CLIMBAZOLE

Climbazole is predominantly used in anti-dandruff shampoos and various antimicrobial foams or soaps.
The primary use of Climbazole is as an antifungal active ingredient in cosmetic and personal care formulations, especially in anti-dandruff shampoos, scalp treatments, and lotions.
Climbazole is an antifungal drug, which is frequently used in the treatment of skin fungal infections.

CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol

SYNONYMS:
Climbazole, 38083-17-9, Baypival, Climbazol, Crinipan AD, BAY-E 6975, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, 2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-, MFCD00055505, 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, NSC-759808, DTXSID6046555, 1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone, CHEBI:83719, 1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone, 9N42CW7I54, NCGC00166153-01, Baysan, 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, DTXCID4026555, Climbazolum, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone, Climbazol [INN-Spanish], Climbazolum [INN-Latin], CAS-38083-17-9, Climbazole [INN:BAN], EINECS 253-775-4, BRN 0618020, Bay e 6975, UNII-9N42CW7I54, CCRIS 8169, MEB 6401, Climbazole (Standard), 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone, CLIMBAZOLE [INN], EC 253-775-4, CLIMBAZOLE [MART.], CLIMBAZOLE [USP-RS], CLIMBAZOLE [WHO-DD], SCHEMBL39729, US9138393, Climbazole, US9144538, Climbazole, 5-23-04-00209 (Beilstein Handbook Reference), MLS004773943, BAY e-6975, CHEMBL1437764, HY-B1151R, OWEGWHBOCFMBLP-UHFFFAOYSA-, BDBM181112, HMS2090O13, HMS3652P05, HMS3744O15, Pharmakon1600-01504833, HY-B1151, MEB-6401, Tox21 112343, Tox21_112343, AC-272, DL-358, NSC759808, s4178, 2-BUTANONE, 1-(p-CHLOROPHENOXY)-3,3-DIMETHYL-1-(1-IMIDAZOLYL)-, AKOS015895513, Tox21_112343_1, CCG-213958, CS-4675, DB15580, KS-5112, NSC 759808, Climbazole 10 microg/mL in Cyclohexane, NCGC00166153-02, NCGC00166153-03, SMR001550495, DB-049235, C2025, NS00008150, SW219213-1, Climbazole, PESTANAL(R), analytical standard, H10384, SBI-0653493.0001, AB01275501-01, AB01275501_02, AB01275501_03, AO-295/40848554, Q629373, SR-05000001501, Q-100974, SR-05000001501-1, BRD-A61676498-001-01-7, BRD-A61676498-001-05-8, BRD-A61676498-001-06-6, Climbazole, United States Pharmacopeia (USP) Reference Standard, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one, (RS)-1-(4-CHLOROPHENOXY)-1-IMIDAZOL-1-YL-3,3-DIMETHYLBUTAN-2-ONE, InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

Climbazole is an active ingredient used mainly in body cosmetics.
Climbazole has antifungal properties, so it is used in products for eczema-prone skin and in shampoos for dandruff.
Climbazole's anti-inflammatory properties help to inhibit the growth of unwanted yeasts on the skin and also help to preserve cosmetic products.

Climbazole can provide relief from itchy skin in the case of dandruff.
Climbazole is a high-performance antimicrobial ingredient.
Climbazole effectively inhibits Pytyrosporum ovale fungi that cause dandruff, without irritating the scalp due to hydrolysis.

Climbazole remains stable in both acidic and slightly alkaline conditions, as well as under radiation or heat.
Climbazole is a white to pale yellow crystalline powder with antifungal properties.
Climbazole is chemically classified as an imidazole derivative.

Climbazole is an organic antifungal compound belonging to the azole class of fungicides.
Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.

Climbazole's chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.
Climbazole is a heterocyclic organic compound.
This synthetic ingredient, Climbazole, is insoluble in water but can be dissolved in surfactants and perfume oils.

The chemical formula of Climbazole is C15H17ClN2O2 and it appears as a white crystal powder.
Climbazole is also largely safe for use at lower concentrations.
Climbazole is a white Crystalline Powder used as a very effective anti-dandruff agent.

Climbazole secifically tackles the fungus Malaseezia furfur, the primary cause of dandruff.
Climbazole is 100% natural and a Very Effective Anti-Dandruff Agent
Climbazole is a powerful anti-dandruff active with a long history of successful use.

Climbazole provides excellent activity against the main cause of dandruff, Malassezia species.
Climbazole is suitable for both leave-on and rinse-off hair care formulations.
Climbazole is a high-performance antimicrobial ingredient.

Climbazole effectively inhibits Pytyrosporum ovale fungi that cause dandruff, without irritating the scalp due to hydrolysis.
Climbazole remains stable in both acidic and slightly alkaline conditions, as well as under radiation or heat.
Climbazole CAS 38083-17-9 is an antifungal agent that is frequently used in dandruff shampoos and other scalp care products.

Climbazole belongs to the class of compounds known as imidazole derivatives, which are known for their ability to inhibit the growth of fungi and yeasts.
While it may not be as widely known as other ingredients like ketoconazole or selenium sulfide, Climbazole is gaining popularity due to its effectiveness in treating dandruff and its gentle nature on the scalp.

USES and APPLICATIONS of CLIMBAZOLE:
The primary use of Climbazole is as an antifungal active ingredient in cosmetic and personal care formulations, especially in anti-dandruff shampoos, scalp treatments, and lotions.
Climbazole targets Malassezia species associated with dandruff and seborrheic dermatitis, helping to reduce flaking, itching, and scalp irritation.

Reformulators often combine Climbazole with other antifungal or soothing agents like zinc pyrithione or piroctone olamine to enhance efficacy.
Climbazole has also been studied for anti-inflammatory effects, making it suitable in formulations for sensitive skin, and it finds limited use in veterinary topical antifungal products.

Climbazole, which can be used as preservative in cream, hair cream and foot care products.
In addition, Climbazole can also be used as a dandruff remover in shampoo.
Cosmetic Use: Climbazole is primarily used in anti-dandruff shampoos and scalp treatments.

Climbazole targets and helps eliminate the fungus Malassezia, which is a common cause of dandruff.
By controlling the fungal growth, Climbazole reduces the occurrence of dandruff and provides relief from itching and flaking of the scalp.
Antifungal Action: Climbazole works by inhibiting the biosynthesis of ergosterol, an essential component of the fungal cell membrane.

By disrupting the cell membrane, it prevents the growth and proliferation of fungal cells, leading to their elimination.
Health Benefits: Climbazole has been proven effective in combating dandruff and promoting a healthier scalp.
By controlling the fungus responsible for dandruff, Climbazole can help reduce scalp irritation and improve the overall condition of the hair and scalp.

The dosage of climbazole for use in anti-dandruff shampoos is a maximum of 2%.
The dosage of climbazole for use as a preservative is 0,2 % for skin creams, hair masks and foot preparations and 0,5 % for shampoos.
Climbazole is predominantly used in anti-dandruff shampoos and various antimicrobial foams or soaps.

Climbazole is an antifungal agent commonly used in personal care products, especially in shampoos and anti-dandruff formulations.
Climbazole is effective in controlling fungal growth on the scalp and is known for its antifungal and anti-dandruff properties.

Climbazole is commonly used as a topical antifungal agent, particularly in cosmetic and personal care products to treat dandruff and seborrheic dermatitis by inhibiting the growth of pathogenic fungi such as Malassezia species on the skin and scalp.
Climbazole's effectiveness and stability have led to widespread use in shampoos, lotions, and creams targeted at scalp conditions.

Climbazole’s chemical structure and biological activity are similar to other azole antifungals like ketoconazole and miconazole, but it is primarily used in cosmetic formulations rather than systemic pharmaceutical applications.
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema.

Climbazole is an antifungal drug, which is frequently used in the treatment of skin fungal infections.
Thus, Climbazole is effective against dandruff, eczema and other scalp infections in your hair and scalp.
The antifungal drug, Climbazole, is used in over-the-counter shampoos, conditioners, lotions and face washes.

Climbazole is an antifungal drug, which is frequently used in the treatment of skin fungal infections.
Climbazole is an antifungal agent used in cosmetics to combat dandruff and various scalp conditions caused by fungal infections like Malassezia.
As a broad-spectrum antifungal, Climbazole works by inhibiting the growth of fungi, preventing their proliferation on the scalp.

Climbazole is commonly added to hair care products like shampoos and scalp treatments.
Climbazole provides no formation of coloured complexes with metal ions which cause discoloration in formulations.
Climbazole has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils.

Climbazole's stable in acid and neutral pH ranges and not hygroscopic (does not absorb water from the air).
Climbazole has excellent light, heat and storage stability.
Climbazole is predominantly used in anti-dandruff shampoos and various antimicrobial foams or soaps.

Climbazole is primarily aimed at haircare products where the anti-dandruff properties are renowned for their effectiveness.
Climbazole, however, is found in some eczema treatments for its antifungal properties.
Climbazole is a potent antifungal agent widely recognized for its efficacy in treating various dermatological conditions.

Climbazole is particularly effective against Malassezia species, making it a popular choice in the formulation of anti-dandruff shampoos and topical treatments for seborrheic dermatitis.
Its unique structure allows Climbazole to penetrate the skin effectively, providing rapid relief from itching and irritation while promoting a healthier scalp environment.

In addition to its antifungal properties, Climbazole also exhibits anti-inflammatory effects, making it suitable for use in cosmetic formulations aimed at soothing sensitive skin.
Researchers and formulators appreciate Climbazole's stability and compatibility with a variety of other ingredients, enhancing its versatility in personal care products.

With its proven track record in both pharmaceutical and cosmetic applications, Climbazole stands out as a reliable choice for professionals seeking effective solutions for fungal infections and scalp health.

WHAT IS CLIMBAZOLE USED FOR?
Climbazole is a phenomenal ingredient for hair care products with the ability to improve overall hair and scalp health. 
Climbazole has anti-dandruff properties that clean the scalp thoroughly and prevent microbial growth. 
Climbazole also reduces the sensation of irritation and itching, allowing for healthy hair growth that feels softer and lustrous. 

Apart from hair care, Climbazole extends its goodness to skin care formulations to combat fungal-related skin conditions like tinea versicolor and seborrheic dermatitis. 
Further, Climbazole is a renowned preservative that inhibits the development of bacteria in formulations - increasing their shelf life.

ORIGIN OF CLIMBAZOLE:
Climbazole is synthesized through a multistep chemical process. Initially, 4-chloro-3-nitrobenzonitrile undergoes a reaction with diethylamine to form 4-chloro-3-nitrobenzamide. 

Subsequently, Climbazole is subjected to reduction using a reducing agent like iron powder, resulting in the formation of 4-chloro-3-aminobenzamide. 
Finally, the aminobenzamide compound reacts with chloroacetyl chloride to produce Climbazole. 
Climbazole is also known as Baypival.

WHAT DOES CLIMBAZOLE DO IN A FORMULATION?
*Antidandruff
*Antimicrobial
*Preservative

SAFETY PROFILE OF CLIMBAZOLE:
Climbazole is a safe and non-sensitizing ingredient that does not have any major side effects. 
In rinse-off products like shampoos, Climbazole can be used up to 0.5% concentrations. 
Whereas, only 0.2% Climbazole can be used in leave-on products. 

Climbazole is necessary to stick to the recommended guidelines to avoid adverse reactions. 
Overexposure to Climbazole can cause rashes, redness, and itching. 
Although well-tolerated by most skin types, a patch test is recommended.

ALTERNATIVES OF CLIMBAZOLE:
*KETOCONAZOLE, 
*ZINC PYRITHIONE, 
*SELENIUM SULFIDE

PHYSICAL PROPERTIES OF CLIMBAZOLE:
Climbazole generally appears as a white to off-white crystalline powder or fine solid.
Climbazole is practically insoluble in water, with measured water solubility around 58 mg/L at 25 °C, but can dissolve in organic solvents such as ethanol, acetone, and glycols.

Physically, Climbazole has a melting point of approximately 96–100 °C, indicating it is a stable solid at room temperature.
The density of Climbazole is around 1.17–1.25 g/cm³, although some sources report slight variation depending on measurement conditions.
The refractive index of Climbazole is approximately 1.54.

Climbazole has a very low vapor pressure (about 0.001 Pa at 25 °C), meaning it does not readily evaporate at ambient conditions.
Climbazole's log P (octanol-water partition coefficient) is moderately high (around 3.8), indicating it is more soluble in lipid environments than in water.

Chemically, Climbazole is stable to heat and light under normal storage conditions and is not hygroscopic.
Climbazole typically exists as a racemic mixture of two stereoisomers.

CHEMICAL PROPERTIES OF CLIMBAZOLE:
Chemically, Climbazole contains an imidazole ring and a chlorinated aromatic (chlorophenoxy) group attached to a butanone core.
This structure contributes to Climbazole's antifungal activity by interfering with fungal cell membrane synthesis.
Climbazole is classified as a ketone with heterocyclic components and is part of the conazole fungicide family.

Its functional groups lend chemical stability and allow Climbazole to interact effectively with fungal enzymatic pathways.
Climbazole does not undergo rapid hydrolysis in water and persists under typical cosmetic processing conditions, though its low water solubility means it is usually formulated with organic solvents or surfactants for enhanced dispersion in finished products.

HOW TO USE CLIMBAZOLE:
Climbazole has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils.
Climbazole's stable in acid and neutral pH ranges and not hygroscopic, has excellent light, heat and storage stability.
In-vivo efficacy tests have shown the effectiveness of Climbazole in anti-dandruff formulations
The extract is suitable for use in both O/W Emulsions and W/O Emulsions

USAGE AMOUNT OF CLIMBAZOLE:
Usage Level of Climbazole: 0.5 – 1% (Rinse off products), 0.1% - 0.3% (Leave on Products) 
These are maximum levels as defined under EU Cosmetic Regulations.

INDICATIONS AND FORMULATIONS OF CLIMBAZOLE:
Climbazole is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners.
Climbazole may be accompanied by other active ingredients such as zinc pyrithione or triclosan.
Climbazole is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3.
Climbazole is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.

FUNCTIONS (INCI) OF CLIMBAZOLE:
*Anti dandruff : 
Climbazole helps fight against dandruff

*Antimicrobial : 
Climbazole helps slowing the growth of micro-organisms on the skin and counteracts the development of microbes

*Preservative : 
Climbazole inhibits the development of microorganisms in cosmetic products.

CLIMBAZOLE IS PERESENT IN:
This ingredient is present in 0.11% of cosmetics.
*Anti-dandruff shampoo (6.22%)
*Classic shampoo (0.36%)

BENEFITS OF CLIMBAZOLE IN DANDRUFF SHAMPOOS
*Effective Antifungal Action
The most significant advantage of Climbazole is its proven antifungal properties.
Climbazole has been shown to be particularly effective against Malassezia, which is the main culprit in most cases of dandruff.
Unlike some other antifungal agents, Climbazole does not have harsh side effects and works quickly to reduce scalp flaking and itching.

*Gentler on the Scalp
Many dandruff treatments, especially those containing strong chemicals or harsher antifungal agents, can sometimes irritate the scalp or cause dryness.
Climbazole, however, is considered relatively mild compared to other antifungal agents like ketoconazole or selenium sulfide.
This makes Climbazole a great option for people with sensitive skin or those who are prone to scalp irritation from harsher treatments.

*Long-Lasting Results
One of the challenges of dandruff treatment is maintaining the results over time.
Regular use of Climbazole-containing shampoos has been shown to provide lasting relief from dandruff symptoms.
By keeping Malassezia under control, Climbazole helps prevent the recurrence of flakes, providing a long-term solution to dandruff.

*Supports Overall Scalp Health
In addition to combating dandruff, Climbazole promotes a healthy scalp environment.
Climbazole helps maintain proper oil production on the scalp, preventing both excessive oiliness and dryness.
A balanced scalp is crucial for preventing dandruff and maintaining overall hair health.

*Suitable for Frequent Use
Unlike some dandruff treatments that may require periodic breaks to avoid scalp irritation, Climbazole can be safely used on a regular basis.
This makes Climbazole ideal for people who need ongoing dandruff prevention, especially in cases where dandruff is a chronic issue.

EFFECTS OF CLIMBAZOLE OF CLIMBAZOLE:
Climbazole is highly effective at controlling dandruff, which results from the excessive shedding of dead skin cells on the scalp.
The skin flakes, itches and crusts very often in this condition.
Although dandruff is a minor problem it can be very annoying and embarrassing.

The antifungal drug climbazole helps to control the dandruff effectively.
According to a study (2012) of 4 weeks in testing different shampoos, the effects of a pyrithione/climbazole shampoo were more effective in reducing dandruff than an ZPT shampoo.

Scalp eczema has different causes such as genetic allergens, stress and medicines.
Scalp eczema is most of the time an reddened itchy infection, also scaly and greasy patches could appear.
Though eczema is not a fungus, inhibiting infection using an anti-fungal agent, such as climbazole is the key to treat your scalp eczema.

HOW TO USE DANDRUFF SHAMPOOS CONTAINING CLIMBAZOLE:
*Using a shampoo with Climbazole is simple.
Wet your hair thoroughly, apply a generous amount of shampoo, and gently massage Climbazole into the scalp for a few minutes to allow the active ingredients to penetrate and work effectively.

*Rinse thoroughly.
For best results, use the shampoo consistently (about 2–3 times per week), depending on the severity of your dandruff.
If you experience any irritation, reduce the frequency of use or consult with a dermatologist.

Conclusion
Climbazole is an excellent antifungal agent that can significantly improve scalp health and effectively treat dandruff.
Climbazole's mild nature makes it an ideal choice for people with sensitive skin, while its targeted action against Malassezia ensures that dandruff is kept under control.

If you are struggling with dandruff, considering a dandruff shampoo that contains Climbazole could be an effective and long-lasting solution.
As always, if your dandruff persists or worsens, it’s a good idea to consult with a dermatologist to explore additional treatment options.
By incorporating Climbazole into your hair care routine, you can enjoy a healthier scalp, reduced flakiness, and the confidence that comes with a dandruff-free head of hair.

CLIMBAZOLE VS. OTHER DANDRUFF TREATMENT INGREDIENTS:
While climbazole powder is highly effective, it’s important to understand how it compares to other common antifungal ingredients found in dandruff shampoos.

Ketoconazole: 
Ketoconazole is another powerful antifungal agent often used in dandruff shampoos.
While both Climbazole and ketoconazole are effective at reducing Malassezia overgrowth, Climbazole tends to be milder and better tolerated by individuals with sensitive scalps.
Ketoconazole is known to have a slightly stronger potency, but it may cause scalp dryness or irritation in some users.

Selenium Sulfide: 
Selenium sulfide is another ingredient commonly found in dandruff shampoos.
Like Climbazole, it helps reduce the growth of Malassezia, but it can have a drying effect on the scalp and hair.
It is often recommended for more severe cases of dandruff or seborrheic dermatitis, but it can be harsher compared to Climbazole.

Zinc Pyrithione: 
Zinc pyrithione is another widely used active ingredient in dandruff shampoos.
While it’s also effective against Malassezia, Climbazole tends to be more effective in tackling the root cause of dandruff (the overgrowth of yeast) without the side effects like dryness or scalp irritation that can sometimes occur with zinc pyrithione.

FORMULATION GUIDELINES OF CLIMBAZOLE:
SOLUBILITY
Benzyl alcohol (approx) - 55%
Ethanol (96%) - 50%
Phenoxyethanol - 40%
Ethoxydiglycol - 30%
Propylene Glycol - 30%
Butylene Glycol - 30%
Dipropylene Glycol - 30%
Certain perfume oils - 50%
Climbazole is soluble in alcohol, glycols, surfactants and perfume oils but, is insoluble in water.

PROCESSING TRICKS & TIPS OF CLIMBAZOLE:
Climbazole dissolves fast at elevated temperatures
Climbazole is stable in formulations at pH 4 -7

HOW DOES CLIMBAZOLE WORK?
The primary cause of dandruff is the overproduction of skin cells on the scalp, often triggered by Malassezia, a yeast that naturally inhabits the scalp.
Under normal conditions, Malassezia is harmless.

However, when the balance of the scalp ecosystem is disturbed — often due to excess oil, hormonal changes, or stress — Malassezia can proliferate and cause inflammation.
This inflammation leads to increased skin cell turnover, which results in the formation of flakes and the typical symptoms of dandruff.

Climbazole works by targeting and inhibiting the growth of Malassezia on the scalp.
Climbazole does this by disrupting the yeast’s ability to metabolize lipids (fats), which are essential for their growth and reproduction.
Without this essential nutrient, the fungus is unable to thrive and multiply, leading to a reduction in the formation of flakes and a decrease in scalp irritation.

Additionally, Climbazole helps to restore the natural balance of the scalp’s microbiome.
By reducing the overgrowth of Malassezia, it promotes a healthier environment on the scalp where beneficial microorganisms can flourish, helping to maintain a normal scalp function.

WHAT IS DANDRUFF?
Dandruff is the shedding of excessive amounts of dead skin cells from the scalp.
Around 40% of the caucasian population suffer with the itchy, annoying and persistent skin disorder of the scalp.
Although a minor problem, it can be very annoying and embarrassing.
There is no cure for dandruff, only control, Climbazole is an effective control

PHYSICAL and CHEMICAL PROPERTIES of CLIMBAZOLE:
Molecular Weight: 292.76 g/mol
XLogP3-AA: 3.7
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 5
Exact Mass: 292.0978555 Da
Monoisotopic Mass: 292.0978555 Da
Topological Polar Surface Area: 44.1Ų
Heavy Atom Count: 20
Formal Charge: 0
Complexity: 335

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Empirical Formula (Hill Notation): C15H17ClN2O2
CAS Number: 38083-17-9
Molecular Weight: 292.76

Beilstein: 618020
EC Number: 253-775-4
MDL number: MFCD00055505
UNSPSC Code: 41116107
PubChem Substance ID: 329755277
NACRES: NA.24
Physical state: crystalline
Color: white
Odor: odorless
Melting point/range: 96.5 °C
Initial boiling point and boiling range: 260 °C
Flammability (solid, gas): The product is not flammable.

Flammability (solids): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0.058 g/l at 25 °C - slightly soluble
Partition coefficient: n-octanol/water: log Pow: 3.83 at 25 °C

Vapor pressure: No data available
Density: 1.32 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Surface tension: 58 mN/m at 25 °C

Boiling Point: 412°C
Melting Point: 98 - 99°C
pH: 4 - 7
Solubility: Insoluble in water
CAS Number: 38083-17-9
Purity: 98%
Molecular Weight: 292.76
Molecular Formula: C15H17ClN2O2
Physical State: Solid
Solubility: Soluble in water (0.06 mg/ml at 25°C), 
isopropanol, cyclohexanone, chloroform, and methanol.

Storage: Store at -20°C
Melting Point: 96.5°C
Boiling Point: 260°C (lit.)
Density: 1.32 g/cm3 at 20°C
Refractive Index: n20D 1.54
pK Values: pKb: 5.66 (Predicted)
Molecular Formula: C15H17ClN2O2
Formula Weight: 292.8
Purity: ≥98%
Formulation: A crystalline solid
λmax: 223, 275 nm

SMILES: CC(C)(C)C(C(OC1=CC=C(Cl)C=C1)N2C=NC=C2)=O
InChi Code: InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
InChi Key: OWEGWHBOCFMBLP-UHFFFAOYSA-N
Physical Appearance: A solid
Storage: Store at -20°C
M.Wt: 292.76
CAS No.: 38083-17-9
Formula: C15H17ClN2O2
Solubility: insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥59.9 mg/mL in EtOH

Chemical Name: 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Canonical SMILES: CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl
CAS No.: 38083-17-9
Purity: ≥99%
Formula: C15H17ClN2O2
Formula Wt.: 292.76
IUPAC Name: 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Synonym: Baypival
Melting Point: 98-99°C
Appearance: White Crystal Powder

FIRST AID MEASURES of CLIMBAZOLE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of CLIMBAZOLE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of CLIMBAZOLE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CLIMBAZOLE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CLIMBAZOLE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of CLIMBAZOLE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available