CLIMBAZOLE

Climbazole is an imidazole-derived antifungal active widely used in anti-dandruff and scalp-care formulations to control Malassezia-associated dandruff and reduce scalp flaking, itching, and irritation.
Climbazole is commonly used in shampoos, conditioners, leave-on tonics, and scalp treatments where targeted antifungal performance supports long-lasting dandruff control and improved scalp comfort.
Climbazole is valued for strong activity at low use levels, good compatibility with many surfactant systems, and effective performance in rinse-off and leave-on cosmetic formulations when properly solubilized.

CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol

Synonyms: Climbazole, 1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, Climbazol (variant spelling), Climbazole Antifungal, Climbazole Anti-Dandruff Active, Imidazole Antimycotic Climbazole, Climbazole Cosmetic Active, Climbazole Scalp Care Active, Climbazole CAS 38083-17-9, Climbazole Anti-Flaking Agent, Climbazole Dandruff Control Active, Climbazole Imidazole Antifungal, Climbazole, CLIMBAZOLE, Climbazol, Climbazole Antifungal, Climbazole Anti-dandruff Agent, Climbazole Antidandruff, Climbazole Antimycotic, Imidazole Antimycotic (Climbazole), Imidazole-Derived Antifungal (Climbazole), 1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, 1-(4-Chlorophenoxy)-1H-imidazol-1-yl-3,3-dimethylbutan-2-one, 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone, 1-(4-Chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)butan-2-one, 4-Chlorophenoxy Imidazole (Climbazole), Chlorophenoxy Imidazole (Climbazole), 4-Chlorophenoxy Imidazole Ketone (Climbazole), Climbazole Imidazolyl Ketone (descriptive), Climbazole Scalp Antifungal, Climbazole Anti-Malassezia Active, Climbazole Anti-Yeast Agent, Climbazole Dandruff Control Agent, Climbazole Scalp Treatment Active, Climbazole Shampoo Active, Climbazole Hair-Care Ingredient, Climbazole Scalp-Care Ingredient, Anti-Dandruff Active (Climbazole), Climbazole Active, Climbazole Active Ingredient, Climbazole Active Substance, Climbazole Raw Material, Climbazole Ingredient, Climbazole Cosmetic Active, Climbazole Personal Care Active, Climbazole (INCI), Climbazole Cosmetic Grade, Climbazole Personal Care Grade, Climbazole Pharmaceutical Grade, Climbazole Technical Grade, Climbazole Industrial Grade, Climbazole High Purity, Climbazole Assay 98%, Climbazole Assay 99%, Climbazole 98%, Climbazole 99%, Climbazole Powder, Climbazole Fine Powder, Climbazole Crystalline Powder, Climbazole Micronized, Micronized Climbazole, Climbazole Bulk Powder, Climbazole Concentrate (formulation), Climbazole Solution (formulation), Solubilized Climbazole, Climbazole Solubilized (formulation), Climbazole in DPG, Climbazole in Dipropylene Glycol (variant)

APPLICATIONS

Climbazole is used in anti-dandruff shampoos to reduce Malassezia growth and decrease visible scalp flaking.
Climbazole is incorporated into daily-use shampoos to provide ongoing dandruff control with gentle cleansing systems.
Climbazole is used in clarifying shampoos to support scalp reset routines while maintaining antifungal efficacy.

Climbazole is used in scalp therapy shampoos formulated for itchy, irritated scalps to help reduce discomfort linked to dandruff.
Climbazole is incorporated into shampoos for oily scalps to reduce dandruff recurrence in sebum-rich conditions.
Climbazole is used in salon and professional haircare products to deliver targeted scalp anti-flaking performance.

Climbazole is used in conditioners to provide antifungal activity while improving hair softness and combability.
Climbazole is incorporated into 2-in-1 shampoo-conditioner products to simplify dandruff-care routines.
Climbazole is used in scalp conditioners to reduce flaking while supporting a comfortable scalp feel.

Climbazole is used in leave-on scalp tonics to provide extended contact time and long-lasting dandruff control.
Climbazole is incorporated into scalp serums to support anti-flaking performance without heavy residue.
Climbazole is used in scalp lotions designed for sensitive scalps when properly solubilized and stabilized.

Climbazole is used in anti-dandruff hair masks to provide scalp-care benefits during deep-conditioning treatments.
Climbazole is incorporated into scalp exfoliation products to help manage flaking while supporting scalp balance.
Climbazole is used in pre-shampoo scalp treatments to enhance anti-dandruff routines and improve comfort.

Climbazole is used in men’s grooming shampoos and scalp products where dandruff control is a key consumer need.
Climbazole is incorporated into sports and active-lifestyle shampoos to help control dandruff associated with sweating and frequent washing.
Climbazole is used in travel-size anti-dandruff products where high efficacy at low dosage supports compact formulations.

Climbazole is used in sulfate-free shampoo systems when compatibility and solubilization are properly engineered.
Climbazole is incorporated into low-irritation surfactant blends to maintain dandruff control while improving mildness.
Climbazole is used in fragrance-containing products when the solvent system maintains Climbazole stability and clarity.

Climbazole is used in clear shampoos when solubilizers are selected to keep Climbazole fully dissolved and avoid haze.
Climbazole is incorporated into pearlescent shampoos where dispersion and stability are balanced with sensory aesthetics.
Climbazole is used in high-foaming systems when surfactant selection supports both foam and antifungal performance.

Climbazole is used in scalp sprays to deliver light, leave-on antifungal support with minimal residue.
Climbazole is incorporated into scalp wipes and on-the-go scalp-care formats when permitted and properly stabilized.
Climbazole is used in post-styling scalp refreshers to help manage flaking between washes.

Climbazole is used in combination systems with other anti-dandruff actives to broaden performance and reduce recurrence.
Climbazole is incorporated into scalp-care lines that include both rinse-off and leave-on steps for comprehensive control.
Climbazole is used in supportive scalp microbiome-balancing concepts where targeted antifungal control is part of the strategy.

Climbazole is used in dandruff-control products for curly and textured hair to support scalp health without stripping hair oils.
Climbazole is incorporated into low-build-up routines where lightweight deposition helps maintain hair feel.
Climbazole is valued because Climbazole delivers strong antifungal performance at low levels and supports effective, consumer-friendly anti-dandruff formulations.

DESCRIPTION

Climbazole is a crystalline solid typically supplied as a white to off-white powder with low water solubility and good solubility in many organic solvents and selected solubilizer systems.
Climbazole works by inhibiting fungal growth, and Climbazole is especially effective against Malassezia species associated with dandruff and seborrheic scalp conditions.
Climbazole is generally used at low concentrations, and Climbazole performance depends on achieving adequate solubilization, uniform distribution, and sufficient contact time on the scalp.

Climbazole stability depends on formulation pH, temperature, solvent system, and packaging, so stability testing is recommended for finished products.
Climbazole is commonly formulated in rinse-off products and can also be used in leave-on systems when designed to minimize irritation and maintain product clarity.
Climbazole can be combined with conditioning polymers and mild surfactants to improve scalp comfort while maintaining antifungal efficacy.

Climbazole should be stored in tightly closed containers in a cool, dry place protected from heat and strong light.
Climbazole should be handled with appropriate PPE to avoid dust inhalation and unnecessary skin or eye contact during manufacturing.
Climbazole should be used in compliance with applicable cosmetic regulations and concentration limits for the target market.

PROPERTIES

Chemical Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol
Common Name: Climbazole
Chemical Type: Imidazole-derived antifungal active
Appearance: White to off-white crystalline powder
Odor: Mild characteristic odor
Solubility: Practically insoluble in water; soluble in many organic solvents and selected solubilizer systems
Melting Point: ~94–98°C (typical)
pH Stability: Stable in typical cosmetic pH ranges when properly formulated (system dependent)
Partitioning: Lipophilic active requiring solubilization in surfactant or solvent phases
Stability: Stable under recommended storage; sensitive to unsuitable solvent systems and high heat
Storage Temperature: 15–25°C, dry, tightly closed, protected from light
Shelf Life: Typically 24–36 months in original sealed packaging (supplier dependent)

FIRST AID

Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during handling and powder charging.

Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.

Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs or if a significant amount is swallowed.
Never give anything by mouth to an unconscious person.

Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care based on exposure route and symptoms.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves and safety glasses, and use dust protection as needed.
Avoid generating dust and avoid inhalation of fine powder.
Wash hands after handling and before eating, drinking, or smoking.

Ventilation:
Use local exhaust or general ventilation where dust may be generated.
Maintain good airflow during weighing and charging operations.
Minimize airborne particulate accumulation in enclosed areas.

Storage:
Store in tightly closed containers in a cool, dry place.
Protect from heat, moisture, and direct light to maintain stability and appearance.
Keep containers properly labeled and protected from contamination.

Spill and Leak Procedures:
Avoid dust generation and collect spilled material using methods that minimize airborne particles.
Place collected material into suitable containers for disposal according to local regulations.
Clean the area with wet wiping or HEPA vacuum methods to remove residues.

Handling Precautions:
Ensure complete solubilization of Climbazole in the formulation to maximize efficacy and avoid crystallization.
Conduct stability testing across temperature cycles to confirm clarity and active retention.
Use Climbazole according to applicable regulatory limits and good manufacturing practices for cosmetic active ingredients.