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Chlorhexidine gluconate pharma grades mechanism of action involves destabilization of the outer bacterial membrane.
Chlorhexidine gluconate pharma grade is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.
Chlorhexidine gluconate pharma grade has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.
CAS Number: 18472-51-0
Molecular Formula: C22H30Cl2N10.2C6H12O7
Molecular Weight: 897.76
EINECS Number: 242-354-0
Synonyms: CHLORHEXIDINE GLUCONATE (USP IMPURITY), CHLORHEXIDINE GLUCONATE [USP IMPURITY], Dermachlor, Betasept, Otodine, Vetasan, Dental, Paroex, Davis, PwrioChip, Scrub, TrisOphtho, ChlorHex, HexaDermMax, TrisDent, Bactoshield Chg, Chloradine Lube, Chlorhexidin glukonatu [Czech], 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane, Scrub-stat, TrizChlor Flush, BioHexWipesWipes, CeraSootheCHX, gly4Chlor, Ultra HexFlush, Chloradine Scrub, Dermachlor Rinse, Fresh Mouth, MFCD00083599, Scrub Care, Stomodine F, Vital-Chlor, Hexa-Foam, pHiso-Med, Ultra Hex, 1,1'-HBCB, Clx Derm, Hex-Wash, Hexi Dip, Max Chlorhexidine, Oris Chx, Sky Oral Rinse, Clx Derm Spot, Major Oral Rinse, TrizChlor 4, Chlorhexidine 4%, Chlorhexidine Lube, Hex-Tra, VetraSeb CeraDerm, Chlordine 55, Chlordine105, ChlorHex 2X, Hibiclens (TN), Periogard (TN), Chlorhexidine Flush, Chlorhexidine Scrub, Davis Chlorhexidine, Dyna-Hex2, Equine Anti-Fungal, Chlordine 110, Chlordine 510, Dyna-hex 2, Dyna-hex 4, Scrub, Scrub-Stat, Dr. Dean, Peridex (TN), Hex-PLUS, TrizChlor 4 Mousse, Chlorhexidine Shampoo, SUFFUSION, TELFATEAT, Chlohexidine gluconate, Bisbiguanide Teat Dip, Chlordine 110 Dip, Chlorhexidine4% scrub, Chorhexidine Gluconate, Hexi-Dip 1%, Max ChlorhexidineFlush, TrizCHLOR 4 Wipes, Zymadent Dental Wipes, CHLORHEIX-LUBE, VETASAN SCRUB, BLUE RIBBON, Chlorhexidine 4%Scrub, Chlorhexidine Scrub4%, Chlordine Barrier Film, SANI-CLING, Stratford Dental Wipes, FS-106Spray, CHG BARRIER DIP, Chlorhexidine Gluconante, CHLORHEXIDINE2%, Hexi Dip 110, MAX Chlorhexidine 4%, Chem-Star Classic Plus, DYNA-HEX CHG, ChlorHex Maxi Scrub4%, Chlorhexidine Scrub 4%, CHLORHEXIDINESolution, Cutania TrisEDTA Wipes, TrizChlor 4 Conditioner, Antiseptic Foam Handwash, Antiseptic Skin Cleanser, Chlordine 55 Teat Dip, Chlorhexidine Solution2%, Glen Haven TrizChlor 4, Tru-Blu Chlor Hex-Wash, Antiseptic Surgical Scrub, Purell Antimicrobial Foam, Bd E-Z Scrub 107, CLX DERM OTO PLUS, Curaseb Chlorhexidine 4%, Tru-Blu C-Hex 110, Chlordine 105 Teat Dip, Chlordine 510 Teat Dip, Scrub CareExidine-2 CHG, Scrub CareExidine-4 CHG, Antiseptic Cleansing Wipes, BLUE RIBBON SPRA Y, Antimicrobial Foam Handwash, Antimicrobial Skin Cleanser, Chlorhexidinewith Aloe Vera, Chlorhexidine Gluconate 2%, Chlorhexidine Gluconate 4%, Chem-Star Classic Plus Dip, chlorhexidine gluconate cloth, Antibacterial Protective Hand, SCHEMBL34468, 4% CHG Skin Cleansing Kit, C.E.T. Oral Hygiene Rinse, CHLORHEXIDINE 2%SCRUB, Hibiclens for Georgia Pacific, FS-106 S PRAY, NUPRO Chlorhexidine Gluconate, PRE-MOISTENED TOWELETTE, CHLORHEXIDINE SCRUB 2%, Foaming Chlorhexidine Gluconate, ProSense Dental Solution Wipes, Pet MD CHLORHEXIDINE 4%, 0.12% Chlorhexidine Gluconate, CHEMBL4297088, Pre-Scrub IISurgical Hand Scrub, Chlorhexidine Gluconate Oral Rinse, Provon Antimicrobial Foam Handwash, Purell CS Foam Handwash 2% CHG, Carolina Custom Cages Chlorhexidine, Periogard (Chlorhexidine Gluconate), 2% Chlorhexidine Gluconate Solution, Chlorhexidine Gluconate 2% Solution, Chlorhexidine gluconate (JP18/USP), CHLORHEXIDINE GLUCONATE [JAN], FS-106, Bactoshield CHGChlorhexidine Gluconate, CHLORHEXIDINE GLUCONATE [USAN], DentahexOral Rinse for Dogs and Cats, AKOS015896303, AKOS025310696, Antiseptic Skin CleanserExidine-2 CHG, Stratford Chlorhexidine 4% plus TRIS, CHLORHEXIDINE GLUCONATE [VANDF], CHLORHEXIDINE D-DIGLUCONATE [MI], CHLORHEXIDINE GLUCONATE [WHO-DD], Dairyland Brand Sprayable CHG Teat Dip, Milkhouse Brand Sprayable CHG Teat Dip, Cardinal Health Antiseptic Skin Cleanser, D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1), DA-51850, Aplicare Antiseptic Chlorhexidine Gluconate, Chlorhexidine Gluconate 0.12% Oral Rinse, Chlorhexidine Gluconate Liquid Solution 2%, Chlorhexidine Gluconate Liquid Solution 4%, Chlorhexidine Gluconate, 0.12% Oral Rinse, Scrub, Scrub-Stat, Foam Safe, Micro-Guard, Banixx Wound Care Cream with Marine Collagen, C3105, CHLORHEXIDINE GLUCONATE [OR, ChlorhexidineDigluconate,20%Solution;ChlorhexidineGluconate20%SolutionChlorhexidineGluconate20%SolutionBp/Usp/Ep;ChlorhedineGluconate;CHLOROHEXIDINE DIGLUCONATE;CHLOROHEXIDINE GLUCONATE;CHLOROHEXIDINE DIGLUCONATE, SOLUTION;Chlorhexdine digluconate;Chlorhexidin bigluconate
Chlorhexidine gluconate pharma grade is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX).
Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine gluconate pharma grade is a broad spectrum antiseptic.
Chlorhexidine gluconate pharma grade is also useful against fungi and enveloped viruses, though this has not been extensively investigated.
Chlorhexidine gluconate pharma grade is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.
Chlorhexidine gluconate pharma grade is an organochlorine compound and a D-gluconate adduct.
It has a role as an antibacterial agent.
Chlorhexidine gluconate pharma grade is functionally related to a chlorhexidine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Chlorhexidine gluconate pharma grade refers to a high-purity, pharmaceutical-quality form of chlorhexidine gluconate that meets stringent standards set by regulatory agencies (such as USP, BP, or EP).
It is specifically manufactured and tested for use in medical, pharmaceutical, and healthcare applications.
This grade ensures its safety, efficacy, and compliance with pharmacopoeial specifications.
Chlorhexidine gluconate pharma grade has minimal impurities to ensure it is safe for use in sensitive applications.
It complies with pharmacopoeial standards like USP (United States Pharmacopeia), BP (British Pharmacopoeia), or EP (European Pharmacopoeia).
Chlorhexidine gluconate pharma grade is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.
It is one of the most common skin and mucous membrane antiseptic agents in use today.
The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain.
Topical chlorhexidine for disinfection, as well as oral rinses for dental use, carries activity against a broad range of pathogens including bacteria, yeasts, and viruses.
Chlorhexidine gluconate pharma grade was developed in the UK by Imperial Chemical Industries in the early 1950s9 and was introduced to the US in the 1970s.
The FDA withdrew its approval for the use of chlorhexidine gluconate topical tincture 0.5%, due to a significant number of reports concerning chemical and thermal burns associated with the use of this product.
Other formulations of chlorhexidine continue to be available.
Chlorhexidine gluconate pharma grade disrupts bacterial cell membranes by binding to phospholipids and causes leakage of intracellular contents, leading to cell death.
Its cationic nature also inhibits microbial growth by interacting with negatively charged microbial surfaces.
Chlorhexidine gluconate pharma grade is used to sterilize the skin before surgery.
To ensure surgeons’ hands are antiseptically clean.
For disinfecting open wounds and preventing infection.
Chlorhexidine gluconate pharma grade prevents plaque buildup, gingivitis, and oral infections.
Chlorhexidine gluconate pharma grade often prescribed post-dental surgery for faster healing.
Found in hand sanitizers, healthcare-grade soaps, and disinfectant sprays.
Prevents healthcare-associated infections (HAIs) in clinical environments.
Chlorhexidine gluconate pharma grade is used in wound care and disinfectants for animals.
Incorporated into shampoos and washes for pets with skin infections.
Chlorhexidine gluconate pharma grade is utilized in pharmaceutical formulations, skin creams, and topical lotions.
Included in antimicrobial coatings for medical equipment.
Density: 1.06 g/mL at 25 °C(lit.)
vapor pressure: 0.005Pa at 25℃
storage temp.: 2-8°C
solubility: water: soluble50% (w/v)
form: Liquid
color: Colorless
Viscosity: 2.51mm2/s
Water Solubility: 750g/L at 20℃
λmax: 257nm(H2O)(lit.)
Sensitive: Light Sensitive
Merck: 14,2091
InChIKey: YZIYKJHYYHPJIB-UUPCJSQJSA-N
SMILES: N(C1C=CC(Cl)=CC=1)C(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1C=CC(Cl)=CC=1.[C@@H](O)([C@@H](O)C(=O)O)[C@H](O)[C@H](O)CO |&1:34,36,41,43,r|
LogP: -1.81 at 20.7℃
Produced under strict Chlorhexidine gluconate pharma grade guidelines, ensuring low levels of residual solvents, heavy metals, and microbial contamination.
Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family.
Its mechanism of action involves destabilization of the outer bacterial membrane.
Chlorhexidine gluconate pharma grade is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family.
Its mechanism of action involves destabilization of the outer bacterial membrane.
Chlorhexidine gluconate pharma grade is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
Superior to alcohol-based disinfectants for prolonged microbial control.
Chlorhexidine gluconate pharma grade effective against resistant strains like Methicillin-resistant Staphylococcus aureus (MRSA).
Chlorhexidine gluconate pharma grade integral in infection control protocols in ICUs and surgical wards.
Chlorhexidine gluconate pharma grade suitable for patients with sensitive or compromised skin.
Chlorhexidine gluconate pharma grade is used on intact and broken skin.
Effective even in the presence of organic matter like blood and pus.
Broad-spectrum antimicrobial activity effective against bacteria, fungi, and some viruses.
Chlorhexidine gluconate pharma grade prolonged action due to its ability to bind to the skin and mucous membranes.
Low toxicity at recommended concentrations, making it suitable for routine use.
Minimal systemic absorption when used topically; toxicity is low in approved concentrations.
Chlorhexidine gluconate pharma grade can cause mild irritation to skin and mucous membranes in some individuals.
Chlorhexidine gluconate pharma grade avoid contact with eyes and middle ear as it can cause damage.
Chlorhexidine gluconate pharma grade store in a cool, dark place to preserve potency and stability.
Active ingredient in prescription-based antimicrobial drugs.
Chlorhexidine gluconate pharma grade is used in manufacturing topical creams, ointments, and sprays.
Incorporated into controlled-release devices like Periochip for treating periodontal disease.
Chlorhexidine gluconate pharma grade essential for cleaning hospital equipment, surfaces, and operating theaters.
Included in antiseptic body washes for patients undergoing surgery.
Improves healing rates by preventing biofilm formation.
Chlorhexidine gluconate pharma grade is used in wound irrigation solutions and hydrogel formulations.
Found in dermatologically approved acne cleansers.
Ingredient in intimate hygiene products for reducing microbial infections.
Chlorhexidine gluconate pharma grade medicated teat dips in dairy animals to prevent mastitis.
Uses:
Chlorhexidine gluconate pharma grade is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry.
Chlorhexidine gluconate pharma grade is used in hospitals to prevent infection of patients during surgeries and can also be found in mouthrinses.
Chlorhexidine gluconate pharma grade is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of Chlorhexidine gluconate pharma grade, a biguanide compound used as an antiseptic agent with topical antibacterial activity.
Chlorhexidine gluconate pharma grade is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane.
Subsequently, Chlorhexidine gluconate pharma grade penetrates into the cell and causes leakage of intracellular components leading to cell death.
Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine gluconate pharma grade 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative.
Chlorhexidine gluconate pharma grade is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast.
It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.
Chlorhexidine gluconate pharma grade is a preservative generally used in concentrations of 0.01 to 0.1 percent to protect against bacteria.
It is unstable at high temperatures.
Chlorhexidine gluconate pharma grade is more widely used in europe than in the united States.
Chlorhexidine gluconate pharma grade is the most effective of a series of antibacterial biguanides originallydeveloped in Great Britain.
The antimicrobial properties of the biguanides were discoveredas a result of earlier testing of these compounds aspossible antimalarial agents.
Although thebiguanides are technically not bisquaternary ammoniumcompounds and, therefore, should probably be classifiedseparately, they share many physical, chemical, and antimicrobialproperties with the cationic surfactants.
Thebiguanides are strongly basic, and they exist as dications atphysiological pH.
In chlorhexidine, the positive charges arecounterbalanced by gluconate anions (not shown).
Likecationic surfactants, these undergo inactivation when mixedwith anionic detergents and complex anions such as phosphate,carbonate, and silicate.
Chlorhexidine gluconate pharma grade has broad-spectrum antibacterial activitybut is not active against acid-fast bacteria, spores, orviruses.
It has been used for such topical uses as preoperativeskin disinfection, wound irrigation, mouthwashes, andgeneral sanitization.
Chlorhexidine gluconate pharma grade is not absorbedthrough skin or mucous membranes and does not causesystemic toxicity.
Chlorhexidine gluconate pharma grade may be used as a pharmaceutical reference standard for the determination of the analyte in eye drop formulations using capillary electrophoresis technique with contactless conductivity detection.
These Secondary Standards are qualified as Certified Reference Materials.
These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Chlorhexidine gluconate pharma grade is used in solutions for wound care, surgical hand scrubs, and skin disinfectants.
Found in mouthwashes and oral rinses for gingivitis prevention.
Chlorhexidine gluconate pharma grade is used in medicated solutions and scrubs for animals.
Typically used in concentrations of 0.12%, 2%, or 4% depending on the formulation and intended use.
Supplied in aqueous or alcohol-based solutions, creams, or gels.
Chlorhexidine gluconate pharma grade is used in preoperative skin preparations to reduce infection risk.
Found in surgical hand scrubs and body washes for healthcare professionals.
Chlorhexidine gluconate pharma grade is used to clean and disinfect wounds, cuts, and abrasions.
Promotes healing by preventing infection and biofilm formation.
Chlorhexidine gluconate pharma grade is used to clean and maintain catheter insertion sites.
Reduces the risk of bloodstream infections in hospitalized patients.
Incorporated into medical devices like catheters and surgical implants to prevent microbial colonization.
Chlorhexidine gluconate pharma grade treats gingivitis, periodontitis, and oral infections.
Reduces plaque formation and bacterial load in the oral cavity.
Chlorhexidine gluconate pharma grade prescribed after dental surgeries like extractions or implants to prevent infection.
Found in products like PerioChip, a slow-release antimicrobial used in periodontal pockets.
Widely used in healthcare and public settings to prevent infection spread.
Chlorhexidine gluconate pharma grade found in alcohol-based hand sanitizers for added antimicrobial activity.
Chlorhexidine gluconate pharma grade active ingredient in dermatological products for reducing skin bacterial load and treating acne.
Found in feminine and general hygiene products to prevent infections.
Chlorhexidine gluconate pharma grade is used to clean wounds and infections in pets and livestock.
Found in shampoos and sprays for animals with skin conditions.
Chlorhexidine gluconate pharma grade is used to prevent mastitis in dairy cows by disinfecting teats before and after milking.
Cleans and protects surgical sites on animals to ensure proper healing.
Chlorhexidine gluconate pharma grade essential for reducing healthcare-associated infections (HAIs), including MRSA and VRE.
Chlorhexidine gluconate pharma grade is used to disinfect hospital surfaces and medical instruments.
Chlorhexidine gluconate pharma grade is used in high-risk patients to prevent infections, especially in intensive care units.
Chlorhexidine gluconate pharma grade is used as a sanitizer for equipment and surfaces to ensure food safety.
Applied to high-touch surfaces in industrial settings to reduce microbial growth.
Chlorhexidine gluconate pharma grade provides an effective barrier against microbial infections in burn patients.
Often combined with alcohol for enhanced efficacy in pre-surgical cleaning.
Embedded in hospital textiles, dressings, and medical tapes for infection control.
Safety Profile:
Prolonged or repeated exposure to concentrated solutions may cause skin redness, dryness, or irritation.
Some individuals may experience mild burning or itching sensations.
Rare cases of hypersensitivity reactions, including contact dermatitis or urticaria.
Severe allergic responses, such as anaphylaxis, have been reported but are uncommon.
Direct contact with the eyes can cause pain, redness, tearing, and potential corneal damage.
Rinse eyes immediately with water if contact occurs and seek medical attention.
Chlorhexidine gluconate pharma grade inhalation of vapors, aerosols, or sprays (especially during industrial use) can irritate the respiratory tract.
Chlorhexidine gluconate pharma grade symptoms may include coughing, difficulty breathing, or sore throat.
