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Ceramide 2 is an essential skin molecule that is able to capture and bind water required by the epidermis to remain supple, smooth and hydrated.
Ceramide 2 is used in make-up products, skin and body care for dry and mature skin.
Ceramide 2 also fights against skin aging and preserves the skin's youth.
CAS: 100403-19-8
MF: C24H47NO3
MW: 397.63488
EINECS: 309-560-3
Synonyms
CAPROYL SPHINGOSINE;HYDROXYCAPROYL PHYTOSPHINGOSINE;HYDROXYCAPRYLOYL PHYTOSPHINGOSINE;HYDROXYLAUROYL PHYTOSPHINGOSINE;LACTOYL PHYTOSPHINGOSINE;PHYTOSPHINGOSINE LACTATE;Ceramides;Einecs 309-560-3
Ceramide 2 provides restructuring function and maintains moisture and integrity of the cutaneous barrier.
Ceramide 2 is synthetic in origin.
Ceramide 2 by Croda acts as a skin conditioning agent.
Ceramide 2 imparts anti-aging, nourishing, strengthening, protective and barrier repairing effect.
Ceramide 2 is identical to natural ceramide 2 and provides restructuring function.
Ceramide 2 maintains moisture and integrity of the cutaneous barrier & leaves the epidermis supple, smooth and hydrated.
Ceramide 2 also fights against skin aging and preserves the skin's youth.
Ceramide 2 is used in formulating after sun, body care, eye color, face/ neck skin care, face color, foot care, leg care, lip color, nail care & color products.
Complies with IECIC.
The ceramides mixture consists of hydroxy and non-hydroxy fatty acid-containing ceramides.
Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires the coordinated action of serine palmitoyl transferase and ceramide synthase.
They have been shown to mediate antiproliferative responses such as apoptosis, growth arrest, differentiation, and senescence.
Ceramides, fatty acid and cholesterol constitute the extracellular lipid matrix of epidermal barrier in an approximately equimolar ratio and are assembled in a dense orthorhombic lateral packing within SC interstices.
Among them, ceramides are central to the permeability barrier structure and function.
Epidermal ceramides account for approximately 50 % of total epidermal lipid by weight.
In addition, ceramides also act as an active second messenger, regulate keratinocyte proliferation and differentiation, enhance proinflammatory cytokines production, and modulate immune responses.
Aberrant metabolism and function of ceramides is involved in the pathogenesis of several inflammatory skin diseases, including psoriasis, atopic dermatitis (AD) and ichthyosis.
Ceramides are fatty molecules consisting of a long chain of carbon and hydrogen atoms with a carboxyl group at one end.
They form the major constituent of the lipid bilayer that makes up cell membranes.
Ceramides perform many important functions in both the brain and mitochondria, where they regulate membrane permeability and mitochondrial functions.
The structural analysis of ceramides has shown that they contain two hydrocarbon chains, which can be modified by enzymes to produce different types of ceramide.
One type is sphingomyelin and is found in high levels in neuronal cell membranes.
Sphingomyelin has a phase transition temperature of about 40°C, whereas another type, cerebroside, has a phase transition temperature closer to 25°C.
Ceramide also contains an amide bond between two long-chain fatty acids, which is important for its stability and function.
Ceramide 2 can be broken by enzymes such as ceramidase or sphingomyelinase to form free fatty acids.
Ceramide 2 Chemical Properties
Storage temp.: Store at -20°C
Solubility: Methanol: 25 mg/mL
Form: A crystalline solid
Color: Off-white to light yellow
LogP: 13.577 (est)
CAS DataBase Reference: 100403-19-8(CAS DataBase Reference)
Uses
Ceramide 2 is widely used in cosmetics, including shampoos, deodorants and make-up.
Ceramide 2 is a family of naturally occurring lipids that act primarily in the skin’s uppermost layer, forming a protective barrier and reducing natural transepidermal water loss.
Ceramides repair the stratum corneum layer in cases of dry skin, improve skin hydration, and increase the feeling of softness.
They are beneficial for stressed, sensitive, scaly, rough, dry, aged, and sun-damaged skin.
Ceramides play an essential role in the structure of superficial epidermal layers and form an integral part of the intercellular membrane network.
They help generate and sustain the skin’s barrier function.
Ceramide 2 is extremely important: if the stratum corneum’s hydration is maintained, then it functions more normally in terms of flexibility and desquamation, its integrity is upheld, and the skin is less susceptible to irritation.
Ceramide 2 production decreases with age, accentuating any tendency to dry skin.
When incorporated into a skin care preparation, the topical application of ceramides could benefit the stratum corneum if the ceramides manage to fill the intercellular spaces and if they are hydrolyzed by the correct extracellular enzymes on the skin.
Such application also can stimulate ceramide production in the skin, thereby increasing the skin’s natural lipid content and reinforcing the skin’s protective barrier, measured through transepidermal water loss.
Topically applied ceramides have been shown to capture and bind water, necessary for the skin to remain supple, smooth, and hydrated.
natural ceramides are obtained from animals and plants.
While ceramides can be synthetically manufactured, Ceramide 2 is hard to obtain an identical equivalent to those found in nature, making them expensive raw materials.
1. Cosmetics
Ceramide 2 is the most recent years developed a new generation of moisturizing agent is a lipid soluble substance, it constitutes the physical structure of the stratum corneum of skin similar to quickly penetrate the skin, and cuticle of the water, forming a kind of network structure, to seal in moisture.
Increase with age and into old age, exist in human skin will gradually reduce ceramide, dry skin and rough skin, skin type and other abnormal symptoms appear is due to a decrease in the amount of ceramide.
So to prevent such skin abnormalities, added ceramide is an ideal way.
2. Functional Foods
Taking ceramide, absorbed in the small intestine and transferred to the blood, and then transported to the body, so that the skin cells to obtain a good recovery and regeneration, but also allows the body’s own neural acid biosynthesis.
