CLIMBAZOLE

Climbazole is a broad-spectrum antifungal agent primarily used in personal care products, particularly in anti-dandruff shampoos, to combat Malassezia species associated with scalp conditions.
Climbazole exhibits strong activity against fungi and yeasts while maintaining excellent compatibility with hair and skin.
Its effectiveness and mildness make Climbazole a preferred ingredient in hair and skincare formulations targeting fungal-related issues.

CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol

Synonyms: Climbazole, 1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, Antifungal Agent Climbazole, Anti-Dandruff Climbazole, Scalp Treatment Climbazole, Hair Care Active Climbazole, 4-Chlorophenoxyimidazolylbutanone, Imidazolyl Chlorophenoxy Butanone, Climbazole Cosmetic Grade, Anti-Fungal Shampoo Ingredient, Climbazole Ketoconazole Alternative, Anti-Dandruff Active Climbazole, Fungal Inhibitor Climbazole, Climbazole Pharma Grade, Imidazole-Based Antifungal, Climbazole Scalp Therapy, Broad-Spectrum Antifungal Climbazole, Climbazole Anti-Fungal Compound, Climbazole Hair Care Additive

APPLICATIONS

Climbazole is extensively used in anti-dandruff shampoos to treat and prevent dandruff by inhibiting the growth of Malassezia fungi on the scalp.
Climbazole is included in scalp treatments and conditioners for its soothing effects and ability to restore scalp health.
Climbazole is employed in hair tonics to control itching and flaking associated with dandruff.

Climbazole is a key ingredient in medicated skincare products targeting fungal infections, such as seborrheic dermatitis and pityriasis versicolor.
Climbazole is utilized in body washes and soaps designed to address fungal skin conditions.
Climbazole is applied in leave-on hair treatments to maintain scalp cleanliness and reduce fungal recurrence.

Climbazole is used in personal care formulations for sensitive skin, providing relief from fungal-related irritation.
Climbazole is found in anti-fungal foot creams and sprays, offering protection against athlete's foot and other fungal conditions.
Climbazole is included in facial cleansers to combat fungal acne and improve skin texture.

Climbazole is employed in pet care products, such as shampoos and sprays, to treat fungal infections in animals.
Climbazole is used in industrial hygiene products, including fungal-resistant coatings and sanitizers.
Climbazole is incorporated into formulations for sportswear detergents to inhibit fungal growth in moist environments.

Climbazole is widely used in anti-dandruff shampoos for its antifungal properties.
Climbazole is applied in hair care products to prevent and control scalp infections caused by fungi.

Climbazole is incorporated into skincare formulations to treat seborrheic dermatitis and related conditions.
Climbazole is used in cosmetic products to enhance scalp health and reduce flaking.

Climbazole is added to conditioners and hair serums to improve scalp hygiene and comfort.
Climbazole is utilized in medicated creams and lotions for its ability to inhibit fungal growth.
Climbazole is an active ingredient in pharmaceutical preparations for treating Pityriasis Versicolor.

Climbazole is included in anti-fungal soaps and body washes for its broad-spectrum efficacy.
Climbazole is used in personal care products to soothe itchiness and irritation associated with fungal infections.

Climbazole is employed in formulations for treating fungal infections of the nails and skin.
Climbazole is a key component in medicated shampoos designed for sensitive or irritated scalps.

Climbazole is used in dermatological treatments to prevent recurrence of fungal infections.
Climbazole is added to anti-dandruff sprays for targeted application to problem areas.

Climbazole is used in combination with other active ingredients like zinc pyrithione for enhanced efficacy.
Climbazole is included in foot creams to treat athlete’s foot and other fungal conditions.
Climbazole is utilized in topical gels and solutions for fungal-related scalp disorders.

Climbazole is incorporated into hygiene products to address odor caused by microbial activity.
Climbazole is employed in over-the-counter and prescription medications for fungal skin conditions.

Climbazole is an effective component in anti-itch lotions for fungal infections of the skin and scalp.
Climbazole is used in pet care products to treat fungal skin infections in animals.

DESCRIPTION

Climbazole is a white to off-white crystalline powder with excellent solubility in alcohols and glycols, making it suitable for a wide range of personal care formulations.
This imidazole-based compound is known for its high efficacy against fungi and yeasts, particularly species responsible for dandruff and other scalp disorders.
Climbazole is mild and non-irritating, allowing it to be used in products designed for frequent use.

Climbazole exhibits excellent stability under normal storage and formulation conditions, retaining its antifungal activity over time.
Its effectiveness at low concentrations makes Climbazole a cost-effective and efficient ingredient in cosmetic and pharmaceutical products.

Climbazole is an antifungal compound with the chemical formula C15H17ClN2O2.
Climbazole appears as a white to off-white crystalline powder with a faint characteristic odor.

Climbazole is poorly soluble in water but highly soluble in organic solvents like ethanol and propylene glycol.
Climbazole is effective against fungi such as Malassezia, a common cause of dandruff and seborrheic dermatitis.

Climbazole works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes.
Climbazole is commonly used in concentrations ranging from 0.1% to 0.5% in cosmetic and pharmaceutical products.

Climbazole is considered safe for use in personal care products when used within regulatory limits.
Climbazole is stable under normal storage conditions and retains its efficacy in various formulations.

Climbazole is often used in conjunction with other active ingredients to provide comprehensive scalp care.
Climbazole is highly valued for its dual role in treating fungal infections and improving scalp and skin health.

PROPERTIES

Chemical Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol
Common Name: Climbazole
Appearance: White to off-white crystalline powder
Density: Approx. 1.3 g/cm³
Melting Point: Approx. 96–98°C
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water; soluble in alcohols and glycols
pH (10% Solution): Neutral to slightly acidic (approx. 6–7)
Reactivity: Stable under normal conditions; avoid strong acids and oxidizing agents
Chemical Stability: Stable in recommended storage conditions
Storage Temperature: Store below 25°C in a dry, well-ventilated area
Vapor Pressure: Negligible

FIRST AID

Inhalation:
If dust or vapors of Climbazole are inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Wash the affected area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Remove contaminated clothing and wash before reuse.

Eye Contact:
Flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
If Climbazole is ingested, rinse the mouth thoroughly with water.
Do not induce vomiting unless instructed by medical personnel.
Seek immediate medical attention if discomfort persists.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.

HANDLING AND STORAGE

Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and protective clothing, when handling Climbazole.
Use in a well-ventilated area to minimize exposure to airborne particles.

Ventilation:
Ensure proper ventilation during handling to prevent the accumulation of airborne dust or fumes.
Use local exhaust systems if necessary.

Avoidance:
Avoid direct contact with eyes, skin, and clothing.
Do not eat, drink, or smoke while handling.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Contain spills to prevent further release.
Sweep or vacuum the material carefully to avoid creating dust and collect for disposal.
Dispose of waste according to local regulations.

Storage:
Store in a cool, dry, well-ventilated area away from moisture and incompatible materials.
Keep containers tightly closed when not in use.
Protect from contamination and extreme temperatures.

Handling Cautions:
Avoid exposure to strong acids or oxidizing agents.
Ensure storage containers are clean and compatible with the material.