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CLIMBAZOLE

CAS NUMBER: 38083-17-9

EC NUMBER: 253-775-4

MOLECULAR FORMULA: C15H17ClN2O2

MOLECULAR WEIGHT: 292.76

IUPAC NAME: 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one


Climbazole is a white Crystalline Powder used as a very effective anti-dandruff agent.
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. 
Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.
Climbazole's chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations:
Climbazole is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. 
Climbazole may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

What is Climbazole and How is it Used in Cosmetic Products?
Climbazole is an additive and antifungal agent used in: 
-over-the-counter shampoos
-conditioners
-lotions
-face washes to treat human fungal skin infections like eczema and dandruff. 

Dandruff is suffered by as much as half of the population and about one in every ten individuals in the United States will develop eczema during their lifetime. 
This agent helps to treat these moderate to severe fungal infections and their symptoms such as redness, and dry, itchy, and flakey skin without causing irritation to the affected area when used properly.

Climbazole is an anti-fungal ingredient that is used in over the counter shampoos to treat dandruff caused by a fungal infection. 
Most dandruff problems are a result of fungus, and the most effective treatment is a dandruff shampoo that delivers the medication directly to the scalp.

Climbazole is a powerful anti-dandruff active with a long history of successful use. 
Climbazole provides excellent activity against the main cause of dandruff
Climbazole is suitable for both leave-on and rinse-off hair care formulations.

Climbazole provides no formation of coloured complexes with metal ions which cause discoloration in formulations. 
Climbazole has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils. 
Climbazole's stable in acid and neutral pH ranges and not hygroscopic (does not absorb water from the air). 
Climbazole has excellent light, heat and storage stability.

Products to use in:
Climbazole is primarily aimed at haircare products where the anti-dandruff properties are renowned for their effectiveness. 
Climbazole however is found in some eczema treatments for its antifungal properties.

How to Use Climbazole?
Climbazole has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils. 
Climbazole's stable in acid and neutral pH ranges and not hygroscopic, has excellent light, heat and storage stability.

Climbazole is known to be an antifungal drug, which is frequently used in the treatment of skin fungal infections. 
Thus, Climbazole effectively treats dandruff as well as other scalp infections. 

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. 
Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. 
After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff under the climbazole 0.65% shampoo, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. 
The cosmetic acceptability was very good by the majority.

Climbazole is the effective solution to the persistent dandruff, scaling and itcing problems of the scalp. 
Climbazole contains:
-Climbazole, a new antimycotic agent, comparable with ketoconazole, with a powerful action against Pityrosporum ovale
-Salicylic Acid, with keratolytic action
-Capryloyl Glycine, with sebum regulating and soothing action
-Panthenol, with soothing action

Climbazole does not contain tar and has a pleasant smell, while its gentle cleansing base creates rich foam and makes hair soft and easy to style.
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. 
Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff. 
Climbazole's chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

The Climbazole is a topical antifungal agent often used in the treatment of fungal skin infections in humans, such as dandruff and eczema. It is therefore found mainly in anti-dandruff products.
Climbazole's functions:
Anti dandruff : Climbazole Helps fight against dandruff
Antimicrobial : Climbazole Slows the growth of micro-organisms on the skin and counteracts the development of bacteria
Preservative : Climbazole Inhibits the development of microorganisms in cosmetic products.

Climbazole is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. 
Climbazole is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Climbazole is a potent inducer and inhibitor of P450-dependent drug metabolizing enzymes, which is also used as antifungal and antidandruff agent.

Climbazole is an imidazole antifungal agent. 
Climbazole inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. 
Climbazole also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. 

Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

Climbazole has broad-spectrum bactericidal properties. 
Climbazole is mainly used for anti itching and anti dandruff conditioning shampoo and hair care shampoo. 
Climbazole can also be used for antibacterial soap, shower gel, medicated toothpaste, mouthwash, etc 

Climbazole is an antifungal medication. 
Climbazole kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection
Climbazole is an antifungal medication used to treat fungal infections of the skin such as dandruff and eczema. 

PHYSICAL PROPERTIES:

-Molecular Weight: 292.76    

-XLogP3-AA: 3.7    

-Exact Mass: 292.0978555    

-Monoisotopic Mass: 292.0978555    

-Topological Polar Surface Area: 44.1 Ų    

-Heavy Atom Count: 20    

-Formal Charge: 0    

-Complexity: 335

-Melting point: 96-100°C

-Boiling point: 447.5±40.0 °C(Predicted)

-Density: 1.17±0.1 g/cm3(Predicted)

-Refractive index: 1.54

-Storage Temperature: Inert atmosphere,Room Temperature

-pka: 5.66±0.22(Predicted)

-Color: white

-Form: solid

Climbazole is not a steroid medication. 
Climbazole's regular application on the scalp relieves itching and discomfort in persons suffering from dandruff.
Climbazole is an antifungal medicine which is used for the treatment of dandruff.

Climbazole is topical antifungal agent commonly used to treat human fungal skin infections such as dandruff and eczema.
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. 
Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff. 
Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

CHEMICAL PROPERTIES: 

-Isotope Atom Count: 0    

-Defined Atom Stereocenter Count: 0    

-Undefined Atom Stereocenter Count: 1    

-Defined Bond Stereocenter Count: 0    

-Undefined Bond Stereocenter Count: 0    

-Covalently-Bonded Unit Count: 1    

-Compound Is Canonicalized: Yes

-Hydrogen Bond Donor Count: 0    

-Hydrogen Bond Acceptor Count: 3    

-Rotatable Bond Count: 5

Climbazole is a common ingredient used in cosmetics as preservative, also know by its chemical name 1-(4- chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone.
The use of Climbazole is currently restricted in the European Union up to a maximum authorized concentration of 0.5% in a finished product. 
However, the previous opinions of the SCCS had assessed its presence in different cosmetic product categories combined -as shampoo, hair lotion, etc.- up to 0.5 % for leave on cosmetics and up to 2% as anti-dandruff agent in rinse-off hair products.

Climbazole, although relatively obscure when compared to some active ingredients, is found in a number of dandruff shampoos. 
Climbazole was first commercially manufactured in 1998, and between 1999 and 2004 it’s estimated that 110million units were sold globally

How does climbazole work?
Climbazole is an ‘imidazole antifungal’ – the same class as many of the popular treatments for seborrheic dermatitis (e.g. ketoconazole, miconazole, clotrimazole). 
These work by inhibiting ‘lanosterol 14α-demethylase’, the enzyme responsible for producing steroids needed to maintain fungi cell membranes

STORAGE OF CLIMBAZOLE:

Climbazole should be stored in locked containers.
Climbazole should be stored in a well-ventilated place.
The Climbazole container must be dry.

Climbazole should be stored at -20°C
Climbazole should be stored in a moisture-free environment.
Climbazole should be stored in a dry container.

Climbazole should be stored in an inert atmosphere.
Climbazole Should be stored separately from strong reagents.
Climbazole should not be exposed to constant temperature changes.

SYNONYMS:

Climbazole
Climbazol
1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-
1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Baypival
Baysan
Climbazolum
1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone
1-(4-Chlorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone
Climbazol [INN-Spanish]
Climbazolum [INN-Latin]
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone
1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone
1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone
1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone
(+/-)-Climbazole-d4
1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone
1-NAPHTHYLACETICANHYDRIDE
Pharmakon1600-01504833
2-BUTANONE, 1-(p-CHLOROPHENOXY)-3,3-DIMETHYL-1-(1-IMIDAZOLYL)-
Climbazole 10 microg/mL in Cyclohexane
Climbazole
1-(4-chloranylphenoxy)-1-imidazol-1-yl-3,3-dimethyl-butan-2-one
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one
1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one

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