PRODUCTS

BUTYLPARABEN

CAS NUMBER: 94-26-8

EC NUMBER: 202-318-7

MOLECULAR FORMULA: C11H14O3

MOLECULAR WEIGHT: 194.23

IUPAC NAME: butyl 4-hydroxybenzoate

Butylparaben is an organic molecular entity.
Butylparaben is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.
Butylparaben appears as odorless white crystals or crystalline powder.
Butylparaben is Tasteless, but numbs the tongue.
Aqueous solutions slightly acidic to litmus

Butylparaben, or butyl p-hydroxybenzoate, is an organic compound with the formula C4H9O2CC6H4OH.
Butylparaben is a white solid that is soluble in organic solvents.
Butylparaben has proven to be a highly successful antimicrobial preservative in cosmetics.
Butylparaben is also used in medication suspensions, and as a flavoring additive in food.

Members of the paraben family are found in fruit and vegetable products, such as barley, flax seed, and grapes.
Butylparaben has also been found to be produced in some microorganisms including Microbulbifer

Uses and Reactions:
Butylparaben is one of the most common bactericidal/fungicidal additives in cosmetics.
Butylparaben has been used in cosmetic products since the 1940s and in pharmaceutical products since 1924.

Butylparaben's effective antimicrobial properties, in particular those against mold and yeast.
Butylparaben is now found in more than 20,000 cosmetic products including eye shadow, facial moisturizer/treatment, anti-aging cream, foundation, and sunscreen.

Butylparaben is also used as low-ionic strength solutions as a preservative in some foods and drugs.
In most cosmetics paraben is used at low levels, ranging from 0.01 to 0.3%.
Butylparaben is used in low concentrations in liquid and solid medication suspensions, such as Tylenol (acetaminophen) and ibuprofen.

Mechanism of Action:
The exact mechanism of how parabens work is unknown but they are proposed to act by inhibiting DNA and RNA synthesis, and enzymes like ATPase and phosphotransferase in some bacterial species.
Butylparaben has also been suggested that they interfere with membrane transport processes by disrupting the lipid bylayer and possibly causing the leakage of intracellular constituents.

Regulation and Controversy:
The committee has stated that it considers the use of Butylparaben and propylparaben as preservatives in finished cosmetic products as safe to the consumer, as long as the sum of their individual concentrations does not exceed 0.19%

Butylparaben is a type of paraben.
Parabens are a class of chemicals that are used to preserve your skincare and cosmetic products to make them last and prevent the growth of bacteria, yeasts, and mold.
In recent years there has been controversy around the use of parabens, particularly in the clean beauty world due to their link to sensitivity and the potential for parabens to mimic hormones in the body.

Butylparaben is synthetically made for use in skincare and cosmetic formulations; however, this ingredient does naturally occur in some fruits and vegetables, such as barley, flaxseed, and grapes.
Butylparaben prevents the growth of bacteria, yeasts, and molds in your skincare and cosmetic formulations.
Butylparaben helps to increase the shelf life and stabilize the product.
Butylparaben Works well with most ingredients.

What Are the Benefits of Having Butylparaben in Formulations?
Butylparaben functions as a preservative in cosmetics and personal care products.
In most formulations, parabens are used at very low levels ranging from 0.01 to 0.3%.
The use of preservatives is necessary to prevent microbial contamination, as well as to prevent the product from degrading or going rancid.
Preservatives like ethylparaben are vital to the safety of a formulation.

Butylparaben, with the chemical formula of C11H14O3 is an antimicrobial preservative used in many cosmetics, as a food flavoring agent and as a suspending agent for medications.
Butylparaben used in industry is synthetically created, but natural parabens also exist in nature.

Butylparaben, or butyl paraben, is a member of the paraben family, which has the formula C4H9.
Butylparaben is used as an antimicrobial preservative in cosmetics such as eye shadow, foundation, sunscreen, facial moisturizer and skin anti-aging treatment.
Butylparaben is also used in medication suspensions, and as a flavoring additive in food.

Butylparaben has been used as a preservative in cosmetics, food, and pharmaceutical industry for years.
Butylparaben is used in moisturizers, hair care products, make up kits and shaving products.
There were some issues regarding the safety of this chemical, but no proven data is available as per USFDA.
They have set some guidelines for the safe use of parabens.

Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics
Butylparaben is also used in medication suspensions, and as a flavoring additive in food.

Butylparaben is mainly used as antiseptics in cosmetics, food and medicine.
Butylparaben is also can be used as feed preservatives and intermediates of organic synthesis.

Butylparaben is used as a preservative because it inhibits the growth of fungi and bacteria in, for example, personal care products.
Butylparaben appears as white crystal powder, having slightly special odor.
Butylparaben is slightly soluble in water, being soluble in alcohol, ether and chloroform.

Production Method:
Butylparaben is derived from the esterification between p-hydroxybenzoic acid and butanol.
Butanol and p-hydroxybenzoic acid are heated together for being dissolved, slowly added dropwise of sulfuric acid, continue the refluxing for 8h.
After cooling, add 4% sodium carbonate solution, separate the water layer, steam out the butanol, let it cool, filter to obtain the crude product, and then carry out ethanol recrystallization (solubility in ethanol: 200g/100ml).
Take sulfuric acid as a catalyst; derive it from the reaction between p-hydroxybenzoic acid and butanol.

USES OF BUTYLPARABEN:
-Butylparaben can be used for the antibacterial and anticorrosion of drugs, cosmetics and food.
-As a kind of preservative; Because of the low solubility in water, Butylparaben is usually prepared into ethanol solution, acetic acid solution or sodium hydroxide solution.
To improve the solubility, several different esters are often used.
For example, three parts of isobutyl, four parts of isopropyl and three parts of butyl are formulated as a co-soluble mixture and the mixture is used as an oil-in-water emulsifier.
This preparation is easy to use in soy sauce and other foods, the solubility of butyl ester alone can be increased by 2 to 3 times.
For soy sauce, 5% sodium hydroxide solution can be added to the goods of 20% to 25%, and then slowly added to the sauce having been heated to about 80 ℃.
Acetic acid solution or ester type emulsifier can also be used.
The usage amount of anti-mold soy sauce is 0.05~0.10g/L.
Vinegar can be used in acetic acid or sodium hydroxide solution.
Soft drinks can be used in the solution of sodium hydroxide, but usually used in combination with benzoic acid and dehydroaceti acid.
-Used as organic synthesis intermediates; the anti-corrosion additives of medicine, food, cosmetics, film and high-grade products; reagents.
Being used as germicide preservative of food is Butylparaben's major application.
In the p-hydroxybenzoic acid esters, it can give the strongest anti-corrosion bactericidal effect.
Because of its poor water solubility, it is often used with other esters in combination.
-For preservatives and disinfectants

Butylparaben has little or no odor.
Butylparaben occurs as colorless crystals or a white, crystalline, odorless or almost odorless, tasteless powder.
Butylparaben is used as an antimicrobial

Butylparaben is used as a preservative in:
-many creams
-lotions
-ointments
-other cosmetics
-foods (salad dressings, mayonnaise, spiced sauces, mustard, frozen dairy products, baked products),
-pharmaceutical preparations
-dentifrices

Butylparaben is active against molds, fungi and yeasts, but less active against bacteria.
Butylparaben is prepared by esterifying p-hydroxybenzoic acid with butyl alcohol in the presence of an acid catalyst, such as sulfuric acid, and an excess of the specific alcohol.
Butylparaben is prepared by esterification of p-hydroxybenzoic acid with n-butanol.

Butylparaben is Insoluble in water
Butylparaben is incompatible with strong oxidizing agents and strong caustics

Pharmaceutical Applications:
Butylparaben is widely used as an antimicrobial preservative in cosmetics and pharmaceutical formulations.
Butylparaben may be used either alone or in combination with other paraben esters or with other antimicrobial agents.
In cosmetics, Butylparaben is the fourth most frequently used preservative.
As a group, the parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used in formulations. However, this may raise the pH of poorly buffered formulations.

Butylparaben is now found in more than 20,000 cosmetic products including eye shadow, facial moisturizer/treatment, anti-aging cream, foundation, and sunscreen.
Butylparaben is also used as low-ionic strength solutions as a preservative in some foods and drugs.
In most cosmetics paraben is used at low levels, ranging from 0.01 to 0.3%.

Parabens are man-made chemicals often used in small amounts as preservatives in cosmetics, pharmaceuticals, foods, and beverages.
Common parabens are methylparaben, ethylparaben, propylparaben, and butylparaben.
Often more than one paraben is used in a single product.

Butylparaben is a colorless, crystalline solid or powder.
Butylparaben is odorless.
Butylparaben is moderately soluble in water.
Butylparaben is used as a food preservative and antifungal agent.
Butylparaben is also used in many personal care products.

Butylparaben is also used in medication suspensions, and as a flavoring additive in food.
Butyl paraben is mainly used as antiseptics in cosmetics, food and medicine.
Butylparaben is also can be used as feed preservatives and intermediates of organic synthesis.

Butylparaben is used as an antimicrobial preservative in cosmetics such as:
-eye shadow
-foundation
-sunscreen
-facial moisturizer
-skin anti-aging treatment

PHYSICAL PROPERTIES OF BUTYLPARABEN:

-Molecular Weight: 194.23

-XLogP3: 3.6

-Exact Mass: 194.094294304

-Monoisotopic Mass: 194.094294304

-Topological Polar Surface Area: 46.5 Å²

-Physical Description: white crystals with little or no odour

-Color: white

-Form: Crystalline powder

-Odor: Odorless

-Boiling Point: 157.00°C

-Melting Point: 68.5 °C

-Flash Point: 181 °C

-Solubility: less than 1 mg/mL

-Vapor Pressure: 2.51X10-4 mm Hg

-LogP: 3.57

-Henrys Law Constant: 6.0X10-9 atm-cu m/mol

-Stability/Shelf Life: Stable under recommended storage conditions

-Autoignition Temperature: 495 °C

-Dissociation Constants: pKa = 8.47

-Collision Cross Section: 150.14 Å²

Butylparaben is also used in medication suspensions, and as a flavoring additive in food.
Butylparaben, or butyl paraben, is a member of the paraben family, which has the formula C4H9.

Butylparaben has been used as a preservative in cosmetics, food, and pharmaceutical industry for years.
Butylparaben is used in moisturizers, hair care products, make up kits and shaving products.

There were some issues regarding the safety of this chemical, but no proven data is available as per USFDA.
They have set some guidelines for the safe use of parabens.
Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics

CHEMICAL PROPERTIES OF BUTYLPARABEN:

-Hydrogen Bond Donor Count: 1

-Hydrogen Bond Acceptor Count: 3

-Rotatable Bond Count: 5

-Heavy Atom Count: 14

-Formal Charge: 0

-Complexity: 171

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

STORAGE OF BUTYLPARABEN:

Butylparaben should be stored in a ventilated environment.
Butylparaben should be stored at low temperatures.
Butylparaben should be stored in dry bottles.

Aqueous solutions of Butylparaben at pH 3-6 can be sterilized by autoclaving without degradation.
At pH 3-6, aqueous solutions are stable at room temperature for up to about 4 years.

Solutions at pH 8 or higher are subject to rapid hydrolysis.
Butylparaben should be kept in a clean place.

Butylparaben must be kept at constant pressure.
Butylparaben should be stored away from immediate reaction agents.
Butylparaben should be kept in a moisture-free environment.

SYNONYMS:

Butyl 4-hydroxybenzoate
Butyl paraben
Butyl p-hydroxybenzoate
Nipabutyl
Butoben
Butyl chemosept
Butyl parasept
Tegosept B
Butyl tegosept
Butyl butex
Tegosept Butyl
Aseptoform butyl
Preserval B
Butyl parahydroxybenzoate
n-Butyl p-hydroxybenzoate
Butyl-Parasept
Benzoic acid, 4-hydroxy-, butyl ester
4-(Butoxycarbonyl)phenol
n-Butyl parahydroxybenzoate
4-Hydroxybenzoic acid butyl ester
n-Butyl hydroxybenzoate
n-Butyl-p-hydroxybenzoate
n-butyl 4-hydroxybenzoate
Benzoic acid, p-hydroxy-, butyl ester
n-Butyl-paraben
p-Hydroxybenzoic acid butyl ester
n-Butyl-4-hydroxybenzoate
Butylparaben (NF)
Butylparaben (TN)
Butylparaben [NF]
p-Hydroxybenzoic acid, butyl ester
4-Hydroxybenzoic acid, butyl ester
p-Hydroxybenzoic butyl ester
Butyl parahydroxybenzoate (TN)
Butylparaben [USAN]
butyl-p-hydroxybenzoate
n-Butyl paraben
Butyl Par asept
butyl p-hydroxy benzoate
p-Hydroxy butyl benzoate
p-Hydroxybenzoic acid n-butyl ester
butyl-paraben
Butyl //p//-Hydroxybenzoate
N-Butyl-P-Hydroxybenzoate,(S)
Butyl parahydroxybenzoate (JP15)
Butyl parahydroxybenzoate (JP17)
Butyl 4-hydroxybenzoate, >=99%
BUTYL PARA HYDROXY BENZOATE
Pharmakon1600-01505995
4-Hydroxybenzoic acid-n-butyl ester
p-Hydroxybenzoic acid, n-butyl ester
Butyl 4-?Hydroxybenzoate(Butyl Paraben)
Butyl 4-hydroxybenzoate, >=99.0% (GC)
Butyl 4-hydroxybenzoate, SAJ first grade, >=99.0%
4-Hydroxybenzoic acid-n-butyl ester