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CCT (CAPRIC CAPRYLIC TRIGLYCERIDE)

CCT (Capric Caprylic Triglyceride) is a natural coconut and palm kernel oil derived mixture of glycerin triester with caprylic and capric acids, which can be used as an alternative to mineral and vegetable oils. 
CCT (Capric Caprylic Triglyceride) is a mixed ester composed of caprylic and capric fatty acids attached to a glycerin backbone.
CCT (Capric Caprylic Triglyceride) is an excellent moisturising emollient oil with good skin care properties, giving a pleasant non-slippery after feel on the skin. 

CAS:    73398-61-5
MF:    C21H39O6-
MW:    387.53076
EINECS:    277-452-2

CCT (Capric Caprylic Triglyceride) is derived from coconut oil and glycerine and is considered an excellent emollient and skin-replenishing ingredient. 
Of note, its mix of fatty acids replenish skin’s surface and help CCT (Capric Caprylic Triglyceride) to resist moisture loss.
CCT (Capric Caprylic Triglyceride) can also function as a thickener or penetration enhancer, but its chief job is to moisturised and replenish skin. 
CCT (Capric Caprylic Triglyceride)’s value for skin is made greater by the fact that it’s considered gentle.
As a raw material CCT (Capric Caprylic Triglyceride) is clear, non-viscous liquid. 
CCT (Capric Caprylic Triglyceride) is known to improve to the spreadability of formula.

Safety assessments have deemed CCT (Capric Caprylic Triglyceride) safe in cosmetic formulations in concentrations below 50%, with reported uses varying between 0.1% to 35%.
Despite what is often purported on the internet skin care advice sites, there is no research showing CCT (Capric Caprylic Triglyceride) is “comedogenic” or pore clogging. 
Theoretically, because its molecular weight of 408 is below 500 Daltons, CCT (Capric Caprylic Triglyceride) technically has the ability to penetrate the pore lining, but even that doesn’t inherently mean it will clog pores.
CCT (Capric Caprylic Triglyceride) is an ingredient used in soaps and cosmetics. 
CCT (Capric Caprylic Triglyceride)’s usually made from combining coconut oil with glycerin. 
CCT (Capric Caprylic Triglyceride) is sometimes called capric triglyceride. 
CCT (Capric Caprylic Triglyceride)’s also sometimes mistakenly called fractionated coconut oil.

CCT (Capric Caprylic Triglyceride) has been widely used for more than 50 years. 
CCT (Capric Caprylic Triglyceride) helps smooth skin and works as an antioxidant. 
CCT (Capric Caprylic Triglyceride) also binds other ingredients together, and can work as a preservative of sorts to make the active ingredients in cosmetics last longer.
CCT (Capric Caprylic Triglyceride) is valued as a more natural alternative to other synthetic chemicals found in topical skin products. 
Companies that claim that their products are “all natural” or “organic” often contain CCT (Capric Caprylic Triglyceride).
While CCT (Capric Caprylic Triglyceride)’s technically made of natural components, the caprylic triglyceride used in products isn’t usually found in nature. 
A chemical process separates the oily liquid so that a “pure” version of CCT (Capric Caprylic Triglyceride) can be added to products.

CCT (Capric Caprylic Triglyceride) are compounds made of naturally occurring fatty acids. 
They’re a clear liquid and slightly sweet to the taste. 
The high fat content in triglycerides, along with their texture and antioxidant qualities, make them of particular use for soap and skin care products.
CCT (Capric Caprylic Triglyceride) is a mixed ester composed of caprylic and capric fatty acids attached to a glycerin backbone. 
CCT (Capric Caprylic Triglyceride) is sometimes erroneously referred to as fractionated coconut oil, which is similar in composition but typically refers to coconut oil that has had its longer chain triglycerides removed. 
Chemically speaking, fats and oils are made up mostly of triglycerides whose fatty acids are chains ranging from 6–12 carbon atoms, in this case the ester is comprised of capric (10 carbon atoms) and caprylic (8 carbon atoms).

CCT (Capric Caprylic Triglyceride) is a specialized esterification of Coconut Oil using just the Caprylic and Capric Fatty Acids, while Fractionated Coconut Oil is a, standard, distillation of Coconut Oil which results in a combination of all of the fatty acids, pulled through the distillation process. 
CCT (Capric Caprylic Triglyceride) is non-greasy and light weight. 
CCT (Capric Caprylic Triglyceride) comes in the form of an oily liquid and mainly works as an emollient, dispersing agent and solvent.
CCT (Capric Caprylic Triglyceride) is a super smooth ingredient that locks in moisture on the skin and hair without leaving them greasy or oily. 
CCT (Capric Caprylic Triglyceride) is found in a large variety of cosmetic and skin care products such as lipstick, eyeliners, and moisturizers. 
CCT (Capric Caprylic Triglyceride) is also an antioxidant that protects the skin and preserves the product it is added in. 
Even though it is derived from oils, CCT (Capric Caprylic Triglyceride) is not comedogenic and does not cause acne or breakouts.

CCT (Capric Caprylic Triglyceride) is a commonly used ingredient in soaps and cosmetics. 
CCT (Capric Caprylic Triglyceride) is usually produced from a combination of coconut oil and glycerin. 
CCT (Capric Caprylic Triglyceride) is sometimes referred to as capric triglyceride or sometimes erroneously referred to as fractionated coconut oil. 
CCT (Capric Caprylic Triglyceride) have been used for over 50 years. 
CCT (Capric Caprylic Triglyceride) has a skin-smoothing effect and good antioxidant activity. 
Besides, CCT (Capric Caprylic Triglyceride) also has the role of binding other ingredients together and can act as a preservative to help the active ingredients in cosmetics last longer.
CCT (Capric Caprylic Triglyceride) are considered a natural substitute for other synthetic chemicals found in topical products. 

CCT (Capric Caprylic Triglyceride) are saturated fatty acids naturally present in coconut and palm oil. 
They are considered to be medium-chain fatty acids. 
CCT (Capric Caprylic Triglyceride) is also known as decanoic acid and caprylic acid is also known as octanoic acid. 
To isolate these fatty acids they are separated from the glycerine compound and the other fatty acids present in the coconut or palm oil. 
CCT (Capric Caprylic Triglyceride) is usually achieved by steam hydrolysis where intense heat and pressure is applied to break apart the structure of the oil. 
CCT (Capric Caprylic Triglyceride) are then isolated from the other fatty acids and combined together with the glycerine compound by a process called ‘esterification’ to form the ingredient ‘capric/caprylic triglyceride’. 
This new ingredient has different physical properties than the original oil CCT (Capric Caprylic Triglyceride) came from. 
CCT (Capric Caprylic Triglyceride) feels dryer, less greasy and is highly stable.

CCT (Capric Caprylic Triglyceride) is monolayer lipids that can form a barrier to protect the colon from toxic substances. 
They have been shown to inhibit the production of tumour necrosis factor-α (TNF-α) in colorectal adenocarcinoma cells and reduce the number of caco-2 cells. 
These compounds are also used as a nutrient supplement for cell cultures. 
CCT (Capric Caprylic Triglyceride) have been shown to be irritant in humans, but not in mice. 
The level of irritation is related to their fatty acid composition, with caproic acid being more irritating than methyl anthranilate. 

CCT (Capric Caprylic Triglyceride) Chemical Properties
Density: 0.94-0.96
Vapor pressure: 0-0Pa at 20℃
Solubility: Soluble in all proportions at 20°C in acetone, benzene, 2-butanone, carbon tetrachloride, chloroform, dichloromethane, ethanol, ethanol (95%), ether, ethyl acetate, petroleum ether, special petroleum spirit (boiling range 80–110°C), propan- 2-ol, toluene, and xylene. 
Miscible with long-chain hydrocarbons and triglycerides; practically insoluble in water.
Form: Liquid
InChI: InChI=1S/C21H40O6/c1-2-3-4-10-13-18(21(26)27-17-19(23)16-22)14-11-8-6-5-7-9-12-15-20(24)25/h18-19,22-23H,2-17H2,1H3,(H,24,25)/p-1
InChIKey: YWHITOKQSMJXEA-UHFFFAOYSA-M
LogP: 8.2-10.9
EPA Substance Registry System: CCT (Capric Caprylic Triglyceride) (73398-61-5)

A colorless to slightly yellowish oily liquid that is practically odorless and tasteless. 
CCT (Capric Caprylic Triglyceride) solidifies at about 0°C. 
The oil is free from catalytic residues or the products of cracking. 
CCT (Capric Caprylic Triglyceride) containing the tri-glycerides of medium chain, saturated fatty acids mainly C-8 (Caprylic) and C-10 (Capric).

Uses
CCT (Capric Caprylic Triglyceride) have been used in a variety of pharmaceutical formulations including oral, parenteral, and topical preparations.
In oral formulations, CCT (Capric Caprylic Triglyceride) are used as the base for the preparation of oral emulsions, microemulsions, selfemulsifying systems, solutions, or suspensions of drugs that are unstable or insoluble in aqueous media, e.g. calciferol. 
CCT (Capric Caprylic Triglyceride) have also been investigated as intestinalabsorption enhancersand have additionally been used as a filler in capsules and sugar-coated tablets, and as a lubricant or antiadhesion agent in tablets.
In parenteral formulations, CCT (Capric Caprylic Triglyceride) have similarly been used in the production of emulsions, solutions, or suspensions intended for intravenous administration.

In rectal formulations, CCT (Capric Caprylic Triglyceride) have been used in the preparation of suppositories containing labile materials. 
In cosmeticsand topical pharmaceutical preparations, CCT (Capric Caprylic Triglyceride) are used as a component of ointments, creams, and liquid emulsions.
Therapeutically, CCT (Capric Caprylic Triglyceride) have been used as nutritional agents.
Diets containing CCT (Capric Caprylic Triglyceride) are used in conditions associated with the malabsorption of fat, such as cystic fibrosis, since medium-chain triglycerides are more readily digested than long-chain triglycerides. 
CCT (Capric Caprylic Triglyceride) have been particularly investigated for their use in total parenteral nutrition (TPN) regimens in combination with longchain triglycerides.
Although similar to long-chain triglycerides, CCT (Capric Caprylic Triglyceride) have a number of advantages in pharmaceutical formulations, which include better spreading properties on the skin; no impedance of skin respiration; good penetration properties; good emollient and cosmetic properties; no visible film on the skin surface; good compatibility; good solvent properties; and good stability against oxidation.

Production Methods    
CCT (Capric Caprylic Triglyceride) are obtained from the fixed oil extracted from the hard, dried fraction of the endosperm of Cocos nucifera L. 
Hydrolysis of the fixed oil followed by distillation yields the required fatty acids, which are then re-esterified to produce the CCT (Capric Caprylic Triglyceride).
Although the PhEur 6.0 specifies that CCT (Capric Caprylic Triglyceride)s are obtained from coconut oil, medium-chain triglycerides are also to be found in substantial amounts in the kernel oils of certain other types of palm-tree, e.g. palm kernel oil and babassu oil. 
Some animal products, such as milk-fat, also contain small amounts (up to 4%) of the CCT (Capric Caprylic Triglyceride).

Synonyms    
ODO
odo
Einecs 277-452-2
MEDIUM-CHAINTRIGLYCERIDE
Decanoyl- and octanoyl glycerides
Mixed decanoyl octanoyl glycerides
Glycerides, mixed decanoyl and octanoyl
Glycerin, mixed triester with caprylic acid and capric acid
CAPRYLIC/CAPRIC TRIGLYCERIDES
MEDIUM-CHAINTRIGLYCERIDE
Mixed decanoyl octanoyl glycerides
Caprylic / capric triglyceride
Decanoyl- and octanoyl glycerides
Einecs 277-452-2
Glycerin, mixed triester with caprylic acid and capric acid
73398-61-5
glyceryl caprylate-caprate
11-(2,3-dihydroxypropoxycarbonyl)heptadecanoate

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