PRODUCTS

CALCIUM DISODIUM EDTA (EDTA-CaNa2)

Calcium Disodium EDTA (EDTA-CaNa2) is also used for chelation therapy.
Calcium Disodium EDTA (EDTA-CaNa2) can be used to preserve texture, flavor and color of many food products.
Calcium Disodium EDTA (EDTA-CaNa2) is also used to promote stability and increase the shelf life of certain foods.

CAS Numbers: 62-33-9 (anhydrous), 23411-34-9 (hydrate), 6766-87-6 (dihydrate)
EC Number: 200-529-9
Chemical Name: Calcium disodium ethylenediaminetetraacetate
IUPAC Name: Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
Molecular Formula: C₁₀H₁₂CaN₂Na₂O₈·xH₂O
Molecular Weight: 410.31 g/mol

SYNONYMS:
Calcium disodium versenate, others, calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate, Sodium calcium edetate, Edetate Calcium Disodium, Ethylenediaminetetraacetic Acid Calcium Disodium Salt, E385, Adsorbonac, Edathamil, Chelaton, EDTA Calcium Disodium, EDTA-Ca 10%, CaNa2 EDTA, EDTA calcium disodium, Ethylenediaminetetraacetic acid calcium disodium salt hydrate, Ethylenediaminetetraacetic acid calcium disodium salt, (Ethylenedinitrilo)tetraacetic acid calcium disodium salt, EDTA calcium disodium salt, Edathamil, Ethylenediaminetetraacetic acid calcium disodium salt dihydrate, Calcium disodium EDTA, calciate(2-),((n,n’-1,2-ethanediylbis(n-(carboxymethyl)glycinato))(4-)-n,n’,o,, calcitetracematedisodium, calciumdisodium(ethylenedinitrilo)tetraacetate, calciumdisodiumedathamil, calciumdisodiumedta, calciumdisodiumethylendiaminetetraacetate, calciumdisodiumversenate, calciumtitriplex, Calcium disodium EDTA, Edetate calcium disodium, Sodium calcium edetate, Calcium disodium ethylenediaminetetraacetate, E385, Edtacal, Mosatil, Tetacin, Antallin, Chelaton, Edetamin, Ledclair, Calcium disodium versenate, Disodium calcium EDTA, Calcium disodium (ethylenedinitrilo)tetraacetate

Calcium Disodium EDTA (EDTA-CaNa2) is an odorless crystalline powder with a slightly salty flavor.
Calcium Disodium EDTA (EDTA-CaNa2) is a popular food additive, used as a preservative and flavoring agent.
Calcium Disodium EDTA (EDTA-CaNa2) works as a chelating agent.

This means Calcium Disodium EDTA (EDTA-CaNa2) binds to metals and prevents them from participating in chemical reactions that might cause discoloration or flavor loss.
The FDA has approved Calcium Disodium EDTA (EDTA-CaNa2) as a safe food additive but has set limitations on the amount of the substance a food can contain.

Calcium Disodium EDTA (EDTA-CaNa2) is poorly absorbed by your digestive tract and the maximum Acceptable Daily Intake (ADI) is 0.9 mg per pound (1.9 mg per kg) of body weight per day.
Calcium Disodium EDTA (EDTA-CaNa2) is a crystalline powder with a slightly salty flavor.

Calcium Disodium EDTA (EDTA-CaNa2) is a popular food additive that prevents spoilage and preserves flavor and color.
Calcium Disodium EDTA (EDTA-CaNa2) is difficult to be degraded.

Calcium Disodium EDTA (EDTA-CaNa2) is a chelator that is primarily used for the management of patients with severe lead poisoning (blood lead concentrations >70 mcg/dL) in conjunction with dimercaprol (British anti-Lewisite {BAL}).
Calcium Disodium EDTA (EDTA-CaNa2) was replaced by succimer for the treatment of patients with lead concentrations between 45 and 70 mcg/dL.

In a clinical trial with much criticism, Calcium Disodium EDTA (EDTA-CaNa2) reduced adverse cardiovascular outcomes in patients with a history of myocardial infarction.
We recommend against using Calcium Disodium EDTA (EDTA-CaNa2) for lead chelation because of the potential for life-threatening hypocalcemia.

Calcium Disodium EDTA (EDTA-CaNa2) was discovered and synthesized in the 1930s and approved by the US Food and Drug Administration (FDA) as a food additive in the 1940s.
Investigations on Calcium Disodium EDTA (EDTA-CaNa2) for lead toxicity and for Calcium Disodium EDTA (EDTA-CaNa2) for the reversal of cardiovascular disease began in the 1950s.

Calcium Disodium EDTA (EDTA-CaNa2) is an ionic, water-soluble compound with an anhydrous molecular weight of 374.27 Da.
Calcium Disodium EDTA (EDTA-CaNa2) is also referred to as calcium disodium versenate, calcium disodium EDTA, or calcium disodium ethylenediaminetetraacetic acid.

Calcium Disodium EDTA (EDTA-CaNa2) belongs to the family of polyaminocarboxylic acids.
Although Calcium Disodium EDTA (EDTA-CaNa2) is capable of chelating many metals, its current use is almost exclusively in the management of lead poisoning.

The term chelate has its origin in the Greek word chele, which means “claw,” implying an ability to tightly grasp the metal.
Implicit in chelation is the formation of a ring-structured complex.
When Calcium Disodium EDTA (EDTA-CaNa2) chelates lead, the calcium is displaced and the lead takes its place, forming a stable ring compound.

Bone is the primary source of lead chelated by Calcium Disodium EDTA (EDTA-CaNa2).
The blood lead concentration drops due to urinary elimination; however, once chelation is stopped, redistribution to soft tissues, including the brain, and then bone occurs.

Although zinc, iron, manganese, copper, and mercury are also capable of displacing calcium and forming a stable chelate, for a number of reasons, only the effect on zinc is clinically significant.
Calcium Disodium EDTA (EDTA-CaNa2) is a highly polar drug with a small volume of distribution (Vd) due to its polar nature and approximates that of the extracellular fluid compartment regardless of renal function.

Calcium Disodium EDTA (EDTA-CaNa2), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, including both short-term and long-term lead poisoning.
Calcium Disodium EDTA (EDTA-CaNa2) came into medical use in the United States in 1953.

Calcium Disodium EDTA (EDTA-CaNa2) is in the chelating agent family of medication.
Calcium Disodium EDTA (EDTA-CaNa2) is a salt of edetate with two sodium atoms and one calcium atom.
Calcium Disodium EDTA (EDTA-CaNa2) works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.

Calcium Disodium EDTA (EDTA-CaNa2) is a different formulation which does not have the same effects.
Calcium Disodium EDTA (EDTA-CaNa2)'s primary use is to treat lead poisoning, for which it is an alternative to succimer.

Calcium Disodium EDTA (EDTA-CaNa2) is given by slow injection into a vein or into a muscle.
For lead encephalopathy Calcium Disodium EDTA (EDTA-CaNa2) is typically used together with dimercaprol.

USES and APPLICATIONS of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
Calcium Disodium EDTA (EDTA-CaNa2) is used as a separating agent.
Calcium Disodium EDTA (EDTA-CaNa2) is a kind of stable water-soluble metal chelate.
Calcium Disodium EDTA (EDTA-CaNa2) can chelate multivalent ferric ions.

Calcium and Ferrum exchange forms the more stable chelate.
Calcium Disodium EDTA (EDTA-CaNa2) can be used for foliar fertilizers.
Applications of Calcium Disodium EDTA (EDTA-CaNa2): Agricultural Nutrients; Fertilizer.

Calcium Disodium EDTA (EDTA-CaNa2) is a chelating agent, that binds to metals, and is widely used as a food additive to prevent colour & flavour deterioration.
Calcium Disodium EDTA (EDTA-CaNa2) is also used to help stabilise pharmaceutical products, detergents, shampoos, soaps, agricultural sprays, contact lens cleaners and cosmetics as well as in the textile and paper industries.

Calcium Disodium EDTA (EDTA-CaNa2) Applications: Food additives, Pharmaceutical, Cosmetics, Personal care (soap, shampoo), Textile Manufacture, Paper industry, and Agriculture.
Medical Use of Calcium Disodium EDTA (EDTA-CaNa2): Chelating agent for treating heavy metal poisoning, especially lead

Food Industry: Calcium Disodium EDTA (EDTA-CaNa2) is Preservative and stabilizer (E385) to maintain color and flavor
Cosmetics and Personal Care: Calcium Disodium EDTA (EDTA-CaNa2) stabilizes formulations by binding metal ions
Industrial Applications: Calcium Disodium EDTA (EDTA-CaNa2) is used in detergents, water treatment, and as a metal ion scavenger

Calcium Disodium EDTA (EDTA-CaNa2) is used as a separating agent.
Calcium Disodium EDTA (EDTA-CaNa2) is a kind of stable water-soluble metal chelate.
Calcium Disodium EDTA (EDTA-CaNa2) can chelate multivalent ferric ions.

Calcium and Ferrum exchange forms the more stable chelate.
Calcium Disodium EDTA (EDTA-CaNa2) can be used for foliar fertilizers.
Calcium Disodium EDTA (EDTA-CaNa2) is applied as a trace element in agriculture and as a coloring agent and food additive in the food industry.

Calcium Disodium EDTA (EDTA-CaNa2) is used in many food, cosmetic and industrial products, due to its preserving and stabilizing abilities.
Calcium Disodium EDTA (EDTA-CaNa2) is also used for chelation therapy to treat lead and mercury toxicity.
Calcium Disodium EDTA (EDTA-CaNa2) is widely used in beauty and cosmetic products.

Calcium Disodium EDTA (EDTA-CaNa2) allows for better cleaning use, as it enables cosmetic products to foam.
Calcium Disodium EDTA (EDTA-CaNa2) binds with metal ions and prevents metals from accumulating on the skin, scalp or hair.
Soaps, shampoos, lotions and contact lens solutions are examples of cosmetic and personal care products that may contain Calcium Disodium EDTA (EDTA-CaNa2).

Calcium Disodium EDTA (EDTA-CaNa2) is also found in many industrial products, such as paper and textile, due to its ability to prevent discoloration.
Calcium Disodium EDTA (EDTA-CaNa2) is frequently used in products like laundry detergents, industrial germicides and other cleaning products.

Chelation therapy uses Calcium Disodium EDTA (EDTA-CaNa2) to treat metal toxicity, such as lead or mercury poisoning.
Calcium Disodium EDTA (EDTA-CaNa2) binds to the excessive metal in your blood, which is then excreted through urine.
While Calcium Disodium EDTA (EDTA-CaNa2) is only FDA-approved to treat metal poisoning, some holistic healthcare providers suggest chelation therapy as an alternative treatment for conditions like autism, heart disease and Alzheimer’s.

Calcium Disodium EDTA (EDTA-CaNa2) may also be used to treat plutonium poisoning.
Calcium Disodium EDTA (EDTA-CaNa2) does not appear to be useful for poisoning by tetra-ethyl lead.
Calcium Disodium EDTA (EDTA-CaNa2) is found in food, cosmetic and industrial productions.

BENEFITS OF CALCIUM DISODIUM EDTA (EDTA-CaNa2):
Chelation Therapy:
Calcium Disodium EDTA (EDTA-CaNa2) is effectively binds heavy metals, facilitating their excretion

Preservative Qualities:
Calcium Disodium EDTA (EDTA-CaNa2) extends shelf life of products by preventing oxidative degradation

Stabilizing Agent:
Calcium Disodium EDTA (EDTA-CaNa2) maintains clarity and prevents discoloration in formulations
Calcium Disodium EDTA (EDTA-CaNa2) is a substituted diamine.
As a raw nutrition material, Calcium Disodium EDTA (EDTA-CaNa2) can be used in agriculture to prevent and correct Calcium deficiencies.

IT CONTAINS CALCIUM DISODIUM EDTA (EDTA-CaNa2):
The following are common foods that contain Calcium Disodium EDTA (EDTA-CaNa2):
*Salad dressings, sauces and spreads
*Mayonnaise
*Pickled vegetables, such as cabbage and cucumbers
*Canned beans and legumes
*Canned carbonated soft drinks
*Distilled alcoholic beverages
*Canned crab, clam and shrimp

WHAT IS CALCIUM DISODIUM EDTA (EDTA-CaNa2) IN FOOD?
Calcium Disodium EDTA (EDTA-CaNa2) generally does not cause significant harm to the human body, excessive intake or overuse may still have a certain risk and toxicity.

Overuse of Calcium Disodium EDTA (EDTA-CaNa2) may affect the kidneys and nervous system, and lead to symptoms such as kidney stones, kidney damage, and neurological abnormalities.
In addition, Calcium Disodium EDTA (EDTA-CaNa2) may bind with calcium ions, leading to the depletion of calcium ions and affecting the normal physiological functions of the body.

WHAT IS CALCIUM DISODIUM EDTA (EDTA-CaNa2) USED FOR?
In the industrial field, Calcium Disodium EDTA (EDTA-CaNa2) can be used in industries such as electroplating, textiles, printing and dyeing, pigments, paints, plastics, cosmetics, etc., as a complexing agent and stabilizer for metal ions to enhance product performance and stability.

In the agricultural field, Calcium Disodium EDTA (EDTA-CaNa2) can be used in pesticides and fertilizers to increase the stability of pesticides, improve fertilizer utilization, and promote crop growth.

In the pharmaceutical field, Calcium Disodium EDTA (EDTA-CaNa2) can be used to prepare complexes and chelates for drugs, thereby enhancing drug stability and efficacy.
In the field of environmental protection, Calcium Disodium EDTA (EDTA-CaNa2) can be used for the chelation and adsorption of heavy metal ions, reducing the environmental pollution caused by heavy metal ions.

PROPERTIES OF CALCIUM DISODIUM EDTA (EDTA-CaNa2):
*White crystal powder，
*easy to dissolve in water，
*Calcium exists as chelating state.

PHYSICAL and CHEMICAL PROPERTIES of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
Appearance: Free-flowing White Powder
Chelated Calcium Content (C10H12N2O8CaNa2•2H2O): 98.0% Min.
Calcium Content: 10.0% Min.
pH Value (1% aqueous solution): 6.5-7.5
pH Value (20% aqueous solution): 6.5-8.0
Aquosity: 5.0%-13.0%
Heavy Metals, mg/kg: 10 Max.
Calcium Content: 10±0.5%
Water-solubility: About 800g/L (20°C), about 1500g/L (80°C)
Bulk Density: About 690Kg/m³

Product name: Calcium disodium EDTA
Molecular Formula: C10H12N2O8CaNa2•2H2O
Molecular weight: M=410.13
CAS No.: 23411-34-9
Appearance: White powder
Molecular Formula: C10H12CaN2Na2O8
Appearance: White Crystalline Powder
CAS: 62-33-9
MF: C10H12CaN2Na2O8.xH2O
MW: 374.27
EINECS: 200-529-9

Product Categories: Organic-metal salt; Ca (Calcium) Compounds;
Classes of Metal Compounds;
Typical Metal Compounds; chelating agent
Mol File: 62-33-9.mol
Physical state: solid
Form: powder
Color: white
Odor: odorless
Odor threshold: not determined

Other safety parameters:
pH (value): 6–7 (in aqueous solution: 10 g/l)
Melting point/freezing point: not determined
Boiling point or initial boiling point and boiling range: not determined
Flash point: not applicable
Evaporation rate: not determined
Flammability (solid, gas): non-combustible
Explosive limits: not determined
Explosion limits of dust clouds: not determined
Vapor pressure: not determined

Density: not determined
Bulk density: 600 kg/m³
Relative vapour density: not applicable
Solubility(ies):
Water solubility: not determined
Partition coefficient n-octanol/water (log KOW): -10.42
Auto-ignition temperature: 292 °C (relative self-ignition temperature for solids)
Decomposition temperature: >295 °C
Viscosity: not relevant (solid)

Explosive properties: none
Oxidizing properties: none
Information for relevant hazard classes according to GHS:
hazard classes acc. to GHS (physical hazards): not relevant
Other information: there is no additional information
Appearance: White crystalline powder
Odor: Odorless
Solubility: Soluble in water
pH (1% solution): Approximately 6.0 – 8.0
Stability: Stable under normal storage conditions

FIRST AID MEASURES of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of CALCIUM DISODIUM EDTA (EDTA-CaNa2):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available