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Cetrimonium chloride = cetyltrimethylammonium chloride = CTAC
CAS number: 112-02-7
Chemical formula: C19H42ClN
EC / List number: 203-928-6
In cosmetics and personal care products, all three ingredients CTAC is used as antistatic agent.
CTAC Chloride and Cetrimonium Bromide are also used as cosmetic biocides and surfactants (cleansing, emulsifying, and suspending agents) and Steartrimonium Chloride is used as a surfactant.
Cetrimonium Chloride is an ingredient used in hair care and skincare products to reduce static and improve the safety and longevity of products.
Centrimonium chloride is a quaternary ammonium salt and is the same class of ingredients as cetrimonium bromide and steartrimonium chloride.
Centrimonium chloride is used mainly in hair care products such as shampoos but is also used in some cleansing body products as well.
CTAC chloride helps to inhibit static electricity that is built up between the hair strands, causing flyaways and frizz.
Cetrimonium Chloride also acts as a mild preservative.
Cetrimonium chloride is a quaternary ammonium salt, Cetrimonium Chlorides concentration in cosmetics is highly controlled by state regulations.
Cetrimonium Chloride is very similar to another conditioning ingredient called behentrimonium chloride.
Indeed, only the number of carbon atoms they contain differs, which slightly changes the feel of the conditioner on the hair when you apply Cetrimonium Chloride, cetrimonium chloride being very light, almost imperceptible when the hair is still wet, whereas, with behentrimonium, you can really feel the product.
Cetrimonium chloride is an anti-static ingredient that helps condition the hair.
Not only conditioning Cetrimonium Chloride also acts as a preservative by preventing the growth of bacteria in liquid solutions, and therefore help products to last longer.
Cetrimonium Chloride is also a surfactant: partly water-soluble and partly oil-soluble, Cetrimonium Chloride allows oil and water to become dispersed and give products a good consistency and a gentle cleansing foam.
Cetrimonium Chloride is a cationic quaternary ammonium salt that is used as a light hair conditioning agent.
CTAC use in conditioners and cream rinses improves both wet and dry combing and reduces static electricity.
As Cetrimonium Chloride is cationic, Cetrimonium Chloride is used primarily in conditioning products rather than in shampoos.
Cetrimonium Chloride is a 29 - 30% active solution of cetyl trimethyl ammonium chloride.
CAS Number: 112-02-7
Molecular Formula: C₁₉H₄₂N•Cl
Appearance: White to Pale Beige Solid
Melting Point: >229°C (dec.)
Molecular Weight: 284.543545
Storage: Room Temperature
Solubility: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
Category: Building Blocks; Catalyst;
Cetrimonium Chloride Applications: Cetrimonium Chloride, is a topical antiseptic.
Cetrimonium Chloride is also used in hair conditioners and shampoos, as a conditioning agent
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
Cetrimonium Chloride also finds use as a topical antiseptic and a preservative due to Cetrimonium Chlorides ability to inhibit the growth of microorganisms.
Cetrimonium Chloride is used as a surfactant (for cleansing and emulsifying) and a suspending agent.
While we've seen Cetrimonium Chloride formulated at 2% in leave on hair products, Cetrimonium Chloride is Safe as Used with Qualifications, that being Cetrimonium Chlorides use at up to 0.25% in leave on products.
This is due to the potential for Cetrimonium Chloride to be a skin irritant at higher amounts.
Cetrimonium chloride, or cetyltrimethylammonium chloride (CTAC), is a topical antiseptic and surfactant.
Long-chain quaternary ammonium surfactants, such as cetyltrimethylammonium chloride (CTAC), are generally combined with long-chain fatty alcohols, such as stearyl alcohols, in formulations of hair conditioners and shampoos.
The cationic surfactant concentration in conditioners is generally of the order of 1–2% and the alcohol concentrations are usually equal to or greater than those of the cationic surfactants.
The ternary system, surfactant/fatty alcohol/water, leads to a lamellar structure forming a percolated network giving rise to a gel.
Cetrimonium Chloride usages:
When Cetrimonium Chloride used as a Conditioning agent, Cetrimonium Chloride does not have any usage restrictions.
However when Cetrimonium Chloride used in a formulation as a preservative Cetrimonium Chloride is restricted to 0.1% under EU law.
Typical Uses of Cetrimonium Chloride
-Hair Conditioner
-Skin Conditioning Creams
-Shampoo
-Antiseptic formulations
-Part of a Preservative System
We would not recommend using Cetrimonium Chloride in leave-on formulations as it can be a skin irritant when left on the skin, it is suited to rinse-off formulations.
Is cetrimonium chloride a silicone? If not, what is it and what is its purpose in my hair-care product?
When this ingredient appears on a label with amodimethicone and trideceth-12, does this mean the amodimethicone is now water soluble?
This question comes up frequently, because something about that name seems similar to some of the names seen for different silicones.
The actual chemical name of Cetrimonium Chloride is cetyl (hexadecyl, more properly) trimethyl-ammonium chloride (CTAC).
Cetrimonium Chloride is definitely not a silicone or silicone derivative.
Cetrimonium Chloride is a quaternized ammonium molecule (frequently abbreviated as quat), and Cetrimonium Chloride has a single positive charge at the head group.
CTAC belongs to a family of molecules known as cationic surfactants, which can be used as emulsifying or conditioning agents.
Some other commonly used molecules in this group are cetrimonium bromide (CTAB), behentrimonium chloride, and quaternium-15.
Cetrimonium Chloride is a clear water-like liquid and is mainly used in the hair care products to prevent the build-up of static charge over the hair shaft.
Cetrimonium Chloride is used as an emulsifier that helps in mixing water and dirt and is useful in getting rid of accumulated dirt, grime.
Cetrimonium Chloride prohibits the multiplication of microorganisms in the product formulations.
Commonly Cetrimonium Chloride is used between 0.1% and 2% as a conditioning agent in Conditioners.
What Is Cetrimonium Chloride?
Cetrimonium Chloride, Cetrimonium Bromide and Steartrimonium Chloride are quaternary ammonium salts.
In cosmetics and personal care products, Cetrimonium Chloride is used in the formulation of hair conditioners, hair dyes and colors, other hair care products, and in some skin care products.
Why is Cetrimonium Chloride used in cosmetics and personal care products?
All three ingredients prevent or inhibit the buildup of static electricity.
Cetrimonium Chloride and Cetrimonium Bromide also help to cleanse the skin or to prevent odor by destroying or inhibiting the growth of microorganisms and by helping water to mix with oil and dirt so that they can be rinsed away.
Cetrimonium Chloride also help to form emulsions by reducing the surface tension of the substances to be emulsified and help to distribute or to suspend an insoluble solid in a liquid.
Scientific Facts about Cetrimonium Chloride:
Cetrimonium Chloride and Bromide, and Steartrimonium Chloride, carry a positive charge that attracts them to the slightly negatively charged skin and hair proteins, accounting for their use as antistatics.
In addition, Cetrimonium Bromide has the ability to disrupt the surface membranes of microorganisms and has been used in antiseptics.
Cetrimonium chloride is a quaternary ammonium used in cosmetics for its antistatic properties.
As Cetrimonium Chloride is a cationic surfactant, it allows water and oil to be dispersed, and thus to promote soft and pleasant consistencies.
Cetrimonium Chloride is often used in hair care instead of (or sometimes with) silicones.
Cetrimonium Chloride can also be used as a preservative.
Cetrimonium Chloride is a quaternary cationic conditioner.
Cetrimonium Chloride has anti-static, anti-frizz & detangling properties.
Cetrimonium Chloride can be used with non-ionic and cationic surfactants and most polar solvents.
Cetrimonium Chloride is an ingredient for multiple hair care applications.
Preservatives, like centrimonium chloride help to reduce the likelihood of contamination.
This ensures that your product is safe to use for longer.
Without preservatives your product would only be safe to use for a few days to a few weeks depending on the type of product and whether it is a water or oil-base.
Definitely not long enough to get through your favorite cream.
Anti-static
Centrimonium chloride is an anti-statc ingredient which means it reduces flyawys and frizz caused by static electricity.
As the hair strands rub against each other or a fabric such as a pillowcase or hat, they cause static electricity.
You’re probably familiar with static electricity through science class where your teacher rubbed a balloon against some long-locked student’s hair and made it stand up.
This effect is what tends to cause flyaways and frizz.
Anti-static ingredients, like centrimonium chloride help to reduce this, smoothing the hair and often adding shine.
Centrimonium chloride is a positively charged molecule which means it sttratc the slightly negatively charged skin and hair proteins.
Is Cetrimonium Chloride Safe?
Centrimonium chloride has been evaluated by the Cosmetic Ingredient Review Expert Panel, a group that is responsible for independently evaluating the safety and efficacy of skincare and cosmetic ingredients.
The Expert Panel reviewed the available scientific data and concluded that centrimonium chloride is safe for use in rinse off products and leave on products up to 0.25%.
Chemical name: Cetrimonium Chloride
Chemical family: Quaternary ammonium salts
Industries: Personal Care (Hair Care)
Description: Cationic surfactant with anti-static and conditioning effect.
As emulsifier, Cetrimonium Chloride provides non-irritating emulsions with a unique sensory profile, velvety textures and boosting moisturization.
Cetrimonium Chloride properties
-Conditioner
-Thickener
-Antistatic
Rinse off products are products that are designed to be rinsed off shortly after application, think cleansers, soaps etc.
Leave on products are products that are designed to be left on for extended periods of time such as moisturizers.
These two product types often have different safety recommendations as the time they spend on the skin is so different.
This is why centrimonium chloride has different safety recommendations for these product types.
Use: Non cumulative effect.
Cetrimonium Chloride contains only water as solvent.
Hair rinse application.
Use % : between 1 - 5 % as active.
Hair becomes: smooth, shining, with better anti-static, easily combed
Thickener for acid cleaners.
Is Cetrimonium Chloride A Silicone?
Centrimonium is not a silicone ingredient.
Despite Cetrimonium Chlorides use in many products used for curly or frizzy hair Cetrimonium Chloride works in a different way to silicones.
Silicones coat the hair strand and prevent the buildup of static electricity where centrimonium chloride helps to neutralise static.
Is Centrimonium Chloride Vegan?
Yes, centrimonium chloride is considered a vegan ingredient.
However, Cetrimonium Chloride is always best to check that all the other ingredients in your product are also vegan if you are looking for a vegan product.
This also includes the company’s animal testing policy as well.
Cetrimonium Chloride contains only water as solvent.
General cationic surfactant, Hair conditioner base.
Cetrimonium Chloride be easy to comb, to finish a soften hair.
Cetrimonium Chloride not contain IPA, favorable for low odor products.
Cetrimonium chloride is mainly present in many commercial shampoos to prevent the static and buildup in the hair.
But if we consider Cetrimonium Chlorides effects on the hair, it can be dangerous and hazardous to your hair.
If used for a longer time, Cetrimonium Chloride can affect the color of your hair and also make them dry and dehydrated.
This happens because Cetrimonium Chloride potentially strips off the protective layer of your hair and makes it vulnerable to damage.
What is Cetrimonium Chloride?
Cetrimonium Chloride is a positively charged surfactant which can also be used as a conditioning agent.
What does Cetrimonium Chloride do for the hair?
CTAC's typically found in conditioners and/or leave-in conditioners.
Cetrimonium Chloride gently cleanses the hair while providing conditioning/detangling abilities, softness and making the hair smoother.
Though Cetrimonium Chloride can cleanse the hair, it does not remove product build up.
Cetrimonium Chloride also stops the build up of static electricity in hair, which in turn makes the hair smoother and easy to manage.
Cetrimonium Chloride APPEARANCE
Clear to pale yellow liquid
Cetrimonium Chloride DESCRIPTION
Cetrimonium Chloride, is a topical antiseptic.
Cetrimonium Chloride is also used in hair conditioners and shampoos, as a conditioning agent
Cetrimonium Chloride FUNCTION
Cetrimonium chloride is used as a detangler in hair care products.
Cetrimonium Chloride is added to most shampoos and conditioning agents since it can attract negatively charged hair proteins making hair smoother and more manageable thereby eliminating tangles and knots.
Cetrimonium chloride and its counterparts are also perfect for destroying odor in packaged products.
SYNONYMS
Incroquat CTC 30, Cetyl Trimethylammonium Chloride Salt Aqueous, Uniquat C30; Cetyltrimethylammonium Chloride; Cetyl Trimethyl Ammonium Chloride; Hexadecyltrimethylammonium Chloride
Cetrimonium Chloride STORAGE
Store Cetrimonium Chloride in closed original container at temperatures between 15øC and 25øC.
CAS Number: 112-02-7
CHEBI: 53581
ChemSpider: 7862
ECHA InfoCard: 100.003.571
PubChem CID: 8154
UNII: UC9PE95IBP check
CompTox Dashboard (EPA): DTXSID6026901
Cetrimonium Chloride compound has been depositing itself into each of your hair strands for years, resulting in a shiny, smooth ‘do.
But don’t worry, you haven’t exposed yourself to a health emergency.
Recent data suggests Cetrimonium Chloride’s perfectly safe in its proper uses and concentrations.
Cetrimonium chloride, also known as cetyltrimethylammonium chloride (CTAC) and N,N,N,-trimethyl, is a topical surfactant found in personal care products, particularly for hair.
As a chloride, you’ll find this alcohol-like ingredient in cosmetic crafting shops in the form of a clear liquid.
Chemically, Cetrimonium Chloride is a cationic long-chain quaternary ammonium surfactant that is often combined with long-chain fatty alcohols, like stearic alcohol, by formulators of hair conditioner and shampoo.
Practically, cetrimonium chloride smooths strands of hair to control frizz, fly-aways, and rambunctious curls.
In fact, Cetrimonium Chloride is so effective at detangling wind-whipped hair that you’ve almost certainly used it.
Cetrimonium Chloride’s as common in hair conditioning agents as soap is to shampoo.
Cetrimonium chloride is also an emulsifier, meaning Cetrimonium Chloride helps mix two or more solutions that would normally separate (i.e. oil and water).
Because shampoo and conditioner can be made with natural plant oils but is meant to be water-soluble, Cetrimonium Chloride helps create a perfect texture, look, and lather.
INCI: Cetrimonium chloride
Appearance: Clear water-like liquid.
Usage rate:
Up to 0.25% in leave-on products as per the CIR.
The CIR states cetrimonium chloride is “safe for use in rinse-off products”; I’ve found recommended usage rates for rinse-off products starting at 0.25% topping out between 4–10%.
Texture: Thin liquid that foams when agitated.
Scent: Alcohol-like
pH: 3–9 with solutions 2%–10%.
Charge: Cationic (positive)
Solubility: Water
Why do we use Cetrimonium Chloride in formulations?
Cetrimonium chloride is an excellent conditioning agent for hair, with anti-static, anti-frizz, and detangling properties.
Cetrimonium Chloride also functions as an emulsifier and surfactant, helping boost rinse-off and stabilize emulsions.
Cetrimonium Chloride is one of the most researched and reviewed ingredients.
BENEFITS OF CETRIMONIUM CHLORIDE: The emulsifying Cetrimonium Chloride has the following benefits:
Exhibits anti-microbial property:
Cetrimonium Chloride inhibits the growth of micro-organisms and prolongs the shelf life of formulations.
Cetrimonium Chloride acts as an antistatic agent: Cetrimonium Chloride neutralize the electrons generated through static electricity.
Cetrimonium Chloride helps in the easy combing of wet hair and prevents the formation of knots in the hair.
Cetrimonium Chloride makes hair more manageable.
Acts as an emulsifier: Cetrimonium Chloride is able to keep oil and water mixed and prevents them from dispersing into their separate constituents which helps in cleansing the accumulated dirt, grime off the hair.
Acts as a surfactant: Cetrimonium Chloride is an effective surfactant as it reduces the surface tension and evenly distributes the product when it is applied.
CAS Number 112-02-7
Weight Average: 320.0
Monoisotopic: 319.3005781
Chemical Formula C19H42ClN
InChI Key WOWHHFRSBJGXCM-UHFFFAOYSA-M
InChI InChI=1S/C19H42N.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;/h5-19H2,1-4H3;1H/q+1;/p-1
IUPAC Name hexadecyltrimethylazanium chloride
SMILES [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C
Cetrimonium Chloride Storage & Shelf Life: Stored somewhere cool, dark, and dry, Cetrimonium Chloride has a three year shelf life.
Cetrimonium Chloride Description: Liquid quaternary cationic conditioner.
Colorless to light yellow liquid.
Alcohol-like odor.
Soluble in water.
pH (2% Solution): 3.5-6.0.
Activity: 29% active substances.
CAS: 112-02-7, 7732-18-5
INCI Name: Cetrimonium chloride, water
Cetrimonium Chloride Benefits:
Excellent conditioner with anti-static, anti-frizz & detangling properties
Has good emulsifying properties able to mix oil and water
Especially effective for softening coarse hair
Has mild anti-microbial properties
Excellent compatibility with non-ionic and cationic surfactants and most polar solvents
Use: Use level 0.5-4%, add to water phase.
For external use only.
One of the secrets of the industry is ingredients are often sold in blends.
That makes them easier to incorporate into the formulation.
This decreases time to make, which translates to money.
In our case, there is a blend of amodimethicone, cetrimonium chloride, and trideceth-12 used.
By doing this, Cetrimonium Chloride makes the amodimethicone easy to incorporate and the overall product more stable.
We probably wouldn’t have included on its own because we already have some good products in the formula.
Sometimes having different types of molecules for conditioning help the whole formula.
Detergents were the original preservative agents in the industry and include such well-known examples as benzalkonium chloride (BAK) and cetrimonium chloride.
Cetrimonium Chloride are known to cause bacterial cell membrane instability by disrupting the lipid component.
This leads to extrusion of the intracellular content and cell death.
Cetrimonium Chloride mainly used to prevent static and build-up in the hair.
Cetrimonium Chloride can also cleanse the skin/hair and eliminate odor by preventing the growth of microorganisms, and by enabling water to mix with dirt and rinse it away.
In addition, by reducing the surface tension of other ingredients and working to distribute and suspend insoluble solids in liquid, Cetrimonium Chloride helps form emulsions.
Cetrimonium Chloride is mainly used in hair products such as hair dye, shampoo/conditioner, styling gel, mousse, detangler, dandruff treatment and relaxer.
Cetrimonium Chloride helps prevent or inhibit the build-up of static electricity and helps to cleanse the skin or to prevent odor by destroying or inhibiting the growth of microorganisms and by helping water to mix with oil and dirt so that they can be rinsed away.
Cetrimonium Chloride also helps to form emulsions by reducing the surface tension of the substances to be emulsified and helps to distribute or to suspend an insoluble solid in a liquid.
Recommended inclusion level between 0.5 and 4% depending on the type of formula and use Cetrimonium Chloride's being put to.
Add to water phase if applicable.
For external use only.
Cetrimonium Chloride applications: Hair conditioners, hair shampoos, hair rinses, anti-frizz products.
Cetrimonium Chloride is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Cetrimonium Chloride is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Cetrimonium Chloride consumer Uses
Cetrimonium Chloride is used in the following products: washing & cleaning products, cosmetics and personal care products, air care products, polishes and waxes, perfumes and fragrances and biocides (e.g. disinfectants, pest control products).
Other release to the environment of Cetrimonium Chloride is likely to occur from: indoor use as processing aid.
Article service life
Other release to the environment of Cetrimonium Chloride is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Cetrimonium Chloride can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
Cetrimonium Chloride can be found in products with material based on: wood (e.g. floors, furniture, toys) and fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys).
Cetrimonium Chloride uses by professional workers
Cetrimonium Chloride is used in the following products: coating products, adhesives and sealants, fillers, putties, plasters, modelling clay, polymers and washing & cleaning products.
Cetrimonium Chloride is used in the following areas: building & construction work.
Other release to the environment of Cetrimonium Chloride is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Cetrimonium Chloride formulation or re-packing
Cetrimonium Chloride is used in the following products: cosmetics and personal care products, polymers, textile treatment products and dyes and washing & cleaning products.
Release to the environment of Cetrimonium Chloride can occur from industrial use: formulation of mixtures.
Cetrimonium Chloride uses at industrial sites
Cetrimonium Chloride is used in the following products: textile treatment products and dyes, pH regulators and water treatment products, washing & cleaning products, biocides (e.g. disinfectants, pest control products), metal surface treatment products, lubricants and greases and polymers.
Cetrimonium Chloride is used in the following areas: building & construction work and offshore mining.
Cetrimonium Chloride is used for the manufacture of: textile, leather or fur and mineral products (e.g. plasters, cement).
Release to the environment of Cetrimonium Chloride can occur from industrial use: in the production of articles, in processing aids at industrial sites and as processing aid.
Cetrimonium Chloride manufacture
Release to the environment of Cetrimonium Chloride can occur from industrial use: manufacturing of the substance.
The analysts and writers of the report concluded that the ingredient is “safe for use in rinse-off products and safe for use at concentrations of up to 0.25% in leave-on products.”
Finally, Cetrimonium Chloride’s on the list of accepted preservatives created by the European
At this point, you might be wondering, “So is the amount of cetrimonium chloride in my shampoo safe?”
What Is Cetrimonium chloride?
Cetrimonium chloride is a waxy solid.
What Does Cetrimonium chloride Do in Our products?
Cetrimonium chloride is a preservative and antistatic agent.
Cetrimonium Chloride can also be used as an antiseptic and disinfectant.
Cetrimonium Chloride is often found in hair conditioner, shampoo, styling products, hairspray, and other personal care products.
Cetrimonium Chloride is a quaternary ammonium compound with the following functions.
Antistatic Agent, Cosmetic Biocide, Emulsifying agent and Surfactant, Antimicrobial, Preservative.
INCI: Cetrimonium Chloride.
Cetrimonium Chloride is soluble in water.
Cetrimonium Chloride is the mainstay of hair conditioners.
Cetrimonium Chloride works in a very simple way.
Damaged hair has an electric charge, this is why you get flyway hair.
The hair shafts are literally repelling one another.
Conditioners work by neutralising that charge and replacing it with a lubricious layer of loveliness.
Let’s have a look at the details.
The very top layer of the hair shaft is protected by tiny plates.
These are hard and shiny and have a very slight positive charge.
When these plates are in good condition, your hair is in good condition.
Cetrimonium Chloride shines and the very slight surface charge means that hair shafts repel one another so the hairs don’t stick to each other and glide smoothly when combed.
This is what most of us want from our hair most of the time.
When the plates get damaged or even lost altogether, the situation is very different.
The hair below the plates has a dull appearance.
And even worse, Cetrimonium Chloride has a strong negative charge.
The very slight mutual repulsion that is beneficial in hair that is in good condition becomes an extreme force pushing the hair shafts away.
This creates the unmanageable fly away hair that in some extreme cases even sticks up.
So your hair is now not smooth, shiny and able to glide along the comb.
Cetrimonium Chloride is dull, fractious and gives every indication of having a mind of its own.
And that mind is a malicious one.
Hexadecyltrimethylammonium Chloride, also known as Cetrimonium bromide, is an amine based cationic quaternary surfactant used as an antiseptic agent against fungi and bacteria, and as a buffer solution for the extraction of DNA.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Synonyms
Alkyltriethylammonium chloride
Cetyl trimethyl ammonium chloride
Cetyltrimethylammonium chloride
CTAC
Hexadecyltrimethylammonium chloride
N-hexadecyltrimethylammonium chloride
N,N,N-trimethyl-1-hexadecanaminium chloride
Palmityltrimethylammonium chloride
Trimethylhexadecylammonium chloride
Cetrimonium Chloride is a mono-alkyl quaternary.
Cetrimonium Chloride, C-16 based conditioning active provides a good balance of hair conditioning with ease of use in formulation.
Cetrimonium Chloride should be used where light to moderate conditioning and detangling performance is desired.
Cetrimonium Chloride is cold water soluble, shows good wet, dry combability and clean rinse-ability.
Cetrimonium Chloride should be utilized in the following areas: leave-in and rinse-off conditioners, conditioning mousses, combing creams and hair masks.
INCI:
Cetrimonium Chloride
Claims:
Antistatic Agent
Cosmetic Biocides
Deodorant Agents
Surfactants - Emulsifying Agents
Applications/Recommended for:
Hair care (Shampoos, Conditioners & Styling) > Conditioners & Detangling products
Repeated insult patch tests of concentrations of up to 0.25% Cetrimonium Chloride produced no sensitization reactions, although irritation was observed during induction.
Cetrimonium Bromide caused developmental effects following intraperitoneal injection of 35 or 10 mg/kg.
Dermal exposure to 2% Cetrimonium Chloride produced no evidence of developmental effects; nor did 2.5% Steartrimonium Chloride.
All mutagenesis assays used were negative.
Cetrimonium Bromide, Cetrimonium Chloride, and Steartrimonium Chloride are listed as alkyl (C12-C22) trimethyl ammonium bromide and chloride in the Cosmetics Regulation of the European Union.
These ingredients may be used as preservatives at a maximum concentration of 0.1%.
INCI Name: Cetrimonium Chloride
Other names: Hexadecyl Trimethyl Ammonium Chloride
Palmityl Trimethyl Ammonium Chloride
1-Hexadecanaminium, N,N,N-trimethyl-, chloride
CAS: 112-02-7
EC No.: 203-928-6
Molecular formula: C16H33(CH3)3NCl
Appearance: White powder
Purity: ≥99%
Packing: 20kg/ cardboard drum
Storage: Avoid using with the anionic surfactant in the same bath.
Cetrimonium Chloride should not be stored for high than 100°C for a long time and heated at 120°C or higher for a long time.
Cetrimonium Chloride Functions:
-Antimicrobial,
-Antistatic,
-Emulsifying,
-Preservative,
-Surfactant
Cetrimonium Chloride Properties:
Hexadecyl Trimethyl Ammonium Chloride is soluble in isopropanol, soluble in water, generates a lot of foam when shaken, and has good compatibility with cationic, nonionic and amphoteric surfactants.
Hexadecyl Trimethyl Ammonium Chloride has excellent penetration, softening, emulsification, antistatic, biodegradability and bactericidal properties.
Hexadecyl Trimethyl Ammonium Chloride has good chemical stability, heat resistance, light resistance, pressure resistance, strong acid and alkali resistance.
Cetrimonium Chloride is an excellent conditioner with anti-static, anti-frizz & detangling properties, has emulsifying properties able to mix oil and water, especially effective for softening coarse hair, antimicrobial properties.
Cetrimonium Chloride Applications: Hair conditioners, hair shampoos, hair rinses, anti-frizz products.
Cetrimonium chloride, or cetyltrimethylammonium chloride (CTAC), is commonly used in hair conditioners and shampoos, as a conditioning agent.
Cetrimonium Chloride is a cationic quaternary ammonium salt that is used as a light hair conditioning agent.
Cetrimonium Chlorides use in conditioners and cream rinses improves both wet and dry combing and reduces static electricity.
As Cetrimonium Chloride is cationic, Cetrimonium Chloride is used primarily in conditioning products rather than in shampoos.
Cetrimonium Chloride or CTAC is an emulsifier, surfactant and quaternary ammonium salt that is used in hair conditioners, shampoo, dyes, and other personal hair care products.
By appearance, Cetrimonium Chloride is clear water-like liquid with an alcohol-like odor.
Cetrimonium Chloride is a conditioning agent that is usually used with other two ingredients, namely, Cetrimonium bromide and Steartrimonium chloride.
These three work in a group to prevent the development of “static electricity”.
Cetrimonium chloride is a cationic quaternary compound like BTMS, incroquate CR and cetrimonium bromide.
Cetrimonium Chloride is a water-soluble antistatic agent, surfactant and has some antimicrobial properties.
Cetrimonium Chloride performs a similar conditioning function to BTMS-50 and cetrimonium bromide but is not nearly as lubricating so it ideally should not be used on its own especially for dry hair types.
You need to add either a humectant or a fatty alcohol to make it more conditioning.
Fatty alcohols: cetyl alcohol or cetearyl alcohol
Humectants: glycerine or propylene glycol
That said, Cetrimonium Chlorides detangling capabilities are superior to both BTMS and cetrimonium bromide.
Importantly, Cetrimonium Chloride can be added to surfactant formulations because it is water-soluble where as BTMS-50 and cetab cannot.
Cetac is a different compound to cetrimonium chloride.
Cetrimonium Chloride is composed of:
29-30% cetrimonium chloride
If you have very fine, tangle-prone hair try formulating a conditioner with cetrimonium chloride on its own to see how Cetrimonium Chloride perform otherwise combine it with other ingredients to create a more complete conditioner, e.g. add cetyl alcohol or cetearyl alcohol or glycerin.
Cetrimonium Chloride usage rate: 0.5% to 5% in rinse-off products; 2% can be optimal to get the detangling benefit.
2% will get rid of any silicone build-up in your hair.
Check the Material Safety Data Sheet (MSDS).
Usage rate in leave-on products can be as little as 0.25%,
You can add cetrimonium chloride to any phase: heated oil phase, heated water phase or the cool-down phase.
You may find your conditioner is less watery if you add it during the cool down phase.
Cetrimonium Chloride Applications
-Body Care
-Eye Contour Care
-Face / Neck Skin Care
-Facial Cleansers
-Hair Conditioners - Rinse off
-Hair Relaxing / Permanent Waves
-Lip Care
-Shampoos
EU Cosmetic Regulation
Cetrimonium Chloride, Cetrimonium Bromide and Steartrimonium Chloride are quaternary ammonium salts.
The quaternary nitrogen atom in these compounds always carries a positive charge regardless of the pH of the system.
Why Puracy Uses Cetrimonium chloride
We use cetrimonium chloride to aid in the coverage, feel, and evaporation of our foaming hand sanitizer.
The Cosmetic Ingredients Review has deemed the ingredient as safe for use in cosmetics when formulated to be nonirritating.
One study found the ingredient is considered safe for use in rinse-off cosmetic products and in leave-on products in concentrations of up to 0.25% and/or formulated to be nonirritating.
How Cetrimonium chloride Is Made
Cetrimonium chloride is a quaternary ammonium salt.
While Cetrimonium Chloride’s typically purchased in a 30% concentration, by the time it’s mixed with the other condition ingredients, soaps, and plant oils, most conditioners contain less than 2% of this ingredient.
The FDA has reported this ingredient as being commonly found in lotion at 0.2%.
This ingredient can be made synthetically, but Public Goods derives it from vegetable oils.
In addition, we use dimethicone, a skin protectant, to keep our conditioner as gentle as possible.
Risk Factors of Cetrimonium Chloride
The FDA, EWG, and the European Chemicals Agency (ECHA) stress the fact that this chemical may cause eye and skin irritation.
Therefore, consider skipping this ingredient when making baby shampoo formulations.
Cetrimonium Bromide, Cetrimonium Chloride, and Steartrimonium Chloride are quaternary ammonium salts used for a variety of purposes in cosmetics at concentrations of up to 10%.
Cetrimonium Bromide given orally is poorly absorbed from the intestine and is excreted in feces.
Cetrimonium Bromide applied dermally is absorbed into the skin, but not rapidly.
Dermal irritation and sensitization and ocular irritation are seen with these quaternary ammonium salts.
Cetrimonium Bromide was embryotoxic and teratogenic in mice following intraperitoneal injection of 35 mg/kg; only teratogenic effects were observed with 10 mg/kg.
Embryotoxic effects consistent with maternal toxicity were seen in a rat-feeding study using 50 mg/kg/day.
Dermal exposure to 2% Cetrimonium Chloride produced no evidence of teratogenieity; nor did 2.5% Steartrimonium Chloride.
All mutagenesis assays used were negative.
Repeated insult patch tests of concentrations of up to 0.25% Cetrimonium Chloride produced no sensitization reactions, although irritation was observed during induction.
Based on the available data Cetrimonium Bromide, Cetrimonium Chloride, and Steartrimonium Chloride are considered safe for use in rinse-off cosmetic products but are safe only at concentrations of up to 0.25% in leave-on products.
CAS Number: 112-02-7
EINECS/ELINCS No: 203-928-6
Restriction (applies to EU only): VI/44
COSING REF No: 32590
Chem/IUPAC Name: 1-Hexadecanaminium, N,N,N-trimethyl-, chloride
ammonium compounds, quaternary, hexadecyltrimethyl-, chloride
ammonium, hexadecyltrimethyl-, chloride
ammonyx 16/50
ammonyx CETAC
ammonyx CETAC-30
arquad 16-29W
cetrimonium chloride (CTA 25)
cetyl trimethyl ammonium chloride
cetyl(trimethyl)ammonium chloride
cetyltrimethyl ammonium chloride
cetyltrimethylammonium chloride
Cetrimonium Chloride's an anti-static, conditioning ingredient that helps keep hair looking and feeling smooth.
Cetrimonium Chloride also acts as a preservative by preventing the growth of bacteria in liquid solutions, so products last longer.
Cetrimonium Chloride's partly water-soluble and partly oil-soluble, so oil and water become dispersed and give products a good consistency and a gentle cleansing foam.
Cetrimonium chloride is a quaternary ammonium salt.
Cetrimonium Chlorides concentration in cosmetics is highly controlled by state regulations.
Cetrimonium Chloride's similar to another conditioning ingredient, behentrimonium chloride with only the number of carbon atoms they contain being the main difference, which slightly changes the feel of the conditioner on the hair when you apply it.
Cetrimonium chloride is a positively charged or cationic ingredient that acts as an excellent detangler by reducing combing forces, which reduces friction on our hair.
We can use Cetrimonium Chloride as the main ingredient in a light detangler or conditioner or as an addition to rinse off or leave in conditioners.
Add Cetrimonium Chloride at up to 2% in leave in conditioners or detanglers, and at 1% or so in conditioners.
Cetrimonium Chloride will reduce the viscosity of the conditioner.
1-hexadecanaminium, N,N,N-trimethyl-, chloride
1-hexadecanaminium, N,N,N-trimethyl-, chloride (1:1)
hexadecyl trimethyl ammonium chloride
hexadecyl(trimethyl)ammonium chloride
hexadecyl(trimethyl)azanium chloride
hexadecyltrimethyl ammonium chloride
N-hexadecyltrimethyl ammonium chloride
hexadecyltrimethylamine, chloride
hexadecyltrimethylammonium chloride
Mainly used to prevent static and build-up in the hair.
Cetrimonium Chloride can also cleanse the skin/hair and eliminate odor by preventing the growth of microorganisms, and by enabling water to mix with dirt and rinse it away.
In addition, by reducing the surface tension of other ingredients and working to distribute and suspend insoluble solids in liquid, Cetrimonium Chloride helps form emulsions.
Cetrimonium Chloride is mainly used in hair products such as hair dye, shampoo/conditioner, styling gel, mousse, detangler, dandruff treatment and relaxer.
Description: Cetrimonium Chloride 25% Active
INCI: Cetrimonium Chloride
Solubility: Water Soluble
Benefits: Great Anti-Static active to reduce fly-away and improve the manageability of the hair.
Cetrimonium Chloride also helps with wet combability.
Origin: Natural Starting Materials
Activity: 25% active aqueous solution
Cetrimonium Chloride Applications: This ingredient is a great addition to any conditioner or leave-in styling treatment.
Cetrimonium Chloride can also be used in wash-off products where there are no anionic surfactants present.
Add Cetrimonium Chloride into the water phase during any stage of manufacturing.
Cetrimonium Chloride Useage: 0.5 - 2%
N-hexadecyltrimethylammonium chloride
hexadecyltrimethylammonium chloride (6CI)
hexadecyltrimethylammoniumchloride
incroquat CTC-30
palmityltrimethylammonium chloride
quartamin 60L
quartamin 60W
quartamin 60W25
quartamin 60W30
quaternary ammonium compounds, C14-18-alkyltrimethyl, chlorides
trimethyl-1-hexadecanaminium chloride
N,N,N- trimethyl-1-hexadecanaminium chloride
N,N,N- trimethyl-1-hexadecanaminiumchloridtrimethylcetylammonium chloride
N,N,N- trimethylhexadecan-1-aminium chloride
trimethylhexadecylammonium chloride
CAS: 112-02-7
Formula: C19H42ClN
Cetrimonium Chloride Uses
Cetrimonium chloride is used as a hair conditioner, fabric softener, and anti-static agent for hair and fibers.
Cetrimonium Chloride makes fabrics and hair less prone to static electricity buildup by making them slightly conductive.
Cetrimonium Chloride Description: Pale yellow to yellow clear liquid.
Free amine and amine hydrochloride: NMT 1.5% w/w
pH (10% w/v solution in water): 5.0 - 8.0
Ash contents: NMT 0.3% w/w
Assay: 48.0% - 52.0% w/w
If you want to be sure you’re avoiding any irritating quats, try Public Goods’ Shampoo Bar made with saponified plant oils and aloe vera juice for hair.
Cetrimonium Chloride’s RSPO certified, paraben-free, cruelty-free, sulfate-free, eco-friendly, vegan-friendly, organic, and does not contain cetyl trimethyl ammonium chloride.
Cetrimonium Chloride Smells nice.
Quat’s Up With Cetrimonium Chloride?
Cetrimonium Chloride’s hard to believe that chemical ingredients with intimidating names can be safe, but many of them are derived from natural ingredients.
That’s why Cetrimonium Chloride’s so important as a consumer to do your due diligence.
112-02-7
Hexadecyltrimethylammonium chloride
Cetrimonium chloride
Cetyltrimethylammonium chloride
N,N,N-trimethylhexadecan-1-aminium chloride
N-Hexadecyltrimethylammonium chloride
Hexadecyl trimethyl ammonium chloride
Cetyl trimethyl ammonium chloride
Trimethylcetylammonium chloride
Arquad 16-50
CETAC
CTAC
HTAC
TRIMETHYLHEXADECYLAMMONIUM CHLORIDE
Arquad 16-29
Palmityltrimethylammonium chloride
1-Hexadecanaminium, N,N,N-trimethyl-, chloride
UNII-UC9PE95IBP
N,N,N-Trimethyl-1-hexadecanaminium chloride
hexadecyl(trimethyl)ammonium chloride
MFCD00011773
CHEBI:53581
hexadecyl(trimethyl)azanium;chloride
UC9PE95IBP
cetyltrimethyl ammonium chloride
68002-63-1
cetyl(trimethyl)ammonium chloride
Quaternary ammonium compounds, C14-18-alkyltrimethyl, chlorides
Dehyquart A
Trimethyl-1-hexadecanaminium chloride
Aliquat 6
1-Hexadecanaminium, N,N,N-trimethyl-, chloride (1:1)
Adogen 444
Cetrimonium Chloride used responsibly by formulators, cetyl trimethyl ammonium chloride is generally regarded as safe in rinse-off products like conditioner.
Cetrimonium Chloride combined with dimethicone and calming ingredients like aloe vera gel, minor skin irritations may be non-issue altogether.
Cetrimonium Chloride Causes skin irritation.
Cetrimonium Chloride Causes serious eye irritation.
May cause drowsiness or dizziness.
Wash thoroughly after handling.
Avoid breathing mist or vapours.
Use only outdoors or in a well-ventilated area.
Wear protective gloves and eye/face protection.
If on skin: Wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do.
Continue rinsing.
Unii UC9PE95IBP
Preferred Substance Name CETRIMONIUM CHLORIDE
Rn 112-02-7
Ec 203-928-6
Ncit C83614
Rxcui 1311525
Pubchem 8154
Molecular Formula C19H42N.Cl
Inchikey WOWHHFRSBJGXCM-UHFFFAOYSA-M
Cetrimonium Chloride Exposure controls
Ventilation and engineering measures : Use with adequate ventilation.
Apply technical measures to comply with the occupational exposure limits.
Where reasonably practicable this should be achieved by the use of local exhaust ventilation and good general extraction.
Smiles [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C
Unii Type INGREDIENT SUBSTANCE
RN 112-02-7
EC 203-928-6
NCIT C83614
RXCUI 1311525
PUBCHEM 8154
MF C19H42N.Cl
INCHI KEY WOWHHFRSBJGXCM-UHFFFAOYSA-M
SMILES [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C
If eye irritation persists: get medical advice/attention.
If inhaled: Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER or doctor/physician if you feel unwell.
Store in a well-ventilated place. Keep container tightly closed.
Store locked up.
Cetrimonium Chloride Ingestion :
Move to fresh air.
If breathing is difficult, give oxygen by qualified medical personnel only.
If breathing is irregular or stopped, administer artificial respiration.
When symptoms persist or in all cases of doubt seek medical advice.
Cetrimonium Chloride Inhalation :
For skin contact, wash with soap and water while removing contaminated clothing.
If skin irritation or rash occurs, seek medical advice/attention.
Wash contaminated clothing before reuse.
Cetrimonium Chloride Skin contact :
Flush eyes with water for at least 15 minutes while holding eyelids open.
If irritation or symptoms develop, seek medical attention.
Cetrimonium Chloride Eye contact :
Most important symptoms and effects, both acute and delayed
Causes serious eye irritation.
Symptoms may include redness, pain, tearing and conjunctivitis.
Cetrimonium Chloride Causes skin irritation.
Symptoms may include redness, blistering, pain and swelling.
May cause respiratory irritation. Symptoms may include coughing, choking and wheezing.
Ingestion may cause severe irritation to the mouth, throat and stomach.
May cause headache, nausea, dizziness and other symptoms of central nervous system depression.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Precautionary statement(s)
Cetrimonium Chloride hazards
Other hazards which do not result in classification:
Burning produces obnoxious and toxic fumes.
Ingestion may cause severe irritation to the mouth, throat and stomach. May cause respiratory tract irritation.
In case of insufficient ventilation wear suitable respiratory equipment.
Respiratory protection : None required under normal conditions.
If airbourne concentrations are above the permissible exposure limit or are not known, use NIOSH-approved respirators.
Advice should be sought from respiratory protection specialists.
Gloves impervious to the material are recommended.
Wear as appropriate: Any liquid-tight rubber or vinyl gloves.
Advice should be sought from glove suppliers.
Wear sufficient clothing to prevent skin contact.
Surfroyal CTAC
Genamin CTAC
Dehyquart A-CA
Morpan CHA
Quartamin 60W
Ammonyx Cetac 30
Arquad 16
Intexsan CTC 29
Intexsan CTC 50
Barquat CT 29
Intexan CTC 29
Variquat E 228
Carsoquat CT 429
Cation PB 40
HDTMA-Cl
Catinal CTC 70ET
Dodigen 1383
Lebon TM 16
Lebon TM 60
Caswell No. 167A
CETRIMONIUM CHLORIDE is classified as :
-Antimicrobial
-Antistatic
-Emulsifying
-Preservative
-Surfactant
Cetrimonium Chloride application:
Cetyltrimethylammonium chloride (CTAC) is a cationic surfactant that can be used in the synthesis of mesoporous molecular sieves and micelle complexes.
Cetrimonium Chloride can also be used as a dispersant to prevent aggregation of nanoparticles.
Why Is Centrimonium Chloride Used?
Preservative
Preservatives, despite the bad reputation that has been unfairly bestowed upon them by the beauty industry, are one of the most important parts of the formulation process.
Preservatives help to prevent the growth of bacteria, yeasts and molds that can grow in your product due to use and exposure to the air.
Cetrimonium Chloride often occurs when you scoop out your product or take off the lid to use it.
An eyewash station and safety shower should be made available in the immediate working area.
General hygiene considerations :Avoid contact with skin, eyes and clothing.
Avoid breathing mist or vapor. Wash thoroughly after handling.
Remove and wash contaminated clothing before re-use.
Handle in accordance with good industrial hygiene and safety practice.
Synonyms
N-Hexadecyl trimethyl ammonium Chloride
Cetrimonium Chloride
Hexadecyl Trimethyl Ammonium Chloride
HTAC
Cetyl trimethyl ammonium Chloride
CTAC
N-ethyl-N,N-dimethylhexadecan-1-aminium chloride
CETYL TRIMITHYL AMMONIUM CHLORIDE
N-Hexadecy trimethyl ammonium Chloride
1631
Cetyltrimethylammonium Chloride(CTMAC, CTAC)
EC 203-928-6
C19H42ClN
Cetrimonium chloride (BAN)
DSSTox_RID_78243
DSSTox_GSID_26901
SCHEMBL24536
ACMC-2099c7
cetyl trimethylammonium chloride
cetyltrimethyl-ammonium chloride
CHEMBL1895807
DTXSID6026901
AMY33367
Tox21_202555
ANW-16373
AKOS015899168
AKOS015960532
(1-Hexadecyl)trimethylammonium chloride
FS-4302
NCGC00164283-02
NCGC00260104-01
AK158937
CAS-112-02-7
Do you need Cetrimonium Chloride?
No, but Cetrimonium Chloride is very useful for hair products.
Strengths: Excellent conditioning agent
Weaknesses: Low maximum usage rate for leave-on products due to high potential for skin irritation.
Alternatives & Substitutions: You’d need something else liquid and cationic at a bare minimum; something like honeyquat or Polyquaternium-7 could be a good place to start.
Cetrimonium Bromide and Steartrimonium Chloride could also be good alternatives, but these may be harder for home crafters to source.
How to Work with Cetrimonium Chloride
Include cetrimonium chloride in the heated water phase of recipes.
Cetrimonium Chloride can also be cold-processed if the recipe requires no heat.
Cetrimonium Chloride Reactivity: Not normally reactive.
Chemical stability: Stable under normal conditions.
Possibility of hazardous reactions: Hazardous polymerization does not occur.
Conditions to avoid: Exposure to sunlight.
Avoid contact with incompatible materials.
Incompatible materials: Oxidizing agents.
Cetrimonium Chloride Skin protection :
Eye / face protection : Wear chemical splash goggles to prevent dusts from entering the eyes.
Other protective equipment : Other equipment may be required depending on workplace standards.
What Does Cetrimonium Chloride do for Hair?
Cetrimonium Chloride often confused with silicone because of the lightweight feel it gives every lock, cetrimonium chloride is actually a quaternary ammonium surfactant, or ‘quat’ for short.
Other quaternary ammonium compounds include polyquaternium-7 and quaternium-15 and yes, you’ll see them on many hair care product labels as well.
As a surfactant, Cetrimonium Chloride acts more like a detergent that lifts dirt, debris, and oil and reduces static electricity-induced fly-aways.
What is Cetrimonium Chloride?
Cetrimonium chloride is a liquid quaternary ammonium salt, typically purchased as an aqueous solution with approximately 30% concentration.
Cetrimonium Chloride functions as a conditioning agent and surfactant in our products.
Is Cetrimonium Chloride Safe?
The Environmental Working Group (EWG) gives cetrimonium chloride a 4 on the safety scale, with its worst score in the allergies and immunotoxicity category.
Of course, we strive for products with a score of 0.
But let’s take a closer look to Cetrimonium Chloride.
A peer-reviewed article published in Cosmetic Ingredients Review asserts that with appropriate concentrations of the chemical, no reaction or sensitization is observed.
These concentrations included skin exposure to 2% cetrimonium chloride and repeated insult patch tests (6 weeks of skin pokes with the chemical) of concentrations of up to 0.25%.
Cetrimonium Chloride bond looks like a tadpole; a single positive charge at the headgroup leads a tail of bonds that straighten out stubborn, dry hair.
Because Cetrimonium Chloride’s a cationic surfactant (meaning positively charged), it attracts the negative charges produced by the daily shuffle, especially in cold, dry weather.
Cetrimonium Chloride’s anti-frizz and anti-static.
