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CHLORHEXIDINE DIACETATE


EC / List no.: 200-302-4
CAS no.: 56-95-1
Mol. formula: C22H30Cl2N10.2C2H4O2


CHLORHEXIDINE DIACETATE is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.


Pharmacology and Biochemistry
MeSH Pharmacological Classification
CHLORHEXIDINE DIACETATE used on humans and other animals that destroy harmful microorganisms or inhibit their activity. 
CHLORHEXIDINE DIACETATE distinguished from DISINFECTANTS, which are used on inanimate objects.

Disinfectants
CHLORHEXIDINE DIACETATE used on inanimate objects that destroy harmful microorganisms or inhibit their activity. 
Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. 
CHLORHEXIDINE DIACETATE distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals.

Mouthwashes
Solutions for rinsing the mouth, possessing cleansing, germicidal, or palliative properties.

Uses
• Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing    
• Drug product, or related to the manufacturing of drugs; modified by veterinary, animal, or pet if indicated by source    
• Personal care products, including cosmetics, shampoos, perfumes, soaps, lotions, toothpastes, etc    
• Includes preservatives used in cosmetics, film, wood preserving agents, foods, etc
• Substances used for preventing, destroying or mitigating pests    
• Active ingredients in a product (often active ingredients in pesticide, if so also tagged with 'pesticide')    
• Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing    
• Inert ingredients in a pesticide        

DESCRIPTION
Application
CHLORHEXIDINE DIACETATE Used to study mechanism of membrane dysruption by bis(biguanide) molecules.
Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. 
Chlorhexidine diacetate has been used to study the inactivation of HIV and the immobilization of sperm. 
Chlorhexidine diacetate was used to study effective skin antisepsis and disinfection of medical devices as well as the effects of antimicrobials on dental plaque.
Packaging
25, 100 g in poly bottle
Biochem/physiol Actions
Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. 
Chlorhexidine diacetate is effective against both Gram-positive and Gram-negative bacteria. 
Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Chlorhexidine diacetate (2%) and chlorhexidine gluconate (4%) has a rapid onset of action and a persistent effect but variable and inconsistent activity against viruses and fungi.
Chlorhexidine binds to the protein of the stratum corneum, forming a persistent residue that can kill bacteria emerging from sebaceous glands, sweat glands, and hair follicles during surgery.
Another approved antiseptic for preoperative skin preparation, 2% chlorhexidine gluconate plus 70% isopropyl alcohol (ChloraPrep), provided significantly more persistent antimicrobial activity on abdominal sites at 24 hours after application than either of the components used separately.

Chlorhexidine has low toxicity as a skin scrub or as an aqueous solution for wound disinfection, oral lavage, and mucous membranes of the urinary tract.
Although chlorhexidine diacetate can be toxic to fibroblasts in vitro, in vivo lavage with dilute chlorhexidine (0.05%) is not harmful to wound healing.
However, the least known bactericidal concentration (0.05%) of chlorhexidine diacetate causes synovial ulceration, inflammation, and fibrin accumulation in the talocrural joints of horses.
Chlorhexidine (0.0005%) potentiated with 3.2 mM EDTA and 0.05 mM Tris buffer (hydroxymethylaminomethylamine) is 90% lethal to Escherichia coli, Staphylococcus aureus, and Streptococcus zooepidemicus and is not harmful to the synovium or articular cartilage of the talocrural joints of ponies.
Chlorhexidine (0.02%), like 1% povidone-iodine, promotes intra-abdominal adhesion formation and therefore should not be used for peritoneal lavage.

Where is chlorhexidine diacetate found?
Chlorhexadine Diacetate is a disinfectant and antiseptic used to disinfect skin prior to surgery and to sterilize instruments used prior to surgery. 
Also found in personal care products for its antiseptic properties.
How can you avoid contact with chlorhexidine diacetate?
Avoid products that list any of the following names in the ingredients:

• Chlorhexidine diacetate
• Chlorhexidine acetate
• Bactigras
• Hibitane diacetate
• Caswell No. 481E
• Chlorohexidine diacetate
• Chlorhexidine di(acetate)
• Chlorhexidine acetate (VAN)
• Chlorhexidine acetate [USP]
• Bis(p-chlorophenyldiguanidohexane) diacetate
• 1,6-Bis(p-chlorophenylbiguanido)hexane diacetate
• 1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate
• 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate
• 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate
• 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)diacetate
• 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetate
• 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, diacetate
• Chlorhexidine acetate (USP)
• chlorhexidine diacetate salt
• 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide), diacetate
• BIGUANIDE, 1,1'-HEXAMETHYLENEBIS(5-(p-CHLOROPHENYL)-, DIACETATE
• 2,4,11,13-Tetraazatetradecanediimidamide, N,N'-bis(4-chlorophenyl)-3,12-diimino-, diacetate
• Chlorhexidine diacetate salt monohydrate

What are some products that may contain chlorhexidine diacetate?
Urinary catheters
Wound cleaners
Mouthwash

Synonyms: 1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Diacetate
An antiseptic and disinfectant agent. 
Chlorhexidine diacetate is effective against a wide range of bacteria, some fungi and some viruses, and an agent for the prevention of gingivitis. 
Commercial ophthalmic products have used this agent to replace thimerosal as a preservative.

Chlorhexidine diacetate salt is a diacetate derivative of a cationic polybisbiguanide that has bactericidal, anti-fungal and anti-viral activity. 
Chlorhexidine diacetate has also been used for in vivo pharmacokinetic research to investigate drug release rates.

Chlorhexidine diacetate, when placed into physiological pH, dissociates into its cationic form and binds to the negatively charged bacterial wall. 
This binding will cause cytosolic leakage at low concentrations and lytic effects at high chlorohexidine concentrations. 
However, chlorhexidine activity can be halted upon interaction with anionic compounds.

Product Specifications
Chlorhexidine diacetate salt

Formula: C22H­30Cl2N10 ∙ 2C2H4O2

MW: 625.55 g/mol

Storage/Handling: Store at room temperature.

Product Description
Chlorhexidine Diacetate

Application Notes
Chlorhexidine diacetate is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. 
Chlorhexidine diacetate has been used to study the inactivation of HIV and the immobilization of sperm. 
Chlorhexidine diacetate was used to study effective skin antisepsis and disinfection of medical devices as well as the effects of antimicrobials on dental plaque.

Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications
Antiseptic | Disinfectant agent | Chemical Synthesis

Biochemical Physiological Actions    
Chlorhexidine diacetate is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. 
Its mechanism of action involves destabilization of the outer bacterial membrane. 
Chlorhexidine diacetate is effective against both Gram-positive and Gram-negative bacteria. Chlorhexidine diacetate is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Chlorhexidine diacetate and povidone-iodine were evaluated for fibroblast toxicity on a primary line of canine embryonic fibroblasts, and for bactericidal efficacy against Staphylococcus aureus. 
The cultured fibroblasts or S. aureus were exposed for 30 minutes to incremental dilutions of 0.5 to 0.0005% chlorhexidine diacetate, 5.0 to 0.05% povidone-iodine, or physiologically buffered saline as a control. 
To determine survival, fibroblasts were trypsinized and counted; S. aureus colonies were counted on brain-heart infusion agar. 
Survival for both groups was expressed by calculating the number of living cells in test dilutions as a percentage of the number in control cultures. 
Fibroblast survival occurred at chlorhexidine concentrations less than 0.013% and at povidone-iodine concentrations less than 0.5% (p < 0.05). 

Chlorhexidine diacetate is a broad-spectrum biocide effective against Gram-positive bacteria, Gram-negative bacteria and fungi. 
Chlorhexidine diacetate is used primarily as its salts (e.g., the dihydrochloride, diacetate, and digluconate). Chlorhexidine inactivates microorganisms with a broader spectrum than other antimicrobials (e.g. antibiotics) and has a quicker kill rate than other antimicrobials (e.g. povidone-iodine). 
Chlorhexidine diacetate has both bacteriostatic (inhibits bacterial growth) and bactericidal (kills bacteria) mechanisms of action, depending on its concentration. 
Chlorhexidine diacetate kills by disrupting the cell membrane. 
The most common side effects associated with chlorhexidine gluconate oral rinses are: 
1) an increase in staining of teeth and other oral surfaces; 
2) an increase in calculus formation;  
3) an alteration in taste perception; 
4) toothache; 
5) upper respiratory tract infection;
6) headache.

Chlorhexidine and its Diacetate and Digluconate salts are used in cosmetics as preservatives. Chlorhexidine Digluconate was slightly toxic in oral and inhalation studies. 
At cosmetic use concentrations, Chlorhexidine Digluconate was not irritating to the eyes or skin. 
Positive sensitization reactions were cited in provocative patch testing at 1.0% concentration in patients with eczema, but not in predictive patch testing of 0.05% in normal subjects. 
In bacterial assays, Chlorhexidine tested both positive and negative for mutagenesis. 
In two mammalian systems, Chlorhexidine Digluconate was not genotoxic. 
p-Chloroaniline is a degradation product of Chlorhexidine salts. 
A study of the degradation of Chlorhexidine revealed minor amounts of p-chloroaniline after 36 weeks storage. Chlorhexidine Digluconate was not carcinogenic in a 2-year drinking water study. 
On the basis of the data presented in this report, it is concluded that Chlorhexidine and its salts are safe for use in cosmetic products at concentrations up to 0.14% calculated as Chlorhexidine free base; 0.19% as Chlorhexidine Diacetate; 0.20% as Chlorhexidine Digluconate; and 0.16% as Chlorhexidine Dihydrochloride


    
Chlorhexidine diacetate is a biguanide disinfectant with rapid bactericidal activity against both Gram-positive and Gram-negative organism. 
The antibacterial effect of chlorhexidine diacetate is related to its action on the bacterial cell membrane and to precipitation of intracellular contents


Chemical Properties
Chlorhexidine Diacetate is white or almost white, microcrystalline powder


Uses
antimicrobial agent in, e.g., cosmetic and disinfection solutions, eye drops, uterine antiseptics, toothpaste, mouthwash, hand and wound deansers.

Chlorhexidine Diacetate is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. 
Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. 
Chlorhexidine diacetate is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. 
Chlorhexidine diacetate has both bactericidal and bacteriostatic mechanisms of action. 
Aqueous solutions of chlorhexidine are most stable within the pH range of 5-8. 
Above pH 8.0 chlorhexidine base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable. 
Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

An antiseptic antibacterial agent commonly used as a disinfectant in eye drops, deodorants, creams, and others; an active ingredient in mouthwash to prevent and control dental plaque;


What Is Chlorhexidine Diacetate?
Chlorhexidine Diacetate is an odorless, white crystalline powder. 
In cosmetics and personal care products, Chlorhexidine and its salts (Chlorohexidine Dihydrochloride, Chlorhexidine Digluconate, Chlorhexidine Diacetate) are used in the formulation of eye makeup, makeup foundations, mouthwashes, hair dyes and bleaches, and other skin care and hair care products.

Why is Chlorhexidine Diacetate used in cosmetics and personal care products?
Chlorhexidine, Chlorhexidine Dihydrochloride, Chlorhexidine Digluconate and Chlorhexidine Diacetate are used as cosmetic biocides, oral care agents and preservatives.

Follow this link for more information about how preservatives protect cosmetics and personal care products.

Scientific Facts: 
Chlorhexidine has a strong bactericidal effect which has led to its widespread use. 
In addition to its use in cosmetics and personal care products, Chlorhexidine has been used in medical practice and these ingredients, particularly the Digluconate salt, have extensive use in dentistry because they inhibit plaque formation.

Product description
Chlorhexidine is an antiseptic mainly used in dental medicines like mouth rinses, sprays or toothpaste to prevent plaque and gingivitis. 
Chlorhexidine is also used on plasters, in ointments or powders and as an effective preservative against bacteria and moulds in cosmetics.

Comprehensive documentation for drug registration of Chlorhexidine can be provided by Biesterfeld as referred.

Chlorhexidine based concentrate for use in solution as a post-milking teat dip. 
When used properly, it helps reduce the incidence of mastitis due to germicidal properties.
Mixes with water and glycerin to create a sanitizing and moisturizing teat dip. 
Available in a scented or non-scented solution.

What is CHLORHEXIDINE DIACETATE and where is it found?
This chemical is an antimicrobial agent used as a disinfectant to control bacteria in cosmetic and disinfection solutions, eye drops, uterine antiseptics, toothpaste, mouthwash, hand and wound cleansers. 
Further research may identify additional product or industrial usages of this chemical.

What else is CHLORHEXIDINE DIACETATE called?
This chemical can be identified by different names, including:
Arlacide A, Hexamethylenebis(5-(pchlorophenyl) biguanide) diacetate, Bactigras, Nolvasan, Chlorasept 2000, Tetraazatetradecanediimidamide,N,N' -bis(4-chlorophenyl) -3,12-diimino-, diacetate., Chlorohexidine Acetate

Chlorhexidine diacetate salt is an antiseptic antibacterial agent commonly used as a disinfectant in eye drops, deodorants, creams, and others. 
Chlorhexidine is also used as an active ingredient in mouthwash to prevent and control dental plaque.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 
Cas Number: 56-95-1

Molecular Formula: C22H30Cl2N10•2C2H4O2

Molecular Weight: 625.55

Mechanism of Action: Chlorhexidine diacetate is a cationic molecule which interacts with and alters the negatively charged bacterial cell wall. 
This interaction leads to leakage of cellular components at low concentrations and cellular lysis at higher concentrations.

Storage Conditions: ≤30°C

Chlorhexidine diactetate is a salt of Chlorhexidine used in cosmetics as a preservative.

Restriction in Europe: V / 42
The maximum authorized concentration in ready-to-use cosmetic preparations is 0.3% (in chlorhexidine).
Its functions (INCI)
Antimicrobial: Helps slow the growth of microorganisms on the skin and opposes the growth of microbes
Oral hygiene agent: Provides cosmetic effects to the oral cavity (cleaning, deodorization and protection)
Preservative: Inhibits the development of microorganisms in cosmetic products.


Chlorhexidine acetate was not considered to be a high priority for assessment of potential risks to human health, based upon the application of the simple exposure and hazard tools developed for categorization of substances on the Domestic Substances List.

Chlorhexidine acetate is an organic substance that is used primarily as a disinfectant and antibacterial agent. 
The substance does not naturally occur in the environment.

Based on reported industrial and commercial/consumer use patterns and certain assumptions, chlorhexidine acetate is predicted to be released in wastewater (before treatment; about 1% from industrial use), to surface water (up to 43% from consumer/commercial uses), to soil (up to 43% via the application of biosolids and manure), and through waste disposal (incineration and landfill; ~10%). Chlorhexidine acetate is a salt and dissociates in water to produce the acetate counterion and chlorhexidine. 
Chlorhexidine is a strong base and is expected to protonate in water at pH 6 to 9, such that virtually all (~99%) of the substance will exist with two of its amine groups positively charged.

Experimental and predicted data suggest that chlorhexidine acetate will persist in water, soil and sediment. 
Its physical and chemical properties suggest that chlorhexidine acetate has a low bioaccumulation potential. 
Experimental acute toxicity data for chlorhexidine acetate and chlorhexidine show that they have the potential to cause acute harm to aquatic organisms at low concentrations.


USES OF Chlorhexidine Acetate

Chlorhexidine and its salt forms (acetate, gluconate, and hydrochloride) are broad-spectrum antiseptics used for sterilization, cleaning skin and hands, and disinfecting wounds, and are generally effective against a wide variety of bacteria and yeasts.

In Canada, chlorhexidine acetate is listed in the Drug Products Database as an active ingredient in more than 30 drugs for human or veterinary use and hard-surface disinfectants . 
Three of the products are drugs for human use: over-the-counter gauze dressing for skin loss wounds over-the-counter spray for minor burns and sunburns; and anti-cavity dental varnish requiring a prescription. 
Two of the products are for hard-surface disinfection: disinfectant of animal accommodations for veterinary use only and floor cleaner of an all-in-one floor mopping system. 
The remainder of the products are drugs for veterinary use only and include bovine udder wash; bovine teat dips; anti-infective skin ointment ; and oral rinse for cats and dogs.
Chlorhexidine acetate is listed in the Natural Health Products Ingredient Database  as a non-natural health product because it is not a naturally occurring substance included in Schedule 1 of the Natural Health Products Regulations. 
Chlorhexidine diacetate is not listed in the Licensed Natural Health Products Database; therefore, no current licensed natural health products contain this substance as a medicinal ingredient or as a non-medicinal ingredient.

Chlorhexidine acetate is not listed as an approved food additive under Division 16 of the Food and Drug Regulations, nor has it been identified as being used/present in formulations of incidental additives or used in food packaging materials.

Chlorhexidine acetate is on the Cosmetic Ingredient Hotlist, Health Canada’s administrative list of ingredients that are intended to be prohibited or restricted for use in cosmetics in Canada, and is permitted in cosmetics in concentrations equal to or less than 0.19%. 
One cosmetic product (aftershave) containing chlorhexidine acetate has been identified in the Cosmetic Notification System database.

Chlorhexidine acetate is not currently present in Canada as a formulant in pest control products, as it is not listed in the Pest Management Regulatory Agency List of Formulants.

Chlorhexidine acetate has also been identified as a component of foot baths for farm visitors.

This substance has been used in Finland and Sweden in non-agricultural pesticides, preservatives and other (undefined) products in the areas of health/social work and the manufacture of chemicals/chemical products; however, use patterns were reported as confidential.

What Chlorhexidine Acetate with Cetrimide is used for
Chlorhexidine Acetate with Cetrimide is a sterile solution used as a general antiseptic. 
The solution is used for cleaning and disinfecting wounds and as the antiseptic treatment of burns.

Chlorhexidine Acetate with Cetrimide is used as a topical (on the skin) solution (external use on the skin) and must not be administered intravenously (via injection).
This medicine is not expected to affect your ability to drive a car or operate machinery.

IUPAC NAMES
acetic acid; (1E)-2-[6-[[amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
chlorhexidine di(acetate)
Chlorhexidine di(acetate) hydrate
Chlorhexidine Diacetate
N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] diacetate
N-(4-chlorophenyl)-1-3-(6-{N-[3-(4-chlorophenyl)carbamimidamidomethanimidoyl]amino}hexyl)carbamimidamidomethanimidamide; bis(acetic acid)


SYNONYMS: 
Hibitaneacetate
N,N’’-Bis(4-Chlorophenyl)-3,12-diimino-2,4-11,13-tetraazatetradcanediimidamide
HIBITANE DIACETATE
CHLORHEXIDINE ACETATE
CHLORHEXIDINE DIACETATE MONOHYDRATE
CHLORHEXIDINE DIACETATE SALT
CHLOROHEXIDINE ACETATE
2-[n'-[6-[[amino-[[amino-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]carbamimidoyl]-1-(4-chlorophenyl)guanidine diacetate
1,1'-HEXAMETHYLENEBIS[5-(4-CHLORO-PHENYL)BIGUANIDE] DIACETATE MONOHYDRATE
1,6-DI(N-P-CHLOROPHENYL-DIGUANIDO) HEXANE DIACETATE
1,6-BIS[N5-(P-CHLOROPHENYL)-N1-BIGUANIDO]HEXANE DIACETATE SALT
1,6-BIS(N-P-CHLOROPHENYLDIGUANIDO)HEXANE DIACETATE
Chlorhexidine Acetate (200 mg)
Chlorhexidine Acatate
1,6-Bis(4-chlorophenyldiguanidino)hexane Diacetate
1,1&apos
CB2771984
Chlorhexidine acetate (chlorhexidine acetate)
2,4,11,13-Tetraazatetradecanediimidamide,N,N''-bis(4-chlorophenyl)-3,12-diimino-, acetate
orhexidine Diacetate
Chlorohexadine acetate
CHLORHEXIDINE DIACETATE CRYSTALLINE
1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide]diacetate salt
1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane
Chlorhexidine di(acetate)
CHLORHEXIDINECITRATE
1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane: 1,1μ-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
Chlorhexidine hydrate diacetate salt
Chlorhexidine monohydrate diacetate salt
Bactigras
Arlacide A
Chlorhexidine·diacetic acid
MPB Chlorhexidine Diacetate
Chlorhexidine.diacetate research grade
Chlorhexidine Acetate (500 mg)G0E0080.996mg/mg(an)
Chlorhexidine Acetate (500 mg)
Chlorhexidine diacet
1,1’-hexamethylenebis(5-(p-chlorophenyl)-biguaniddiacetate
1,1’-hexamethylenebis(5-(p-chlorophenyl)biguanide)diacetate
1,6-bis(5-(p-chlorophenyl)biguandino)hexanediacetate
1,6-di(4’-chlorophenyldiguanidino)hexanediacetate
10,040diacetate
2,4,11,13-Tetraazatetradecanediimidamide,N,N’’-bis(4-chlorophenyl)-3,12-diimino-,diacetate
1,1'-HEXAMETHYLENEBIS[5-(P-CHLOROPHENYL)BIGUANIDE]) DIACETATE SALT
Chlorhexidine di
Chlorhexidine Diacetate Joyce
4/5000 Benzalkonium bromide
Chlorhexidine Acetate (Hibitane)
Chlorhexidine diacetate CRS
Chlorhexidine Diacetate >
Chlorhexidine acetate,>98%
3-methyl-1-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-1,4-dien-3-o
hlorhexidine acetate
Chlorhexidine Diacetate fandachem
Chlorhexidine acetate fandachem
Hibitane diacetate fandachem
1,1′-(Hexane-1,6-diyl)bis[5-(4-chlorophenyl)biguanide] diacetate


 

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