CLIMBAZOLE

Climbazole is a synthetic antifungal agent widely used in cosmetic and personal care formulations, especially in dandruff control and scalp treatment products.
It is highly effective against Malassezia species and other fungi responsible for dandruff, seborrheic dermatitis, and scalp irritation.
Climbazole is valued for its fast-acting, gentle performance and compatibility with a broad range of hair and skin care formulations.

CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Formula: C₁₅H₁₇ClN₂O₂
Molecular Weight: 292.76 g/mol

Synonyms: Climbazole, 1-(4-Chlorophenoxy)-1-imidazolyl-3,3-dimethylbutan-2-one, 1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1H-imidazol-1-yl)butan-2-one, Climbazolum, Climbazol, Anti-dandruff agent Climbazole, Climbazole antifungal, Climbazole powder, Climbazole active, Climbazole USP, Climbazole BP, Climbazole pharmaceutical grade, Climbazole cosmetic grade, Climbazole imidazole derivative, Climbazole active ingredient, Climbazole antimicrobial agent, Climbazole hair care additive, Climbazole anti-seborrheic, 4-Chlorophenoxy imidazole ketone, Climbazole skin care agent, Climbazole anti-fungal additive, Climbazole cosmetic fungicide, Anti-fungal Climbazole, 1H-Imidazole-1-butane Climbazole, Climbazole scalp care ingredient, Climbazole shampoo additive, Climbazole dandruff treatment agent, Climbazole 38083-17-9, Climbazole EC 253-775-4, Climbazole antifungal compound, Climbazole therapeutic additive, Climbazole topical antifungal

APPLICATIONS

Climbazole is widely used in anti-dandruff shampoos to reduce scalp flaking and fungal overgrowth.
Climbazole is included in scalp treatment serums and lotions for controlling seborrheic dermatitis and itchiness.
Climbazole is employed in hair conditioners and scalp masks for long-term antifungal protection.

Climbazole is applied in facial cleansers and anti-acne treatments for its antifungal and antimicrobial action.
Climbazole is used in body washes and soaps formulated for sensitive or fungal-prone skin.
Climbazole is incorporated in anti-itch creams and topical ointments for fungal-related skin conditions.

Climbazole is used in deodorants and foot creams to inhibit fungal growth and improve skin hygiene.
Climbazole is suitable for inclusion in dermatological preparations for treating fungal dermatitis.
Climbazole is added to combination formulations with zinc pyrithione or piroctone olamine for enhanced anti-dandruff efficacy.

Climbazole is compatible with various surfactants, emulsifiers, and active agents in rinse-off and leave-on formulations.
Climbazole is beneficial in cosmetic products targeting scalp balance and long-term dandruff prevention.
Climbazole is used in color-safe hair care lines due to its non-disruptive formulation profile.

Climbazole is widely used in anti-dandruff shampoos, where it helps to treat scalp conditions caused by dandruff, by inhibiting the growth of yeast-like fungi responsible for flaking and itching.
Climbazole is employed in the formulation of scalp treatments, where it helps to soothe and protect the scalp, reducing irritation, inflammation, and fungal infections.

Climbazole is used in the production of hair care products, such as conditioners and serums, where it helps improve the health of the scalp, providing antifungal benefits while promoting a clean, balanced environment for hair growth.
Climbazole is used in cosmetic formulations for its antifungal properties, particularly in products aimed at treating seborrheic dermatitis and other fungal-related skin conditions.

Climbazole is used in the formulation of personal care products like body washes and soaps, where it helps to treat fungal infections on the skin while maintaining skin health and preventing dryness or irritation.
Climbazole is employed in the development of antifungal creams and ointments, where it helps to treat skin infections such as athlete’s foot, ringworm, and other dermatophyte-related conditions.

Climbazole is used in the production of topical treatments for acne, where it helps reduce the growth of acne-causing bacteria and prevent inflammation on the skin.
Climbazole is applied in the production of facial masks and skincare treatments, where it helps balance the skin microbiome and reduce fungal or yeast overgrowth that can lead to skin problems.
Climbazole is used in the preparation of foot care products, where it helps treat fungal infections such as athlete’s foot while improving the overall health and condition of the skin.

Climbazole is used in the formulation of hair loss treatments, where its antifungal properties help create an optimal environment for healthy hair growth by preventing scalp imbalances that could hinder hair growth.
Climbazole is used in the development of eczema and psoriasis treatments, where it helps to reduce fungal activity that could exacerbate flare-ups, promoting healing and skin comfort.

Climbazole is employed in body and facial scrubs, where it helps cleanse the skin while combating fungal infections and maintaining overall skin health.
Climbazole is used in the formulation of anti-aging products, where it helps to regulate the skin's microbiome, improving skin tone and texture by reducing inflammation and fungal overgrowth.

Climbazole is applied in deodorants and antiperspirants, where it helps inhibit the growth of odor-causing bacteria and fungi, promoting long-lasting freshness.
Climbazole is used in the formulation of pet care products, particularly in treating fungal skin infections in pets such as ringworm or yeast-related conditions.
Climbazole is used in the development of wound care products, where it helps reduce the risk of fungal infection in cuts, abrasions, and other open skin areas.

Climbazole is employed in the production of topical antifungal treatments for eczema and other fungal skin conditions, where it helps control symptoms and reduce flare-ups.
Climbazole is used in the preparation of scalp and skin exfoliating products, where it helps to remove buildup while promoting a healthy, fungus-free environment.

Climbazole is used in the formulation of therapeutic bath additives, where it helps treat fungal infections on the body while soothing and protecting the skin.
Climbazole is used in the production of shampoos for treating fungal infections on pets, providing effective relief from itching and fungal-related issues.
Climbazole is employed in the manufacture of antifungal wipes for personal hygiene, where it helps prevent the spread of fungal infections on the skin, especially in areas prone to fungal growth.

Climbazole is used in hair styling products, where it helps maintain scalp health and reduce the risk of dandruff and fungal infections that could affect hair quality.
Climbazole is applied in the production of skin treatment products designed to protect against fungal infections, particularly for areas that are prone to moisture and yeast-related growth.

Climbazole is used in facial and hand sanitizers to help eliminate fungal contamination, providing additional protection against skin infections.
Climbazole is employed in the preparation of dermatological products that treat and prevent fungal infections, improving skin health and appearance.

DESCRIPTION

Climbazole is a white to off-white crystalline powder with low odor and excellent formulation compatibility.
It is a substituted imidazole ketone compound that provides selective antifungal activity, targeting the cell membrane synthesis of fungi.
Climbazole has a broad-spectrum antifungal effect and is particularly effective against Malassezia species responsible for dandruff and scalp irritation.

Climbazole exhibits good skin and scalp tolerance, making it suitable for frequent-use personal care products.
It enhances the efficacy of hair and skin formulations without affecting the foaming, texture, or fragrance characteristics.
Climbazole is photostable and chemically stable in both aqueous and oil-based systems.

Climbazole supports product shelf life and microbial safety in cosmetic applications.
Its low usage concentration provides effective fungal control without overburdening the formulation.
Climbazole is compliant with global cosmetic regulatory standards, including the EU Cosmetic Regulation.

Climbazole is an antifungal agent commonly used in personal care, pharmaceutical, and cosmetic products to prevent and treat fungal infections, particularly in scalp and skin treatments.
Climbazole is a broad-spectrum antifungal compound that targets and inhibits the growth of dermatophytes and yeasts, such as Malassezia, which are commonly responsible for dandruff and other scalp conditions.

Climbazole is a white, crystalline powder that is soluble in alcohol and oils, making it ideal for use in a variety of topical formulations such as shampoos, creams, and lotions.
Climbazole works by disrupting the cell membrane function of fungi, inhibiting their ability to proliferate and reducing the symptoms associated with fungal infections, including itching and inflammation.

Climbazole is a highly effective treatment for dandruff and seborrheic dermatitis, where it helps to balance the scalp's microbiome and reduce flakiness and irritation caused by fungal overgrowth.
Climbazole is often used in combination with other active ingredients in hair care and skin care formulations, where it enhances the overall efficacy of the product in treating fungal-related skin conditions.

Climbazole has a low toxicity profile and is considered safe for use in both cosmetic and pharmaceutical applications, making it an ideal choice for products aimed at treating fungal conditions without causing harm to the skin.
Climbazole is known for its stability in a wide range of pH levels, which allows it to be used in formulations with varying acidity or alkalinity without losing its effectiveness.

Climbazole is biodegradable and considered to be an environmentally friendly option in the treatment of fungal infections, particularly in cosmetic products that are washed off after application.
Climbazole is a well-regulated compound in personal care products, with its usage in concentrations that ensure both safety and efficacy in treating and preventing fungal conditions on the skin and scalp.

PROPERTIES

Chemical Formula: C₁₅H₁₇ClN₂O₂
Molecular Weight: 292.76 g/mol
Common Name: Climbazole
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
Solubility: Slightly soluble in water; soluble in ethanol and propylene glycol
Melting Point: Approx. 96–100°C
pH (in solution): 5.0–6.0 (depending on system)
Stability: Stable in a broad pH range and at standard formulation temperatures
Reactivity: Inert under normal formulation conditions
Storage Temperature: Store at 15–25°C in a dry, tightly sealed container
Shelf Life: 24–36 months in original packaging

FIRST AID

Inhalation:
Move the affected person to fresh air.
Seek medical attention if irritation or discomfort persists.

Skin Contact:
Wash skin thoroughly with soap and water.
Seek medical attention if redness or irritation occurs.

Eye Contact:
Rinse eyes immediately with clean water for at least 15 minutes.
Seek medical help if irritation persists.

Ingestion:
Rinse mouth with water.
Do not induce vomiting unless instructed by a physician.
Seek medical attention if symptoms appear.

Note to Physicians:
Treat symptomatically.
No specific antidote required.

HANDLING AND STORAGE

Handling:
Wear protective gloves and goggles during bulk handling.
Avoid contact with eyes and prolonged skin exposure.
Use in well-ventilated areas or under extraction systems.

Spill and Leak Procedures:
Sweep up or vacuum without generating dust.
Dispose according to local environmental regulations.

Storage:
Store Climbazole in a cool, dry, and well-ventilated area.
Keep containers tightly sealed and protected from heat and moisture.
Avoid exposure to strong oxidizing agents.

Handling Cautions:
Prevent environmental contamination.
Ensure labeling and storage according to safety standards.
Handle under standard hygiene protocols.