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Ceramide NS belongs to a larger group of ceramides that are naturally occurring, long chains of lipids (fats) that are major components of skin’s outer layers.
In fact, skin’s composition is 50% ceramides.
Ceramide NS in particular is a sphingosine-based ceramide, which when included in skin care formulas, helps skin produce more of its own ceramides.
CAS: 2304-81-6
MF: C36H71NO3
MW: 565.95
Synonyms
D-ERYTHRO-SPHINGOSINE, N-STEAROYL-;D-ERYTHRO-SPHINGOSINE, N-STEAROYLDIHYDRO;C18 CERAMIDE;C18-D-ERYTHRO-CERAMIDE;C18 DIHYDROCERAMIDE;C18 DIHYDROSPHINGOSINE;18:0 CERAMIDE;(2S, 3R)-2-STEAROYLAMINOOCTADECANE-1,3-DIOL
Ceramide NS helps skin better retain its moisture, while simultaneously strengthening its barrier against external stimuli.
Ceramide NS is a N-acylsphingosine in which the ceramide N-acyl group is specified as octadecanoyl (stearoyl).
Ceramide NS has a role as a mouse metabolite.
Ceramide NS is a N-acylsphingosine and a N-stearoyl-sphingoid base.
Ceramide NS is functionally related to an octadecanoic acid.
Ceramide NS based derivatives are present in low levels during neurodegeneration.
Ceramide NS favors endoplasmic reticulum based stress and autophagy in glioma cells.
Low levels of Ceramide NS are implicated in human head and neck squamous cell carcinoma.
Ceramide NS may inhibit tumor progression.
In the rat Kainate injury model, Ceramide NS has an increasing content in the brain after injury.
Ceramide NS might facilitate the exocytosis of glutamate from damaged neurons, thus propagating neuronal injury.
Ceramide NS information for any accuracy or completeness is as per the existing knowledge furnished during the creation of the webpage.
The purchaser, user or importer of record is responsible for determining the accuracy of items at the time of ordering as Ceramide NS may change without notice as per current product specification.
Ceramide NS is solely intended for research purposes and is not approved for human consumption.
Ceramide NS Chemical Properties
Melting point: 99-101 °C
Alpha: [α]D20 -2～-5゜ (c=0.5, CHCl3)
Boiling point: 630.97°C (rough estimate)
Density: 0.9512 (rough estimate)
Refractive index: 1.6630 (estimate)
Storage temp.: −20°C
Solubility: Chloroform (Slightly, Heated, Sonicated), Methanol (Sparingly)
pka: 13.54±0.20(Predicted)
Form: White to off-white powder.
Color: White to Off-White
BRN: 1717539
Stability: Stable, but may be heat sensitive - store below 4 ℃.
Incompatible with strong oxidizing agents.
InChIKey: VODZWWMEJITOND-NXCSZAMKSA-N
Uses
The sphingolipid Ceramide NS is a potent inhibitor of the mitochondrial permeability transition pore.
