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CHLOROACETAMIDE
CAS NO.: 79-07-2
EC/LIST NO .: 201-174-2
Chloroacetamide (2-chloroacetamide) is a chlorinated organic compound with the molecular formula ClCH2CONH2.
Chloroacetamide is a colorless solid although older samples appear yellow.
Chloroacetamide has a characteristic odor and is readily soluble in water.
This substance is an industrial preservative used in the textile and paper industries for waxes and synthetic polymers.
Chloroacetamide is used in vegetable tanning liquors and on finished leather during drying and storage.
Chloroacetamide is a white to pale yellow powder with a faint characteristic odor.
Chloroacetamide is soluble in water and alcohol and very slightly soluble in ethe
Chloroacetamide is prepared from reactions of ethyl chloroacetate with ammonia or from reactions of chloroacetyl chloride and ammonium acetate
Chloroacetamide (CAA) is a preservative used in various cosmetic,personal care and household products.
Chloroacetamide is a white to pale yellow powder.
In cosmetics and personal care products, Chloroacetamide has had use in hair, bath, body and hand cleansing and personal products.
Chloroacetamide is a preservative used in several applications such as in cutting metalwork fluids, in paints or in glues.
Chloroacetamide can induce contact dermatitis in hairdressers, or in shoemakers when used as a leather preservative.
Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields.
Chloroacetamide is a biocide in agriculture, glues, paints and coatings.
Chloroacetamide inhibits very-long-chain fatty acid elongase
Acetamide, Chloroacetamide, also known as chloroacetamide, is an industrial chemical.
These compounds, also known as anilides, are very often used for weed control in maize, in combination with triazines.
Chloroacetamides are extracted from soil by polar and medium polarity solvents and their determination is generally carried out without further purification.
Extraction from water is performed by reversed-phase solid-phase extraction (SPE) or by liquid–liquid extraction with low polarity solvents and clean-up of extracts on silica columns is necessary in some cases.
Analysis of these herbicides in plants is done by extraction with polar solvents, followed by purification by liquid–liquid partition or column chromatography on silica or alumina adsorbents.
Analytical methods for the determination of these herbicides in air have been reported, using several adsorbents or an ethylene glycol phase for their extraction from air.
NPD and MS are the detectors most widely used in the determination of chloroacetamides; the ECD is also sometimes used.
Chloroacetamide belongs to the class of organic compounds known as chloroacetamides.
These are organic compounds with the general formula RNHC(=O)CH2Cl, where R= organyl group.
Chloroacetamide decomposes when heated above 225 °C and creates toxic gases including chlorine and nitrogen oxides.
Chloroacetamideis used as an herbicide and a preservative. 2-Chloroacetamide is a very strong basic compound (based on its pKa).
Chloroacetamide is a colorless (older samples appear yellow) crystalline substance with characteristic smell, readily soluble in water.
Chloroacetamide (2-chloroacetamide) is a chlorinated organic compound with the molecular formula CHCl2CONH2.
Chloroacetamideis suspected of reproductive toxicity and teratogenicity. This compound has been identified in human blood as reported by (PMID: 31557052 ).
Chloroacetamide is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives.
Technically 2-Chloroacetamide is part of the human exposome.
The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health.
An individual's exposure begins before birth and includes insults from environmental and occupational sources.
A wide range of organic chemicals are offered by us which includes 2 chloroacetamide,colorless to pale yellow crystalline chemical with a characteristic odor.
Chloroacetamide is highly flammable and combustible at high temperature.
Chloroacetamide is a colorless to pale yellow crystalline chemical with a characteristic odor.
Chloroacetamide is insoluble in alcohol and ether and soluble in water.
Chloroacetamide is a highly toxic chemical and may prove hazardous in case of skin contact and the extreme over-exposure may also result in death.
The substance is also bad for cardiovascular system, lungs, reproductive system and central nervous system (CNS).
Chloroacetamide is highly flammable and combustible at high temperature.
Chloroacetamide is produced by ammonolysis of esters of chloroacetic acid:
ClCH2CO2CH3 + NH3 → ClCH2C(O)NH2 + CH3OH
Assay: 99%
Appearance: White crystalline powder
Capacity: 1500MT per year
Packaging: 25kg bag
Sample: available
Category: Pharmaceutical Intermediates
Chemical Name: Chloroacetamide; 2-Chloroacetamide
CAS No.: 79-07-2
Molecular Formula:C2H4ClNO
Molecular Weight:93.51
Item: Specifications Results
Appearance: White crystalline powder White crystalline powder
Acidity %: ≤0.08 0.06
Melting range℃: 116-122 118.0-119.1
Water content(by KF) % : ≤0.20 0.06
Purity(by HPLC) %: ≥99 99.32
Ammonium Chloride Assay %: ≤0.5 0.05
Conclusion: The results conforms with Enterprise standards
Analytical methods for the separation and/or determination of Chloroacetamide include thin layer ~hromatography,'~) fluorometry, infrared spectrometry, and gas chromatography
Chloroacetamide is suitable for use with anionic, cationic, and nonionic surfactants.
However, it is incompatible when used with strong acids or bases
Amides of chloroacetic acids are soft alkylating agents and are among the most popular covalent binders.
They are synthesized using amide coupling reaction of chloroacetic acids with primary and secondary amines:
Besides cherry-picking from around 2 000 chloroacetamides from stock you can acquire a small library of these covalent ligands already plated in DMSO solution for fast supply.
Conducted stability tests show that compounds remain in frozen DMSO solution at least within 1 year without any significant degradation.
Chloropropianates.
Somewhat less reactive amides of α-chloropropionic acid can be also employed in discovery of selective covalent probes.
Synthesis of new covalent ligands.
We offer a unique possibility to produce a customized library of chloroacetamides and / or chloropropianates.
Based on our experience in making these covalent compounds and availability of over 40k amines in our stock we have enumerated a library of REAL (readily accessible) covalent compounds.
We will produce at least 80% compounds from your selection within only 4-6.
preservative in cosmetic and pharmaceutical creams, shampoos, bath lotions, etc.; preservative in glues, cooling fluids.
Chloroacetamide has been used as an herbicide,preservative.
and in the manufacturing of pharmaceuticals.
Used for synthesis of chloroacetonitrile sulfameprazine and other organic compounds used in organic synthesis, pharmaceutical intermediates and synthesis of chloroacetonitrile sulfameprazine 3-methoxypyrazine and other organic compounds
This is a chemical preservative found in cosmetic and pharmaceutical creams such as shampoos and bath lotions.
Chloroacetamide is also used as a preservative in glues and cooling fluids.
Chloroacetamide is used as a preservative and antiseptic in cosmetics.
Chloroacetamide containing Chloroacetamide are typically applied to the eye area, skin, face, and hair.
Cosmetics formulated with Chloroacetamide may be applied from once a day to several times a day and may stay in contact with the skin for several hours.
The formulations also have the potential for repeated application over the course of many years.
Chloroacetamide and thiocarbamate herbicides have many properties in common:
both herbicide classes are effective only as preemergence herbicides;
they inhibit early seedling growth and cause similar injury symptoms in susceptible species;
they are detoxified in plants by glutathione conjugation;
they have a similar spectrum of selectivity;
they can be applied safely in certain susceptible grass crops when applied with antidotes;
and they can inhibit the synthesis of lipids, isoprenoids, and other metabolic processes requiring coenzyme A.
Chloroacetamidecan be hypothesized that these similarities are due to the ability of the chloroacetamides and the sulfoxide of thiocarbamates to bind covalently to enzymes, coenzymes, or metabolic intermediates containing sulfhydryl (-SH) groups.
Chloroacetamide is used as surface-active agent in home laundry, cleaning products & household formulated cleaners, other industrial uses, petroleum production, polymer processing.
Chloroacetamide is used as a preservative in cosmetics and in household (e.g. cleaning) products.
Chloroacetamide is used as a biocide in a variety of products such as paints and glues.
Chloroacetamide is also used as a preservative in soluble cutting oils, and in the leather-, paper-, textile- and plastic industries.
To a minor extent, it is used for chemical synthesis in the pharmaceutical industry.
In cosmetics, chloroacetamide is often used as a mixture of chloroacetamide and sodium benzoate (70% / 30%) in rinse-off products at the level of 0.15% and in leave-on products at a maximum concentration of 0.3%.
The 70% chloroacetamide / 30% sodium benzoate mixture is called CA 24.
Used as Herbicide.
Used as Preservative in Cosmotic and Pharmaceutical creams, Shampoos, bath lotions, e.t.c;
Used as a biocide in a variety of products such as glues, Paints & Cooling fluids
Surface-active agent in home laundry, cleaning products & household formulated cleaners, other indust uses (petroleum prodn, polymer processing).
Chloroacetamide is also used as a preservative in soluble cutting oils, and in the leather-, paper-, textile- and plastic industries.
Chloroacetamide is used for chemical synthesis in the pharmaceutical industry.
Pharmaceutical intermediate to synthesize chlorine acetonitrile, sulfonamide and 3-methyl pyrazine, etc.
cosmetics and creams,
shampoos, bath body gels, adhesives and
as a preservative in coolants
Contact dermatitis and respiratory problem may occur.
IUPAC NAME:
2-chloroacetamide
SYNONYMS:
201-174-2
2-Chloracetamid
2-Chloroacetamide
2-Chloroacétamide
79-07-2
AB5075000
Acetamide, 2-chloro-
CHLOROACETAMIDE
[79-07-2]
122775-20-6 [RN]
