CHLORHEXIDINE (DIGLUCONATE)

Chlorhexidine (digluconate) is a water-soluble salt of chlorhexidine widely used as a broad-spectrum antimicrobial agent in medical, pharmaceutical, dental, cosmetic, veterinary, and industrial applications.
Chlorhexidine (digluconate) exhibits rapid bactericidal activity and prolonged residual antimicrobial effect against Gram-positive and Gram-negative bacteria, as well as yeasts.
Chlorhexidine (digluconate) is valued for its strong efficacy, good skin tolerance, and suitability for aqueous formulations.

CAS Number: 18472-51-0
EC Number: 242-354-0
Molecular Formula: C₂₂H₃₀Cl₂N₁₀ · 2C₆H₁₂O₇
Molecular Weight: ~897.76 g/mol

Synonyms: Chlorhexidine (digluconate), Chlorhexidine Digluconate, Chlorhexidine Gluconate, CHG, Chlorhexidine (Digluconate), Chlorhexidine Digluconate, Chlorhexidine Gluconate, CHDG, CHG, Chlorhexidine Digluconate Solution, Chlorhexidine Gluconate Solution, Chlorhexidine Digluconate Topical Solution, Chlorhexidine Digluconate Antiseptic, Chlorhexidine Digluconate Antimicrobial, Chlorhexidine Digluconate Disinfectant, Chlorhexidine Digluconate Biocide, Chlorhexidine Digluconate Germicide, Chlorhexidine Digluconate Bactericide, Chlorhexidine Digluconate Bacteriostatic Agent, Chlorhexidine Digluconate Broad-Spectrum Antiseptic, Chlorhexidine Digluconate Broad-Spectrum Antimicrobial, Chlorhexidine Digluconate Infection Control Agent, Chlorhexidine Digluconate Clinical Antiseptic, Chlorhexidine Digluconate Medical Antiseptic, Chlorhexidine Digluconate Healthcare Antiseptic, Chlorhexidine Digluconate Hospital Antiseptic, Chlorhexidine Digluconate Surgical Antiseptic, Chlorhexidine Digluconate Surgical Scrub Agent, Chlorhexidine Digluconate Preoperative Antiseptic, Chlorhexidine Digluconate Skin Antiseptic, Chlorhexidine Digluconate Wound Antiseptic, Chlorhexidine Digluconate Topical Antimicrobial, Chlorhexidine Digluconate Dermatological Antiseptic, Chlorhexidine Digluconate Oral Antiseptic, Chlorhexidine Digluconate Dental Antiseptic, Chlorhexidine Digluconate Mouthwash Active, Chlorhexidine Digluconate Oral Rinse Active, Chlorhexidine Digluconate Gingivitis Control Agent, Chlorhexidine Digluconate Dental Plaque Control Agent, Chlorhexidine Digluconate Veterinary Antiseptic, Chlorhexidine Digluconate Livestock Antiseptic, Chlorhexidine Digluconate Hand Scrub Active, Chlorhexidine Digluconate Hand Wash Active, Chlorhexidine Digluconate Hygiene Disinfectant, Chlorhexidine Digluconate Personal Hygiene Antimicrobial, Chlorhexidine Digluconate Surface Disinfectant (context), Chlorhexidine Digluconate Sanitizing Agent, Chlorhexidine Digluconate Infection Prevention Agent, Chlorhexidine Digluconate Anti-Infective Agent, Chlorhexidine Digluconate Controlled-Release Active (pharma), Chlorhexidine Digluconate Aqueous Solution, Chlorhexidine Digluconate Concentrate, Chlorhexidine Digluconate Dilution Stock, Chlorhexidine Digluconate Bulk Solution, Chlorhexidine Digluconate Raw Material, Chlorhexidine Digluconate API, Chlorhexidine Digluconate Active Ingredient, Chlorhexidine Digluconate Pharmaceutical Grade, Chlorhexidine Digluconate Medical Grade, Chlorhexidine Digluconate Industrial Grade, Chlorhexidine Digluconate Cosmetic Grade, Chlorhexidine Digluconate Personal Care Grade, Chlorhexidine Digluconate Specialty Chemical, Chlorhexidine Digluconate Fine Chemical, Chlorhexidine Digluconate Disinfection Chemical, Chlorhexidine Digluconate Formulation Ingredient, Chlorhexidine Digluconate Functional Additive, Chlorhexidine Digluconate Antimicrobial Additive, Chlorhexidine Digluconate Biocidal Additive

APPLICATIONS

Chlorhexidine (digluconate) is used in medical antiseptic products.
Chlorhexidine (digluconate) is applied for preoperative skin disinfection and surgical hand scrubs.
Chlorhexidine (digluconate) provides long-lasting antimicrobial protection on skin.

Chlorhexidine (digluconate) is widely used in pharmaceutical formulations.
Chlorhexidine (digluconate) is incorporated into topical solutions, sprays, creams, and gels.
Chlorhexidine (digluconate) supports infection prevention in healthcare environments.

Chlorhexidine (digluconate) is used in dental and oral care products.
Chlorhexidine (digluconate) is formulated into mouthwashes and dental gels.
Chlorhexidine (digluconate) reduces plaque formation and gingival inflammation.

Chlorhexidine (digluconate) is applied in cosmetic and personal care formulations.
Chlorhexidine (digluconate) functions as an antimicrobial agent and preservative booster.
Chlorhexidine (digluconate) enhances microbiological stability of products.

Chlorhexidine (digluconate) is used in veterinary medicine.
Chlorhexidine (digluconate) is applied for animal skin disinfection and wound care.
Chlorhexidine (digluconate) ensures broad antimicrobial coverage in veterinary hygiene.

Chlorhexidine (digluconate) is employed in industrial and institutional disinfectants.
Chlorhexidine (digluconate) is used for surface and equipment sanitation.
Chlorhexidine (digluconate) maintains antimicrobial effectiveness over time.

Chlorhexidine (digluconate) is used as a broad-spectrum antiseptic in medical settings.
Chlorhexidine (digluconate) reduces bacterial load on skin and mucous membranes.

Chlorhexidine (digluconate) is used in hospital disinfection protocols.
Chlorhexidine (digluconate) helps prevent healthcare-associated infections.

Chlorhexidine (digluconate) is used in preoperative skin preparation.
Chlorhexidine (digluconate) lowers the risk of surgical site infections.

Chlorhexidine (digluconate) is used in wound care products.
Chlorhexidine (digluconate) supports infection control in minor and chronic wounds.

Chlorhexidine (digluconate) is used in oral hygiene products.
Chlorhexidine (digluconate) reduces dental plaque and gingivitis.

Chlorhexidine (digluconate) is used in mouthwashes.
Chlorhexidine (digluconate) helps control oral bacterial populations.

Chlorhexidine (digluconate) is used in periodontal treatments.
Chlorhexidine (digluconate) supports management of gum inflammation.

Chlorhexidine (digluconate) is used in dental surgery aftercare.
Chlorhexidine (digluconate) helps prevent postoperative oral infections.

Chlorhexidine (digluconate) is used in catheter care products.
Chlorhexidine (digluconate) reduces microbial colonization on medical devices.

Chlorhexidine (digluconate) is used in hand antiseptic formulations.
Chlorhexidine (digluconate) provides persistent antimicrobial activity on skin.

Chlorhexidine (digluconate) is used in intensive care units.
Chlorhexidine (digluconate) supports infection prevention protocols.

Chlorhexidine (digluconate) is used in veterinary antiseptic products.
Chlorhexidine (digluconate) helps manage bacterial skin infections in animals.

Chlorhexidine (digluconate) is used in animal wound care solutions.
Chlorhexidine (digluconate) supports hygiene and healing in veterinary practice.

Chlorhexidine (digluconate) is used in pharmaceutical formulations.
Chlorhexidine (digluconate) acts as an active antimicrobial ingredient.

Chlorhexidine (digluconate) is used in cosmetic hygiene products.
Chlorhexidine (digluconate) helps control microbial contamination.

Chlorhexidine (digluconate) is used in personal care cleansing products.
Chlorhexidine (digluconate) improves microbial safety of formulations.

Chlorhexidine (digluconate) is used in burn treatment preparations.
Chlorhexidine (digluconate) reduces infection risk in damaged skin.

Chlorhexidine (digluconate) is used in disinfectant sprays.
Chlorhexidine (digluconate) provides long-lasting antimicrobial protection.

Chlorhexidine (digluconate) is used in laboratory disinfection.
Chlorhexidine (digluconate) supports aseptic working conditions.

Chlorhexidine (digluconate) is widely used in medical and dental applications.
Chlorhexidine (digluconate) demonstrates good stability in aqueous formulations.
Chlorhexidine (digluconate) is compatible with many formulation excipients.

DESCRIPTION

Chlorhexidine (digluconate) is a water-soluble salt of chlorhexidine.
Chlorhexidine (digluconate) appears as a clear to pale yellow aqueous solution.
Chlorhexidine (digluconate) has strong antimicrobial activity against bacteria.

Chlorhexidine (digluconate) is effective against Gram-positive and Gram-negative organisms.
Chlorhexidine (digluconate) shows limited activity against spores and certain viruses.
Chlorhexidine (digluconate) binds to skin and mucous membranes for prolonged action.

Chlorhexidine (digluconate) disrupts microbial cell membranes.
Chlorhexidine (digluconate) causes leakage of intracellular components.
Chlorhexidine (digluconate) exhibits rapid bactericidal effects at higher concentrations.

Chlorhexidine (digluconate) should be stored in tightly closed containers.
Chlorhexidine (digluconate) should be protected from light and contamination.
Chlorhexidine (digluconate) is valued for its effectiveness, persistence, and safety when properly used.

Chlorhexidine (digluconate) is typically supplied as a clear to pale yellow aqueous solution.
Chlorhexidine (digluconate) has a faint characteristic odor.
Chlorhexidine (digluconate) is the digluconate salt form of chlorhexidine, offering high water solubility.

Chlorhexidine (digluconate) exhibits cationic properties in solution.
Chlorhexidine (digluconate) binds strongly to negatively charged surfaces such as skin, mucous membranes, and bacterial cell walls.
Chlorhexidine (digluconate) disrupts microbial cell membranes, causing leakage of intracellular components and cell death.

Chlorhexidine (digluconate) demonstrates rapid antimicrobial action.
Chlorhexidine (digluconate) provides persistent residual activity after application.
Chlorhexidine (digluconate) shows low systemic absorption when used topically.

Chlorhexidine (digluconate) is stable under recommended storage conditions.
Chlorhexidine (digluconate) is incompatible with anionic surfactants and soaps.
Chlorhexidine (digluconate) requires careful formulation to maintain antimicrobial performance.

PROPERTIES

Chemical Formula: C₂₂H₃₀Cl₂N₁₀ · 2C₆H₁₂O₇
Molecular Weight: ~897.76 g/mol
Appearance: Clear to pale yellow liquid (aqueous solution)
Odor: Faint characteristic odor
Physical Form: Commonly supplied as 20% aqueous solution
Density: ~1.06 g/cm³ at 25°C (20% solution)
Melting Point: Not applicable (aqueous salt; decomposes before melting)
Boiling Point: Not applicable (aqueous solution)
Solubility in Water: Completely soluble
Solubility in Alcohols: Slightly soluble
Solubility in Nonpolar Solvents: Insoluble
pH (5% aqueous solution): ~5.0–7.0
Ionic Character: Cationic
Thermal Stability: Stable under normal storage temperatures
Antimicrobial Spectrum: Broad-spectrum antibacterial and antifungal activity
Residual Activity: High; binds to skin and mucous membranes
Chemical Stability: Stable in neutral to mildly acidic conditions
Incompatibilities: Anionic surfactants, soaps, strong oxidizing agents
Storage Stability: Good when protected from light and contamination

FIRST AID

Inhalation:
Move to fresh air if mist is inhaled.
Seek medical attention if irritation persists.

Skin Contact:
Generally safe for topical use.
Rinse with water if irritation develops.

Eye Contact:
Rinse immediately with plenty of water for at least 15 minutes.
Seek medical attention promptly.

Ingestion:
Rinse mouth with water.
Do not induce vomiting.
Seek medical attention immediately.

Note to Physicians:
Treat symptomatically and provide supportive care.

HANDLING AND STORAGE

Handling:
Use protective gloves and eye protection during handling.
Avoid contact with eyes and incompatible materials.

Avoidance:
Avoid mixing with anionic surfactants and soaps.
Avoid product contamination during use.

Spill Procedures:
Absorb with inert material and clean area with water.
Dispose of waste according to local regulations.

Storage:
Store in tightly closed, properly labeled containers.
Keep in a cool, dry, well-ventilated area.
Protect from direct sunlight, freezing, and contamination.