PRODUCTS

CETEARETH-12

CAS No.: 68439-49-6
EC No.: 500-212-8

CETEARETH-12

Ceteareth-12
INCI: Ceteareth-12
What is Ceteareth-12?
A polyethylene glycol ether of Cetearyl Alcohol

Use & Benefits:
Has the ability to form emulsions while reducing the surface tension. It also serves as a wetting agent. As an emulsifier it will consist of a hydrophilic head and hydrophobic tail. This allows it to reduce the surface tension by putting itself between the water and oil interface and stabilizing it.
Ceteareth-12 Is seen as safe in cosmetic products however after evaluation by the- CIR Cosmetic Ingredient Review it has been concluded that its should not be used on broken damaged skin as there have been reports that PEG ingredients when applied on damaged skin lead to kidney damage.

Ceteareth-12 is a synthetic compound that functions as an emulsifier and wetting agent in a variety of cosmetics and personal care products.

Origin
The group of ceteareth ingredients are synthetic compounds that are synthesized through a process known as ethoxylation, a chemical reaction in which ethylene oxide is added to a substrate. In regards to the ceteareth ingredients, there are two substrates: cetyl alcohol and stearyl alcohol, which are both naturally derived from coconut oil. The number associated with the ceteareth (i.e. ceteareth-12) indicates the average number of repeating ethylene oxide units in the molecule. There are a total of 32 different types of ceteareth ingredients.

Function
In cosmetics and personal care products, ceteareth-12 functions as an emulsifier and wetting agent. It can be found in skin care products, hair conditioners, suntan and indoor tanning products, and hair dyes, colors, and tints.

As an emulsifier, ceteareth-12 consists of a water-loving hydrophilic head and an oil-loving hydrophobic tail. The hydrophilic head is directed to the aqueous phase and the hydrophobic tail to the oil phase. This structure enables ceteareth-12 to reduce the surface tension by positioning itself at the oil/water or air/water interface, which has a stabilizing effect on the emulsion.

Ceteareth-12 has an HLB value of 13.5. HLB (Hydrophile-Lipophile Balance) is an empirical expression for the relationship of the hydrophilic and lipophilic groups of an emulsifier. An HLB greater than 10 means that the substance is soluble in water. High HLB emulsifiers such as ceteareth-12 give rise to oil-in-water emulsions.

Emulsifiers like ceteareth-12 are used in formulations that contain both water and oil components. Mixing water and oil together creates a dispersion of oil droplets in water (and vice versa). However, these two phases can separate if the product is left to settle. To address this problem, an emulsifier like ceteareth-12 can be added to the system to help the droplets remain dispersed. Emulsifiers improve the consistency of a product, which enables an even distribution of topical skin care benefits.

Ceteareth-12 also functions as a wetting agent. Wetting agents make products easier to spread and prevent the product from balling up on the surface of skin. This makes wetting agents useful ingredients for creams and lotions.

Safety
The safety of ceteareth-12 and the other ceteareth ingredients has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The Panel evaluated the scientific data and noted that the ceteareth ingredients should not be used on damaged skin. This conclusion was based on research that kidney damage resulted when polyethylene glycol (PEG) ingredients were applied to the damaged skin of burn patients. Since ceteareth ingredients are the polyethylene glycol ethers of cetearyl alcohol, the Panel recommends avoiding use of ceteareth ingredients on damaged skin. Overall, the CIR Expert Panel concluded that the ceteareth ingredients were safe as used in cosmetics and personal care products.

Despite the approval of ceteareth-12 by the CIR Expert Panel, there are concerns about the presence of ethylene oxide in this ingredient. This is because the process of ethoxylation may lead to contamination with 1,4-dioxane, a potentially dangerous by-product. 1,4-dioxane is a known animal carcinogen that penetrates readily into the skin. According to the National Toxicology Program, “1,4-dioxane is reasonably anticipated to be a human carcinogen.” It has also been linked with skin allergies. However, the potential presence of 1,4-dioxane can be controlled through purification steps to remove it before blending ceteareth-12 into cosmetic formulations.

Ceteareth-12
What Is It?
Ceteareths (Ceteareth-2, Ceteareth-3, Ceteareth-4, Ceteareth-5, Ceteareth-6, Ceteareth-7, Ceteareth-8, Ceteareth-9, Ceteareth-10, Ceteareth-11, Ceteareth-12, Ceteareth-13, Ceteareth-14, Ceteareth-15, Ceteareth-16, Ceteareth-17, Ceteareth-18, Ceteareth-20, Ceteareth-22, Ceteareth-23, Ceteareth-24, Ceteareth-25, Ceteareth-27, Ceteareth-28, Ceteareth-29, Ceteareth-30, Ceteareth-33, Ceteareth-34, Ceteareth-40, Ceteareth-50, Ceteareth-55, Ceteareth-60, Ceteareth-80, Ceteareth-100) are liquids to waxy solids. In cosmetics and personal care products, Ceteareth ingredients are used in skin care products, moisturizers, hair conditioners, suntan and indoor tanning products and hair dyes, colors, and tints.

Why is it used in cosmetics and personal care products?
Ceteareth-2 to -18, and Ceteareth-22, help to form emulsions by reducing the surface tension of the substances to be emulsified. Ceteareth-22 is also used to decrease the thickness of liquid cosmetics and personal care products. Ceteareth-20 to -40 help other ingredients to dissolve in a solvent in which they would not normally dissolve, and along with Ceteareths-50 to -100, clean the skin and hair by helping water to mix with oil and dirt so that these substances can be rinsed away.

Scientific Facts:
Ceteareths are made from cetearyl alcohol, which is a mixture of cetyl and stearyl alcohol, and ethylene oxide. The numerical value represents the average number of molecules of ethylene oxide added to generate the specific Ceteareth ingredient. For example, Ceteareth-2 is made by reacting Cetearyl Alcohol with an average of 2 molecules of ethylene oxide.

USE
Cosmetic
Ceteareths function in cosmetics as surfactants; Ceteareths -2 to -18 are used as emulsifying agents, Ceteareths -20 to -40 are used as solubilizing agents and cleansing agents (except for Ceteareth-22 which is used as an emulsifying agent and viscosity decreasing agent), and Ceteareths -50 to -100 are used as cleansing agents (Wenninger and McEwen 1997). The product formulation data submitted to the Food and Drug Administration (FDA) in January 1996 reported that these ingredients were collectively used in 680 cosmetic formulations (Table 1) (FDA 1996). There were no reported uses for many Ceteareths.The concentrations at which these ingredients are used are not known because concentration of use values are no longer reported to the FDA by the cosmetic industry (FDA 1992). However, data provided earlier to the FDA (1984) indicated that the highest concentration of use was 50%. Maximum concentrations reported for individual ceteareths include: Ceteareth-3 at 5%, Ceteareth-5 at 10%, Ceteareth-6 at 25%, Ceteareth-10 at 5%, and Ceteareth-12 at 50%, Ceteareth-15 at 5%, Ceteareth-17 at 5%, and Ceteareth-20 at 10% (FDA 1984). Recent information supplied from one company indicated use of Ceteareth-15 at 1.35% in facial cleansers, 2.0% in shampoos, 3.5% in cuticle conditioners, and 10% in hair dressing formulations (CTFA 1996).

APPEARANCE
White waxy solid
DESCRIPTION
In cosmetics and personal care products, Ceteareth ingredients are used in skin care products, moisturizers, hair conditioners, suntan and indoor tanning products and hair dyes, colors, and tints.
FUNCTION
Universal emulsifier to make o/w emulsions, compatible with all kinds of oils & active ingredients, very effective protective colloid that stabilizes all kinds of dispersed systems, can be combined with other emulsifiers, optimal use with gel-forming thickeners.
SYNONYMS
Ceteareth-12; T/N: Unimul B-1; T/N: Emulgin B1; Polyoxyethylene Cetearyl Ether; Ethoxylated Fatty Alcohol; Chemonic CT-12; Jeecol CS-12; Ceterayl Alcohol and Ceteareth-12; Polyoxyethylene Ether of Cetyl/Stearyl Alcohol
STORAGE
Keep container tightly closed. Store in dry, cool place, and protect from moisture.

Ceteareth-12
Medicines Ceteareth-12
Overview Uses Side-effects Precautions Interactions Contraindications
Overview
Ceteareth-12 is used for Dry skin and other conditions.
This salt may also be used for purposes not listed in this medication guide.
Detailed information related to Ceteareth-12's uses, side-effects, reviews, questions, interactions, and precautions is as follows:

Uses
Ceteareth-12 is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

Dry skin
Ceteareth-12 may also be used for purposes not listed here.

Learn more: Uses

Side-effects
Please consult your physician or pharmacist or product package for this information.

Precautions
Please consult your physician or pharmacist or product package for this information.

Interactions withCeteareth-12
Please consult your physician or pharmacist or product package for this information.

When not to useCeteareth-12
Please consult your physician or pharmacist or product package for this information.
Frequently asked Questions

IsCeteareth-12safe to use when pregnant?

Yes

IsCeteareth-12safe while breastfeeding?

Yes

Is it safe to drive or operate heavy machinery when using this product?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when usingCeteareth-12medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Ceteareth-12. Always consult with your doctor for recommendations specific to your body and health conditions.

Is this medicine or product addictive or habit forming?
Most medicines don't come with a potential for addiction or abuse. Usually, the government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
Can i stop using this product immediately or do I have to slowly wean off the use?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Other important Information onCeteareth-12
Missing a dose
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.

Overdosage ofCeteareth-12
Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Ceteareth-12, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
Please consult your physician or pharmacist or product package for more information.

Storage ofCeteareth-12
Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Ceteareth-12.

ExpiredCeteareth-12
Taking a single dose of expired Ceteareth-12 is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.

What are the uses of Ceteareth-12?
Ceteareth-12 is a medicine that is used for the treatment of Dry skin and other conditions.
The complete list of uses and indications for Ceteareth-12 is as follows:
Dry skin
Ceteareth-12 may also be used for purposes not listed here.
Reviews - Ceteareth-12 Uses
The following are the results of on-going survey on tabletwise.net for Ceteareth-12. These results only indicate the perceptions of the website users. Please base your medical decisions only on the advice of a doctor or a registered medical professional.

Is it safe to drive or use heavy machinery while using this product?
If you experience side effects such as drowsiness, dizziness, hypotension (low blood pressure) or headache while using Ceteare-12 / Ceteareth-12, it may not be safe to drive and / or use a construction machine. If the medication used causes drowsiness, dizziness or lowers your blood pressure, you should not drive. Pharmacists also advise patients not to drink alcohol with the medication, as alcohol intensifies side effects such as drowsiness. Please check for these effects on your body when using Ceteare-12 / Ceteareth-12. Always consult your doctor for advice specific to your body and health condition.
Is this drug or product addictive or addictive?
Many drugs are not marketed as addictive or abusive. Often ministries categorize drugs into controlled and non-addictive drugs. For example, this classification is H and X in India and II and V in the USA. Please check the box to make sure the drug belongs to such a special classification. Finally, do not try to self-medicate and increase your body's dependence without the advice of a doctor.

Can I stop using this product right away or do I get rid of it gradually?
Some drugs should be tapered or their use should not be stopped suddenly to avoid withdrawal effects. Consult your doctor for advice specific to your body, health condition, and other medications you can use.
Other important information on Ceteare-12 / Ceteareth-12
Forgetting to take a dose
If you forget to take a dose, use it immediately. If your next dose is too close to your time, stop taking the missed dose and stick to your dosing schedule. Do not take extra doses to treat the missed dose. If you regularly forget your doses, set an alarm or ask a family member to remind you. Please consult your doctor to make changes to your dosing schedule or to make up for missed doses if you have recently forgotten too many doses.

Overdose of Ceteare-12 / Ceteareth-12
Do not use more than prescribed dose. Consuming more of the drug will not improve your symptoms; on the contrary, it can cause poisoning or serious side effects. If you suspect that you or a relative has used an overdose of Ceteare-12 / Ceteareth-12, please visit your nearest hospital's emergency department. To help doctors, bring essential information such as a medicine box, bottle or label with you.
Do not give your medication to someone else, even if you know they have the same condition or they appear to be in similar situations. This can cause an overdose.
For more information, ask your pharmacist or check the package insert.

Storage of Ceteare-12 / Ceteareth-12
Store medicines at room temperature, away from heat and light. Do not freeze medicines unless it is written on the package insert. Keep medicines out of the reach of children and pets.
Do not pour medicines into the toilet or sink unless you are told to do so in the package insert. Drugs disposed in this way can pollute the nature. Please consult your pharmacist or doctor for more details on how to safely discard Ceteare-12 / Ceteareth-12.
Expired Ceteare-12 / Ceteareth-12
Taking a single dose of expired Ceteare-12 / Ceteareth-12 is likely to cause an adverse event. Consult your GP or pharmacist for appropriate advice or if you feel unwell. Expired medications will not be effective in treating the conditions on your prescription. To stay safe, it is very important not to use expired medications. If you have a chronic illness that requires constant medication, such as heart disease, seizures, and life-threatening allergies, it is even more important to stay in touch with your GP so that you can replace expired medications immediately.

Synonyms:
Ceteareth-12; CETEARETH-12; alcohols C16-18 ethoxylated (peg-12); brij CS12; C16-18 alcohols, ethoxylated (12 mol EO average molar ratio); hetoxol CS-12; peg-12 cetyl/stearyl ether; polyethylene glycol (12) cetyl/stearyl ether; polyoxyethylene (12) cetyl/stearyl alcohol ether; polyoxyethylene (12) cetyl/stearyl ether; Ceteareth-12; T/N: Unimul B-1; T/N: Emulgin B1; Polyoxyethylene Cetearyl Ether; Ethoxylated Fatty Alcohol; Chemonic CT-12; Jeecol CS-12; Ceterayl Alcohol and Ceteareth-12; Polyoxyethylene Ether of Cetyl/Stearyl Alcohol; Ceteareth-12; CETEARETH-12; Ceteareth-12; CETEARETH-12; Alcohols C16-18; ethoxylated; Ceteareth-12; Polyoxyethylene glycol ether of cetearyl alcohol; PEG-12 Cetearyl alcohol; Polyoxy Cetearyl Alcohol; alcohols C16-18 ethoxylated (peg-5); C16-18 alcohols, ethoxylated (5 mol EO average molar ratio); hetoxol CS-5; peg-5 cetyl/stearyl ether; polyethylene glycol (5) cetyl/stearyl ether; polyoxyethylene (5) cetyl/stearyl alcohol ether; polyoxyethylene (5) cetyl/stearyl ether; (C16-C18) Alkyl alcohol ethoxylate; Ceteareth-12; CETEARETH-12; Ceteareth-12; CETEARETH-12; (C16-C18) Fatty alcohol, ethylene oxide reaction product; (C16-C18)Alkyl alcohol ethoxylate; (C16-C18)Alkyl alcohol, ethoxylate; Alcohols, C16-18, ethoxylated; Aliphatic (C16-C18)alcohol, ethoxylated; Cetomacrogolum; Cetomacrogolum [INN-Latin]; Ethoxylated C16-18 alcohols; Ethoxylated fatty alcohols (C16-18); Ceteareth-12; CETEARETH-12; Polyoxyl 20 cetostearyl ether; SDA 19-065-00; UNII-0A92O98YL9; UNII-1R9DCZ5FOX; UNII-28VZG1E234; UNII-2AAD28764Q; UNII-2RJS3559D3; Ceteareth-12; CETEARETH-12; UNII-30JD5RDD6R; UNII-4W0XA5SY57; UNII-788S3R02S3; UNII-7V4MR24V5P; UNII-821KR82QH3; UNII-821RF3P03C; UNII-867H4YOZ8Z; UNII-8FA93U5T67; UNII-ATB309OMWW; UNII-DK070R75PW; Ceteareth-12; CETEARETH-12; UNII-FJV4K0Y9C0; UNII-GJS3UC254B; UNII-H11625KU5F; UNII-I15E27T29F; UNII-K040NYS337; UNII-K1063X2D39; UNII-K9YLE2L8PA; UNII-PL7TNO2NMW; Ceteareth-12; CETEARETH-12; UNII-R42C2O714B; UNII-YRC528SWUY; Alcohols, C16-18, ethoxylated; Alcohols, C16-18, ethoxylated; alpha-Alkyl-omega-hydroxypoly(oxypropylene) and/or poly(oxyethylene) polymers where the alkyl chain contains a minimum of six carbons, minimum number average molecular weight (in amu) 1,100; (C16-C18) Alkyl alcohol ethoxylate; Ceteareth-12; CETEARETH-12; AliphaticC16-18-alcohol,ethoxylated; C16-18-Alkylalcohol,ethoxylate; C16-18-Alkylalcoholethoxylate; cremophor¨a25; ethoxylatedfattyalcohols(c16-18); CETEARETH-2; CETEARETH-3; 68439-49-6; Alcohols, C16-18, ethoxylated; Ethoxylated C16-18 alcohols; Ceteareth-12; CETEARETH-12; Ceteareth-12; CETEARETH-12; alcohols C16-18 ethoxylated (peg-12); brij CS12; C16-18 alcohols, ethoxylated (12 mol EO average molar ratio); hetoxol CS-12; peg-12 cetyl/stearyl ether; polyethylene glycol (12) cetyl/stearyl ether; polyoxyethylene (12) cetyl/stearyl alcohol ether; polyoxyethylene (12) cetyl/stearyl ether; Ceteareth-12; T/N: Unimul B-1; T/N: Emulgin B1; Polyoxyethylene Cetearyl Ether; Ethoxylated Fatty Alcohol; Chemonic CT-12; Jeecol CS-12; Ceterayl Alcohol and Ceteareth-12; Polyoxyethylene Ether of Cetyl/Stearyl Alcohol; Ceteareth-12; CETEARETH-12; Ceteareth-12; CETEARETH-12; Alcohols C16-18; ethoxylated; Ceteareth-12; Polyoxyethylene glycol ether of cetearyl alcohol; PEG-12 Cetearyl alcohol; Polyoxy Cetearyl Alcohol; alcohols C16-18 ethoxylated (peg-5); C16-18 alcohols, ethoxylated (5 mol EO average molar ratio); hetoxol CS-5; peg-5 cetyl/stearyl ether; polyethylene glycol (5) cetyl/stearyl ether; polyoxyethylene (5) cetyl/stearyl alcohol ether; polyoxyethylene (5) cetyl/stearyl ether; (C16-C18) Alkyl alcohol ethoxylate; Ceteareth-12; CETEARETH-12; Ceteareth-12; CETEARETH-12; (C16-C18) Fatty alcohol, ethylene oxide reaction product; (C16-C18)Alkyl alcohol ethoxylate; (C16-C18)Alkyl alcohol, ethoxylate; Alcohols, C16-18, ethoxylated; Aliphatic (C16-C18)alcohol, ethoxylated; Cetomacrogolum; Cetomacrogolum [INN-Latin]; Ethoxylated C16-18 alcohols; Ethoxylated fatty alcohols (C16-18); Ceteareth-12; CETEARETH-12; Polyoxyl 20 cetostearyl ether; SDA 19-065-00; UNII-0A92O98YL9; UNII-1R9DCZ5FOX; UNII-28VZG1E234; UNII-2AAD28764Q; UNII-2RJS3559D3; Ceteareth-12; CETEARETH-12; UNII-30JD5RDD6R; UNII-4W0XA5SY57; UNII-788S3R02S3; UNII-7V4MR24V5P; UNII-821KR82QH3; UNII-821RF3P03C; UNII-867H4YOZ8Z; UNII-8FA93U5T67; UNII-ATB309OMWW; UNII-DK070R75PW; Ceteareth-12; CETEARETH-12; UNII-FJV4K0Y9C0; UNII-GJS3UC254B; UNII-H11625KU5F; UNII-I15E27T29F; UNII-K040NYS337; UNII-K1063X2D39; UNII-K9YLE2L8PA; UNII-PL7TNO2NMW; Ceteareth-12; CETEARETH-12; UNII-R42C2O714B; UNII-YRC528SWUY; Alcohols, C16-18, ethoxylated; Alcohols, C16-18, ethoxylated; alpha-Alkyl-omega-hydroxypoly(oxypropylene) and/or poly(oxyethylene) polymers where the alkyl chain contains a minimum of six carbons, minimum number average molecular weight (in amu) 1,100; (C16-C18) Alkyl alcohol ethoxylate; Ceteareth-12; CETEARETH-12; AliphaticC16-18-alcohol,ethoxylated; C16-18-Alkylalcohol,ethoxylate; C16-18-Alkylalcoholethoxylate; cremophor¨a25; ethoxylatedfattyalcohols(c16-18); CETEARETH-2; CETEARETH-3; 68439-49-6; Alcohols, C16-18, ethoxylated; Ethoxylated C16-18 alcohols; Ceteareth-12; CETEARETH-12