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Clorophene is an effective chlorinated aromatic compound used in formulations that require durable antimicrobial and preservative performance.
Clorophene helps protect products and treated materials from microbial contamination while supporting hygiene and product stability.
Clorophene's strong activity at relatively low use levels makes it useful in disinfectant, cleaning, preservation, and specialty industrial applications.
CAS Number: 120-32-1
EC Number: 204-385-8
Molecular Formula: C13H11ClO
Molecular Weight: 218.68 g/mol
Synonyms: 2-Benzyl-4-chlorophenol, 120-32-1, Clorophene, Clorophene, Santophen 1, Phenol, 4-chloro-2-(phenylmethyl)-, 4-Chloro-2-benzylphenol, Neosabenyl, Septiphene, 5-Chloro-2-hydroxydiphenylmethane, Benzylchlorophenol, Santophen I germicide, Santophen I, Santophen 1 flake, Clorofeno, Ketolin-H, Orthobenzylparachlorophenol, Orthobenzyl-p-chlorophenol, Clorofenum, NSC-59989, 4-Chloro-alpha-phenyl-o-cresol, DTXSID5020154, 7560BB0BO3, NSC59989, DTXCID30154, chlorofene, RefChem:577754, 204-385-8, Clorofene, O-BENZYL-P-CHLOROPHENOL, Bio-Clave, p-Chloro-o-benzylphenol, Ketolin H, Clorophene [USAN], 2-benzyl-4-chloro-phenol, MFCD00020140, NCI-C61201, 4-Chloro-.alpha.-phenyl-o-cresol, Clorofene [INN], Phenol, 4-chloro-2-benzyl-, NSC 59989;Santophen, o-Cresol, 4-chloro-.alpha.-phenyl-, Clorophene (USAN), NCGC00091532-02, NCGC00091532-04, 4-Chloro-2-(phenylmethyl)phenol, Caswell No. 083, Sentiphene, Clorofenum [INN-Latin], Clorofeno [INN-Spanish], Preventol BP, CAS-120-32-1, ortho-benzyl-para-chlorophenol, CCRIS 6205, HSDB 5179, o-Cresol, 4-chloro-alpha-phenyl-, 4-Chloro-alpha-phenyl-ortho-cresol, EINECS 204-385-8, NSC 59989, 4-Chloro-2-benzyl phenol, EPA Pesticide Chemical Code 062201, BRN 1959194, Clorophen, UNII-7560BB0BO3, AI3-08523, Nipacide BCP, benzyl chloro phenol, Santophen 1 (TN), CLOROPHENE [MI], CLOROPHENE [HSDB], WLN: QR DG B1R, CLOROFENE [WHO-DD], CLOROPHENE [MART.], SCHEMBL78119, 4-06-00-04636 (Beilstein Handbook Reference), MLS002454423, SCHEMBL380452, orb1909603, orb1940359, orb3139480, SCHEMBL5004345, CHEMBL1328919, SCHEMBL23612301, SCHEMBL29377427, 2-Benzyl-4-chlorophenol, 95%, NCKMMSIFQUPKCK-UHFFFAOYSA-, MSK2543, 2-Hydroxy-5-chlorodiphenylmethane, CHEBI:228003, HMS3041D07, Tox21_111146, Tox21_202985, Tox21_400046, SBB056562, AKOS001434264, Tox21_111146_1, EBC-332138, NCGC00091532-01, NCGC00091532-03, NCGC00091532-05, NCGC00091532-06, NCGC00260530-01, AC-10752, BS-20052, SMR000777843, ST029301, SY048947, DB-041547, HY-118547, B0812, CS-0066335, NS00008968, EN300-21338, D03564, D88696, SBI-0653892.0001, T25266, F320130, Q22829551, Z104495406, Clorophene;o-Benzyl-p-Chlorophenol; 4-Chloro-2-(phenylmethyl)phenol; 5-Chloro-2-hydroxydiphenylmethane; Benzyl-p-chlorophenol, InChI=1/C13H11ClO/c14-12-6-7-13(15)11(9-12)8-10-4-2-1-3-5-10/h1-7,9,15H,8H2
Clorophene is a chlorinated phenolic compound with documented antimicrobial and antiseptic properties.
Clorophene's bioactivity is primarily attributed to disruption of microbial cell membranes and interference with essential cellular processes, producing inhibitory effects against a range of Gram-positive and Gram-negative bacteria.
In vitro studies of Clorophene have demonstrated antibacterial activity at low concentrations, with particularly notable effects against Gram-positive organisms.
Clorophene's lipophilic phenolic structure facilitates interaction with microbial membranes, increasing membrane permeability and contributing to cellular leakage and loss of viability.
Clorophene has also been investigated for antifungal activity and broader preservative applications.
Historically, Clorophene's antimicrobial properties supported applications in disinfectant and antiseptic formulations.
In vivo and practical-use studies have primarily focused on Clorophene's ability to reduce microbial burden when applied topically or incorporated into antimicrobial preparations.
Clorophene remains useful as a research compound for investigating phenolic antimicrobial mechanisms, membrane-disrupting activity, microbial growth inhibition, and formulation strategies involving chlorinated antiseptic agents.
Clorophene is a chlorinated phenolic antimicrobial compound commonly used for its bactericidal, preservative, and disinfecting properties.
Chemically known as 2-benzyl-4-chlorophenol, Clorophene is effective against a range of microorganisms and is used in disinfectant formulations, preservatives, soaps, personal care products, and certain industrial applications.
Clorophene is generally supplied as a white to off-white crystalline solid with low water solubility but good solubility in many organic solvents.
Clorophene's antimicrobial activity and chemical stability make it suitable for formulations where long-lasting microbial control and preservation are required.
Clorophene, with the CAS number 120-32-1, is an organic compound that belongs to the class of chlorinated phenols.
Clorophene is characterized by its aromatic structure, which includes a phenolic hydroxyl group and multiple chlorine substituents.
Clorophene typically appears as a white to pale yellow solid and is known for its antiseptic and disinfectant properties.
Clorophene is soluble in organic solvents but has limited solubility in water.
Clorophene is often used in various applications, including as a preservative in cosmetics and personal care products, as well as in some industrial processes.
Due to its chlorinated nature, Clorophene can exhibit toxicity and environmental persistence, necessitating careful handling and regulation.
Additionally, Clorophene has been studied for its potential effects on human health and the environment, leading to scrutiny regarding its use in consumer products.
Overall, while Clorophene serves practical purposes, its chemical characteristics and potential risks require attention in both industrial and consumer contexts.
Applications of Clorophene:
Clorophene is used in household, hospital, and veterinary disinfectants; Also used as a fungicide, herbicide, antimicrobial, and cosmetics preservative
Clorophene is used as a disinfectant (swimming pool decks, industrial water systems, poultry houses and other farming premises, food processing, and restaurants).
Clorophene is used as an antimicrobial and preservative ingredient in a variety of industrial, institutional, and specialty formulations where control of bacterial and fungal growth is required.
Clorophene is commonly incorporated into disinfectant products, antiseptic preparations, cleaning formulations, soaps, deodorizing products, and preservative systems.
Clorophene may also be used in certain cosmetic and personal care formulations where permitted by applicable regulations and where antimicrobial protection is needed.
In industrial applications, Clorophene can be used to help protect formulated products and treated materials against microbial deterioration during storage and use.
Clorophene is also suitable for hygiene products, specialty cleaners, and surface-treatment formulations that require persistent antimicrobial activity.
Because of its low solubility in water, Clorophene is generally incorporated with suitable solvents, surfactants, or formulation aids to achieve uniform distribution and effective performance.
Clorophene's antimicrobial properties make it useful in formulations designed to reduce odor formation, microbial contamination, and product spoilage.
The exact use level and suitability of Clorophene depend on the formulation type, intended application, and local regulatory requirements.
Stability and Reactivity of Clorophene:
Chemical Stability:
Clorophene is stable under normal recommended storage and handling conditions.
Reactivity:
No hazardous reactions are expected under normal conditions.
Conditions to Avoid:
Avoid excessive heat, ignition sources, and incompatible chemicals.
Incompatible Materials:
Avoid strong oxidizing agents and acids.
Hazardous Decomposition Products:
Thermal decomposition or combustion may produce carbon monoxide, carbon dioxide, hydrogen chloride, and irritating fumes.
Handling and Storage of Clorophene:
Safe Handling:
Avoid breathing dust and prevent contact with skin and eyes.
Hygiene Measures:
Wash hands thoroughly after handling and do not eat, drink, or smoke in the work area.
Storage Conditions:
Keep the container tightly closed in a cool, dry, and well-ventilated place.
Storage Precautions:
Protect from heat and light and keep away from incompatible materials.
First Aid Measures of Clorophene:
Inhalation:
Move the affected person to fresh air and seek medical attention if symptoms occur.
Skin Contact:
Remove contaminated clothing and wash the skin thoroughly with soap and water.
Eye Contact:
Rinse immediately with plenty of water for at least 15–20 minutes and obtain medical attention.
Ingestion:
Rinse the mouth and seek medical advice promptly.
Firefighting Measures of Clorophene:
Suitable Extinguishing Media:
Use dry chemical powder, carbon dioxide, or water spray.
Specific Hazards:
Combustion may produce toxic or irritating fumes.
Firefighter Protection:
Wear suitable protective clothing and self-contained breathing apparatus when necessary.
Firefighting Procedures:
Cool exposed containers and prevent contaminated firefighting water from entering the environment.
Accidental Release Measures of Clorophene:
Personal Precautions:
Avoid breathing dust and prevent skin and eye contact.
Environmental Precautions:
Prevent release into drains, waterways, and soil because Clorophene is very toxic to aquatic life with long-lasting effects.
Cleanup Methods:
Carefully collect spilled solid material without generating dust and place it in suitable labeled containers.
Surface Cleaning:
Clean contaminated surfaces thoroughly after material collection.
Exposure Controls/Personal Protection of Clorophene:
Engineering Controls:
Provide adequate ventilation and minimize airborne dust.
Respiratory Protection:
Use suitable particulate respiratory protection where dust exposure cannot be adequately controlled.
Hand Protection:
Wear suitable chemical-resistant protective gloves.
Eye Protection:
Wear safety goggles or protective eyewear.
Skin Protection:
Wear appropriate protective clothing to minimize skin contact.
Hygiene Measures:
Wash hands and exposed skin thoroughly after handling.
Environmental Exposure Controls:
Avoid uncontrolled release to the environment.
Identifiers of Clorophene:
Name: 2-benzyl-4-chlorophenol
CAS Number: 120-32-1
ECHA EINECS: 204-385-8
FDA UNII: 7560BB0BO3
Nikkaji Web: J39.614A
Beilstein Number: 1959194
MDL: MFCD00020140
XlogP3: 4.00 (est)
Molecular Weight: 218.68187000
Formula: C13 H11 Cl O
IUPAC Name: 4-Chloro-2-benzylphenol
CAS Number: 120-32-1
EC Number: 204-385-8
Molecular Formula: C13H11ClO
Molecular Weight: 218.68 g/mol
Formula: C13H11ClO
InChI: InChI=1S/C13H11ClO/c14-12-6-7-13(15)11(9-12)8-10-4-2-1-3-5-10/h1-7,9,15H,8H2
InChI key: InChIKey=NCKMMSIFQUPKCK-UHFFFAOYSA-N
SMILES: C(C1=C(O)C=CC(Cl)=C1)C2=CC=CC=C2
InChI: InChI=1S/C13H11ClO/c14-12-6-7-13(15)11(9-12)8-10-4-2-1-3-5-10/h1-7,9,15H,8H2
InChI Key: NCKMMSIFQUPKCK-UHFFFAOYSA-N
Canonical SMILES: C1=CC=C(C=C1)CC2=C(C=CC(=C2)Cl)O
CAS: 120321
Molecular weight: 218.68
Formula: C13H11ClO
Color/Form: Neat
InChI: InChI=1S/C13H11ClO/c14-12-6-7-13(15)11(9-12)8-10-4-2-1-3-5-10/h1-7,9,15H,8H2
InChI key: InChIKey=NCKMMSIFQUPKCK-UHFFFAOYSA-N
SMILES: Oc1ccc(Cl)cc1Cc1ccccc1
Melting point: 45-48°C
HS code: 2908.19.6000
Properties of Clorophene:
Appearance: White to off-white crystalline solid or powder
Odor: Characteristic phenolic odor
Molecular Formula: C13H11ClO
Molecular Weight: 218.68 g/mol
Melting Point: Approximately 65–68 °C
Boiling Point: Approximately 330 °C
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 48.50 °C. @ 760.00 mm Hg
Boiling Point: 339.60 °C. @ 760.00 mm Hg (est)
Flash Point: 319.00 °F. TCC ( 159.20 °C. ) (est)
logP (o/w): 4.410 (est)
Molecular Weight: 218.68 g/mol
XLogP3: 4
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 2
Exact Mass: 218.0498427 Da
Monoisotopic Mass: 218.0498427 Da
Topological Polar Surface Area: 20.2 Ų
Heavy Atom Count: 15
Complexity: 189
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Specifications of Clorophene:
InChI Formula: InChI=1S/C13H11ClO/c14-12-6-7-13(15)11(9-12)8-10-4-2-1-3-5-10/h1-7,9,15H,8H2
Formula Weight: 218.0498
Chemical Name or Material: 2-Benzyl-4-chlorophenol
