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Naturally occurring in the skin, Ceramide EOP, also known as ceramide 1, is part of the extracellular matrix that consists of mainly lipids; these waxy molecules are found between the skin cells, resulting in them playing a vital role in keeping the skin surface healthy and hydrated.
There are over 340 specific species of ceramides found, and ceramide EOP was the first to be identified in labs in 1982; it has a unique structure which is enriched in fatty acids and linoleic acid and can form a water-proof film on the outer layer of the skin.
Ceramide EOP helps the skin from drying out and combats any free radicals from penetrating the skin and causing some levels of damage.
CAS: 179186-46-0
MF: C63H125NO6
MW: 992.67
Synonyms
Octadecanoic acid, 27-[[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]amino]-27-oxoheptacosyl ester;Ceramide EOP
Ceramide EOP is currently not in stock but may be available through custom synthesis.
To ensure cost efficiency, the minimum order quantity is 1 gram.
The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries).
Quotes for quantities below 1 gram will not be provided.
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Note: If Ceramide EOP becomes available in stock in the future, pricing will be listed accordingly.
Naturally occurring in the skin, also known as Ceramide EOP is part of the extracellular matrix that consist of mainly lipids, these waxy molecules are found between the skin cells resulting in them playing a vital role in keeping the skin surface healthy and hydrated.
There are over 340 specific species of ceramides found, and ceramide EOP is the first to be identified in labs in 1982, it has a unique structure which is enriched in fatty acids, linoleic acid and can form a water-proof film on the outer layer of the skin.
This helps the skin from drying out and combats any free radicals from penetrating the skin and causing some levels of damage.
Ceramide EOP Chemical Properties
Boiling point: 958.7±65.0 °C(Predicted)
Density: 0.926±0.06 g/cm3(Predicted)
pka: 13.65±0.20(Predicted)
InChIKey: MIUIRGGKIICMBP-NFOZDHADSA-N
Uses
Ceramide EOP, also known as Ceramide NP, plays a crucial role in skin barrier function by contributing to the structural integrity of the lipid matrix in the stratum corneum.
Ceramides are essential components of the extracellular lipid matrix, along with cholesterol and free fatty acids, forming a protective barrier against water loss and external irritants.
Studies have shown that ceramides, including Ceramide EOP, are vital for skin hydration, cell adhesion, and epidermal differentiation, thus helping to maintain skin barrier function. Furthermore, incorporating ceramides into skincare formulations, such as ceramide-containing cleansers and moisturizers, has been demonstrated to repair barrier damage caused by conditions like acne vulgaris and enhance skin barrier function by reducing dryness, redness, and scaling.
Therefore, Ceramide EOP is a critical player in maintaining skin health and integrity through its contribution to the skin barrier function.
Ceramide EOP (5.0% Emulsion) is a golden component in ceramides, typically playing a role in connecting lipid bilayers.
Ceramide EOP is the true king of moisturization, king of barrier, and king of healing.
Ceramide EOP has a new effect of improving skin elasticity and has better solubility for better formula building.
1.Moisturizing
As the most abundant component of intercellular lipids, Ceramide EOP plays a very important role in the skin.
First of all, ceramide has a large number of hydrophilic groups, which has a strong affinity for water, can prevent the loss of water and electrolytes, and has an endogenous moisturizing effect.
2.Delaying skin aging
As age increases, the ceramides and moisture present in the stratum corneum of human skin gradually decrease.
Timely replenishment of ceramides can help delay skin aging and keep skin young.
3.Repairing skin barrier
According to the "brick wall theory" of the skin's natural barrier, keratinocytes are equivalent to bricks, and sebum membranes and intercellular lipids (ceramides, fatty acids, cholesterol, etc.) are cement, they stack up to form a "wall", thus forming a skin's natural protective barrier, ceramides are an important component in the brickwork structure and play a role in protecting the skin barrier.
At the same time, ceramide and cell epidermal proteins can be connected through ester bonds to bond cells, preventing dryness, scaling, and scaly skin.
4.Reducing atopic dermatitis
For patients with atopic dermatitis, or patients with dermatitis caused by exposure to surfactants or organic solvents, Ceramide EOP's in the skin will be rapidly lost.
The pathogenesis of atopic dermatitis is unclear and may be related to genetic factors, immune factors, skin barrier dysfunction, mental factors, lifestyle habits and environmental factors.
Research shows that the primary mechanism of atopic dermatitis may be skin barrier dysfunction, especially the reduction of ceramide NP content in lipids, which is one of the main reasons for the impairment of skin barrier function.
Timely replenishment of ceramides in the skin, especially ceramide NP, has important clinical significance in guiding medication for patients with atopic dermatitis.
5.Soothing skin
Ceramide EOP maintains skin moisture by forming a network structure in the stratum corneum, improving dry skin, reducing scaling, and relieving redness, itching and other discomforts.
6.Small amounts do the trick
As a long-chain ceramide, EOP can span the lipid bilayer and maintain the lipid bilayer membrane structure, so only a very small amount is required to have a good effect.
Ceramide EOP mainly has the function of forming skin protection, increasing skin oxygen stability, promoting healing, improving skin elasticity, and preventing allergic eczema.
