PRODUCTS

BUTYLATED HYDROXYTOLUENE

DESCRIPTION:

Butylated hydroxytoluene is a lipophilic organic compound, chemically a derivative of phenol, that is useful for its antioxidant properties.
Butylated hydroxytoluene is primarily used as an antioxidant food additive.
Butylated hydroxytoluene is used as a preservative ingredient in some foods.

CAS NUMBER: 128-37-0

EC NUMBER: 204-881-4

MOLECULAR FORMULA: C15H24O

MOLECULAR WEIGHT: 220.35

DEFINITION:

Butylated hydroxytoluene is used as a preservative ingredient in some foods.
With this usage, Butylated hydroxytoluene maintains freshness or prevents spoilage.
Butylated hydroxytoluene may be used to decrease the rate at which the texture, color, or flavor of food changes.
Some food companies have voluntarily eliminated Butylated hydroxytoluene from their products or have announced that they were going to phase it out.
Butylated hydroxytoluene is also used as an antioxidant in products such as metalworking fluids, cosmetics, pharmaceuticals, rubber, transformer oils, and embalming fluid.
In the petroleum industry, where Butylated hydroxytoluene is known as the fuel additive AO-29, it is used in hydraulic fluids, turbine and gear oils, and jet fuels.,

Butylated hydroxytoluene is also used to prevent peroxide formation in organic ethers and other solvents and laboratory chemicals.
Butylated hydroxytoluene is added to certain monomers as a polymerisation inhibitor to facilitate their safe storage.
Some additive products contain Butylated hydroxytoluene as their primary ingredient, while others contain the chemical merely as a component of their formulation.
Butylated Hydroxytoluene is an organic chemical composed of 4-methylphenol modified with tert-butyl groups at positions 2 and 6.
Butylated hydroxytoluene inhibits autoxidation of unsaturated organic compounds.

Butylated hydroxytoluene is used in food, cosmetics and industrial fluids to prevent oxidation and free radical formation.
Butylated hydroxytoluene is a white crystalline solid.
Butylated hydroxytoluene is a lipophilic (fat-soluble) organic compound that is primarily used as an antioxidant food additive (E number E321) as well as an antioxidant additive in cosmetics, pharmaceuticals, jet fuels, rubber, petroleum products, electrical transformer oil, and embalming fluid.
Butylated hydroxytoluene is also found in certain plants, including soft-necked garlic.
Butylated hydroxytoluene is a synthetic phenolic compound mainly used as an antioxidant and preservative in the food industry.

Butylated hydroxytoluene is used to prevent the lipid oxidation in oils and fat-containing foods.
Butylated hydroxytoluene is a lab-made chemical that is added to foods as a preservative.
Butylated hydroxytoluene is an antioxidant.
Butylated hydroxytoluene may damage the protective outer layer of viral cells.

This may keep the viruses from multiplying and/or doing more damage.
Butylated hydroxytoluene is an additive used as an antioxidant in foods, such as packet cake mixes, potato crisps, salted peanuts, and dehydrated mashed potatoes.
Butylated hydroxytoluene is a lipophilic organic compound.
More specifically, Butylated hydroxytoluene is a synthetic antioxidant widely used in multiple sectors, including food additives, cosmetics and personal care products, pharmaceuticals, plastics/rubbers and other petroleum products.
Butylated hydroxytoluene is reducing the free-radical induced damage and spoilage.

Butylated hydroxytoluene helps maintain the properties and performance of products when exposed to air.
Butylated hydroxytoluene is reported to be used as an antioxidant at a range of concentrations (0.0002 - 0.8%) across a wide spectrum of cosmetic product types, dermally applied and sprayable products.
Butylated hydroxytoluene is commonly used as a food and cosmetics additive.
Butylated hydroxytoluene exhibits antioxidative and anti-inflammatory activities.
Butylated hydroxytoluene may also display neuroprotective benefit.
Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products.

Butylated hydroxytoluene is a Ferroptosis inhibitor.
Butylated hydroxytoluene is closely related synthetic antioxidants used as preservatives in lipsticks and moisturizers, among other cosmetics.
Butylated hydroxytoluene is also widely used as food preservatives.
Butylated hydroxytoluene is an antioxidant used in a variety of products.

Butylated hydroxytoluene is a white crystalline solid, about the same granular size as household sugar.
Butylated hydroxytoluene is used in products containing oils.
Butylated hydroxytoluene is useful in cosmetics like lipsticks, powders, personal care products, as well as in perfumes, moisturizers, and personal cleanliness products, skin cleansers, and skin care products
Butylated hydroxytoluene is an antioxidant that helps delay rancidity of oils and fats in natural oils, food products and cosmetics.
Butylated hydroxytoluene is 2, 6 ditertiarybutyl-4-methyl phenol; commonly referred to as butylated hydroxytoluene BHT).

Butylated hydroxytoluene has excellent solubility in fats and oils.
Butylated hydroxytoluene is used singly or with other antioxidants BHT imparts stability to a wide variety of products like fats and oils.
Butylated hydroxytoluene is a white solid of melting point 70°C with mild characteristic odor.
Butylated hydroxytoluene is readily fat-soluble and sparingly water soluble and is used primarily an antioxidant additive, extending the shelf life of products with unsaturated (and especially polyunsaturated) fatty acid moieties.
Butylated hydroxytoluene is an organic compound that is used in the food, cosmetic, and pharmaceutical industry as an antioxidant.

Butylated hydroxytoluene is a substituted derivative of phenol. BHT helps to prevent the formation of free radicals and oxidation.
When used in food products, Butylated hydroxytoluene delays oxidative rancidity of fats and oils, and prevents loss of activity of oil-soluble vitamins.
Butylated hydroxytoluene is chiefly used as an antioxidant food additive and can be found in packaged food items.
Butylated hydroxytoluene is also added to plastics and rubber which is used to store fatty food items.

When added to cosmetics and personal care products, Butylated hydroxytoluene slows down their deterioration and increases their shelf life.
Butylated hydroxytoluene is used in manufacturing eyeliners, lipsticks, blushes, foundation, cleansers, and perfumes.
Butylated hydroxytoluene is widely used to stabilise product formulations.
Butylated hydroxytoluene works by preventing food from going rancid.

Butylated hydroxytoluene's antioxidant properties fight oxidation in the cells and protect their outer layer from damage.
Butylated hydroxytoluene is a stabiliser that can be found in cosmetic products.
Butylated hydroxytoluene acts as an antioxidant that helps maintain the properties and performance of a product.
Butylated hydroxytoluene is used in various cosmetic products, including certain formulas containing fats or in aqueous emulsions containing certain active ingredients or plant extracts.
Butylated hydroxytoluene is an antioxidant used in certain products to stabilise and protect the raw materials themselves, and less as an ingredient in and of itself.

Butylated hydroxytoluene can resist high temperatures.
Butylated hydroxytoluene is therefore very useful in certain raw material manufacturing processes.
Butylated hydroxytoluene is an antioxidant that prevents the oxidation of products, and in particular the fatty phase of formulas that are likely to rancor or degrade when in contact with the air.
Butylated hydroxytoluene is used as an antioxidant and can be a food additive.
Butylated hydroxytoluene is insoluble in water, but freely soluble in toluene and hydrocarbon solvents, alcohol, and acetone.

Butylated hydroxytoluene is an organic constituent applicable in various industries due to its ability to prevent oxidation in products.
Butylated hydroxytoluene is commonly used as a food and cosmetics additive.
Butylated hydroxytoluene exhibits antioxidative and anti-inflammatory activities.

APPEARANCE:

Colorless, white or quasi-white crystalline or crystalline powder.
Easily dissolved in acetone, soluble in ethanol and insoluble in water and propylene glycol.

APPLICATION:

As antioxidant in pharmaceuticals, cosmetics and oil& fat in food.
Delay or prevent oxidative rancidity of oil and fat and loss of fat-soluble vitamins.
Butylated hydroxytoluene can be used alone or in combination with synergists such as citric acid and phosphoric acid.
Butylated hydroxytoluene has antiviral activity and can be used for treatment of lip surface simple cell rash.

USAGES:

-food additive
-household product ingredient
-industrial additive
-personal care product/cosmetic ingredient
-pesticide ingredient
-plastic/rubber ingredient and medical/veterinary/research

USES:

Butylated hydroxytoluene is a synthetic antioxidant used to improve the stability of cosmetic products, pharmaceuticals, fat-soluble vitamins, biomaterials, petroleum products, plastics and synthetic rubbers, and it serves as an anti-skinning agent in paints and inks.
Butylated hydroxytoluene is used to help preserve and stabilise the flavour, colour and freshness.
Butylated hydroxytoluene is used between 0.0002 and 0.8% as an antioxidant in wide spectrum of dermally applied or sprayable cosmetic product types.
Low levels are used in oral care products.
Butylated hydroxytoluene is an antioxidant.

INCOMPATIBILITY:

Butylated hydroxytoluene belongs to phenol and has phenol-like reaction characteristics.
Incompatibility with strong oxidants such as peroxide and potassium permanganate, can cause spontaneous combustion.
Butylated hydroxytoluene will change color and lose activity with iron salt, and it will rapidly decompose with acid.

SOLUBILITY:

-0.4 mg/L in water at 20 °C
-0.6 mg/L in water at 25 °C
-1.5 mg/L at 30 ºC and 6 mg/L at 60 ºC
-Freely soluble in toluene
-55.9 wt% in n-heptane at 29.5 °C
-34 wt% in ethanol at 28.7 °C
-31.1 wt% in 1-octanol at 29.5 °C

PROPERTIES:

-Sulfate: ≤0.002%
-Free phenol: ≤0.02%
-Related substances: ≤0.5%
-Water: ≤0.1%
-Residue on ignition: NMT 0.1%
-Heavy metals: ≤0.0004%
-Arsenic: ≤0.0001%

TECHNICAL INFORMATION:

-Appearance: Crystalline
-Physical State: Solid
-Solubility: Soluble in ethanol (100 mg/ml)
-Storage: Store at room temperature
-Melting Point: 69-73° C (lit.)
-Boiling Point: 265° C (lit.)
-Density: 1.05 g/cm3 at 20° C
-Refractive Index: n20D 1.50
-pK Values: pKa: 12.76

INDUSTRIAL PRODUCTION:

The chemical synthesis of Butylated hydroxytoluene in industry has involved the reaction of p-cresol (4-methylphenol) with isobutylene (2-methylpropene), catalyzed by sulfuric acid:

CH3(C6H4)OH + 2 CH2=C(CH3)2 → ((CH3)3C)2CH3C6H2OH

Alternatively, Butylated hydroxytoluene has been prepared from 2,6-di-tert-butylphenol by hydroxymethylation or aminomethylation followed by hydrogenolysis.

REACTIONS:

The species behaves as a synthetic analog of vitamin E, primarily acting as a terminating agent that suppresses autoxidation, a process whereby unsaturated (usually) organic compounds are attacked by atmospheric oxygen.
Butylated hydroxytoluene stops this autocatalytic reaction by converting peroxy radicals to hydroperoxides.
Butylated hydroxytoluene effects this function by donating a hydrogen atom:

RO2• + ArOH → ROOH + ArO•
RO2• + ArO• → nonradical products

where R is alkyl or aryl, and where ArOH is BHT or related phenolic antioxidants.
Each Butylated hydroxytoluene consumes two peroxy radicals.

PROPERTIES:

-Molecular Weight: 220.35
-XLogP3-AA: 5.3
-Hydrogen Bond Donor Count: 1
-Hydrogen Bond Acceptor Count: 1
-Rotatable Bond Count: 2
-Exact Mass: 220.182715385
-Monoisotopic Mass: 220.182715385
-Topological Polar Surface Area: 20.2 Å²
-Heavy Atom Count: 16
-Complexity: 207
-Isotope Atom Count: 0
-Defined Atom Stereocenter Count: 0
-Undefined Atom Stereocenter Count: 0
-Defined Bond Stereocenter Count: 0
-Undefined Bond Stereocenter Count: 0
-Covalently-Bonded Unit Count: 1
-Compound Is Canonicalized: Yes

SPECIFICATION:

-vapor density: 7.6 (vs air)
-vapor pressure: <0.01 mmHg ( 20 °C)
-assay: ≥99%
-form: powder or crystals
-autoignition temp.: 878 °F
-bp: 265 °C (lit.)
-mp: 69-73 °C (lit.)
-application(s): flavors and fragrances

STORAGE:

Butylated hydroxytoluene will change color and inactivate when exposed to light, humidity and heat, and may cause explosion if placed in a high-temperature environment in a closed container.
Preserve in well-closed containers.

SYNONYM:

128-37-0
Antioxidant KB
3,5-Di-tert-butyl-4-hydroxytoluene
2,6-ditert-butyl-4-methylphenol
Antioxidant 4K
Sumilizer BHT
Topanol O
Topanol OC
Vanlube PC
Antioxidant DBPC
Sustane BHT
Tenamene 3
Vanlube PCX
Antioxidant 29
Antioxidant 30
Nonox TBC
Tenox BHT
Chemanox 11
Ionol 1
Agidol
Catalin CAO-3
Advastab 401
Ionol
BUKS
Parabar 441
Paranox 441
2,6-Di-tert-butyl-4-cresol
Catalin antioxydant 1
Antrancine 8
Vulkanox KB
Di-tert-butyl-p-cresol
2,6-Bis(1,1-dimethylethyl)-4-methylphenol
Ional
AO 4K
CAO 1
CAO 3
Di-tert-butyl-p-methylphenol
FEMA No. 2184
o-Di-tert-butyl-p-methylphenol
4-Methyl-2,6-tert-butylphenol
2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
2,6-Di-tert-butyl-p-methylphenol
AO 29
NCI-C03598
2,6-ditert-butyl-4-methyl-phenol
2,6-DI-T-BUTYL-P-CRESOL
4-Methyl-2,6-di-tert-butylphenol
Butyl hydroxy toluene
2,6-Di-terc.butyl-p-kresol
4-Hydroxy-3,5-di-tert-butyltoluene
P 21
Bht
4-Methyl-2,6-di-terc. butylfenol
2,6-Di-tert-butyl-4-methyl-phenol
1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene
Di-tert-butylcresol
Dbpc
E321
p-Cresol, 2,6-di-tert-butyl-
NSC-6347
CHEMBL146
2,6-ditertiary-butyl-p-cresol
INS NO.321
CHEBI:34247
INS-321
1P9D0Z171K
2,6-di-tert-butyl-4-methyl phenol
NCGC00091761-03
Tonarol
DSSTox_CID_216
Antioxidant MPJ
E-321
Antioxidant 4
Toxolan P
Alkofen BP
Swanox BHT
Tenamen 3
Antox QT
Antioxidant 264DSSTox_RID_75440
Agidol
DSSTox_GSID_20216
Bht
Antioxidant T 501
Nocrac 200
Caswell No. 291A
Dbpc
Annulex BHT
AOX 4K
AOX 4
Butylhydroxytoluenum
MFCD00011644
CAS-128-37-0
Butylohydroksytoluenu
CCRIS 103
Butylohydroksytoluenu
Ionol CP-antioxidant
Di-tert-butyl-p-cresol
HSDB 1147
BHT 264
NSC 6347
EINECS 204-881-4
2,6-Di-terc.butyl-p-kresol
EPA Pesticide Chemical Code 022105
2,6-Di-tert-butyl-4-methylhydroxybenzene
Popol
UNII-1P9D0Z171K
AI3-19683
4-Methyl-2,6-di-terc. butylfenol
Lowinox BHT
Nipanox BHT
BHT Swanox
BHT, food grade
4-Methyl-2,6-di-t-butyl-phenol
Ionol BHT
Ralox BHT
2, food grade
3IM
Dibutyl-para-cresol
2,6-bis(tert-butyl)-4-methylphenol
Spectrum_001790
BHT FCC/NF
SpecPlus_000768
Methyldi-tert-butylphenol
Spectrum3_001849
Spectrum5_001612
BHT
Hydagen DEO (Salt/Mix)
BHT [FCC]
EC 204-881-4
2,6-di-Butyl-para-cresol
2.6-di-t-butyl-p-cresol
SCHEMBL3950
2,6-ditert-butyl-p-cresol
p-Cresol,6-di-tert-butyl-
Di-tert-Butylparamethylphenol
BSPBio_003238
KBioSS_002281
2,6-di-tert.butyl-p-cresol
Di-tert-Butyl-4-methylphenol
MLS000069425
BIDD:ER0031
DivK1c_006864
SPECTRUM1600716
2,6-bis-tert-butyl-p-cresol
2,6-di-tert-butyl-paracresol
2,6-di-tert. butyl-p-cresol
2,6-di-tert.-butyl-p-cresol
2,6-di-tert-butyl-para-cresol
2,6-di-tert-Butyl-methylphenol
2,6-ditertbutyl-4-methylphenol
DTXSID2020216
2,6-di-t butyl-4-methylphenol
2.6-di-t-butyl-4-methylphenol
FEMA 2184
KBio1_001808
KBio2_002280
KBio2_004848
KBio2_007416
KBio3_002738
2,6-di-tert-butyl-4-methylenol
2,6-di-tert-butyl-4methylphenol
2,6-di-tert-butyl4-methylphenol
2,6-di-tertbutyl-4-methylphenol
2,6-ditert.butyl-4-methylphenol
NSC6347
2,6-Di(tert-butyl)hydroxytoluene
2,6-di(t-butyl)-4-methylphenol
2,6-di-t- butyl-4-methylphenol
2,6-di-t-butyl 4-methyl phenol
2,6-di-t-butyl-4-methyl phenol
2,6-di-t-butyl-4-methyl-phenol
3,5-di-t-butyl-4-hydroxytoluene
HMS2091E21
HMS2231M22
HMS3369G17
HMS3750M21
Pharmakon1600-01600716
2,1-dimethylethyl)-4-methylphenol
2,6-di-tert-butyl 4-methylphenol
2,6-di-tert-butyl-4 methylphenol
2,6-di-tert-butyl4-methyl phenol
2,6-di-tert.butyl-4-methylphenol
2,6-ditert.-butyl-4-methylphenol
2.6-di-tert-butyl-4-methylphenol
4-methyl-2,6-di-tert.butylphenol
2,6-di-ter-butyl-4-methyl-phenol
2,6-Di-tert.-Butyl4-methylphenol
2,6-ditertiarybutyl-4-methylphenol
2.6-di- t-butyl- 4-methylphenol
AMY40200
HY-Y0172
STR04334
ZINC1481993
2,6 -di-tert-butyl-4-methylphenol
2,6-di(tert-butyl)-4-methylphenol
2,6-Di-tert-butyl-p-cresol, 8CI
2,6-di-tert.-butyl-4-methylphenol
Tox21_113537
Tox21_201093
Tox21_303408
2,6-di-tert-butyl-p-cresol (BHT)
2,6-Di-tert-butyl-para-methylphenol
BDBM50079507
NSC759563
s6202
STL277184
2,6-di-tert. butyl-4-methyl phenol
2,6-Di-(tert-butyl)-4-methylphenol
AKOS000269037
Tox21_113537_1
CCG-207937
CS-W020053
NSC-759563
Phenol, 2,6-di-tert-butyl-4-methyl-
NCGC00091761-01
NCGC00091761-02
NCGC00091761-04
NCGC00091761-05
NCGC00091761-06
NCGC00091761-07
NCGC00257275-01
NCGC00258645-01
AC-10553
BUTYLHYDROXYTOLUENE [EP MONOGRAPH]
SMR000059076
2,6-Di-tert-butyl-4-methylphenol, 99%
BUTYLHYDROXYTOLUENUM [WHO-IP LATIN]
SBI-0052890.P002
2,6-Di-tert-butyl-4-methylphenol, >=99%
D0228
FT-0610731
Phenol,6-bis(1,1-dimethylethyl)-4-methyl-
2,6-bis-(1,1-dimethylethyl)-4-methylphenol
4-Methyl-2,6- di(1,1-dimethylethyl)phenol
4-METHYL-2,6-DITERTIARY-BUTYL-PHENOL
EN300-52982
PK04_181024
2,6-Di-tert-butyl-1-hydroxy-4-methyl benzene
D02413
D77866
MLS-0146297.0001
AB00053233_09
Phenol, 3,5-bis(1,1-dimethylethyl)-4-methyl-
2,6-Bis(1,1-dimethylethyl)-4-methylphenol, 9CI
2,6-Di-tert-butyl-4-methylphenol, puriss., 99%
A937188
AC-907/25014329
Q221945
SR-01000735918
SR-01000735918-2
W-108376
9FC4DFC8-480D-487C-A74A-2EC9EECE92C4
BENZENE,1,3-DITERT.BUTYL,2-HYDROXY,5-METHYL
BRD-K53153417-001-01-3
BRD-K53153417-001-06-2
2,6-D[(CH3)3C]2C6H2(CH3)OHi-tert-butyl-p-cresol
F0001-0395
Z764922868
2,6-Di-tert-butyl-4-methylphenol, purum, >=99.0% (GC)
WLN: 1X1 & 1 & R BQ E1 CX1 & 1 & 1