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CAS: 1119-97-7
Cetrimide, or alkyltrimethylammonium bromide, is an antiseptic which is a mixture of three quaternary ammonium compounds: tetradonium bromide (TTAB or MITMAB), cetrimonium bromide (CTAB), and laurtrimonium bromide (DTAB or LTAB).[1] It was first discovered and developed by ICI and introduced under the brand name Cetavlon.[2] It is used as a 1-3 % solution for cleaning roadside accident wounds.[3] ICI also introduced Savlon, which was a combination of cetrimide and chlorhexidine.
Cetrimide; Myristyltrimethylammonium bromide; Tetradonium bromide; Tetradecyltrimethylammonium bromide; MITMAB; N,N,N-trimethyltetradecan-1-aminium bromide; Tetradecyl Trimethyl Ammonium Bromide; TTAB; Myrtrimonium bromide; 8044-71-1; MFCD00011770; 1-Tetradecanaminium, N,N,N-trimethyl-, bromide; Trimethyltetradecylammonium bromide; trimethyl(tetradecyl)azanium;bromide; Trimethyl(tetradecyl)ammonium bromide; MTAB; UNII-8483H94W1E; trimethyl(tetradecyl)azanium bromide; CHEBI:3565; Mytab; Tetradecyltrimethylammonium (bromide)
8483H94W1E; 1-Tetradecanaminium, N,N,N-trimethyl-, bromide (1:1); Morpan T; Quaternium 13; DSSTox_CID_24367; trimethyltetradecylamine, bromide; Myrtrimonium bromide;Cetrimide BP;; MTAB; Microcide II; Morpan T;; Alkyltrimethylammonium bromide; CHEMBL113150; Myristyltrimethylammonium bromide, 99%; Tetradonio bromuro; Tetradonio bromuro [DCIT]; Tetradonium bromide [INN]; Tetradonii bromidum; CAS-1119-97-7; Ammonium, trimethyltetradecyl-, bromide; Bromuro de tetradonio; Trimethylmyristylammonium bromide; Bromure de tetradonium; Tetradonii bromidum [INN-Latin]; NCGC00166121-01; EINECS 214-291-9; Bromure de tetradonium [INN-French]; Bromuro de tetradonio [INN-Spanish]; N,N,N-Trimethyl-1-tetradecanaminium bromide; Myristyl trimethyl ammonium bromide; Cetrimide (JAN); N-Tetradecyltrimethylammonium bromide; ACMC-2099bx; (1-TETRADECYL)TRIMETHYLAMMONIUM BROMIDE; AMMONIUM, TETRADECYLTRIMETHYL-, BROMIDE; EC 214-291-9; SCHEMBL59988; Myristyltrimethylaminium bromide; DTXSID0044367; Tetradecyltrimethylammmonium bromide
HY-D0839; Trimethyltetradecyl Ammonium Bromide; Tox21_112327; Tox21_302067; ANW-16363; SBB060106; AKOS015907427; Tox21_112327_1; JC10043; MCULE-6081426921; VA10560; NCGC00166121-03; NCGC00255707-01; AK117184; AS-12887; DB-050409; B7620; CS-0014809; FT-0604996; ST51046346; (1-Tetradecyl)trimethylammonium bromide, 98%; C11279; D02164; T-6750; A802464; A839915; Q27106133; UNII-24QSH2NL8N component CXRFDZFCGOPDTD-UHFFFAOYSA-M
Alkyltrimethylammonium bromide is a surfactant and can be used to study the forces and stability of foam films produced from soluble cationic surfactants.
Alkyltrimethylammonium bromide has been used in a study to assess the adsorption of sugar surfactants at the air/water interface. It has also been used in a study to investigate dynamical features in cationic micelles.
What is Cetrimide? Cetrimide is an antiseptic agent, meaning it has various antibacterial, antifungal and other antimicrobial properties and can be applied to skin or mucous membranes to avoid or minimize the risk of infection. It is also a surfactant, meaning it functions as a detergent with cleaning properties.
Cetrimide is a quaternary ammonium disinfectant with properties typical of cationic surfactants. ... The combined detergent and antibacterial properties of cetrimide make it useful in cleansing dirty or infected wounds.
Cetrimide shampoo is relatively renowned for treating a wide range of scalp and hair issues. It is quite effective in clearing dandruff.
Cetrimide Cream is used to prevent infection and help with healing minor burns, wounds, cuts, grazes, abrasions and scalds. The Cetrimide Cream should be applied thinly and evenly over the affected area of the skin, and can be used for both children and adults.
Cetrimonium bromide ([(C16H33)N(CH3)3]Br; cetyltrimethylammonium bromide; hexadecyltrimethylammonium bromide; CTAB) is a quaternary ammonium surfactant. It is one of the components of the topical antiseptic cetrimide. ... As with most surfactants, CTAB forms micelles in aqueous solutions.
These agents are only slightly more tolerable than benzalkonium chloride. They, too, can irritate the eyes and give rise to allergies. Other preserving agents that you should avoid are: Cetrimide.
Cetrimide is an antiseptic and disinfectant first aid medicine used for cleaning wounds and treating minor burns, scalds, abrasions, and even seborrheic dermatitis. It is also used to cure insect bites, sunburn and pimples. Several topical creams, solutions, gels, and sprays are composed of Cetrimide, owing to its bactericidal properties. Additionally, Cetrimide is also used to sterilize surgical and medical instruments.
Uses of Cetrimide
• To cleanse the wounds
• Treatment of some skin disorders
• To treat minor burns and to prevent infection in cuts, small bruises, chapped hands, and nappy rash
Article service life
Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). This substance can be found in products with material based on: paper used for articles with intense direct dermal (skin) contact during normal use such as personal hygiene articles (e.g. nappies, feminine hygiene products, adult incontinence products, tissues, towels, toilet paper) and paper used for articles with intense direct dermal (skin) contact during normal use such as printed articles (e.g. newspapers, books, magazines, printed photographs).
Widespread uses by professional workers
This substance is used in the following products: laboratory chemicals and cosmetics and personal care products.
This substance is used in the following areas: health services and scientific research and development.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Formulation or re-packing
This substance is used in the following products: perfumes and fragrances, cosmetics and personal care products, laboratory chemicals, pharmaceuticals and water treatment chemicals.
Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites
This substance is used in the following products: cosmetics and personal care products.
This substance is used in the following areas: health services and scientific research and development.
Release to the environment of this substance can occur from industrial use: as processing aid.
Manufacture
Release to the environment of this substance can occur from industrial use: manufacturing of the substance.
Cetrimide is a quaternary ammonium antiseptic. Very dilute solutions of concentrations up to 1% are used for topical application. Adverse reactions after topical use have been reported earlier. In the index case a single application of pure cetrimide powder (100%) for pustules resulted in skin necrosis of the areas. This was due to the local irritant necrotic effect of cetrimide. No systemic side effects or toxicity was observed. This is because dermal absorption has been documented to be very low.
Indications and Dosage
Topical/Cutaneous
Dandruff, Scalp psoriasis, Seborrhoeic dermatitis
Adult: As 10% liq, in combination w/ undecenoic acid: Apply 1/2 to 1 teaspoonful 3 times during 1st wk, then twice wkly thereafter to the wetted scalp or hair. For application to other areas, apply sufficient amount as required and allow to remain in contact for 2 min.
Child: Same as adult dose.
Topical/Cutaneous
Superficial burns, Wound cleansing
Adult: As 0.5% cream: Apply directly to affected area. As 0.5% spray: Spray onto affected area from a distance of 2-4 inches bid or tid.
Child: Same as adult dose.
Incompatibility
Incompatible w/ anionic surfactants (e.g. soaps), bentonite, iodine, phenylmercuric nitrate, alkali hydroxides.
Contraindications
Hypersensitivity.
Adverse Reactions
Skin irritation and sensitisation. Rarely, burns (w/ concentrated soln).
Patient Counseling Information
Avoid application to the eyes, body cavities, and badly inflamed skin.
Drug Interactions
Enhanced bactericidal activity w/ preparations containing alcohol.
Action
Description: Cetrimide is a quaternary ammonium compound similar to cationic surfactants w/ bactericidal activity against gm+ve and some gm-ve bacteria. It dissociates in aqueous soln into a smaller inactive anion and a relatively large and complex cation that is responsible for the surface activity.
Cetrimide is an antiseptic agent, meaning it has various antibacterial, antifungal and other antimicrobial properties and can be applied to skin or mucous membranes to avoid or minimize the risk of infection. It is also a surfactant, meaning it functions as a detergent with cleaning properties.
As a pharmaceutical ingredient, it is used in various products mainly for topical use in sprays, gels and creams for a range of purposes, including cleaning burns and wounds, for disinfecting skin before injections or surgery, and for treating fungal infections or nappy rash.
Cetrimide product have proven efficacy against a broad spectrum of microorganisms (gram + and – & acid fast bacteria, yeast, moulds). They are effective through a wide pH range, are surface active/adhesive cationic agents and do not add unpleasant odour/colour to finished formulations.
Product Description [Visual description of the appearance of the product (eg colour etc)] eg :white and smooth cream Pharmacodynamics Cetrimide is a quaternary ammonium cationic disinfectant with bactericidal activity against grampositive and some gram-negative organisms. Cetrimide is relatively ineffective against viruses. Pharmacokinetics No information available Indication For the treatment of cuts, abrasions, burns and wounds. Recommended Dosage Apply directly to the affected part 2 to 3 times daily. Suitable for adults, children, and the elderly. Mode of Administration Topical cream Contraindications Contra-indicated in patients with known hypersensitivity to cetrimide.
Also known as Cetrimide, Cetrimoni Bromidum and Tetradecyl trimethyl ammonium bromide (TTAB), Strong Cetrimide Solution 40% BP Pharma with isopropyl alcohol (CAS No. 1119-97-7) consists of around 20% dodecyl trimethyl ammonium bromide and approcimately 80% trimethyl tetradecyl ammonium bromide, as well as approximately 7.5% volume by volume (v/v) isopropyl alcohol.
Packaging sizes:
Item number: 200kg drum
Cetrimide is a quaternary ammonium compound. Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action. Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death. This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Pharmacodynamic properties
Therapeutic Group: D08A – Antiseptics and Disinfectants
These solutions are intended for use as an external irrigating solution and as an effective disinfectant against Gram-positive and Gram negative bacteria. Chlorhexidine is more effective against Gram-positive bacteria than Gram- negative bacteria, including some Pseudomonas and Proteus species that may be less sensitive.
Pharmacokinetic properties
Given the method for use of these solutions, absorption through the skin is minimal, no significant levels being found in blood.
Preclinical safety data
Given its topical application, the potential toxicity of these products is very low.
Cetrimide Agar is a selective medium for the isolation and enumeration of Pseudomonas aeruginosa strains from biological samples of animal origin, pharmaceutical and cosmetic products. Its typical composition meets the combination of Pharmacopoeine prepared for the control of cosmetic products and NF EN ISO 22717 standards.
In Vivo Use Guide
Wound cleansing - Topical : Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area. Seborrhoeic dermatitis - Topical : Adult: Apply 10% shampoo solution onto the scalp.
Route of Administration: Topical
In Vitro Use Guide
Cetrimide, at 30 ug/ml inhibited growth of Aspergillus niger.
Cetrimide is a quaternary ammonium disinfectant with properties typical of cationic surfactants. Solutions of these surfactants have emulsifying and detergent properties and bactericidal activity against both Gram-positive and Gram-negative organisms but higher concentrations are necessary to kill the latter. The combined detergent and antibacterial properties of cetrimide make it useful in cleansing dirty or infected wounds.
Storage
If you have this product at home, it should be kept in the original container, in a safe place, out of reach of children. A locked cupboard at least one and a half metres above the ground is a good place to store medicines.
Chlorhexidine and Cetrimide Irrigation Solution should be stored below 25 degrees C and protected from light.
Do not leave Chlorhexidine and Cetrimide Irrigation Solution in the car on hot days.
Cetrimide is an antiseptic and disinfectant first aid medicine used for cleaning wounds and treating minor burns, scalds, abrasions, and even seborrheic dermatitis. It is also used to cure insect bite. Several topical creams, solutions, gels, and sprays are composed of Cetrimide, owing to its bactericidal properties
Uses of Cetrimide
What is it prescribed for?
• Seborrheic Dermatitis and Scalp psoriasis
This medicine is used along with other medicines to treat seborrheic dermatitis and scalp psoriasis, conditions characterized by symptoms such as red, scaly, itchy patches of skin on the scalp and persistent dandruff.
• Wound cleansing
This medicine is used for cleaning wounds and to prevent infection in cuts, small wounds, grazes, nappy rash, chapped hands, etc.
• Minor burns
This medicine is used to treat minor burns. It kills bacteria and promotes rapid healing of the burns.
Cetrimide Uses
Cetrimide is used to prevent infections.
How Cetrimide works
Cetrimide is an antiseptic which treats infection in the affected area and relieves irritation.
Cetrimide has antiseptic properties and is used for cleaning wounds and treating minor burns, abrasions and scalds, and for curing seborrhoeic dermatitis. This medication is also used for sterilizing surgical instruments.
This medicine contains properties including antibacterial, antifungal and other antimicrobial actions. Cetrimide can be applied to the skin or mucous membrane to minimize or avoid the risk of infection. It also works as a surfactant, it has cleansing properties and functions like a detergent. It is also used to disinfecting the skin before surgery or infections and for treating nappy rash or fungal infections.
This medication helps in treating the following problems in the human body:
• Scabies
• Psoriasis
• Burns
• Skin Disinfectant
IUPAC
(1-Tetradecyl)trimethylammonium bromide
Cetrimida
CETRIMIDE
Cetrimide
Cetrimide bp
Myristyltrimethylammonium bromide
N,N,N-trimethyltetradecan-1-aminium bromide
TETRADECYL-TRIMETHYL-AMMONIUMBROMIDE
Tetradecyltrimethylammonium Bromide
Tetradecyltrimethylammonium bromide
Tetradonium bromide
tetradonium bromide
Tetradonium bromide
tetradonium bromide
Tetradonium bromide
trimethyl(tetradecyl)azanium bromide
TRADE
Cetrimid
Cetrimide
N-Tetradecyl-N,N,N-trimethylammonium bromide
Polyflex PES-50
