant.
-BHT is used in foods that contain oil and fat. 

-Butylated Hydroxytoluene functions as an antioxidant for preventing spoilage of fats and oils in baked goods by binding oxygen molecules. 
Oxygen molecules react preferentially with Butylated Hydroxytoluene rather than oxidizing the fats or oils. 
-In addition, Butylated Hydroxytoluene preserves food aroma, color, and flavor.
-Add directly to the shortening, as well as to baked goods containing fats, to prevent fat rancidity. 
-Butylated Hydroxytoluene sometimes appears alone in a food, but often is used in combination with other chemicals that also have an antioxidant activity, including BHA, PG, TBHQ, citric acid, phosphoric acid, and ascorbic acid. 
Butylated Hydroxytoluenes effectiveness increases with the addition of synergists.

-Butylated hydroxytoluene (BHT, 2,6-di-tert-butyl-4-methylphenol) is a common food additive. 
-BHT is found in many types of food including butter, meats, cereals, chewing gum, baked goods, snack foods, dehydrated potatoes and beverages. 
-Butylated Hydroxytoluene is used to preserve food odor, color and flavor. 
-BHT is oxidized preferentially in fats or oils, protecting the foods from spoilage.
-Butylated hydroxytoluene (2,6-Di-tert-butyl-4-methylphenol) also known as BHT or butylhydroxytoluene, is a synthetic α-tocopherol analogue antioxidant and preservative in the foods, cosmetics and pharmaceutical industry for scavenging hydrogen peroxide). 

-During storage, food quality is reduced quickly because of microbial spoilage and chemical reactions. 
The most important quality deterioration in the food systems is caused by chemical processes called lipid oxidation. 
In this process unsaturated fatty acids reacting with molecular oxygen via a free radical chain mechanism. 
As a consequence, hydroperoxides are formed which are unstable and decompose relatively quickly into aldehydes, ketones, alcohols, acids, esthers or hydrocarbons. 
These secondary oxidative products are responsible for food quality, nutrition, safety, colour and consumers’ acceptance. 
The variables that affect the susceptibility of lipids to oxidation are temperature, fatty acid composition, antioxidants, metals, enzyme-catalyzed reactions, and water. 
In order to slow or control food’s lipid oxidation, manufacturers use antioxiative substances. 
The most commonly used is butyl butylated hydroxytoluene (BHT), by directly adding them to food products.

-Butylated hydroxytoluene (BHT) is a synthetic antioxidant authorized for use in fats and oils, only for the professional manufacture of heat-treated food, in frying oil and frying fat (excluding olive pomace oil) and in lard, fish oil, beef, poultry and sheep fat. 
-Butylated hydroxytoluene is widely used in cosmetic and personal care products as an antioxidant and a stabilizing agent. 
-Butylated hydroxytoluene aids in maintaining the properties and performance of products such as odor, color, and texture, as they are exposed to air and prone to oxidation. 
-Butylated hydroxytoluene (BHT) is commonly used in cosmetic formulations as an antioxidant. 
-In addition to personal care products and makeup, Butylated hydroxytoluene is also widely used in plastics and foods. 

-BHT (or 2,6-di-tert-butyl-p-cresol) is a white to yellowish crystalline solid that prevents the oxidation of fats and oils, and helps to extend a product's shelf-life. 
-Dibutyl hydroxytoluene (BHT) is a powerful antioxidant that has many applications in the food industry, the polymer industry, especially the rubber industry, and the cosmetics industry.
-Dibutyl hydroxytoluene (BHT) is naturally a white crystalline that can be used as a pesticide in agriculture and also has the power and ability to eliminate fats. 
-In the oil and gas industry and Dibutyl hydroxytoluene is used in the production of turbine and hydraulic oils and jet fuel.
-BHT is insoluble in water but can be easily dissolved in fats and non-polar solvents, chemically BHT is a stable substance, and BHTs use in food production can help to increase shelf life and maintain productions quality.

-In the production of polymeric materials, especially rubber parts, one of the most important things to pay attention is their proximity to oxygen and the risk of oxidation, which affects the service life of products and manufactured parts.
To prevent this problem, polymer designers and engineers use some antioxidants like BHT in the product formulation to increase the shelf life of the products and delay oxidation.
-The main use of BHT in food production is as a factor to increase the shelf life of canned foods, vegetables, and other products.
-BHT with BHTs antioxidant properties can prevent the spoilage of liquids and foods and helps to increase the quality of taste and color of products. 
-The antioxidant properties of BHT are also widely used in the production of cosmetics and personal care products, such as lipsticks, moisturizers, skincare creams, and sunscreens.

-The use of BHT can increase the shelf life of these products and help increase the volume of products and improve their quality.
-Butylated Hydroxytoluene can also be applied directly to the skin for treating cold sores. 
-Butylated Hydroxytoluene is also known for protecting the upper layer of skin cells from viruses and bacteria. 
-Butylated Hydroxytoluene can be used as a preservative and stabilizer in products containing fats and oils. 
-Butylated hydroxytoluene (BHT) has potent effectiveness in inhibiting the growth of microorganisms like yeasts, molds, C. hungaricus, and L. casci if the concentration of these phenol antioxidants is increased. 
Butylated hydroxytoluenes strong antimicrobial properties prevent the spread of viruses and bacteria that damage your skin.

-Butylated Hydroxytoluene can also be added as a preservative in skin care products and cosmetic products as Butylated hydroxytoluene contains potent antioxidants that prevent the deterioration of formulas due to reactions of other ingredients with oxygen. 
These antioxidants act by obstructing the multiplication of peroxy radicals.
-Butylated Hydroxytoluene has a neutralizing effect on free oxygen radicals that might prove to be hazardous for your skin. 
BHT also stops or slows down the deterioration of fats and oils in cosmetic formulations. 
Butylated Hydroxytoluene is also used to stabilize color, odor, texture, etc. cosmetics by stabilizing the colorants used in them.
-BHT also offers some penetration ability to the cosmetic formulas. 
Still, the penetration isn’t deep enough, and therefore, you might have to combine Butylated Hydroxytoluene with other cosmetic raw materials that improve the delivery of active ingredients.

-Butylated Hydroxytoluene can obstruct the growth of free radicals and bacterias. 
Therefore Butylated Hydroxytoluene is considered to be a good addition to makeup products like eyeliners, blush, lipsticks, foundations but Butylated Hydroxytoluene can also be used in cosmetic applications like skin cleansers, creams, moisturizers, etc.
-Butylated Hydroxytoluene is considered safe in skin cleansers if Butylated Hydroxytoluene is used in low concentrations. 
The antioxidative properties present in these skin cleansers work to neutralize the oxidation process caused by free radicals. 
Butylated Hydroxytoluene also protects the skin from cell damage.
-BHT is used in several cosmetic and skincare products, particularly formulations containing oil and fats in a water base. 
As BHT is an antioxidant Butylated Hydroxytoluene is used to stabilize and protect the key ingredients from deterioration. 
Unlike many other natural antioxidants, BHT can resist high temperatures, making Butylated Hydroxytoluene useful in the manufacturing process of products as well. 

-BHT primarily is not only in makeup products such as eyeliner, lipstick, blush, and foundation, but also Butylated Hydroxytoluene finds in various other cosmetic products like moisturizers, cleansers, and perfume. 
-BHT also has applications as an antioxidant in foods that contain fats and oils, or in packaging material for fat-containing foods. 
-BHT stands for butylated hydroxytoluene, Butylated Hydroxytoluene is a preservative and antioxidant that is used in skincare and cosmetic formulations to stabilize the formulation and prevent oxidation.
-BHT is an antioxidant that helps to stabilize the formulation and reduce contamination of the product through use.
-Butylated Hydroxytoluene works well with most ingredients including most other antioxidants, helping to boost their effectiveness.

Why Is BUTYLATED HYDROXYTOLUENE Used in Skincare?
As an antioxidant, Butylated Hydroxytoluene helps fight against the deterioration of cosmetic products caused by free radicals. 
Oxygen molecules are normally stable and unreactive because they have an even number of electrons. 
However, when reactions occur that leave the oxygen molecule with an odd number of electrons, the molecule becomes unstable and highly reactive. 
Since they are highly reactive, they want to either donate that single electron to another molecule or accept an electron from another molecule so that they can become stabilized. 
This can lead to the degradation of cosmetic products, so ingredients such as BHT are used to maintain product integrity.
In order to combat free radicals, BHT functions as a synthetic analog of vitamin E. 
Similar to vitamin E, BHT prevents autoxidation. 
Autoxidation is a process whereby unsaturated organic compounds are attacked by atmospheric oxygen. 
This can cause changes in color, texture and efficacy of your product. 
BHT prevents this from occurring.

PHYSICAL and CHEMICAL PROPERTIES of BUTYLATED HYDROXYTOLUENE:
Molecular Weight: 220.35
Appearance Form: Crystalline powder
Color: colorless
Odor: odorless
Odor Threshold: Not applicable
pH: No data available
Melting point/freezing point:
Melting point/range: 69 - 73 °C - lit.
Initial boiling point and boiling range: 265 °C - lit.
Flash point: No data available
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: 0,00 hPa at 25 °C - OECD Test Guideline 104
Vapor density: No data available
Relative density: 1,03 g/cm3 at 20 °C -
Water solubility: 0,76 g/l at 20 °C - OECD Test Guideline 105 - slightly soluble
Partition coefficient: n-octanol/water: log Pow: 5,1 - - Potential bioaccumulation
Autoignition temperature: > 400 °C
Decomposition temperature: No data available
Viscosity: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Solubility: BHT is insoluble in water but more soluble in methanol, ethyl alcohol, in benzene, toluene, oils and greases.

FIRST AID MEASURES of BUTYLATED HYDROXYTOLUENE:
-Description of first-aid measures:
If inhaled:
After inhalation: fresh air.
In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with water/ shower.

In case of eye contact:
After eye contact: rinse out with plenty of water. 
Remove contact lenses.
First check the victim for contact lenses and remove if present. 
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes. 
Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

If swallowed:
After swallowing: 
Make victim drink water (two glasses at most). 
Consult doctor if feeling unwell.

FIREFIGHTING MEASURES of BUTYLATED HYDROXYTOLUENE:
-Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Advice for firefighters:
In the event of fire, wear self-contained breathing apparatus.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

ACCIDENTAL RELEASE MEASURES of BUTYLATED HYDROXYTOLUENE:
-Personal precautions, protective equipment and emergency procedures:
Advice for non-emergency personnel: 
Avoid inhalation of dusts. 
Evacuate the danger area, observe emergency procedures, consult an expert.
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area. 
Avoid generation of dusts.

EXPOSURE CONTROLS/PERSONAL PROTECTION of BUTYLATED HYDROXYTOLUENE:
-Control parameters:
Ingredients with workplace control parameters
-Exposure controls:
Appropriate engineering controls
Change contaminated clothing. 
Wash hands after working with substance.
Personal protective equipment
Eye/face protection:
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses.

Skin protection: 
When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min

Respiratory protection:
required when dusts are generated. 
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other
accompanying standards relating to the used respiratory protection system.
Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of BUTYLATED HYDROXYTOLUENE:
Conditions for safe storage, including any incompatibilities:
Tightly closed. 
Dry.
Preserve in well-closed containers.

SYNONYM(S):
2,6-Di-tert-butyl-4-methylphenol
2,6 Di t butyl 4 methylphenol
2,6 Di tert butyl 4 methylphenol
2,6 Di tert butyl p cresol
2,6-Bis(1,1-dimethylethyl)-4-methylphenol
2,6-di-tert-butyl-4-methylphenol
2,6-Di-tert-butyl-p-cresol
4 Methyl 2,6 ditertbutylphenol
4-Methyl-2,6-ditertbutylphenol
BHT
DBPC
Butylhydroxytoluene
Butylhydroxytoluene
Di tert butyl methylphenol
di-tert-butyl-methylphenol
Hydroxytoluene, Butylated
Ionol
Ionol (BHT)
Dibunol