PRODUCTS

CLIMBAZOLE

Climbazole is used in over-the-counter shampoos, conditioners, lotions and face washes.
Climbazole is used for research use only.
Climbazole, which can be used as preservative in cream, hair cream and foot care products.

CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Weight: 292.76
Molecular Formula: C15H17ClN2O2

SYNONYMS:
Climbazole, 38083-17-9, Baypival, Climbazol, Crinipan AD, BAY-E 6975, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, 2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-, MFCD00055505, 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, NSC-759808, DTXSID6046555, 1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone, CHEBI:83719, 1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone, 9N42CW7I54, NCGC00166153-01, Baysan, 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, DTXCID4026555, Climbazolum, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone, Climbazol [INN-Spanish], Climbazolum [INN-Latin], CAS-38083-17-9, Climbazole [INN:BAN], EINECS 253-775-4, BRN 0618020, Bay e 6975, UNII-9N42CW7I54, CCRIS 8169, MEB 6401, Climbazole (Standard), 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone, CLIMBAZOLE [INN], EC 253-775-4, CLIMBAZOLE [MART.], CLIMBAZOLE [USP-RS], CLIMBAZOLE [WHO-DD], SCHEMBL39729, US9138393, Climbazole, US9144538, Climbazole, 5-23-04-00209 (Beilstein Handbook Reference), MLS004773943, BAY e-6975, CHEMBL1437764, HY-B1151R, OWEGWHBOCFMBLP-UHFFFAOYSA-, BDBM181112, HMS2090O13, HMS3652P05, HMS3744O15, Pharmakon1600-01504833, HY-B1151, MEB-6401, Tox21 112343, Tox21_112343, AC-272, DL-358, NSC759808, s4178, 2-BUTANONE, 1-(p-CHLOROPHENOXY)-3,3-DIMETHYL-1-(1-IMIDAZOLYL)-, AKOS015895513, Tox21_112343_1, CCG-213958, CS-4675, DB15580, KS-5112, NSC 759808, Climbazole 10 microg/mL in Cyclohexane, NCGC00166153-02, NCGC00166153-03, SMR001550495, DB-049235, C2025, NS00008150, SW219213-1, Climbazole, PESTANAL(R), analytical standard, H10384, SBI-0653493.0001, AB01275501-01, AB01275501_02, AB01275501_03, AO-295/40848554, Q629373, SR-05000001501, Q-100974, SR-05000001501-1, BRD-A61676498-001-01-7, BRD-A61676498-001-05-8, BRD-A61676498-001-06-6, Climbazole, United States Pharmacopeia (USP) Reference Standard, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one, (RS)-1-(4-CHLOROPHENOXY)-1-IMIDAZOL-1-YL-3,3-DIMETHYLBUTAN-2-ONE, InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

Climbazole is a potent antifungal substance that is commonly found in antidandruff shampoos in Europe.
Climbazole is known for its effectiveness in treating fungal infections and is not currently available in the United States.
Climbazole is an antifungal compound that displays antimicrobial activity against Malassezia, treating dandruff and eczema.

Like other similar compounds, Climbazole likely inhibits 14-α demethylase.
Climbazole is a heterocyclic organic compound.
Climbazole is thus a safe antifungal drug used in the scalp therapy line of Neofollics.

Climbazole helps in effectively fighting dandruff and fungi on the scalp.
Climbazole is a potent antifungal agent.
Climbazole also is a potent inducer of rat hepatic cytochrome P450.

Climbazole is a common ingredient used in cosmetics as preservative, also know by its chemical name 1-(4- chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone.
The use of Climbazole is currently restricted in the European Union up to a maximum authorized concentration of 0.5% in a finished product.

Climbazole is a broad and high-efficient antimicrobial.
Climbazole shows excellent inhibiting effect on pytyrosporum ovale fungi that causes dandruff, without irritating scalp due to hydrolysis.
Climbazole is stable under acidic and little alkali condition, as well as radiation and heat.

This synthetic ingredient, Climbazole, is insoluble in water but can be dissolved in surfactants and perfume oils.
The chemical formula of Climbazole is C15H17ClN2O2 and it appears as a white crystal powder.
Climbazole is also largely safe for use at lower concentrations.

Climbazole is a white Crystalline Powder used as a very effective anti-dandruff agent.
Climbazole secifically tackles the fungus Malaseezia furfur, the primary cause of dandruff.
Climbazole is 100% natural and a Very Effective Anti-Dandruff Agent

Climbazole is a powerful anti-dandruff active with a long history of successful use.
Climbazole provides excellent activity against the main cause of dandruff, Malassezia species.
Climbazole is suitable for both leave-on and rinse-off hair care formulations.

Climbazole provides no formation of coloured complexes with metal ions which cause discoloration in formulations.
Climbazole has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils.

Climbazole's stable in acid and neutral pH ranges and not hygroscopic (does not absorb water from the air).
Climbazole has excellent light, heat and storage stability.
Climbazole is a potent inducer and inhibitor of P450-dependent metabolizing enzymes

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema.
Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.
Climbazole's chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.

Climbazole is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3.
Climbazole is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Climbazole is a small molecule drug with a maximum clinical trial phase of II.

Climbazole is in the form of a white crystalline powder.
Climbazole is generally soluble in oil and some organic compounds.
Climbazole is an excellent antipruritic and anti-dandruff agent.

Climbazole is soluble in ethanol and water mixtures or anionic surfactant solutions.
Climbazole is partially soluble in water.
Climbazole is soluble in ethyl acetate, acetone, benzene, toluene and other organic solvents.

Climbazole is partially soluble in cyclohexane and petroleum ether.
Transparent formulas can be obtained .

USES and APPLICATIONS of CLIMBAZOLE:
Thus, Climbazole is effective against dandruff, eczema and other scalp infections in your hair and scalp.
The antifungal drug, Climbazole, is used in over-the-counter shampoos, conditioners, lotions and face washes.
Climbazole is used for research use only.

Climbazole, which can be used as preservative in cream, hair cream and foot care products.
In addition, Climbazole can also be used as a dandruff remover in shampoo.
Climbazole is used 2% as anti-dandruff agent in rinse-off shampoos and 0.2% as cosmetic preservative in leave on formulations (face cream, hair lotion, foot care) except for cosmetics applied on a full body area (body lotion).

Ideal for application in anti-dandruff shampoo, body wash and soap.
Climbazole is an antifungal agent used in cosmetics to combat dandruff and various scalp conditions caused by fungal infections like Malassezia.
As a broad-spectrum antifungal, Climbazole works by inhibiting the growth of fungi, preventing their proliferation on the scalp.

Climbazole is commonly added to hair care products like shampoos and scalp treatments.
The use of Climbazole as a preservative should therefore only be allowed in face cream, hair lotion, foot care products and rinse-off shampoo.
The maximum concentration of Climbazole should be 0,2 % for face cream, hair lotion and foot care products and 0,5 % for rinse-off shampoo.

The use of Climbazole as a non-preservative should be restricted to rinse-off shampoo, when the substance is used as an anti-dandruff agent.
For such use, the maximum concentration of Climbazole should be 2 %.
Climbazole functions as an antifungal agent.

Climbazole's mechanism of action involves inhibiting the growth of fungi by disrupting the synthesis of ergosterol.
This disruption leads to increased permeability of the cell membrane, ultimately causing the death of the fungal cells.
Climbazole targets and inhibits the enzyme cytochrome P450 14α-demethylase, which is involved in the biosynthesis of ergosterol.

By interfering with this key enzyme, climbazole effectively disrupts the fungal cell membrane structure, leading to its antifungal activity.
This mechanism of action makes climbazole useful in studying fungal cell biology and developing potential antifungal strategies.
Climbazole is an antifungal drug, which is frequently used in the treatment of skin fungal infections.

Climbazole is used Shampoo and hair conditioner.
Climbazole inhibits dandruff fungus permanently and strongly.
Climbazole is a safe, non-irritating product that can be widely used in shampoos.

Climbazole allows you to obtain low-cost formulas with small amounts of use.
Climbazole helps reduce dandruff and cleanse the scalp.
Climbazole relieves symptoms of seborrheic dermatitis such as redness, flaking and itching on the scalp.

Climbazole supports hair health by helping to control fungi and microorganisms on the scalp.
The usage rate varies between 0.5% and 2% depending on the demonstrative effect of Climbazole and its interaction with other substances.
Climbazole works stably at high temperatures and against metal ions.

WHAT IS CLIMBAZOLE USED FOR?
Climbazole is a phenomenal ingredient for hair care products with the ability to improve overall hair and scalp health.
Climbazole has anti-dandruff properties that clean the scalp thoroughly and prevent microbial growth.
Climbazole also reduces the sensation of irritation and itching, allowing for healthy hair growth that feels softer and lustrous.

Apart from hair care, Climbazole extends its goodness to skin care formulations to combat fungal-related skin conditions like tinea versicolor and seborrheic dermatitis.
Further, Climbazole is a renowned preservative that inhibits the development of bacteria in formulations - increasing their shelf life.

ORIGIN OF CLIMBAZOLE:
Climbazole is synthesized through a multistep chemical process. Initially, 4-chloro-3-nitrobenzonitrile undergoes a reaction with diethylamine to form 4-chloro-3-nitrobenzamide.

Subsequently, Climbazole is subjected to reduction using a reducing agent like iron powder, resulting in the formation of 4-chloro-3-aminobenzamide.
Finally, the aminobenzamide compound reacts with chloroacetyl chloride to produce Climbazole.
Climbazole is also known as Baypival.

WHAT DOES CLIMBAZOLE DO IN A FORMULATION?
*Antidandruff
*Antimicrobial
*Preservative

SAFETY PROFILE OF CLIMBAZOLE:
Climbazole is a safe and non-sensitizing ingredient that does not have any major side effects.
In rinse-off products like shampoos, Climbazole can be used up to 0.5% concentrations.
Whereas, only 0.2% Climbazole can be used in leave-on products.

Climbazole is necessary to stick to the recommended guidelines to avoid adverse reactions.
Overexposure to Climbazole can cause rashes, redness, and itching.
Although well-tolerated by most skin types, a patch test is recommended.

ALTERNATIVES OF CLIMBAZOLE:
*KETOCONAZOLE,
*ZINC PYRITHIONE,
*SELENIUM SULFIDE

WHAT IS CLIMBAZOLE AND HOW IS CLIMBAZOLE USED IN COSMETIC PRODUCTS?
Climbazole is an additive and antifungal agent used in over-the-counter shampoos, conditioners, lotions, and face washes to treat human fungal skin infections like eczema and dandruff.

Dandruff is suffered by as much as half of the population and about one in every ten individuals in the United States will develop eczema during their lifetime.

This agent helps to treat these moderate to severe fungal infections and their symptoms such as redness, and dry, itchy, and flakey skin without causing irritation to the affected area when used properly.

DISSOLVING OF CLIMBAZOLE:
Climbazole is first dissolved in alcohol or a nonionic surfactant, then other dissolved components of the formulation are mixed at a temperature of about 70 ℃.

FEATURES CLIMBAZOLE:
Appearance: White crystalline powder
Melting temperature: 94℃~98℃
Water content: ≤0.5%
p-Chlorophenol: ≤0.015%
Molecular weight: 292.76
Cas number: 38083-17-9
Shelf life: 2 years

CLIMBAZOLE FOR HAIR:
Climbazole for hair
Anti-fungal products such as Climbazole can have a positive effect against dandruff and skin infections.
The caring and active ingredients lay the foundation for healthy hair growth and provide rich nutrients to the scalp that are being absorbed by the hair follicles, which stimulates new and stronger hair.

PROPERTIES OF CLIMBAZOLE:
• Exfoliates the scalp and removes sebum build up
• Reduces dandruff and flaking
• Balances microbial activity
• Prevents irritation and itching
• Decreases inflammation and redness
• Is a total nourishment for the scalp

WHY USE CLIMBAZOLE?
Climbazole is an effective antifungal agent in dandruff shampoos, preventing dandruff by stopping the growth of the Malassezia fungus.
Climbazole, which helps maintain the natural balance of the scalp, is a safe and effective solution for long-term use thanks to its non-irritating formula.
In addition to preventing dandruff formation, Climbazole soothes the scalp and supports hair health.

WHAT ARE THE ADVANTAGES OF CLIMBAZOLE?
Climbazole provides strong antifungal effect against dandruff
Climbazole protects the natural balance of the scalp without damaging it.
Climbazole can be used in water and oil based formulas.
Climbazole increases the effectiveness of the treatment by providing a synergistic effect with Zinc pyrithione.

INDICATIONS AND FORMULATIONS OF CLIMBAZOLE:
Climbazole is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners.
Climbazole may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

FORMULATION GUIDELINES OF CLIMBAZOLE:
Solubility
Benzyl alcohol (approx) - 55%
Ethanol (96%) - 50%
Phenoxyethanol - 40%
Ethoxydiglycol - 30%
Propylene Glycol - 30%
Butylene Glycol - 30%
Dipropylene Glycol - 30%
Certain perfume oils - 50%
Climbazole is soluble in alcohol, glycols, surfactants and perfume oils but, is insoluble in water.

PROCESSING TRICKS AND TIPS OF CLIMBAZOLE:
Processing Tricks & Tips
Climbazole dissolves fast at elevated temperatures
Climbazole is stable in formulations at pH 4 -7

PRODUCTS TO USE IN CLIMBAZOLE:
Products to use in
Climbazole is primarily aimed at haircare products where the anti-dandruff properties are renowned for their effectiveness.
Climbazole however is found in some eczema treatments for its antifungal properties.

WHAT IS DANDRUFF?
Dandruff is the shedding of excessive amounts of dead skin cells from the scalp.
Around 40% of the caucasian population suffer with the itchy, annoying and persistent skin disorder of the scalp.
Although a minor problem, it can be very annoying and embarrassing.
There is no cure for dandruff, only control, Climbazole is an effective control

HOW TO USE CLIMBAZOLE:
Climbazole has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils.

Climbazole's stable in acid and neutral pH ranges and not hygroscopic, has excellent light, heat and storage stability.
In-vivo efficacy tests have shown the effectiveness of Climbazole in anti-dandruff formulations
The extract of Climbazole is suitable for use in both O/W Emulsions and W/O Emulsions

ADD CLIMBAZOLE TO NATURALLY HAIR CARE BASES:
Climbazole anti dandruff ingredient can be used directly in Hair Care bases at 0.5% to provide anti-dandruff properties.
Climbazole can be added to a base by first mixing with propylene glycol (or any glycol) and then mixing your glycol and climazole blend into the Hair Care base.

USAGE AMOUNT OF CLIMBAZOLE:
Usage Amount
Usage Level:
0.5 – 1% (Rinse off products), 0.1% - 0.3% (Leave on Products)
These are maximum levels as defined under EU Cosmetic Regulations.

PHYSICAL and CHEMICAL PROPERTIES of CLIMBAZOLE:
Molecular Weight: 292.76 g/mol
XLogP3-AA: 3.7
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 5
Exact Mass: 292.0978555 Da
Monoisotopic Mass: 292.0978555 Da
Topological Polar Surface Area: 44.1Å²
Heavy Atom Count: 20
Formal Charge: 0
Complexity: 335

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Empirical Formula (Hill Notation): C15H17ClN2O2
CAS Number: 38083-17-9
Molecular Weight: 292.76

Beilstein: 618020
EC Number: 253-775-4
MDL number: MFCD00055505
UNSPSC Code: 41116107
PubChem Substance ID: 329755277
NACRES: NA.24
Physical state: crystalline
Color: white
Odor: odorless
Melting point/range: 96.5 °C
Initial boiling point and boiling range: 260 °C
Flammability (solid, gas): The product is not flammable.

Flammability (solids): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0.058 g/l at 25 °C - slightly soluble
Partition coefficient: n-octanol/water: log Pow: 3.83 at 25 °C

Vapor pressure: No data available
Density: 1.32 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Surface tension: 58 mN/m at 25 °C

Boiling Point: 412°C
Melting Point: 98 - 99°C
pH: 4 - 7
Solubility: Insoluble in water
CAS Number: 38083-17-9
Purity: 98%
Molecular Weight: 292.76
Molecular Formula: C15H17ClN2O2
Physical State: Solid
Solubility: Soluble in water (0.06 mg/ml at 25°C),
isopropanol, cyclohexanone, chloroform, and methanol.

Storage: Store at -20°C
Melting Point: 96.5°C
Boiling Point: 260°C (lit.)
Density: 1.32 g/cm3 at 20°C
Refractive Index: n20D 1.54
pK Values: pKb: 5.66 (Predicted)
Molecular Formula: C15H17ClN2O2
Formula Weight: 292.8
Purity: ≥98%
Formulation: A crystalline solid
λmax: 223, 275 nm

SMILES: CC(C)(C)C(C(OC1=CC=C(Cl)C=C1)N2C=NC=C2)=O
InChi Code: InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
InChi Key: OWEGWHBOCFMBLP-UHFFFAOYSA-N
Physical Appearance: A solid
Storage: Store at -20°C
M.Wt: 292.76
CAS No.: 38083-17-9
Formula: C15H17ClN2O2
Solubility: insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥59.9 mg/mL in EtOH

Chemical Name: 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Canonical SMILES: CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl
CAS No.: 38083-17-9
Purity: ≥99%
Formula: C15H17ClN2O2
Formula Wt.: 292.76
IUPAC Name: 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Synonym: Baypival
Melting Point: 98-99°C
Appearance: White Crystal Powder

FIRST AID MEASURES of CLIMBAZOLE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of CLIMBAZOLE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of CLIMBAZOLE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CLIMBAZOLE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CLIMBAZOLE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of CLIMBAZOLE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available