Quick Search
Ceramide 1 belongs to a larger group of ceramides that are found naturally in skin as long chains of lipids (fats).
The “EO” refers to the type of fatty acid correlated with the ingredient and “S” stands for this ceramide’s sphinogsine base.
Healthy skin is made up of 50% ceramides, but when those ceramides decrease, skin’s barrier becomes weaker, making it more vulnerable to external stressors and dehydration.
CAS: 1246303-22-9
MF: C34H71N2O6P
MW: 634.911101
Synonyms
C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium salt);C16 Ceramide-1-Phosphate (d18:1/16:0);N-[(1S,2R,3E)-2-hydroxy-1-[(phosphonooxy)methyl]-3-heptadecen-1-yl]-hexadecanamide,monoammoniumsalt
As a skin care ingredient, topical application of ceramide EOS can step in to help fill this gap and replenish skin’s barrier, so it is better able to defend itself from external stimuli.
Ceramide 1 works best when combined with other ceramides + replenishing ingredients like fatty acids and cholesterol.
Together, these lipid mixtures improve skin’s hydration, resiliency, and suppleness.
They also play a signaling role in maintaining healthy skin.
Ceramide 1 belong to the group of ceramide lipids within the sphingolipids.
Their structure consists of a sphingoid base, specifically sphingosine-phosphate, and a fatty acid.
The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Ceramide 1 is primarily found in the trans-Golgi network and often counters the effects of ceramides.
Thus, a balance of both is essential for homeostasis as imbalances will lead to metabolic dysfunction or disease.
CerP regulates cell growth and survival, acts as inhibitor of apoptosis, and is a mediator of inflammation.
Further, Ceramide 1 also elicits growth and survival in cancers and is thus associated with poor survival.
Ceramide 1 is one of the main forms of C1P found in cells.
Ceramide 1 is created by phosphorylation of C16 ceramide by ceramide kinase.
Ceramide 1 activates cytosolic phospholipase A2α (PLA2α) and stimulates the release of arachidonic acid in A549 cells.
Ceramide 1 Chemical Properties
Storage temp.: -20°C
Solubility: Chloroform:Methanol:NH4OH (80:20:2): Soluble
Form: A solid
Color: White to off-white
Uses
C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium) (C16 Ceramide-1-phosphate (ammonium); Ceramide-1-phosphate (d18:1/16:0) (ammonium)) is an ester product.
