Quick Search
Cocamidopropyl Betaine 35% is an important zwitterionic surfactant, with a mild detergent action that is also more viscous than the other types of surfactant.
Cocamidopropyl Betaine 35%, an amphoteric surfactant, is one of the most commonly used surfactants in cosmetics.
Cocamidopropyl Betaine 35% is synthesized from three substances: a coca fatty acid, dimethylaminopropylamine, and rnonochloroacetic acid.
CAS: 86438-79-1
MF: C19H38N2O3
MW: 342.52
EINECS: 203-490-6
Synonyms
COCO OLEAMIDOPROPYL BETAINE;Mirataine CB;cocoamphodiproprionate;1-propanaminium, N-carboxymethyl-N,N-dimethyl-3-amino-, N-(mixed coco acyl and 9-octadecenoyl) derivs., hydroxides, inner salts;1-propanaminium,N-carboxymethyl-N,N-dimethyl-3-amino-,N-(mixed coco acyl and 9-octadecenoyl)derivs.,hydroxides,inner salts;Cocoyl amide propyldimethyl glycine;N-(3-Cocoamidopropyl)-betaine;N-Cocamidopropyl-N,N-dimethylglycine inner salt
Cocamidopropyl Betaine 35% is patch tested as a 1% concentration in water.
Cocamidopropyl Betaine 35% is a zwitterion, consisting of both a quaternary ammonium cation and a carboxylate.
Cocamidopropyl Betaine 35% is used as a medium strength surfactant.
Cocamidopropyl Betaine 35%, derived from coconut oil, is an amphoteric surfactant widely utilized in an array of products spanning shampoos, body washes, cosmetics, and household cleaners.
Functioning as a gentle surfactant, Cocamidopropyl Betaine 35% effectively reduces surface tension and generates a foaming action when combined with water.
Furthermore, Cocamidopropyl Betaine 35% exhibits remarkable abilities in stabilizing and emulsifying other ingredients within various formulations.
Beyond its practical applications, Cocamidopropyl Betaine 35% plays a significant role in scientific research.
Cocamidopropyl Betaine 35% has been employed to investigate the impact of surfactants on the environment and has contributed to the development of novel surfactants.
Cocamidopropyl Betaine 35% is a mixture of closely related organic compounds derived from coconut oil and dimethylaminopropylamine.
Cocamidopropyl Betaine 35% is available as a viscous pale yellow solution and it is used as a surfactant in personal care products and animal husbandry.
The name reflects that the major part of the molecule, the lauric acid group, is derived from coconut oil.
Cocamidopropyl Betaine 35% to a significant degree has replaced cocamide DEA.
Cocamidopropyl Betaine 35% is a gentle surfactant used in skin care products, mainly face and body washes, that is almost always employed as a secondary cleansing agent, sometimes referred to as a co-surfactant.
When used alone as the sole cleansing agent, Cocamidopropyl Betaine 35% is generally too mild to clean adult skin and hair but is sometimes used as the sole cleansing agent in products for children.
In any rinse-off formula, Cocamidopropyl Betaine 35% also helps increase the lather or foam effect of cleansers.
Cocamidopropyl Betaine 35% may be plant-derived (most often from coconut) or synthetic, with either form considered safe for use in cosmetic products.
Cocamidopropyl Betaine 35% is considered low risk for sensitising skin, although impurities resulting from poor manufacturing - and not cocamidopropyl betaine itself - increase the risk, emphasising the importance of selecting well-formulated skin care products.
Cocamidopropyl Betaine 35% is approved for use up to 3% in leave-on products but its concentration range for rinse-off formulas is much wider, typically between 4-40% depending on the formula’s characteristics.
Cocamidopropyl Betaine 35% Chemical Properties
Solubility: Methanol (Slightly), Water (Sparingly)
Form: Clear Colourless Solution
LogP: 0.326 (est)
Cocamidopropyl Betaine 35% is an organic compound derived from coconut oil and dimethylaminopropylamine.
Cocamidopropyl Betaine 35% is a zwitterion, consisting of both a quaternary ammonium cation and a carboxylate.
Cocamidopropyl Betaine 35% is available as viscous pale yellow solution that is used as a surfactant in personal care products.
Chemistry
Cocamidopropyl Betaine 35% is a fatty acid amide that contains a long hydrocarbon chain at one end and a polar group at the other.
This allows Cocamidopropyl Betaine 35% to act as a surfactant and as a detergent.
Cocamidopropyl Betaine 35% is a zwitterion, consisting of both a quaternary ammonium cation and a carboxylate.
Specifications and properties
Cocamidopropyl Betaine 35% is used as a foam booster in shampoos.
Cocamidopropyl Betaine 35% is a medium-strength surfactant also used in bath products like hand soaps.
Cocamidopropyl Betaine 35% is also used in cosmetics as an emulsifying agent and thickener, and to reduce the irritation that purely ionic surfactants would cause.
Cocamidopropyl Betaine 35% also serves as an antistatic agent in hair conditioners, which most often does not irritate skin or mucous membranes. However, some studies indicate it is an allergen.
Cocamidopropyl Betaine 35% is also used as a co-surfactant with Sodium dodecyl sulfate for promoting the formation of gas hydrates.
Cocamidopropyl Betaine 35%, as an additive, helps to scale up the gas hydrates' formation process.
Cocamidopropyl Betaine 35% is obtained as an aqueous solution in concentrations of about 30%.
Typical impurities of leading manufacturers today:
Sodium monochloroacetate < 5 ppm
Amidoamine (AA) < 0.3%
Dimethylaminopropylamine (DMAPA) < 15 ppm
Glycerol < 3%
The impurities AA and DMAPA are most critical, as they have been shown to be responsible for skin sensitization reactions.
These by-products can be avoided by a moderate excess chloroacetate and the exact adjustment of pH value during betainization reaction accompanied by regular analytical control.
Uses
Cocamidopropyl Betaine 35% is a surfactant derived from a coconut oil salt.
Cocamidopropyl Betaine 35% is particularly effective in shampoos, foam baths, shower foams, and other preparations where high, creamy foam and good skin tolerance are desired.
Cocamidopropyl Betaine 35% is an amphoteric surfactant, which enjoys increasing popularity among cosmetic chemists because of its low potential for irritation of the skin.
Cocamidopropyl Betaine 35% is used especially in shampoos and bath products such as bath and shower gels.
Most cases of allergy are caused by shampoos.
Thus, Cocamidopropyl Betaine 35% is the exception to the rule that allergic reactions arc usually caused by “stay-on” (“leave-on”) cosmetic products.
However, Cocamidopropyl Betaine 35% may also be an allergen in other cosmetic products such as skin care products and deodorants and in contact lens fluids.
Cocamidopropyl Betaine 35% is one of themost common surface-acting agents used incosmetics, including the following:
1. Cosmetics (shampoos, cleansing lotions and gels, detergents, and hair dyes and styling products)
2. Contact lens solutions
3. Antiseptics
Contact allergens
Cocamidopropyl Betaine 35% is a pseudo-amphoteric zwitterion detergent derived from long-chain alkylbetaines.
Cocamidopropyl Betaine 35% is available from many suppliers under more than 50 trade names (including Tego-betain L7 and Ampholyt JB 130).
Exposure occurs via rinse-off products such as liquid soaps, shampoos, and shower gels, but also via leave-on products (for example, roll-on deodorant).
Occupational sources are mainly in hairdressing.
The first synthesis step consists of the reaction of coconut fatty acids with 3-dimethylaminopropylamine, giving cocamidopropyl dimethylamine.
Cocamidopropyl Betaine 35% is converted into cocamidopropyl betaine by reaction with sodium monochloroacetate.
Both dimethylaminopropylamine and cocamidopropyl dimethylamine are thought to be the sensitizers.
Production
Despite the name Cocamidopropyl Betaine 35%, the molecule is not synthesized from betaine. Instead it is produced in a two-step manner, beginning with the reaction of dimethylaminopropylamine (DMAPA) with fatty acids from coconut or palm kernel oil (lauric acid, or its methyl ester, is the main constituent).
The primary amine in DMAPA is more reactive than the tertiary amine, leading to its selective addition to form an amide.
In the second step chloroacetic acid reacts with the remaining tertiary amine to form a quaternary ammonium center (a quaternization reaction).
CH3(CH2)10COOH + H2NCH2CH2CH2N(CH3)2 → CH3(CH2)10CONHCH2CH2CH2N(CH3)2
CH3(CH2)10CONHCH2CH2CH2N(CH3)2 + ClCH2CO2H + NaOH → CH3(CH2)10CONHCH2CH2CH2N+(CH3)2CH2CO2− + NaCl + H2O
