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EC / List no.: 200-431-6
CAS no.: 59-50-7
Mol. formula: C7H7ClO
Chlorocresol appears as a pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C.
Shipped as a solid or in a liquid carrier.
Soluble in aqueous base.
Toxic by ingestion, inhalation or skin absorption.
Used as an external germicide.
Used as a preservative in paints and inks.
Chlorocresol is approved for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, veterinary hygiene, product preservation, preservation of fibres, leather, rubber, or polymers, preservation for working / cutting fluids.
Chlorocresol is used in the following products: cosmetics and personal care products.
Other release to the environment of Chlorocresol is likely to occur from: indoor use.
Chlorocresol is used in the following products: pH regulators and water treatment products, laboratory chemicals and polishes and waxes.
Chlorocresol is used in the following areas: formulation of mixtures and/or re-packaging, health services and scientific research and development.
Chlorocresol is used for the manufacture of: chemicals. Other release to the environment of Chlorocresol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Chlorocresol is used in the following products: metals, coating products, fillers, putties, plasters, modelling clay and fuels.
Release to the environment of Chlorocresol can occur from industrial use: formulation of mixtures.
Chlorocresol is used in the following products: textile treatment products and dyes, pH regulators and water treatment products, non-metal-surface treatment products, inks and toners, leather treatment products and polymers.
Chlorocresol has an industrial use resulting in manufacture of another substance (use of intermediates).
Chlorocresol is used in the following areas: formulation of mixtures and/or re-packaging and printing and recorded media reproduction.
Chlorocresol is used for the manufacture of: chemicals, textile, leather or fur, plastic products and mineral products (e.g. plasters, cement).
Release to the environment of Chlorocresol can occur from industrial use: as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites and as processing aid.
Chlorocresol is a hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4.
A ryanodine receptor agonist.
It has a role as a ryanodine receptor agonist, an antimicrobial agent and a disinfectant.
It is a hydroxytoluene and a member of monochlorobenzenes.
USE AREAS
General adhesives and binding agents for a variety of uses
Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing
Modifier used for chemical, when chemical is used in a laboratory
Term used for colorants, dyes, or pigments; includes colorants for drugs, textiles, personal care products (cosmetics, tatoo inks, hair dye), food colorants, and inks for printing
Drug product, or related to the manufacturing of drugs
Pharmaceutical related
Includes antifoaming agents, coagulating agents, dispersion agents, emulsifiers, flotation agents, foaming agents, viscosity adjustors, etc
Includes food packaging, paper plates, cutlery, small appliances such as roasters, etc.; does not include facilities that manufacture food
Modifier included when source indicates the product is water based
Generic lubricants, lubricants for engines, brake fluids, oils, etc (does not include personal care lubricants)
Modifier included when source indicates the product is water based
Furniture, or the manufacturing of furniture (can include chairs and tables, and more general furniture such as mattresses, patio furniture, etc.)
Sub-category of apparel, including backpacks, purses, and luggage
Shoes, shoe care products, etc.
Manufacturing of or related to machinery, for production of cement or food, air/spacescraft machinery, electrical machinery, etc
Related to metals - manufacturing of metals, casting of metals, production of metals, surface treatment of metals, etc
Related to the manufcturing of pulp or paper products, or paper products in general
Textiles used for clothing or furniture upholstery, processes related to textiles (e.g. softeners, antiwrinkle agents), or the processing/manufacturing of textiles
Various types of paint for various uses
Personal care products, including cosmetics, shampoos, perfumes, soaps, lotions, toothpastes, etc
Substances used for preventing, destroying or mitigating pests
Pesticide for non agricultural use
External germicide; preservative for glues, gums, paints, inks, textile and leather goods.
Chlorocresol is used as a preservative in a wide number of topical preparations and is a rare cause of allergic contact dermatitis and CoU, the mechanism of which remains uncertain.
Chemical Properties
Chlorocresol is a White (pure) or pink crystalline solid.
Crystals turn pink on exposure to air and light. Phenolic odor.
Pharmaceutical Applications
Chlorocresol is used as an antimicrobial preservative in cosmetics and pharmaceutical formulations.
Chlorocresol is generally used in concentrations up to 0.2% in a variety of preparations except those intended for oral administration or that contact mucous membrane.
Chlorocresol is effective against bacteria, spores, molds, and yeasts; it is most active in acidic media.
Preservative efficacy may be reduced in the presence of some other excipients, particularly nonionic surfactants.
Storage
Chlorocresol is stable at room temperature but is volatile in steam.
Aqueous solutions may be sterilized by autoclaving.
On exposure to air and light, aqueous solutions may become yellow colored.
Solutions in oil or glycerin may be sterilized by heating at 1608℃ for 1 hour.
The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.
Chlorocresol is a prill form chlorophenolic, low toxicity biocide developed for the complete in-can protection of water based products.
Chlorocresol is effective against a wide range of microorganisms including gram positive and gram negative bacteria, yeast and fungi.
Microorganisms grow at a rapid rate and without use of the correct biocide, numbers can increase dramatically.
Chlorocresol is prepared by chlorination of m-cresol.
Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.
PRODUCT DETAILS
For the preservation of adhesives, glues, polymer dispersions and emulsions, metalworking/cutting fluids, dyes, industrial lubricants, pigments and filler suspensions, materials in the building industry (e.g., concrete additives, joint cements), paint and coatings, paper, textile, photo, oil industries and leather at all stages of production.
TYPICAL APPLICATIONS
It is recommended that the Chlorocresol Preservative be pre-dissolved (e.g. in alcohol, glycol or caustic soda solution) to ensure the product is evenly distributed in the finished formulation.
Chlorocresol Preservative can also be added in the form of an alkaline stock solution.
A stock solution containing 30% Chlorocresol Preservative can be formulated by stirring 1 kg Chlorocresol Preservative into 1.85 liters of water and 0.5kg 50% caustic soda solution until it dissolves.
Dissolving can be accelerated by gently heating the liquid.
The steam-volatility of Chlorocresol Preservative must be taken in account in the case of certain applications (e.g. when drying glue slurries which contain Chlorocresol Preservative)
Chlorocresol is a chlorinated phenol which is used as an antiseptic and preservative.
For use as a disinfectant such as a hand wash, it is commonly dissolved in alcohol in combination with other phenols.
It is a moderate allergen for sensitive skin.
Properties
Chemical formula: C7H7ClO
Molar mass: 142.58 g·mol−1
Appearance: White/pink solid
Odor: Phenolic
Density: 1.37 g/cm3 (20 °C)
Melting point: 55.55 °C (131.99 °F; 328.70 K)
Boiling point: 235 °C (455 °F; 508 K)
Solubility in water: 3.8 g/l at 20 °C (in water)
Specification :
Technical Specification :
Appearance : White Crystalline Powder
Assay : 99.8 % Min.
Moisture : Less than 0.5% w/w
Melting Range : 64 0 C - 68 0 C
Boiling Point : 235 0 C
Solubility : Slightly soluble in water(4g/L), easily soluble in organic solvent such as alcohols(96 percent in ethanol), ethers, ketones, etc.
Appearance of Solution : The solution is clear and not more intensely coloured than reference solution BY6
Acidity : Not more than 0.2ml of 0.01M NaOH is required to produce a pure yellow colour
Application :
It is frequently used in;
Personal care products, antibacterial hand soap, soap, shampoo and healthy products.
Household & institutional disinfectant and cleansers, Public & hospital Hygiene.
Other fields such as leather, metal machining liquid, concrete, film, glue, textile, oiled, paper, etc.
Fungicides, Industrial
MEDICATION (VET): In topical medicaments and in intrauterine lubricants as antiseptic and preservative (0.1-0.2% concentration).
Chlorocresol and chloracetamide are used in medications, glues, and cosmetics as preservatives.
Antiseptic (topical).
Chlorocresol is a hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.
Chlorocresol has a role as a ryanodine receptor agonist, an antimicrobial agent and a disinfectant.
Chlorocresol is a hydroxytoluene and a member of monochlorobenzenes.
Min. 99.8 % chlorocresol (p-chloro-m-cresol).
- For the preservation of thickener solutions, adhesives (including protein-based formulations), concrete additives, metalworking fluids, textile print thickeners, leather etc.
- For the formulation of disinfectants for use in hospitals, doctor’s offices, industry, institutions and sheds.
The product has a broad and very balanced spectrum of activity covering Gram-positive and Gram-negative bacteria, mould and yeast.
Particularly effective against putrefactive bacteria and therefore suitable for use in products which are difficult to preserve (e.g. protein-based formulations).
Inter alia registered in Europe and USA.
Physical and Chemical Properties
1) PCMX is a security, efficient, anti-mould antiseptic, anti-mildew agent;
2) Solubility: 4g/L in water, freely soluble in organic solvent such as alcohols (96% in alcohols), ether, ketones and strong base aqueous solution, and completely soluble in oil.
3) Friendly to environment, formaldehyde-free, Non-toxic impurities, easily degradable;
4) Well compatibility with anionic surfactant, Non-ionic surfactant and emulgator. Good synergistic effect with other antiseptic and bactericide;
5) PH range of application: 4-12
Application:
1) Personal care products, Such as antibacterial soap, antibacterial shampoo and health care products;
2) Household & institutional disinfectant and cleansers, Public & hospital Hygiene product;
3) Other fields such as leather, metal machining liquid, concrete, film, glue, textile, oiled, paper, etc;
p-Chloro-m-cresol (Chlorocresol) which is also known as chlorocresol is used as an external germicide and bactericide agent.
Chlorocresol has bactericidal activity against Gram positive and Gram negative organisms, along with yeasts, moulds and spores.
Chlorocresol is also used aspreservative for various pharmaceutical preparations like cosmetics,lotions, tanning agents, and topical corticosteroids.
Other than that, Chlorocresol is also used in glues, paints and varnishes, and leather goods.
Moreover, Chlorocresol is used widely in eye drops, injections, shampoos and emulsions due to its disinfectant and antifungal properties.
Chlorocresol's antiseptic property makes it suitable for use in heparin solutions, andin various creams for skin care and dermatological care.
Apart from that, Chlorocresol is reported as potent activator of Ca2+ release mediated by ruthenium red/caffeine-sensitive Ca2+ release channel in skeletal muscle sarcoplasmic reticulum.
Chlorocresol is a potent chlorinated phenolic disinfectant and antiseptic.
Chlorocresol has bactericidal activity against Gram-positive and Gram-negative bacteria and is effective against fungi but has little activity against bacterial spores except at high temperatures.
Chlorocresol is more active in acid than in alkaline solution.
Chlorocresol is used in preparations for disinfection of the skin and wounds.
Chlorocresol is also used as a preservative in cosmetics and in creams and other preparations for external use that contain water.
Chlorocresol is used as a preservative in aqueous injections issued in multidose containers.
Chlorocresol may also be added to aqueous preparations that cannot be sterilised in their final containers and have to be prepared using aseptic precautions.
Concentrations of 0.1% have generally been used.
As for Phenol. The antimicrobial activity of chlorocresol may be reduced by incompatibility (see above), adsorption, increasing pH, or through combination with organic matter (including oils and fats) or nonionic surfactants.
Chlorocresol is less toxic than phenol.
Sensitisation reactions may follow application to the skin and hypersensitivity has occurred after systemic use of injections containing chlorocresol as a preservative.
CAS No: 59-50-7
Physical and Chemical Properties: This product is a security, efficient anti-mould antiseptic.
Slightly soluble in water(4g/L), easy soluble in organic solvent such as alcohols(96 percent in ethanol), ethers, ketones, etc. Freely soluble in fatty oils, and dissolves in solutions of alkali hydroxides.
IUPAC NAMES
4-Chlor- 3-methylphenol
4-Chlor-3-methylphenol
4-chloro-3-methyl phenol
4-Chloro-3-methylphenol
4-chloro-3-methylphenol
4-Chloro-m-cresol
4-chloro-m-cresol
4-Chloro-m-cresol, PCMC, 2-Chloro-5-hydroxytoluene
4-cloro-3-metilfenol
Chlorkresol
Chlorocresol
chlorocresol
chlorocresol
Phenol, 4-chloro-3-methyl-
SYNONYMS
4-chloro-1-hydroxy-3-methylbenzene
4-chloro-3-methyl-pheno
4-chloro-3-methylphenol(p-chlorocresol)
4-Chloro-5-methylphenol
4-chloro-m-creso
PARA CHLORO META CRESOL
PCMC
P-CHLORO-M-CRESOL
ai3-00075
Aptal
Baktol
Baktolan
Candaseptic
caswellno185a
chloro-3-cresol
Chlorocresol
chlorocresol(orparachlorocresol)
chlorocresolo
chlorocresols
chlorocresolum(latin)
chlorokresolum
clorocresol
CMK
epapesticidechemicalcode064206
Lysochlor
m-Cresol, 4-chloro-
m-cresol,4-chloro
Ottafact
Parmetol
Parol
p-Chlor-m-cresol
p-Chlorocresol
p-Chlorometacresol
4-Chloro-m-cresol (OH=1)
4-Chloro-m-cresol 98+ %
4-Chloro-m-cresol~PCMC
4-CHLORO-3-METHYL PHENOL, 1X1ML, MEOH, 5 00UG/ML
4-CHLORO-3-METHYLPHENOL, 5000MG, NEAT
Pcmc(Chlorocresol)
Chloro-M-Cresol(Oh=1)
Chlorokresol
4-Chloro-3-methylphenol, 99+%
p-Chloro-m-cresol (4-Chloro-3-methyl phenol)
PARA-CHLOROCRESOL
4-CHLORO-META-CRESOL
4-CHLORO-3-METHYLTOLUENE
4-Chlor-3-methylphenol
Phenol, 4-chloro-3-methyl-
4-chloro-3-methylphenol solution
Chlorocresol (meta-)
4-CHLORO-3-METHYLPHENOL / 4-CHLORO-M-CRESOL
26) PARA CHLORO META CRESOL
4-Chloro-m-cresol Zone Refined (number of passes:26)
Klorkresol
chlorocresol 4-chloro-m-cresol 4-chloro-3-methylphenol
p-CHLORO-m-CRESOL pure
Parachloromethacresol
High purity 4-Chloro-3-methylphenol CAS:59-50-7
