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CAS Number: 1119-97-7
Molecular Formula: C17H38BrN
Molecular Weight: 336.40
Cetrimide consists of trimethyl tetradecyl ammonium bromide.
Cetrimide is an antiseptic and disinfectant first aid medicine used for cleaning wounds and treating minor burns, scalds, abrasions, and even seborrheic dermatitis.
Cetrimide is also used to cure insect bites, sunburn and pimples.
Several topical creams, solutions, gels, and sprays are composed of Cetrimide, owing to Cetrimide bactericidal properties.
Additionally, Cetrimide is also used to sterilize surgical and medical instruments
Cetrimide is a quaternary ammonium compound.
Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942).
Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action.
Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death.
This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing.
The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Cetrimide is a quaternary ammonium disinfectant, which is toxic to the endothelial and epithelial cells, and contact with the eyes should be avoided
Cetrimide is a mixture of tetradecyltrimethylammonium (mostly), dodecyltrimethylammonium, and hexadecyltrimethylammonium.
Cetrimide is an antiseptic agent, meaning Cetrimide has various antibacterial, antifungal and other antimicrobial properties and can be applied to skin or mucous membranes to avoid or minimize the risk of infection.
Cetrimide is also a surfactant, meaning Cetrimide functions as a detergent with cleaning properties.
As a pharmaceutical ingredient, Cetrimide is used in various products mainly for topical use in sprays, gels and creams for a range of purposes, including cleaning burns and wounds, for disinfecting skin before injections or surgery, and for treating fungal infections or nappy rash.
Cetrimide, or alkyltrimethylammonium bromide, is an antiseptic which is a mixture of three quaternary ammonium compounds: tetradonium bromide (TTAB or MITMAB), cetrimonium bromide (CTAB), and laurtrimonium bromide (DTAB or LTAB).
Cetrimide, a quaternary ammonium synthetic disinfectant has properties similar to that of cationic surfactants.
The surfactant solution of cetrimide has emulsifying and detergent properties.
Cetrimide also has bactericidal activity against both gram-negative and gram-positive organisms.
However, higher concentrations are essential to kill the gram-negative organisms.
The collective antibacterial and detergent properties of cetrimide make Cetrimide advantageous in cleansing infected wounds.
However, Cetrimide is comparatively ineffective against acid-fast bacteria, bacterial spores, fungi, and viruses.
In veterinary medicine, cetrimide is used as a topical antiseptic at concentrations of up to 2%.
Cetrimide is also used as an excipient in an injectable antibiotic formulation intended for use in cattle, sheep and pigs.
When used as excipient, the concentration of cetrimide in the formulation is around 0.25 mg/ml, resulting in a dose of approximately 0.01 mg/kg bw of cetrimide in the target species.
In aqueous solution, cetrimide dissociates to a biologically-active cation and an inactive anion.
Cetrimide is inactive towards bacterial spores, Cetrimide is effective against some viruses and has variable anti-fungal activity.
The cation is also responsible for the surfactant activity.
Cetrimide has a chemical structure similar to that of acetyl choline.
Cetrimide is a partial agonist and has depolarising muscle relaxant activities.
At toxic dose levels, paralysis of the respiratory muscles leads to dyspnoea and cyanosis.
Central nervous system depression may also occur.
Cetrimide has been shown to inhibit the intestinal absorption of substances such as D-glucose, methionine and sodium butyrate in several animal species.
Interference with glucose absorption has also been reported in humans.
The pharmacological mechanism is not known but is thought to involve action on receptor sites involved in the absorption process.
Cetrimide Market: Segmentation
The cetrimide market can be segmented based on application as:
Pharmaceutical
Surgical
Veterinary
Food & Beverages
Cetrimide, an antiseptic agent, retains various antifungal, antibacterial, and other antimicrobial properties.
Cetrimide, an active ingredient can be applied to mucous membranes or skin to minimize or avoid the risk of infection.
The compound is applied on the skin prior to injection.
Cetrimide drugs are effective against minor wounds, burns, cuts, and abrasions, keeping the skin moisturised.
Cetrimide is seldom used as an alcohol denaturant.
Cetrimide can be utilized on the scalp along with shampoo for treatment of a certain type of dermatitis to kill some bacteria, fungi, and viruses on the skin of the scalp.
This in turn can be utilized against dandruff, oily scalp, and psoriasis of scalp.
In the veterinary industry, the product is utilized as a germicide.
Cetrimide is a surfactant and hence has other cleaning applications in the food & beverages industry and other end-use industries.
The cetrimide market can be segmented based on form as:
Cream
Soap
Solution
Powder
Emulsion & ointment
Cetrimide creams are extensively utilized for wound healing and to treat skin related problems.
Cetrimide is also used in the form of a mild solution to prevent infection.
Cetrimide acts as a detergent and disinfectant when utilized in Cetrimide soaps for adults and children.
The powder form of cetrimide is employed in the animal health industry.
Cetrimide powder is also used in industries and hospitals for cleaning of surgical instruments, equipment, and surfaces.
Cetrimide in the form of ointment is utilized as a detergent and antiseptic for sterilization of surgical instruments, and for cleaning of wounds.
Cetrimide lotion can also be used against mycotic keratitis.
However, excessive usage of the product can lead to allergic reactions and can even prove fatal.
Precautions must be taken on the application of cetrimide cream as Cetrimide is incompatible with common soaps and other anionic surfactants.
The effect of the drug on pregnant and lactating women is still unknown.
Thus, Cetrimide is recommended not to use this drug in these conditions.
The common side effects of cetrimide such as skin irritation and redness, nausea, vomiting, and digestive problems are likely to hamper expansion of the market.
Cetrimide is an antiseptic that is applied to the skin or tissue to prevent wound infections and sepsis.
Cetrimide is used in ointments, creams, mouth rinses, plasters or powders. Cetrimide is also an effective preservative against bacteria and moulds in cosmetics.
Cetrimide is a bactericidal cationic surfactant used against Gram-positive bacteria.
Cetrimide is freely soluble in water.
Uses of Cetrimide:
Cetrimide is used as a 1-3 % solution for cleaning roadside accident wounds
Surfactants have been used in the food industry for many centuries.
Naturally occurring surfactants such as lecithin from egg yolk and various proteins from milk are used for the preparation of food products such as mayonnaise, salad creams, dressings, deserts, etc.
Later, polar lipids such as monoglycerides were introduced as emulsifiers for food products.
The growing food and beverage industry is anticipated to boost the demand for cetrimide during the forecast period.
Other Uses of Cetrimide:
To cleanse the wounds,
Treatment of some skin disorders,
To treat minor burns and to prevent infection in cuts, small bruises, chapped hands, and nappy rash.
Properties of Cetrimide:
An exceptional valuable antiseptic and detergent effect against bacteria, fungi and algae.
The effect is intensified in slightly alkaline medium and in warm solution.
An efficient deodorant due to Cetrimide bactericidal effect and Cetrimide ability to react with odiferous substances.
Cetrimide, due to Cetrimide high surface activity, is recommended for disinfection of both living tissues and inanimate surfaces.
Storage of Cetrimide:
Cetrimide should be stored in a well-closed container.
Identifiers of Cetrimide:
Appearance (Colour): White
Appearance (Form): Cyrstalline powder
Solubility (Turbidity) 5% aq. solution: Clear
Solubility (Colour) 5% aq. solution: Colourless
Assay (NT): min. 99%
Loss on drying: max. 1%
Sulphated Ash: max. 0.1%
Iron (Fe): max. 0.001%
Heavy Metals (Pb): max. 0.001%
Specifications of Cetrimide:
Molecular Formula: C17H38BrN
Molecular Weight: 336.40
Storage: Room Temperature
HSN Code: 29239000
IMDG Identification:
UN No.: 1759
IMCO Class No.: 8
Packing Group: III
Synonyms of Cetrimide:
1119-97-7
Cetrimide
Myristyltrimethylammonium bromide
Tetradonium bromide
Tetradecyltrimethylammonium bromide
MITMAB
N,N,N-trimethyltetradecan-1-aminium bromide
Tetradecyl Trimethyl Ammonium Bromide
TTAB
Myrtrimonium bromide
8044-71-1
Trimethyltetradecylammonium bromide
MFCD00011770
1-Tetradecanaminium, N,N,N-trimethyl-, bromide
trimethyl(tetradecyl)azanium;bromide
Trimethyl(tetradecyl)ammonium bromide
MTAB
UNII-8483H94W1E
trimethyl(tetradecyl)azanium bromide
CHEBI:3565
Mytab
Tetradecyltrimethylammonium (bromide)
8483H94W1E
1-Tetradecanaminium, N,N,N-trimethyl-, bromide (1:1)
Morpan T
Quaternium 13
DSSTox_CID_24367
DSSTox_RID_80175
DSSTox_GSID_44367
trimethyltetradecylamine, bromide
Myrtrimonium bromide;Cetrimide BP; MTAB; Microcide II; Morpan T;
Alkyltrimethylammonium bromide
CHEMBL113150
Myristyltrimethylammonium bromide, 99%
Tetradonio bromuro
Tetradonio bromuro [DCIT]
Tetradonium bromide [INN]
Tetradonii bromidum
CAS-1119-97-7
Ammonium, trimethyltetradecyl-, bromide
Bromuro de tetradonio
Trimethylmyristylammonium bromide
Bromure de tetradonium
Tetradonii bromidum [INN-Latin]
NCGC00166121-01
EINECS 214-291-9
Bromure de tetradonium [INN-French]
Bromuro de tetradonio [INN-Spanish]
N,N,N-Trimethyl-1-tetradecanaminium bromide
Myristyl trimethyl ammonium bromide
Cetrimide (JAN)
N-Tetradecyltrimethylammonium bromide
ACMC-2099bx
(1-TETRADECYL)TRIMETHYLAMMONIUM BROMIDE
AMMONIUM, TETRADECYLTRIMETHYL-, BROMIDE
EC 214-291-9
SCHEMBL59988
Myristyltrimethylaminium bromide
DTXSID0044367
Tetradecyltrimethylammmonium bromide
HY-D0839
Trimethyltetradecyl Ammonium Bromide
Tox21_112327
Tox21_302067
ANW-16363
SBB060106
AKOS015907427
Tox21_112327_1
JC10043
MCULE-6081426921
VA10560
NCGC00166121-03
NCGC00255707-01
AK117184
AS-12887
DB-050409
B7620
CS-0014809
FT-0604996
ST51046346
(1-Tetradecyl)trimethylammonium bromide, 98%
C11279
D02164
T-6750
A802464
A839915
Q27106133
UNII-24QSH2NL8N component CXRFDZFCGOPDTD-UHFFFAOYSA-M
C14QAC
Catrimox-14
myristyl trimethylammonium bromide
TDTMA cpd
tetradecyl-trimethylammonium bromide
tetradecyltrimethylammonium
tetradecyltrimethylammonium bromide
tetradecyltrimethylammonium chloride
tetradecyltrimethylammonium hydroxide
tetradecyltrimethylammonium iodide
tetradecyltrimethylammonium mesylate
tetradecyltrimethylammonium oxalate
trimethyl tetradecyl ammonium bromide
trimethyltetradecylammonium bromide
