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Climbazolum (climbazole) is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema.
Climbazolum (climbazole) has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.
Climbazolum (climbazole)'s chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.
CAS: 38083-17-9
MF: C15H17ClN2O2
MW: 292.76
EINECS: 253-775-4
Synonyms
1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one;1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone;BAY MEB-6401;Diadimefon;MEB-6401;Climbazole 0.1;1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole;Crinipan AD;Climbazole;38083-17-9;Climbazol;Baypival;Crinipan AD;BAY-E 6975;Baysan;Climbazolum;1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one;Climbazol [INN-Spanish];Climbazolum [INN-Latin];Climbazole [INN:BAN];2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-;EINECS 253-775-4;Bay e 6975;NSC-759808;BRN 0618020;CCRIS 8169;DTXSID6046555;9N42CW7I54;MEB 6401;CLIMBAZOLE [INN];MFCD00055505;1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one;1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone;CLIMBAZOLE [MART.];1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone;CLIMBAZOLE [USP-RS];CLIMBAZOLE [WHO-DD];DTXCID4026555;1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone;CHEBI:83719;1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone;1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone;EC 253-775-4;5-23-04-00209 (Beilstein Handbook Reference);NSC 759808;NCGC00166153-01;1-(4-Chlorophenoxy)-1-(1H-imidazolyl)-3,3-dimethyl-2-butanone;Climbazol (INN-Spanish);Climbazolum (INN-Latin);2-BUTANONE, 1-(p-CHLOROPHENOXY)-3,3-DIMETHYL-1-(1-IMIDAZOLYL)-;CLIMBAZOLE (MART.);CLIMBAZOLE (USP-RS);1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone;(RS)-1-(4-CHLOROPHENOXY)-1-IMIDAZOL-1-YL-3,3-DIMETHYLBUTAN-2-ONE;CAS-38083-17-9;UNII-9N42CW7I54;Climbazole (Standard);CLIMBAZOLE [INCI];SCHEMBL39729;US9138393, Climbazole;US9144538, Climbazole;MLS004773943;BAY e-6975;CHEMBL1437764;CHEBI:83499;HY-B1151R;OWEGWHBOCFMBLP-UHFFFAOYSA-;BDBM181112;HMS2090O13;HMS3652P05;HMS3744O15;Pharmakon1600-01504833;HY-B1151;MEB-6401;Tox21 112343;Tox21_112343;AC-272;DL-358;NSC759808;s4178;AKOS015895513;Tox21_112343_1;CCG-213958;CS-4675;DB15580;FC20483;KS-5112;Climbazole 10 microg/mL in Cyclohexane;NCGC00166153-02;NCGC00166153-03;SMR001550495;DB-049235;C2025;NS00008150;SW219213-1;Climbazole, PESTANAL(R), analytical standard;H10384;SBI-0653493.0001;AB01275501-01;AB01275501_02;AB01275501_03;AO-295/40848554;Q629373;SR-05000001501;SR-05000001501-1;BRD-A61676498-001-01-7;BRD-A61676498-001-05-8;BRD-A61676498-001-06-6;Climbazole, United States Pharmacopeia (USP) Reference Standard;1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one;1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one;1-(p-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone;rac-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one;1-[(4-Chlorophenoxy)(tert-butylcarbonyl)methyl]imidazole;BAY-e 6975;Climbazole;253-775-4;InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
Climbazolum (climbazole) is an imidazole antifungal agent.
Climbazolum (climbazole) inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro.
Climbazolum (climbazole) also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.
Climbazolum (climbazole) increases the levels of cytochrome P450 in rat liver.
Formulations containing climbazole have been used in the treatment of dandruff.
Climbazolum (climbazole) is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3.
Climbazolum (climbazole) is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Climbazolum (climbazole) is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners.
Climbazolum (climbazole) may be accompanied by other active ingredients such as zinc pyrithione or triclosan.
Climbazolum (climbazole) may cause localized irritation of the skin with symptoms including redness, rashes and itching.
Climbazolum (climbazole) is an antifungal agent used in cosmetics to combat dandruff and various scalp conditions caused by fungal infections like Malassezia.
As a broad-spectrum antifungal, Climbazolum (climbazole) works by inhibiting the growth of fungi, preventing their proliferation on the scalp.
Climbazolum (climbazole) is commonly added to hair care products like shampoos and scalp treatments.
Climbazolum (climbazole) is insoluble in water but can be dissolved in surfactants and perfume oils.
The chemical formula of Climbazole is C15H17ClN2O2 and it appears as a white crystal powder.
Climbazolum (climbazole) is also largely safe for use at lower concentrations.
Climbazolum (climbazole) is an antifungal agent that has been used by the cosmetic industry as an anti-dandruff ingredient.
The effectiveness of dandruff control by this active has already been demonstrated in scientific publications, proving the importance of this active for this purpose.
Climbazole is a potent antifungal agent widely recognized for its efficacy in treating various dermatological conditions.
This compound is particularly effective against Malassezia species, making it a popular choice in the formulation of anti-dandruff shampoos and topical treatments for seborrheic dermatitis.
Its unique structure allows it to penetrate the skin effectively, providing rapid relief from itching and irritation while promoting a healthier scalp environment.
In addition to its antifungal properties, Climbazolum (climbazole) also exhibits anti-inflammatory effects, making it suitable for use in cosmetic formulations aimed at soothing sensitive skin.
Researchers and formulators appreciate its stability and compatibility with a variety of other ingredients, enhancing its versatility in personal care products.
With its proven track record in both pharmaceutical and cosmetic applications, Climbazolum (climbazole) stands out as a reliable choice for professionals seeking effective solutions for fungal infections and scalp health.
Climbazolum (climbazole) is a chemical that has numerous applications in various industries.
Climbazolum (climbazole) is also known as 1-(4-chlorophenoxy)-1H-imidazole-azole and has a CAS number of 38083-17-9.
Some of its other synonyms include Climbazolum (climbazole), Baypase, and 1-(p-Chlorophenoxy)-1H-imidazole.
The compound has a white to off-white crystalline powder appearance and can be synthesized using various manufacturing procedures including halogenation, alkylation, and condensation reactions.
Climbazolum (climbazole) has a molecular formula of C15H14ClN3O and a molecular weight of 291.75 g/mol.
In terms of solubility, Climbazolum (climbazole) is soluble in ethanol, acetone, and water, with a melting point of 147-150 °C.
Climbazolum (climbazole) is commonly used in the cosmetics industry as a potent antifungal agent that inhibits the growth of various types of fungi and bacteria.
Climbazolum (climbazole) is a popular ingredient in anti-dandruff shampoos, hair conditioners and personal care products.
Its anti-fungal properties also make Climbazolum (climbazole) suitable for the treatment of fungal infections on the skin, nails, and scalp.
Furthermore, Climbazolum (climbazole) has been found to exhibit anti-cancer properties that are actively being researched.
According to some studies, Climbazolum (climbazole) can help inhibit the growth of certain cancer cells, making it a potentially useful therapeutic agent in cancer research.
Climbazolum (climbazole) has a density of 1.32 g/cm3 and is characterized by its efficacy as an antifungal and antibacterial agent, making it a valuable ingredient in many industries.
Its diverse range of applications makes Climbazolum (climbazole) an important material for an array of products.
Climbazolum (climbazole) Chemical Properties
Melting point: 96-100°C
Boiling point: 447.5±40.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
Vapor pressure: 0.001Pa at 25℃
Refractive index: 1.54
Storage temp.: Inert atmosphere,Room Temperature
Solubility: Insoluble in water
Form: Solid
Pka: 5.66±0.22(Predicted)
Color: White to Almost white
Water Solubility: 58mg/L at 25℃
BRN: 618020
InChIKey: OWEGWHBOCFMBLP-UHFFFAOYSA-N
LogP: 3.83 at 25℃
CAS DataBase Reference: 38083-17-9(CAS DataBase Reference)
Uses
Climbazolum (climbazole) is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
Climbazolum (climbazole) is a phenomenal ingredient for hair care products with the ability to improve overall hair and scalp health.
Climbazolum (climbazole) has anti-dandruff properties that clean the scalp thoroughly and prevent microbial growth.
Climbazolum (climbazole) also reduces the sensation of irritation and itching, allowing for healthy hair growth that feels softer and lustrous.
Apart from hair care, Climbazolum (climbazole) extends its goodness to skin care formulations to combat fungal-related skin conditions like tinea versicolor and seborrheic dermatitis.
Further, Climbazolum (climbazole) is a renowned preservative that inhibits the development of bacteria in formulations - increasing their shelf life.
Climbazolum (climbazole) has broad-spectrum bactericidal properties, mainly used for anti-itch and anti-dandruff conditioning shampoo, hair care shampoo.
But also for antibacterial soap, shower gel, drug toothpaste, mouthwash, etc.
Climbazolum (climbazole) is a topical antifungal agent used to treat human fungal skin infections.
Climbazolum (climbazole) can be included in over-the-counter Anti Dandruff Shampoo preparations and skin treatment compositions to treat dandruff and eczema in which the cause is fungal infection.
Although Climbazolum (climbazole) is difficult to dissolve in water, it is easily soluble in toluene and some alcohols, and can be dissolved in a variety of surfactants.
Surfactants only need a small amount to make the interface state of their solution system change significantly, with fixed hydrophilic and lipophilic groups, which can be soluble in both water and organic solvents.
Therefore, Gambol can be dissolved in a suitable surfactant and then mixed with water.
