PRODUCTS

CHLOROPHENE

CAS-Number: 120-32-1
EINECS Number: 204-385-8
MDL number: MFCD00020140
PubChem Substance ID: 24879046
IUPAC Name: 2-Benzyl-4-chlorophenol
CAS Name: Phenol, 4-chloro-2-(phenylmethyl)
Molecular formula: C13H11ClO
Molecular weight (g/mol): 218.7 g/mol
Density: 1.19
Melting Point: 45°C to 51°C
Boiling Point: 160°C to 162°C (5mmHg)
Flash Point: 185°C (365°F)

APPLICATIONS

Chlorophene is a multi-site bactericide and fungicide with basic activity at the cell wall, disruption of membrane potentials and general membrane permeability of the cytoplasmic membrane.
Chlorophene adsorbs to the cell membrane, following which the function of membrane proteins is disturbed, and substrate transport and ATP synthesis are inhibited.
The cell membrane loses its semi-permeability and ions and organic molecules escape.
Chlorophene is a halogenated phenolic compound that functions as a biocide and preservative in cosmetics.
Chlorophene is used as a disinfectant , herbicide, and fungicide.
Agrochemicals -> Fungicides
Cosmetics -> Preservative
Chlorophene is Used as a preservative in cosmetics.
Chlorophene is used as a germicide in disinfectant solutions and soaps (HSDB) and as a preservative in metal cutting fluids.
Chlorophene is used in formulating disinfectant and sanitizer products.
Chlorophene is also used in soaps, anionic detergents, cosmetics and aerosol spray products.
Chlorophene is a useful biochemical for proteomics research.
Chlorophene is Used in soaps, anionic detergents, cosmetics and aerosol spray products.
Chlorophene is a useful biochemical for proteomics research.
Chlorophene is Used in household, hospital, and veterinary disinfectants.
Chlorophene is Also used as a fungicide, herbicide, antimicrobial, and cosmetics preservative.
Chlorophene is Used as a disinfectant (swimming pool decks, industrial water systems, poultry houses and other farming premises, food processing, and restaurants).
Chlorophene is Used In household, hospital and veterinary disinfectant preparations.
Chlorophene is used in formulating disinfectant and sanitizer products.
Chlorophene is also used in soaps, anionic detergents, cosmetics and aerosol spray products.
Chlorophene is a useful biochemical for proteomics research.
Chlorophene has non-industrial uses as active constituents in registered agricultural and veterinary chemical products.
Chlorophene is used in agricultural disinfectants.
Chlorophene is used as antimicrobial ingredients and preservatives in cosmetic products.
Chlorophene is also used in general purpose cleaning and washing agents and disinfectants.
Chlorophene is a major household and industrial germicide.
Chlorophene is Used in microscope analysis; used in the synthesis of dye neutral bright green BL, pharmaceutical agrochemicals and pesticides, as well as solvent for refining mineral oil; used in pesticides, pharmaceuticals, dyes, plastics and other industries.
Chlorophene is also used as an alcohol discolourant, selective solvent for refining mineral oil, and microanalysis.
Ortho-benzyl-para-chlorophenol and its salts are used as disinfectants/antimicrobials for controlling variety of bacteria, fungi, algae,
and viruses.
The use sites include swimming pool water related surfaces such as decks, and other hard surface areas surrounding swimming pools refuse/solid waste sites, air washer water systems, evaporative condenser water systems and industrial processing water, and commercial/industrial water cooling systems.
Chlorophene and its salts are also used as disinfectants for farm premises, poultry houses, food processing plants, eating establishments, and federally inspected meat and poultry processing plants.
Chlorophene Labeling for disinfectants registered for use in federally inspected meat, poultry, and egg processing plants, as well as for phenolic-based products used as disinfectants in food preparation, storage, and serving establishments/areas, requires that food products and packaging materials are removed or carefully covered prior to application and that a potable water rinse is employed after treatment.
Phenolic-based products recommended for use as disinfectants on food contact surfaces in eating establishments and homes are limited to sites such as counter tops, stoves, and refrigerators, which followed by a potable water rinse would allow their classification as a nonfood use.
Application of these products as disinfectants on eating utensils, glassware, and similar items would be considered a food use and would require a tolerance or an exemption from the requirements of a tolerance prior to approval.

DESCRIPTION

Chlorophene is a halogenated phenolic compound that functions as a biocide and preservative in cosmetics.
Chlorophene is a flammable, difficult to ignite, colorless to yellowish solid with a phenol-like odor, which is very sparingly soluble in water.
Chlorophene appears as white to light tan or pink flakes or white crystals.
Chlorophene is insoluble in water.
Chlorophene has Slight phenolic odor.
Chlorophene is a halogenated phenolic compound that functions as a biocide and preservative in cosmetics.
In Europe, the maximum authorized concentration allowed for Chlorophene is 0.2%.
The glucuronic acid conjugate, the sulfate ester conjugate, and two other minor metabolites of Chlorophene were profiled in rat urine during pharmacokinetic tests. Chlorophene is incompletely absorbed through rat skin.
In several anumal species these chemicals exhibited low oral toxicity.
Some evidence of toxicity was found in short-term oral toxicity studies in mice and rats with nephropathy as the principal finding.
Rats and mice dosed with Chlorophene for 2 years had a dose-related and sex-related increase in the severity of nephropathy.
In another set of animal tests Chlorophene was found to be an ocular irritant.
There was no readily available inhalation profile for Chlorophene.
Chlorophene was severely irritating to rabbits in most dermal irritation studies.
Chlorophene was found to be mutagenic in four in-vitro mammalian test systems.
However, neoplasms were not observed in rats treated with Chlorophene for 2 years but, in mice treated similarly a significant incidence of neoplasms was observed.
A 1-year National Toxicology Program (NTP) study concluded that Chlorophene was a cutaneous irritant and a weak skin tumor promoter but had no activity as an initiator or complete carcinogen.
Some reactions to Chlorophene occurred in some, but not all, clinical dermal sensitization tests.
Chlorophene is a useful biochemical for proteomics research.
Chlorophene appears as white to light tan or pink flakes or white crystals.
Chlorophene is Insoluble in water.
Chlorophene has Slight phenolic odor.
Chlorophene has White to light tan or pink flakes color.
Chlorophene is incompatible with acids and oxidizing agents .
Chlorophene is sensitive to light.
Chlorophene is Stable at temperatures up to 77°F when protected from light, but storage at 140° F causes decomposition.
Chlorophene (CP) has a single phenyl ring that is hydroxylated in the ortho- position to the methylene bridge, and a single chlorine atom substituent in the para-position to the hydroxyl group on the same ring.
Chlorophene is manufactured by the chlorination of 2-benzylphenol.
Chlorophene is a phenol with a single ionisable functional group.

Physico-Chemical properties

Chlorophene is a solid substance (white to slightly yellow colour) with a minimum purity of 966 g/kg.
The melting point was determined to be 45.9 °C.
Chlorophene does not boil, but decomposes at 110 °C.
Chlorophene has a vapour pressure below 1.0 ∙ 10-3 Pa at 20 °C and Henry's law constant of 1.87 ∙ 10-3 Pa∙m3/mol at 20 °C.
The log Kow for chlorophene was determined to be 4.276 at pH 4 and 25 °C, no significant change in log Kow was seen with an increase in pH.
The surface tension for chlorophene was determined to 57.3 mN/m at 20 °C (0.09g/L), which means that chlorophene is surface active.
The solubility was measured to be above 250 g/L in toluene at 10, 20 and 30 °C.
The water solubility was determined to be 0.083, 0.117 and 0.199 g/L at 10, 20 and 30 °C, respectively.
Chlorophene was not deemed as flammable, oxidizing or explosive.
Chlorophene has no auto flammability up to its melting point.

Hazard Statements
H302: Chlorophene is Harmful if swallowed.
H315: Chlorophene Causes skin irritation.
H318: Chlorophene Causes serious eye damage.
H335: Chlorophene May cause respiratory irritation.
H400: Chlorophene is Very toxic to aquatic life.
H410: Chlorophene is Very toxic to aquatic life with long lasting effects.

SYNONYMS

-Chlorophene
-Preventol BP
-Nipacide BCP
-o-Benzyl-p-chlorophenol
-4-Chloro-alpha-phenyl-o-cresol
-5-Chloro-2-hydroxydiphenylmethane
-2-Benzyl-4-chlorophenol
-clorofene
-clorophene potassium salt
-clorophene sodium salt
-o-benzyl-p-chlorophenol
-ortho-benzyl-para-chlorophenol