PRODUCTS

CALCIUM DIGLUTAMATE

Calcium diglutamate is used to accentuate the flavor and taste of natural foods.
Calcium diglutamate is used for biochemical profiling and cell-based assay applications.
Calcium diglutamate is used food additive with flavor enhancing function.

CAS Number: anhydrous: 5996-22-5
tetrahydrate: 69704-19-4
Chemical formula: C10H16CaN2O8
Molar mass: 332.322 g·mol−1

SYNONYMS:
Calcium Diglutamate, Calcium Biglutamate, Calcium Di-L-Glutamate, Calcium L-Glutamate (1:2), L-Glutamic Acid Calcium Salt, Glutamic Acid Calcium Salt (2:1), Monocalcium Di-L-Glutamate, Monocalcium Glutamate, Calcium Glutamate, Calcium Glutaminate, CDG, Calcium Bisglutamate, Calcium Bis[(2S)-2-amino-4-carboxybutyrate], Calcium L-Glutamate Dihydrate, Calcium diglutamate, Calcium di-L-glutamate, UNII-9FA5OTO85L, Calcium L-glutamate (1:2), 5996-22-5, EINECS 227-838-1, L-Glutamic acid, calcium salt (2:1), 9FA5OTO85L, Glutamic acid, calcium salt (2:1), L-, calcium;(2S)-2-amino-5-hydroxy-5-oxopentanoate, SCHEMBL587122, DTXSID00894986, Calcium bis[(2S)-2-amino-4-carboxybutanoate], Calcium bis[(2S)- 2-amino-4-carboxy-butyrate], Calcium biglutamate, L-Glutamic acid calcium salt,

Calcium Diglutamate is the calcium salt from Glutamic Acid E620, a natural amino acid (building block of protein).
Calcium diglutamate is commercially prepared from molasses by bacterial fermentation.
Calcium diglutamate is also prepared from vegetable protein, such as gluten, or soy protein.

Less used and not as salty, low sodium salt substitute.
Calcium diglutamate is added to any savoury processed protein food.
Calcium diglutamate is in cigarettes and animal food.

Calcium diglutamate is in over 10,000 foods in USA.
Calcium diglutamate (CAS 5996-22-5) is a small molecule compound supplied as a solid powder by TargetMol.
Calcium diglutamate is the calcium salt of glutamic acid.

For industrial use, Calcium diglutamate is obtained by bacterial fermentation of molasses.
Glutamates give the “umami” taste (delicious in Japanese), considered to be the fifth basic taste, along with sweet, sour, salty and bitter.
They can be added in any food, including alcoholic and non-alcoholic beverages in proportions of up to 1%, thus allowing the required amount of salt to be reduced.

Calcium diglutamate, also designated as E623, is the calcium salt of diglutamic acid, which is an organic compound.
Calcium diglutamate is a food additive that exhibits specific binding properties, which finds its application in the food industry.
Calcium Diglutamate is a white crystalline powder with low solubility in water.

Calcium diglutamate's main property is its ability to form cross-links between protein molecules, leading to improved texture, consistency and stability of food products.
Calcium diglutamate, sometimes abbreviated CDG and also called calcium biglutamate, is a compound with formula Ca(C5H8NO4)2.
Calcium diglutamate is a calcium acid salt of glutamic acid.

CDG is a flavor enhancer (E number E623)—Calcium diglutamate is the calcium analog of monosodium glutamate (MSG).
Because Calcium diglutamate is the actual flavor-enhancer, CDG has the same flavor-enhancing properties as MSG but without the increased sodium content.
Notably, only the L isomer is used in flavouring as D-glutamate does not have an umami/savoury flavour.

As a soluble source of calcium ions, Calcium diglutamate is also used as a first-aid treatment for exposure to hydrofluoric acid.
Calcium diglutamate is a novel and potent calcium acid salt
Flavour enhancer; salt substitute Calcium diglutamate, sometimes abbreviated CDG and also called calcium glutamate, is a compound with formula Ca(C5H8NO4)2.

Calcium diglutamate is a calcium acid salt of glutamic acid.
Calcium diglutamate is a flavor enhancer (E number E623).
Calcium diglutamate is the calcium analog of monosodium glutamate (MSG).

Because Calcium diglutamate is the actual flavor-enahancer, DCG has the same flavor-enhancing properties as MSG, but without the increased sodium content.
As a soluble source of calcium ions, Calcium diglutamate is also used as a first-aid treatment for exposure to hydrofluoric acid.
Calcium Diglutamate is the calcium salt of glutamic acid, an amino acid naturally present in proteins and many food products.

Calcium diglutamate consists of one calcium ion bound to two glutamate molecules and is commonly used as a flavor enhancer, calcium source, nutritional ingredient, and specialty chemical.
Calcium diglutamate is known for providing an umami taste while simultaneously contributing calcium to formulations.
Calcium diglutamate is recognized internationally as a food additive under INS No. 623 and is utilized in food, pharmaceutical, nutritional, and industrial applications.

Calcium diglutamate occurs as a stable, water-soluble compound with good compatibility in aqueous systems and processed products.
Calcium diglutamate is sometimes abbreviated as CDG and may also be referred to as calcium biglutamate.

USES and APPLICATIONS of CALCIUM DIGLUTAMATE:
Biotechnology and Research: Calcium diglutamate is occasionally used in laboratory research involving amino acid salts, calcium metabolism studies, mineral bioavailability investigations, and biochemical formulation development.
Animal Nutrition: Calcium diglutamate may be included in animal feed formulations to improve palatability and provide supplemental calcium.
Calcium Diglutamate is used as a flavour enhancer derived from the fermentation of molasses, salt substitute; adverse effects appear in some asthmatic people.

Typical products of Calcium diglutamate are canned vegetables, canned tuna, dressings, potato crisps, stock cubes and many frozen foods.
Calcium diglutamate is used to accentuate the flavor and taste of natural foods.
Calcium diglutamate is used for biochemical profiling and cell-based assay applications.

Calcium diglutamate is used food additive with flavor enhancing function.
Calcium diglutamate is commonly used as a food additive, mainly in the meat and dairy industries.
Calcium diglutamate is used to improve the texture and quality of products such as cured meats, smoked meats, cheeses, as well as in the production of ready meals.

-Food Industry uses of Calcium diglutamate:
Calcium diglutamate is primarily used as a flavor enhancer in food products.
Calcium diglutamate intensifies savory and umami flavors and can improve the overall taste profile of soups, sauces, seasonings, broths, snack foods, processed meats, instant meals, canned foods, and ready-to-eat products.
Calcium diglutamate is also employed in sodium-reduction strategies because it can partially replace sodium-containing flavor enhancers while preserving taste quality.

-Nutritional and Functional Foods uses of Calcium diglutamate:
Calcium diglutamate is utilized as a calcium-fortification ingredient in nutritional products and functional foods.
Calcium diglutamate provides a bioavailable source of calcium while simultaneously contributing flavor enhancement.
Calcium diglutamate can be incorporated into dietary supplements, meal replacements, fortified beverages, and health-oriented food products.

-Pharmaceutical Applications of Calcium diglutamate:
Calcium diglutamate may be used as a source of calcium ions in specialized pharmaceutical formulations and research applications.
Soluble calcium salts can also be utilized in specific chemical and biological applications where calcium supplementation is required.

CALCIUM DIGLUTAMATE and ITS FUNCTIONS IN FOODS
Calcium diglutamate, by forming cross-links in proteins, enables food manufacturers to improve the texture, stability and quality of their products.
This is particularly important for meat and dairy products, where maintaining the right structure is crucial to the final taste and usage experience.

BENEFITS of CALCIUM DIGLUTAMATE:
One of the major benefits of calcium diglutamate is its ability to enhance flavor while simultaneously supplying calcium.
This dual functionality can reduce formulation complexity and improve product efficiency.
Another important benefit is Calcium diglutamate's potential contribution to sodium reduction programs.
Since glutamate compounds are highly effective flavor enhancers, manufacturers may achieve desirable taste profiles while lowering sodium levels.

Calcium diglutamate also exhibits excellent water solubility, allowing uniform distribution throughout liquid and semi-solid systems.
Its stability during processing makes Calcium diglutamate suitable for numerous manufacturing environments.
Calcium diglutamate contributes nutritional value through calcium supplementation and can support mineral fortification strategies in foods and dietary supplements.
Calcium diglutamate is also generally well tolerated when used according to applicable regulatory requirements.

ADDITIONAL TECHNICAL INFORMATION of CALCIUM DIGLUTAMATE:
Calcium diglutamate is classified as a calcium acid salt of glutamic acid.
Upon dissolution in water, Calcium diglutamate dissociates into calcium ions and glutamate species.
Calcium diglutamate is responsible for the characteristic umami taste, while the calcium component contributes mineral nutrition and ionic functionality.
Calcium diglutamate is considered a multifunctional ingredient because it can act simultaneously as a flavor enhancer, calcium fortifier, nutritional ingredient, and formulation aid.
This versatility explains Calcium diglutamate's continued use in food technology, nutrition science, and specialty chemical applications.

CHARACTERISTICS of CALCIUM DIGLUTAMATE:
Calcium diglutamate combines the flavor-enhancing properties of glutamate with the nutritional benefits of calcium.
Unlike sodium-based glutamates, Calcium diglutamate contributes calcium rather than sodium, making it useful in formulations designed to reduce sodium content while maintaining flavor intensity.
Calcium diglutamate is highly water-soluble, exhibits excellent flavor distribution, and remains stable throughout many manufacturing processes.
Because glutamate is a naturally occurring amino acid derivative, calcium diglutamate integrates well into food systems without significantly altering product texture or appearance.
Calcium diglutamate's dual functionality as both a flavor modifier and mineral source makes it particularly valuable in fortified foods, nutritional products, and specialty formulations.

ALTERNATIVE PARENTS of CALCIUM DIGLUTAMATE:
• Pyrimidinecarboxylic acids
• Pyrazolo[1,5-a]pyrimidines
• Pyrimidones
• Benzene and substituted derivatives
• Vinylogous amides
• Heteroaromatic compounds
• Lactams
• Carboxylic acid esters
• Monocarboxylic acids and derivatives
• Azacyclic compounds
• Organopnictogen compounds
• Organooxygen compounds
• Organonitrogen compounds
• Organic oxides
• Hydrocarbon derivatives

SUBSTITUENTS of CALCIUM DIGLUTAMATE:
• Phenylpyrazole
• Pyrazolo[1,5-a]pyrimidine
• Pyrimidine-5-carboxylic acid or derivatives
• Pyrimidine-5-carboxylic acid
• Pyrazolopyrimidine
• Pyrimidone
• Monocyclic benzene moiety
• Benzenoid
• Pyrimidine
• Heteroaromatic compound
• Vinylogous amide
• Carboxylic acid ester
• Lactam
• Carboxylic acid derivative
• Monocarboxylic acid or derivatives
• Azacycle
• Organic nitrogen compound
• Organooxygen compound
• Organonitrogen compound
• Hydrocarbon derivative
• Organic oxide
• Organopnictogen compound
• Organic oxygen compound
• Aromatic heteropolycyclic compound

SYNTHESIS AND REACTIONS of CALCIUM DIGLUTAMATE:
Calcium diglutamate can be prepared by reacting calcium carbonate with two molar equivalents of glutamic acid:
CaCO3 + 2 HOOC(CH2)2CH(NH2)COOH → Ca(OOC(CH2)2CH(NH3)COO)2 + H2O + CO2↑
Concentration of the solution to a syrup under reduced pressure, followed by gradual crystallisation, affords the monohydrate.
Structurally, the glutamate anion is zwitterionic, with the amino group protonated (pKa = 9.47) and both carboxylic-acid groups (pKa = 2.10, 4.07) in their deprotonated carboxylate form.

Calcium di-L-glutamate can be used to prepare other glutamates through metathesis with a soluble sulfate, carbonate or hydroxide salt.
For example, manganese(II) di-L-glutamate can be prepared through metathesis with manganese(II) sulphate:
Ca(OOC(CH2)2CH(NH3)COO)2 + MnSO4 → Mn(OOC(CH2)2CH(NH3)COO)2 + CaSO4↓

PHYSICAL and CHEMICAL PROPERTIES of CALCIUM DIGLUTAMATE:
Chemical Name Calcium Diglutamate
IUPAC Name Calcium bis((2S)-2-amino-5-hydroxy-5-oxopentanoate)
CAS Number 5996-22-5
EC Number (EINECS) 227-838-1
Additional EC Number Reported in Some Databases 242-905-5
INS Number 623
PubChem CID 56841881
ChemSpider ID 2766261

Molecular Formula (Anhydrous) C10H16CaN2O8
Molecular Weight (Anhydrous) 332.32 g/mol
Molecular Formula (Dihydrate Form) C10H20CaN2O10
Molecular Weight (Dihydrate Form) 368.35 g/mol
Chemical Class Calcium Salt of Glutamic Acid
Appearance White crystalline powder or granules
Appearance: White to off-white crystalline powder, granules, or crystals.
Odor: Odorless or nearly odorless.

Taste: Characteristic umami or savory taste.
Physical State: Solid.
Molecular Weight: 332.32 g/mol (anhydrous form).
Density: Approximately 1.32 g/cm³.
Water Solubility: Freely soluble in water.
Hygroscopicity: May absorb moisture under high-humidity conditions.
Dispersibility: Good dispersibility in aqueous systems.
Color: White to slightly cream-colored.

Stability: Stable under normal storage conditions.
Chemical Type: Calcium salt of glutamic acid.
Molecular Formula: C10H16CaN2O8.
Ionic Character: Dissociates in water to release calcium ions and glutamate ions.
pH Behavior: Produces mildly acidic to near-neutral aqueous solutions depending on concentration.
Complex Formation: Capable of participating in metal-ion interactions through carboxylate groups.
Thermal Stability: Generally stable under normal food and industrial processing temperatures.
Hydrogen Bond Donors: 4.

Hydrogen Bond Acceptors: 10.
Rotatable Bonds: 6.
Heavy Atom Count: 21.
Stereochemistry: Contains stereogenic centers derived from L-glutamic acid.
Compatibility: Compatible with many food ingredients, pharmaceutical excipients, and nutritional formulations.
Molecular Weight: 332.32 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 6

Exact Mass: 332.0532563 Da
Monoisotopic Mass: 332.0532563 Da
Topological Polar Surface Area: 207 Å²
Heavy Atom Count: 21
Formal Charge: 0
Complexity: 139
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2

Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
Chemical formula: C10H16CaN2O8
Molar mass: 332.322 g·mol−1
Molecular Formula: C10H16CAN2O8

Molecular Weight: 332.32
Exact Mass: 368.074
CAS #: 5996-22-5
PubChem CID: 56841881
Appearance: Typically exists as solid at room temperature
Density: 1.32g/cm3
Boiling Point: 449ºC at 760 mmHg
Flash Point: 225.3ºC
Index of Refraction: 1.646

Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 6
Heavy Atom Count: 21
Complexity: 139
Defined Atom Stereocenter Count: 2
SMILES: C(CC(=O)O)C(C(=O)[O-])N.C(CC(=O)O)C(C(=O)[O-])N.[Ca+2]
InChi Key: UMVAYAXXQSFULN-QHTZZOMLSA-L
InChi Code: InChI=1S/2C5H9NO4.Ca/c26-3(5(9)10)1-2-4(7)8;/h23H,1-2,6H2,(H,7,8)(H,9,10);/q;;+2/p-2/t2*3-;/m00./s1

Chemical Name: calcium;(2S)-2-amino-5-hydroxy-5-oxopentanoate
Synonyms: Glutamic acid, calcium salt L-; Calcium di-L-glutamate; Calcium diglutamate
HS Tariff Code: 2934.99.9001
Chemical Formula: C16H15N3O3
IUPAC name: ethyl 3-methyl-7-oxo-2-phenyl-1H,7H-pyrazolo[1,5-a]pyrimidine-6-carboxylate
InChI Identifier: InChI=1S/C16H15N3O3/c1-3-22-16(21)12-9-17-14-10(2)13(18-19(14)15(12)20)11-7-5-4-6-8-11/h4-9,18H,3H2,1-2H3
InChI Key: DVXPSCPBKPUDFJ-UHFFFAOYSA-N
Isomeric SMILES: CCOC(=O)C1=CN=C2N(NC(=C2C)C2=CC=CC=C2)C1=O

Average Molecular Weight: 297.3086
Monoisotopic Molecular Weight: 297.111341361
Classification:
Description: Belongs to the class of organic compounds known as phenylpyrazoles.
Phenylpyrazoles are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
Kingdom: Organic compounds
Super Class: Organoheterocyclic compounds
Class: Azoles
Sub Class: Pyrazoles
Direct Parent: Phenylpyrazoles

FIRST AID MEASURES of CALCIUM DIGLUTAMATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of CALCIUM DIGLUTAMATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of CALCIUM DIGLUTAMATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CALCIUM DIGLUTAMATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CALCIUM DIGLUTAMATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of CALCIUM DIGLUTAMATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available