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Calcium Thioglycolate is the calcium salt of thioglycolic acid and Calcium Thioglycolate is widely used as a reducing agent in cosmetic depilatories and hair-removal products.
Calcium Thioglycolate works by breaking disulfide bonds in keratin, and this reduction mechanism allows Calcium Thioglycolate to weaken hair structure so hair can be removed from the skin surface.
Calcium Thioglycolate is valued for effective hair-removal performance in creams and lotions, but Calcium Thioglycolate requires careful formulation control because Calcium Thioglycolate can cause irritation, has a strong characteristic sulfur odor, and must be handled with appropriate safety practices.
CAS Number: 814-71-1
EC Number: 212-394-0
Molecular Formula: Ca(C2H3O2S)2
Molecular Weight: 206.29 g/mol
Synonyms: Calcium Thioglycolate, Calcium Thioglycollate (variant spelling), Calcium Salt of Thioglycolic Acid, Thioglycolic Acid Calcium Salt, Calcium Mercaptoacetate, Calcium 2-Mercaptoacetate, Calcium Thiohydroxyacetate (common naming), Depilatory Calcium Thioglycolate, Hair Removal Reducing Agent, Calcium Thioglycolate Depilatory, Calcium Thioglycolate Reductant, Calcium Thioglycolate Hair Remover, Calcium Thioglycolate, CALCIUM THIOGLYCOLATE, Calcium thioglycolate, Calcium Thioglycolate (depilatory), Depilatory Calcium Thioglycolate, Calcium Thioglycolate Depilatory Agent, Calcium Thioglycolate Hair Removal Agent, Calcium Thioglycolate Reducing Agent (use context), Calcium Thioglycolate (thioglycolate salt), Thioglycolic Acid Calcium Salt, Calcium Salt of Thioglycolic Acid, Calcium 2-Mercaptoacetate, Calcium 2-mercaptoacetate, Calcium Mercaptoacetate, Calcium mercaptoacetate, Calcium Thioglycollate (spelling variant), Calcium Thioglycolate (British spelling variant), Calcium Thioglycolate (INCI) (where listed), Calcium Thioglycolate (cosmetic ingredient), Calcium Thioglycolate (personal care ingredient), Calcium Thioglycolate (hair treatment chemical), Calcium Thioglycolate (perming reducer) (use context), Calcium Thioglycolate (wave lotion reducer) (use context), Calcium Thioglycolate (hair straightening reducer) (use context), Calcium Thioglycolate (chemical depilatory active), Thioglycolate of Calcium, Calcium Thioglycolate Powder, Calcium Thioglycolate Granules, Calcium Thioglycolate Solution, Calcium Thioglycolate Aqueous Solution, Calcium Thioglycolate Concentrate (common wording), Calcium Thioglycolate Technical Grade, Calcium Thioglycolate Cosmetic Grade, Calcium Thioglycolate Industrial Grade, Calcium Thioglycolate High Purity, Calcium Thioglycolate Reagent, Calcium Thioglycolate Analytical Grade, Calcium Thioglycolate Laboratory Grade, Calcium Thioglycolate (CAS 814-71-1), CAS 814-71-1, Calcium Thioglycolate (C4H6CaO4S2) (composition wording), C4H6CaO4S2, Calcium Thioglycolate (EC 212-406-5) (common listing), EC 212-406-5, Calcium Thioglycolate (EINECS 212-406-5), Calcium Thioglycolate (thiol reducing salt), Thiol Reducing Agent (Calcium Thioglycolate), Thioglycolate Reducing Salt (Calcium), Calcium Thioglycolate Hair Dissolver (common trade wording), Calcium Thioglycolate Keratin Reducer (use context), Calcium Thioglycolate Keratin Softener (use context), Calcium Thioglycolate Depilatory Powder, Calcium Thioglycolate Depilatory Cream Ingredient, Calcium Thioglycolate Depilatory Lotion Ingredient
APPLICATIONS
Calcium Thioglycolate is used in depilatory creams to weaken hair keratin and enable easy hair removal with wiping or rinsing.
Calcium Thioglycolate is incorporated into body hair removal creams designed for legs and arms with optimized pH and emollient systems.
Calcium Thioglycolate is used in depilatory lotions where controlled viscosity supports uniform application and consistent performance.
Calcium Thioglycolate is used in depilatory products for sensitive skin areas at carefully controlled concentration and contact time.
Calcium Thioglycolate is incorporated into facial depilatories in low-irritation systems where mildness is prioritized and labeling guidance is strict.
Calcium Thioglycolate is used in bikini-area depilatories with soothing agents and strict consumer-use instructions to minimize irritation risk.
Calcium Thioglycolate is used in shower depilatories where rapid action is needed under wet conditions and rinse-off performance is optimized.
Calcium Thioglycolate is incorporated into depilatory foams to improve spreadability and reduce mess during application.
Calcium Thioglycolate is used in roll-on depilatory formats where controlled dosing supports safer consumer use.
Calcium Thioglycolate is used in salon depilatory products where professional protocols control contact time and skin preparation.
Calcium Thioglycolate is incorporated into professional depilatory systems that include pre-treatment cleansing and post-treatment soothing steps.
Calcium Thioglycolate is used in high-performance hair removal products where efficacy is balanced with skin comfort additives.
Calcium Thioglycolate is used in depilatory formulations with humectants to reduce dryness and improve after-feel.
Calcium Thioglycolate is incorporated into depilatory creams with emollients and occlusives to reduce tightness after rinsing.
Calcium Thioglycolate is used in depilatory products with barrier-support ingredients to improve consumer comfort.
Calcium Thioglycolate is used in depilatories that include fragrance systems to help mask sulfur odor while maintaining stability.
Calcium Thioglycolate is incorporated into formulas with odor-control strategies such as encapsulated fragrance and compatible deodorizing additives.
Calcium Thioglycolate is used in depilatory systems where packaging selection helps reduce odor perception and preserve product quality.
Calcium Thioglycolate is used in hair-removal creams designed for coarse hair types where stronger reduction performance is required.
Calcium Thioglycolate is incorporated into products targeting short contact time while maintaining effective hair weakening.
Calcium Thioglycolate is used in hair-removal products that aim to deliver smoother regrowth feel by reducing hair breakage at the surface.
Calcium Thioglycolate is used in combination depilatory systems where alkalizers adjust pH for optimal keratin reduction.
Calcium Thioglycolate is incorporated into formulations with calcium hydroxide or similar bases to maintain the alkaline conditions needed for efficacy.
Calcium Thioglycolate is used in stability-optimized depilatories where oxidation control helps preserve reducing strength over shelf life.
Calcium Thioglycolate is used in research and development as a standard depilatory reducing agent to evaluate hair breakage and removal efficiency.
Calcium Thioglycolate is incorporated into prototype depilatory bases to screen mildness, odor management, and rinse properties.
Calcium Thioglycolate is valued because Calcium Thioglycolate provides effective disulfide bond reduction for practical, consumer-friendly chemical depilation when used correctly.
Calcium Thioglycolate is used as a depilatory active in hair removal creams and lotions.
Calcium Thioglycolate breaks disulfide bonds in keratin to weaken hair structure.
Calcium Thioglycolate enables hair to be wiped away from the skin surface after processing time.
Calcium Thioglycolate is used in professional depilatory products for salons and cosmetic service settings.
Calcium Thioglycolate supports fast hair reduction on legs, arms, and body areas in approved use.
Calcium Thioglycolate helps produce smooth skin results when used according to instructions.
Calcium Thioglycolate is used in depilatory creams formulated for sensitive skin concepts.
Calcium Thioglycolate is balanced with buffers and emollients to improve user comfort.
Calcium Thioglycolate supports effective hair removal while minimizing irritation risk when properly formulated.
Calcium Thioglycolate is used in facial depilatory products where controlled activity is required.
Calcium Thioglycolate supports removal of fine facial hair in regulated cosmetic products.
Calcium Thioglycolate helps maintain short processing time targets in facial depilatories.
Calcium Thioglycolate is used in bikini-line depilatory products with carefully controlled pH and exposure time.
Calcium Thioglycolate supports targeted hair removal in delicate areas under strict label directions.
Calcium Thioglycolate helps reduce hair presence while maintaining cosmetic product performance goals.
Calcium Thioglycolate is used in men’s depilatory creams for chest, back, and body hair removal.
Calcium Thioglycolate supports thicker-hair removal by providing strong reducing action.
Calcium Thioglycolate helps improve cosmetic grooming outcomes in at-home hair removal routines.
Calcium Thioglycolate is used in depilatory wipes and rapid depilatory systems where a cream base is used.
Calcium Thioglycolate supports fast action and convenient hair removal formats.
Calcium Thioglycolate helps reduce hair structure so it can be removed with a wipe or spatula.
Calcium Thioglycolate is used in depilatory foams and aerosols in some product designs.
Calcium Thioglycolate supports even coverage and controlled contact time on skin.
Calcium Thioglycolate helps deliver consistent hair reduction across treated areas.
Calcium Thioglycolate is used in depilatory formulations that include odor-masking systems.
Calcium Thioglycolate is paired with fragrances and scavengers to reduce sulfur odor perception.
Calcium Thioglycolate helps maintain consumer-acceptable smell profiles in hair removal products.
Calcium Thioglycolate is used in depilatory product development to tune speed of action and residue feel.
Calcium Thioglycolate supports optimization of viscosity and spreadability for uniform application.
Calcium Thioglycolate helps balance efficacy with rinsability in finished products.
Calcium Thioglycolate is used in chemical hair relaxation systems in limited, specialized contexts.
Calcium Thioglycolate supports reduction of keratin disulfide bonds in some hair shaping approaches.
Calcium Thioglycolate helps enable controlled reshaping when followed by appropriate neutralization steps.
Calcium Thioglycolate is used in permanent hair waving chemistry as a reducing agent in some systems.
Calcium Thioglycolate supports softening of hair structure before reformation of disulfide bonds.
Calcium Thioglycolate helps create curl or wave patterns when used in controlled salon processes.
DESCRIPTION
Calcium Thioglycolate is a reducing agent that cleaves keratin disulfide bonds, and this chemical action weakens hair structure so hair can be removed without shaving.
Calcium Thioglycolate is typically used in alkaline depilatory systems, and the high pH both swells hair and supports reduction reactions for improved performance.
Calcium Thioglycolate may cause irritation or chemical burns if misused, so Calcium Thioglycolate depilatories require strict instructions for patch testing, contact time limits, and thorough rinsing.
Calcium Thioglycolate can oxidize over time, so Calcium Thioglycolate formulations often include antioxidants, oxygen-limiting packaging, and controlled manufacturing conditions.
Calcium Thioglycolate has a characteristic sulfur odor, and odor management strategies include fragrance selection, masking agents, and minimizing headspace oxygen.
Calcium Thioglycolate can react with certain metals, so Calcium Thioglycolate products are typically manufactured and filled using compatible equipment and packaging materials.
Calcium Thioglycolate should be stored in tightly closed containers in a cool, dry place away from heat and strong oxidizers.
Calcium Thioglycolate should be handled with appropriate PPE because concentrated material can irritate skin, eyes, and respiratory tract.
Calcium Thioglycolate must be used in compliance with applicable cosmetic regulations and concentration limits for the intended market.
PROPERTIES
Chemical Formula: Ca(C2H3O2S)2
Molecular Weight: 206.29 g/mol
Common Name: Calcium Thioglycolate
Chemical Type: Thiol-based reducing agent (thioglycolate salt)
Appearance: White to off-white crystalline solid or powder (grade dependent)
Odor: Strong characteristic sulfur/thiol odor
Solubility: Soluble in water (grade dependent); forms alkaline solutions in depilatory systems
pH (solution): Typically alkaline in use formulations (system dependent)
Reducing Activity: Strong disulfide bond reducing capacity in keratin systems
Oxidation Sensitivity: Can oxidize to disulfides; protect from air and oxidizers
Reactivity: Reacts with oxidizing agents; avoid contact with strong acids and oxidizers
Stability: Stable under recommended storage; stability depends on moisture and oxygen exposure
Storage Temperature: 15–25°C, tightly closed, protected from heat
Shelf Life: Typically 12–24 months in original sealed packaging (supplier dependent)
FIRST AID
Inhalation:
Move to fresh air if dust or vapors are inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust and avoid inhalation of vapors from alkaline depilatory mixtures.
Skin Contact:
Remove contaminated clothing and rinse skin with plenty of water.
Wash with mild soap after thorough rinsing and do not scrub aggressively.
Seek medical attention if irritation, burns, or persistent redness occurs.
Eye Contact:
Rinse cautiously with water for at least 15 minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek immediate medical attention because alkaline thioglycolates can cause serious eye injury.
Ingestion:
Rinse mouth with water and do not induce vomiting.
Seek immediate medical attention, especially if concentrated product was swallowed.
Never give anything by mouth to an unconscious person.
Note to Physicians:
Treat symptomatically.
Consider corrosive or irritant effects from alkaline formulations.
Provide supportive care and monitor for mucosal irritation or burns.
HANDLING AND STORAGE
Handling:
Use appropriate PPE including chemical-resistant gloves, safety glasses or goggles, and protective clothing.
Avoid skin and eye contact and avoid inhalation of dust.
Handle Calcium Thioglycolate away from food and maintain good hygiene practices.
Ventilation:
Use local exhaust or general ventilation where dust or vapors may be generated.
Provide adequate ventilation during mixing of alkaline depilatory bases.
Avoid confined areas where odor and vapors can accumulate.
Storage:
Store in tightly closed containers in a cool, dry, well-ventilated place.
Protect from heat, moisture, and air exposure to preserve reducing activity.
Keep away from oxidizing agents, acids, and reactive metals.
Spill and Leak Procedures:
Avoid dust generation and collect spilled solid carefully into suitable containers.
For solutions, contain and absorb with inert material and dispose according to local regulations.
Wash spill area with plenty of water while preventing uncontrolled release to drains if required by local rules.
Handling Precautions:
Control pH and contact time in finished depilatories to reduce irritation risk and ensure safe consumer use.
Use oxygen-control strategies to reduce oxidation and maintain consistent depilatory performance over shelf life.
Rotate stock using FIFO practices to maintain consistent quality and predictable reducing strength.
