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Climbazole is also largely safe for use at lower concentrations.
Climbazole is soluble in ethanol and water mixtures or anionic surfactant solutions.
Climbazole is partially soluble in water.
CAS Number: 38083-17-9
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76
EINECS Number: 253-775-4
Synonyms: Climbazole, 38083-17-9, Climbazol, Baypival, Crinipan AD, BAY-E 6975, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, 2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-, MFCD00055505, 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, NSC-759808, DTXSID6046555, 1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone, CHEBI:83719, 1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone, 9N42CW7I54, NCGC00166153-01, Baysan, 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, DTXCID4026555, Climbazolum, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone, Climbazol [INN-Spanish], Climbazolum [INN-Latin], CAS-38083-17-9, Climbazole [INN:BAN], EINECS 253-775-4, BRN 0618020, Bay e 6975, UNII-9N42CW7I54, CCRIS 8169, MEB 6401, Climbazole (Standard), 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone, 1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone, CLIMBAZOLE [INN], EC 253-775-4, CLIMBAZOLE [MART.], CLIMBAZOLE [USP-RS], CLIMBAZOLE [WHO-DD], SCHEMBL39729, US9138393, Climbazole, US9144538, Climbazole, 5-23-04-00209 (Beilstein Handbook Reference), MLS004773943, BAY e-6975, CHEMBL1437764, HY-B1151R, OWEGWHBOCFMBLP-UHFFFAOYSA-, BDBM181112, HMS2090O13, HMS3652P05, HMS3744O15, Pharmakon1600-01504833, HY-B1151, MEB-6401, Tox21 112343, Tox21_112343, AC-272, DL-358, NSC759808, s4178, 2-BUTANONE, 1-(p-CHLOROPHENOXY)-3,3-DIMETHYL-1-(1-IMIDAZOLYL)-, AKOS015895513, Tox21_112343_1, CCG-213958, CS-4675, DB15580, KS-5112, NSC 759808, Climbazole 10 microg/mL in Cyclohexane, NCGC00166153-02, NCGC00166153-03, SMR001550495, DB-049235, C2025, NS00008150, SW219213-1, Climbazole, PESTANAL(R), analytical standard, H10384, SBI-0653493.0001, AB01275501-01, AB01275501_02, AB01275501_03, AO-295/40848554, Q629373, SR-05000001501, SR-05000001501-1, BRD-A61676498-001-01-7, BRD-A61676498-001-05-8, BRD-A61676498-001-06-6, Climbazole, United States Pharmacopeia (USP) Reference Standard, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one, (RS)-1-(4-CHLOROPHENOXY)-1-IMIDAZOL-1-YL-3,3-DIMETHYLBUTAN-2-ONE, InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14 (18-9-8-17-10-18) 20-12-6-4-11(16) 5-7-12/h4-10,14H,1-3H3, 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-buta n-2-one;1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone;BAY MEB-6401, Diadimefon;MEB-6401;Climbazole 0.1;1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole;Crinipan AD
Climbazole is an imidazole antifungal agent.
Climbazole inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro.
Climbazole also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.
Climbazole increases the levels of cytochrome P450 in rat liver.
Formulations containing climbazole have been used in the treatment of dandruff.
Climbazole is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3.
Climbazole is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether
Climbazole is an antifungal agent used in cosmetics to combat dandruff and various scalp conditions caused by fungal infections like Malassezia.
As a broad-spectrum antifungal, Climbazole works by inhibiting the growth of fungi, preventing their proliferation on the scalp.
Climbazole is commonly added to hair care products like shampoos and scalp treatments.
This synthetic ingredient is insoluble in water but can be dissolved in surfactants and perfume oils.
The chemical formula of Climbazole is C15H17ClN2O2 and it appears as a white crystal powder.
Climbazole is soluble in ethyl acetate, acetone, benzene, toluene and other organic solvents.
Climbazole is partially soluble in cyclohexane and petroleum ether.
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema.
Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.
Its chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.
Climbazole is a broad and high-efficient antimicrobial.
It shows excellent inhibiting effect on pytyrosporum ovale fungi that causes dandruff, without irritating scalp due to hydrolysis.
Climbazole is stable under acidic and little alkali condition, as well as radiation and heat.
Ideal for application in anti-dandruff shampoo, body wash and soap.
Climbazole is an additive and antifungal agent used in over-the-counter shampoos, conditioners, lotions, and face washes to treat human fungal skin infections like eczema and dandruff.
Dandruff is suffered by as much as half of the population and about one in every ten individuals in the United States will develop eczema during their lifetime.
This agent helps to treat these moderate to severe fungal infections and their symptoms such as redness, and dry, itchy, and flakey skin without causing irritation to the affected area when used properly.
Climbazole's stable in acid and neutral pH ranges and not hygroscopic (does not absorb water from the air).
Climbazole has excellent light, heat and storage stability.
Climbazole is a potent inducer and inhibitor of P450-dependent metabolizing enzymes
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandru, seborrhoeic dermatitis and eczema.
Climbazole has shown a high in vitro and in vivo ecacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandru.
Climbazole's chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.
Climbazole is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3.
Climbazole is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Climbazole is a small molecule drug with a maximum clinical trial phase of II.
Climbazole is in the form of a white crystalline powder.
Climbazole is generally soluble in oil and some organic compounds.
Climbazole is an excellent antipruritic and anti-dandru agent.
Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.
Melting point: 96-100°C
Boiling point: 447.5±40.0 °C (Predicted)
Density: 1.17±0.1 g/cm3 (Predicted)
Vapor pressure: 0.001 Pa at 25℃
Refractive index: 1.54
Storage temp.: Inert atmosphere, Room Temperature
Solubility: Insoluble in water
Form: Solid
pKa: 5.66±0.22 (Predicted)
Color: White to Almost white
Water Solubility: 58 mg/L at 25℃
BRN: 618020
InChIKey: OWEGWHBOCFMBLP-UHFFFAOYSA-N
LogP: 3.83 at 25℃
Climbazole, which can be used as preservative in cream, hair cream and foot care products.
In addition, it can also be used as a dandruff remover in shampoo.
Climbazole may cause localized irritation of the skin with symptoms including redness, rashes and itching.
It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners.
Climbazole may be accompanied by other active ingredients such as zinc pyrithione or triclosan.
Climbazole is a phenomenal ingredient for hair care products with the ability to improve overall hair and scalp health.
Climbazole has anti-dandruff properties that clean the scalp thoroughly and prevent microbial growth.
This ingredient also reduces the sensation of irritation and itching, allowing for healthy hair growth that feels softer and lustrous.
Apart from hair care, Climbazole extends its goodness to skin care formulations to combat fungal-related skin conditions like tinea versicolor and seborrheic dermatitis.
Further, this ingredient is a renowned preservative that inhibits the development of bacteria in formulations - increasing their shelf life.
Climbazole's mechanism of action involves inhibiting the growth of fungi by disrupting the synthesis of ergosterol.
This disruption leads to increased permeability of the cell membrane, ultimately causing the death of the fungal cells.
Climbazole targets and inhibits the enzyme cytochrome P450 14α-demethylase, which is involved in the biosynthesis of ergosterol.
By interfering with this key enzyme, climbazole eectively disrupts the fungal cell membrane structure, leading to its antifungal activity.
This mechanism of action makes climbazole useful in studying fungal cell biology and developing potential antifungal strategies.
Climbazole is an antifungal drug, which is frequently used in the treatment of skin fungal infections.
Climbazole is used Shampoo and hair conditioner.
Climbazole inhibits dandru fungus permanently and strongly.
Climbazole is a safe, non-irritating product that can be widely used in shampoos.
Climbazole allows you to obtain low-cost formulas with small amounts of use.
Climbazole helps reduce dandru and cleanse the scalp.
Climbazole relieves symptoms of seborrheic dermatitis such as redness, aking and itching on the scalp.
Climbazole supports hair health by helping to control fungi and microorganisms on the scalp.
The usage rate varies between 0.5% and 2% depending on the demonstrative eect of Climbazole and its interaction with other substances.
Climbazole works stably at high temperatures and against metal ions.
Climbazole is synthesized through a multistep chemical process.
Initially, 4-chloro-3-nitrobenzonitrile undergoes a reaction with diethylamine to form 4-chloro-3 nitrobenzamide.
Subsequently, this compound is subjected to reduction using a reducing agent like iron powder, resulting in the formation of 4-chloro-3-aminobenzamide.
Finally, the aminobenzamide compound reacts with chloroacetyl chloride to produce Climbazole.
It is also known as Baypival.
Climbazole is used in over-the-counter shampoos, conditioners, lotions and face washes.
Climbazole is used for research use only.
Climbazole, which can be used as preservative in cream, hair cream and foot care products.
Climbazole is a synthetic compound commonly used as an antifungal agent in various personal care products, such as shampoos, creams, and lotions.
Climbazole is particularly effective against fungal infections of the scalp, such as dandruff, by inhibiting the growth of the fungi responsible for the condition.
As a chemical, it belongs to a class of compounds called imidazoles, which are known for their ability to disrupt the cell membrane of fungi, thereby preventing their growth and reproduction.
Climbazole is also used in the pharmaceutical industry in certain topical treatments, and it has been found to have a broad-spectrum antifungal activity.
It is known by various names, including its chemical identifier 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, and has a variety of applications beyond just antifungal purposes, such as in cosmetic formulations where it helps to improve scalp health.
Climbazole is a heterocyclic organic compound.
Climbazole is thus a safe antifungal drug used in the scalp therapy line of Neofollics.
Climbazole helps in eectively ghting dandru and fungi on the scalp.
Climbazole is a potent antifungal agent.
Climbazole also is a potent inducer of rat hepatic cytochrome P450.
Climbazole is a common ingredient used in cosmetics as preservative, also know by its chemical name 1-(4- chlorophenoxy)-1-imidazol1-yl-3,3-dimethyl-2-butanone.
The use of Climbazole is currently restricted in the European Union up to a maximum authorized concentration of 0.5% in a nished product.
Climbazole is a broad and high-ecient antimicrobial.
Climbazole shows excellent inhibiting eect on pytyrosporum ovale fungi that causes dandru, without irritating scalp due to hydrolysis.
Climbazole is stable under acidic and little alkali condition, as well as radiation and heat.
This synthetic ingredient, Climbazole, is insoluble in water but can be dissolved in surfactants and perfume oils.
The chemical formula of Climbazole is C15H17ClN2O2 and it appears as a white crystal powder.
Climbazole is also largely safe for use at lower concentrations.
Climbazole is a white Crystalline Powder used as a very eective anti-dandru agent.
Climbazole secically tackles the fungus Malaseezia furfur, the primary cause of dandru.
Climbazole is 100% natural and a Very Eective Anti-Dandru Agent
Climbazole is a powerful anti-dandru active with a long history of successful use.
Climbazole provides excellent activity against the main cause of dandru, Malassezia species.
Climbazole is suitable for both leave-on and rinse-o hair care formulations.
Climbazole provides no formation of coloured complexes with metal ions which cause discoloration in formulations.
Climbazole has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils.
Uses:
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
Climbazole, which can be used as preservative in cream, hair cream and foot care products.
In addition, Climbazole can also be used as a dandru remover in shampoo.
Climbazole is used 2% as anti-dandru agent in rinse-o shampoos and 0.2% as cosmetic preservative in leave on formulations (face cream, hair lotion, foot care) except for cosmetics applied on a full body area (body lotion).
Ideal for application in anti-dandru shampoo, body wash and soap.
Climbazole is an antifungal agent used in cosmetics to combat dandru and various scalp conditions caused by fungal infections like Malassezia.
As a broad-spectrum antifungal, Climbazole works by inhibiting the growth of fungi, preventing their proliferation on the scalp.
Climbazole is commonly added to hair care products like shampoos and scalp treatments.
The use of Climbazole as a preservative should therefore only be allowed in face cream, hair lotion, foot care products and rinse-o shampoo.
The maximum concentration of Climbazole should be 0,2 % for face cream, hair lotion and foot care products and 0,5 % for rinse-o shampoo.
The use of Climbazole as a non-preservative should be restricted to rinse-o shampoo, when the substance is used as an anti-dandru agent.
For such use, the maximum concentration of Climbazole should be 2 %.
Climbazole functions as an antifungal agent.
Climbazole is primarily used as an antifungal agent, where its most common application is in the treatment of scalp conditions like dandruff, seborrheic dermatitis, and other fungal infections of the skin.
Climbazole is often incorporated into shampoos, creams, and lotions designed to target the underlying fungal causes of these conditions, providing relief from itching, flaking, and irritation.
Due to its broad-spectrum antifungal properties, it can also be found in certain topical formulations designed to combat athlete’s foot, ringworm, and other dermatophyte infections.
In addition to its dermatological uses, Climbazole is used in cosmetic and personal care products to maintain scalp health and to prevent fungal overgrowth that might lead to hair loss or thinning.
It is sometimes included in products that aim to control oily skin or prevent fungal infections in individuals with compromised immune systems.
Beyond its medical and cosmetic applications, Climbazole is also used in some pharmaceutical formulations for more targeted antifungal treatments, especially in conditions where topical antifungals are required to manage the overgrowth of yeast or fungi on the skin or scalp.
Climbazole is frequently used in products aimed at improving overall scalp health, particularly in individuals who suffer from chronic scalp conditions such as dandruff.
By controlling the growth of Malassezia, a fungus often responsible for dandruff, Climbazole helps to reduce the scaling, itching, and irritation commonly associated with these conditions.
Its effectiveness in inhibiting fungal growth has made it a key ingredient in medicated shampoos, which not only address the symptoms of dandruff but also work to prevent its recurrence when used regularly.
Furthermore, Climbazole is incorporated into a variety of anti-fungal and anti-microbial treatments for the prevention and treatment of infections caused by fungi on the body.
Climbazole is found in some formulations designed to treat conditions like seborrheic dermatitis and eczema, where fungal overgrowth may contribute to inflammation and irritation.
Its ability to target specific fungal strains, while being gentle enough for regular use on the skin, has made it a popular ingredient in dermatological treatments.
Climbazole’s anti-fungal properties have even led to its exploration as a potential therapeutic in veterinary medicine, particularly in treating fungal skin conditions in pets.
The compound's broad-spectrum activity and ability to target fungal growth while maintaining skin health is seen as a promising treatment option for a variety of veterinary skin infections.
Climbazole is also sometimes used in combination with other active ingredients to treat infections in individuals with compromised immune systems or in those prone to recurrent fungal issues.
Climbazole has been shown to be effective in managing superficial fungal infections, helping to support healthy skin recovery while preventing the spread of the infection.
Moreover, due to its stability and effectiveness, Climbazole is also being researched for use in more innovative formulations, such as in products designed for long-term scalp care or in treatments for fungal infections that are more difficult to treat with conventional antifungal agents.
Safety profile:
Climbazole is a safe and non-sensitizing ingredient that does not have any major side effects.
In rinse-off products like shampoos, it can be used up to the concentrations of 0.5%.
Whereas, only 0.2% can be used in leave-on products.
Climbazole is necessary to stick to the recommended guidelines to avoid adverse reactions.
Overexposure to Climbazole can cause rashes, redness, and itching. Although well-tolerated by most skin types, a patch test is recommended.
In the use of cosmetic products with a maximum concentration of 0.5% Climbazole cannot be considered safe, but when it is used as a preservative in hair cosmetics and face cosmetics at 0.5%, it does not pose a risk to the health of the consumer.
Climbazole is a stable acid with a neutral pH that ranges between pH 4-7 and has excellent light, heat and storage abilities.
