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COCAMIDOPROPYLAMINE OXIDE
CAS Number: 68155-09-9
Chem/IUPAC Name: N-[3-(dimethylamino)propyl], N-oxides
Molecular Formula: RCONH(CH2)3N(CH2)2 O
EC number: 268-938-5/931-324-9
Cocamidopropylamine Oxide is a clear to slightly hazy liquid.
In cosmetics and personal care products, Cocamidoproylamine Oxide is used in the formulation of shampoos, hair dyes and colors, and other hair products, as well as bath and skin care products.
A secondary cleansing agent (co-surfactant) that's a good aid next to other (anionic) cleansing agents.
Cocamidopropylamine Oxide improves foam, the mildness of the formula and builds viscosity, pretty much all the things co-surfactants are used for.
Cocamidopropylamine Oxide works as a conditioning agent and surfactant. As a surfactant, Cocamidopropylamine Oxide effectively cleanses the skin/hair by helping water to mix with oil and dirt so that they can be rinsed off.
Cocamidopropylamine Oxide also has the ability increase the foaming capacity of a cosmetic solution and enhance the water solubility of other cleansing agents contained within a product.
Cocamidopropylamine Oxide is conditioning properties help improve the appearance of dry/damaged hair by increasing its body, suppleness and sheen.
You can find this ingredient in personal care products such as cleanser, shampoo, bath oil/salts, acne treatment, body wash, hand sanitizer ,makeup removed, dandruff treatment and bubble bath.
Cocamidopropylamine Oxide works as a conditioning agent and surfactant.
As a surfactant, Cocamidopropylamine Oxide effectively cleanses the skin/hair by helping water to mix with oil and dirt so that they can be rinsed off.
Cocamidopropylamine Oxide also has the ability increase the foaming capacity of a cosmetic solution and enhance the water solubility of other cleansing agents contained within a product.
Cocamidopropylamine Oxide is conditioning properties help improve the appearance of dry/damaged hair by increasing its body, suppleness and sheen.
You can find this ingredient in personal care products such as cleanser, shampoo, bath oil/salts, acne treatment, body wash, hand sanitizer ,makeup removed, dandruff treatment and bubble bath.
The EU Cosmetics Directive permits cocamidopropylamine oxide to be used in cosmetic and personal care products according to the general provisions of the directive.
The Cosmetic Ingredient Review (CIR) Expert Panel has reviewed the scientific data surrounding this ingredient, and determined it as safe to use on rinse-off products.
However, they concluded that the data were insufficient to complete a determination of the safety of its use in leave-on cosmetics.
Clinical studies show that at 5%, cocamidopropylamine oxide is not a dermal irritant or sensitizer. However, applications of 81.5% can cause moderate irritation to skin, and severe irritation to the eyes.
The CIR Expert Panel's research shows that the ingredient generally has low toxicity, although in one study, high oral doses administered to rats were shown to cause hemolytic anemia.
Because there is no available carcinogenicity data, reproductive or developmental toxicity data, it's hard to determine whether the skin could potentially absorb harmful carcinogens from a leave-on product containing this ingredient.
Yet, because this ingredient has a highly polarized molecular structure, the CIR Expert Panel considered that it would be, at most, slowly absorbed by the skin.
Cocamidopropylamine Oxide is a tertiary amine oxide which
functions as a hair-conditioning agent and as a surfactant, currently
used in 60 cosmetic formulations at concentrations between 0.07%
and 4.0%. In an earlier safety assessment, the Cosmetic Ingredient
Review (CIR) Expert Panel had determined that the available data
were insufficient to support the safety of this ingredient in cosmetic products.
Additional data have now been provided and reviewed.
Cocamidopropylamine Oxide was determined to have an acute oral
LD50 between 500 and 1000 mg/kg day−1 using rats.
The acute dermal LD50 in rats was >2174 mg/kg day−1.
A 28-day repeated oral dose toxicity study in rats found hemolytic anemia at 150 and 1000
mg/kg day−1, with a no observed effect level (NOEL) of 15 mg/kg day−1.
At 5%, Cocamidopropylamine Oxide solution was not a primary dermal irritant.
Application of 81.5% Cocamidopropylamine
Oxide to rabbit skin caused moderate irritation under Draize classification scale, but 81.5% Cocamidopropylamine Oxide in rabbit eyes caused severe irritation.
A maximization study classified Cocamidopropylamine Oxide as a nonsensitizer to guinea pig skin. Cocamidopropylamine Oxide was not mutagenic in an Ames test, with and without metabolic activation.
No evidence of increased chromosomal aberrations were noted in human lymphocytes treated with 81.5% Cocamidopropylamine Oxide.
In a clinical study, 7.5%
Cocamidopropylamine Oxide was not a sensitizer, although it did produce some reactions typical of mild irritation.
Although the impurities, amidoamine and dimethylaminopropylamine, have been
implicated in contact allergy reactions to products containing cocamidopropylamine betaine, clinical testing of a product with cocamidopropylamine betaine containing these impurities, at levels
comparable to those found in Cocamidopropylamine Oxide, failed to produce a reaction in 10 individuals known to be sensitive to cocamidopropylamine betaine.
Two repeat-insult patch tests using a facial wash with 1% raw material containing 35% to 36.5% Cocamidopropylamine Oxide did not find evidence of dermal sensitization.
Tests for dermal phototoxicity and photoallergenicity with the same facial wash product also did not produce evidence of effect.
The CIR Expert Panel recognizes that there are data gaps
regarding the use and concentration of this ingredient.
However, the overall information available on types of products in which this ingredient is used and at what concentration indicate a pattern of use, which was considered by the Expert Panel in assessing safety.
Overall, these data demonstrate that Cocamidopropylamine Oxide has low toxicity in animal and in vitro tests.
Although there are no available carcinogenicity data, the available genotoxicity data, combined with the absence of any structural alerts, suggest no carcinogenic potential.
The Panel noted the absence of reproductive and developmental toxicity data. Because this ingredient has a highly polarized molecular structure, the Panel considered
that it would be, at most, slowly absorbed.
Given that most of the uses and the highest use concentration of 4% is found in rinse-off products, the Panel determined that the available data suggest that Cocamidopropylamine Oxide is safe as used in rinse-off products.
Although dermal penetration may be slow, data on the extent of
dermal penetration of Cocamidopropylamine Oxide are needed to
support the safety of leave-on uses. If there is significant dermal absorption, dermal reproductive and developmental toxicity data may be needed.
INTRODUCTION
As described in the International Cosmetic Ingredient Dictionary and Handbook, Cocamidopropylamine Oxide is a tertiary
amine oxide that functions as a hair-conditioning agent and as a
surfactant in cleansing agents, foam boosters, and hydrotropes
(Gottschalck and McEwen 2006).
Cosmetic Ingredient Review (CIR) previously issued a safety
assessment of Cocamidopropylamine Oxide as a cosmetic ingredient with the conclusion that the available data were insufficient
to support safety (Andersen 2000).
Additional unpublished data have been provided and are presented, with the previously available data, in this amended safety
assessment of Cocamidopropylamine Oxide.
Physical characteristics: Clear to slightly hazy liquid (at 25◦C)
Clear to slightly yellow virtually odorless liquid; 29.5% to 31.5% active
Supplied as a 30% or 35% aqueous solution
Average molecular weight: 320
pH: 6–8 (6.5–8.0 at 25◦C)
Solubility: Miscible with water, forms turbid suspensions with ethanol and acetone, immiscible with chloroform
Soluble in water and most hydrophilic solvents
Specific gravity: (25◦C) 0.995
Reactivity: Amine oxides are reported to be thermally unstable
Analytical Methods
Janik and Podg´orski (1988) used potentiometric titration in
isopropyl alcohol and the combination of two-phase and titanometric titration for the simultaneous determination of amine
oxide and unreacted amine, particularly with respect to the
amine impurity, in commercial Cocamidopropylamine Oxide.
The authors concluded that potentiometric titration was the
better method.
Cosmetic
As given in the International Cosmetic Ingredient Dictionary and Handbook, Cocamidopropylamine Oxide functions as a hair conditioning agent, surfactant—cleansing agent, surfactant—foam booster, and surfactant—hydrotrope (Gottschalck and McEwen 2006).
Janik and Podg´orski (1988) stated that Cocamidopropylamine Oxide was the amine oxide most frequently used in various cosmetic formulations.
Voluntary product formulation data submitted by industry
to the Food and Drug Administration (FDA) in 1997 included
Cocamidopropylamine Oxide in a total of 55 cosmetic product
formulations (FDA 1997).
The total number of product formulations reported to the FDA in 2005 was 60 (FDA 2005).
Concentration of use data submitted by one supplier stated
that Cocamidopropylamine Oxide, supplied as 35% active, is
used at a typical range of 5% to 15%, i.e., 1.75% to 5.25% active
(CTFA 1997). A 2005 industry survey found use concentrations
between 0.07% and 4.0% active (CTFA 2005).
Available uses and concentrations as a function of product
category are given in Table 2. The most recent use concentration
data represents the current concentration of use.
According to the Japan Ministry of Health, Labor and Welfare (MHWL), Cocamidopropylamine Oxide is not included on
the list of ingredients that must not be combined in cosmetic
products that are marketed in Japan (MHLW 2005a), or on the
list of restricted ingredients for cosmetic products that are marketed in Japan (MHLW 2005b); nor is its use restricted in the
European Union (European Economic Community 2005).
CONCLUSION
Based on the data contained in this report, the CIR Expert
Panel concluded that Cocamidopropylamine Oxide is safe as a
cosmetic ingredient in rinse-off cosmetic products in the practices of use and concentrations described in this safety assessment, but the data are insufficient to make a determination of safety for use in leave-on cosmetic products.
Application
2 in 1 Shampoo
Automatic Dishwashing Detergents
Bathroom Cleaners
Body Wash
Carwash - Automatic
Carwash - Hand
Dairy Cleaners
Degreasers
Detanglers
Facial Cleansers
Fine Fabric Wash
Floor Cleaners
Hair Conditioners
Hand Dishwashing Detergents
Hand Soaps
Hard Surface Cleaners - Dilutable
Hard Surface Cleaners - Ready to Use
Kitchen Cleaners
Meat Packing Plant Cleaners
Other Institutional and Industrial Cleaning
Shampoos
Soap Bars
Toilet Bowl Cleaners
Warewash Detergents
Great, non-ionic foam booster, stabilizer, and excellent thickener, unaffected by acid and hard water.
Cocamidopropylamine Oxide is compatible with anionic, cationic, amphoteric and non-ionic surfactants and improves the combination property.
Boiling Point, ºC: >100
Cloud Point, °C: -1
Density at 25°C, g/ml: 0.99
Draves Wetting at 25°C, seconds: 24
Flash Point, °C: >94
Form at 25°C: Liquid
Interfacial tension, nM/M: 4.9
Pour Point, °C: -4
Specific Gravity at 25°C: 0.99
Surface Tension, mN/m: 31.9
Viscosity at 25°C, cps: 45
Cocamidopropylamine Oxide is a tertiary amine oxide used in a wide variety of cosmetic formulations.
This ingredient functions as a hair conditioning agent, surfactant-cleansing agent, surfactant-foam booster, and surfactant-hydrotrope.
It may be supplied as 35% active ingredient, and be used at concentrations between 5% and 15%.
As supplied, it contains less than or equal to0.3% free amidoamine and less than or equal to5 ppm dimethylamidopropylamine.
As a class, amine oxides are reported to be relatively nontoxic.
The oral LD50 values of amine oxides range from 2 to 6 g/kg, A 5% active Cocamidopropylamine Oxide solution was not a primary dermal irritant In rabbits.
Amine oxides are reported to be nonirritating to the skin and eyes at 2% and mildly irritating at 10%.
In a clinical study, Cocamidopropylamine Oxide was not a sensitizer, although some mild irritation was produced during the induction phase.
These data were not considered adequate to complete a safety assessment of this ingredient. Additional data needed include: Ultraviolet (UV) absorption data; if absorption occurs in the UVA or UVB range, photosensitization data are needed; Dermal absorption data; if dermal absorption occurs, 28-day dermal toxicity and reproductive and developmental toxicity are needed; and two genotoxicity studies, one using a mammalian system; if positive, a 2-year dermal carcinogenicity assay performed using National Toxicology Program (NTP) methods is needed.
Until these data are provided, the available data are insufficient to support the safety of Cocamidopropylamine Oxide for use in cosmetic products.
Cocamidopropylamine Oxide is a surfactant from the group of amine oxides.
In a neutral and alkaline environment, Cocamidopropylamine Oxide exhibits the properties of non-ionic compounds (it is then compatible with all types of surfactants), while in an acidic environment the properties of cationic compounds (it can be precipitated by compounds of the nature of
anionic).
The commercial product is an aqueous solution with a minimum dry matter content of 30%.
Thanks to very good washing, foaming and foam stabilizing properties, it is used in preparations for washing the body and hair (shampoos, liquid soaps, bath liquids, shower gels).
Cocamidopropylamine Oxide also shows synergism in combination with anionic compounds to reduce skin irritation.
Storage conditions:
Store in properly labeled, tightly closed packages with information in Polish in accordance with applicable standards, in secured rooms against weather conditions, with adequate ventilation, at temperatures up to 40 ° C. Do not use ordinary carbon steel packaging. If stored in these conditions, the product does not change its properties in the period of 12 months from the date of production.
Cocamidopropylamine Oxide is an excellent co-surfactant for mild, low irritancy applications such as shampoo and bubble bath products.
Cocamidopropylamine Oxide is compatible with most surfactants and provides viscosity control, foam boosting and excellent grease cutting in liquid dish wash formulations.
Cocamidopropylamine Oxide works as a conditioning agent and a surfactant.
Cocamidopropylamine Oxide also can boost the water solubility of other cleansing agents contained within a formulation.
Cocamidopropylamine Oxide conditioning properties help improve the appearance of dry and damaged hair in personal care formulations.
Cocamidopropylamine Oxide exhibits synergistic effects when combined with anionic and other non-ionic surfactants.
Cocamidopropylamine Oxide range has low residual hydrogen peroxide, less than 800ppm, whilst the industry norm is 1500ppm. The finished product has a crystal clear ‘water white’ appearance, ensuring no need for additional colourant in the finished formulation.
Foam booster, stabilizer thickening agent for baby products, creams, shaving foams, lotions and concentrated washing or liquid detergents.
Cocamidopropylamine Oxide is an excellent foam booster and foam stabiliser in blends based on other anionic or amphoteric surfactants.
In addition, Cocamidopropylamine Oxide also improves the detergency power of the final formula.
Cocamidopropylamine Oxide use is recommended in high concentrated hand washing-up liquids.
Cocamidopropylamine Oxide is use can be recommended for a wide range of cosmetic and detergent formulae due to its good tolerance by the skin and hair.
Cocamidopropylamine Oxide serve as a cleaning agent, foam booster and stabilizer.
They are used for providing emulsification and dirt suspension. Moreover Amine Oxides show synergistic effects with anionic/nonionic surfactants.
Thus they find excellent application in detergents and shampoos. Foam behavior varies depending on the carbon chain length.
Cocamidopropylamine Oxide
Provides excellent viscosity building, foam boosting and foam stability.
Works very well with alpha olefin sulfonate.
Free of non-biodegradable chelants.
Uses include: Detergent, wetting agent, emulsifier, foam booster for industrial cleaners, shampoos, paper coating, antistatic softeners, and foam stabilizer for foam rubber compounds.
The analogue CAS No. 68155-09-9 which shares the same functional groups with the substance Amides, C12-C14 (even numbered), N-[3-(dimethylamino) propyl], N´-oxides, also has comparable values for the relevant molecular properties.
Cocamidopropylamine Oxide (CAS 68155-09-9) where R=C8-C18, is a tertiary amine oxide where RCO- represents the fatty acids from coconut oil. Coconut oil contains predominantly medium chain triglycerides with roughly 92% saturated fatty acids, 6% monounsaturated fatty acids, and 2% polyunsaturated fatty acids. Of the saturated fatty acids, coconut oil is primarily 44.6% lauric acid, 16.8% myristic acid, 8.2% palmitic acid, 8% caprylic acid, and other seven different saturated fatty acids in small amount. Its only monounsaturated fatty acid is oleic acid while its only polyunsaturated fatty acid is linoleic acid.
Therefore, the source chemical and the target chemical share the following functional groups:
a.- N-Oxide functionality
b.- Amide group
For the source substance, in the chemical structure, the R is substituted by C8-C18 and for the target substance the R is substituted by C12-C14.
Based on company experimental data (reported under the endpoint record Acute toxicity: dermal_47) on the analogue CAS No. 68155-09-9, the read-across approach is applied and the dermal LD50 for the substance Amides, C12-14 (even numbered), N-[3-(dimethylamino)propyl], N'-oxides is greater than 2000 mg/kg bw.
Benefits:
Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 is Effective foam-boosting surfactant offering excellent conditioning, thickening and stabilizing performance.
Cocamidopropylamine Oxide is very mild on the skin.
Moreover, Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 will not be affected by acid and hard water.
Cocamidopropylamine Oxide is compatible with anionic, cationic, amphoteric and non-ionic surfactants
Usages: Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 could be added to formulas as is. Typical use level 1-5% depending on desired foaming and cleansing effects. For external use only.
Applications scopes: Cocamidopropylamine Oxide is widely found in soaps, cleansing systems, hair shampoo, baby products, bubble baths, shaving products.
Raw material source: Coconut oil and dimethylaminodpropylamine
Manufacture: Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 is made by reacting coconut oil with dimethylaminodpropylamine and further with hydrogen peroxide.
GMO: GMO free but not certified
Vegan: Does not contain animal-derived components
Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 is a clear to slightly hazy liquid. In cosmetics and personal care products, Cocamidoproylamine Oxide is used in the formulation of shampoos, hair dyes and colors, and other hair products, as well as bath and skin care products. This product functions as a hair conditioning agent, surfactant - cleansing agents, surfactants - foam boosters or a surfactant.
Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 is made from coconut oil, a vegetable oil extracted from the dried inner flesh of coconuts. The coconut oil is reacted with dimethylaminodpropylamine and further reacted with hydrogen peroxide to form Cocamidopropylamine Oxide.
Features:
1.Cocamidopropylamine Oxide is compatible with all kinds of dye raw material, surfactants, cosmetic raw materials.
2. Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 has the stability to sodium hypochlorite.
3.Forbidden to heating for a long time above 100℃.
4. Excellent stability and good compatibility in acid and alkaline medium is another important advantages of Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9.
5. Cocamidopropylamine Oxide has good biodegradability and low irritation to the skin.
6. What is more, Cocamidopropylamine Oxide has good detergency, flexibility, antistatic property, hard water resistance, bactericidal performance and anti-rust property.
Applications
1. Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 is widely used in daily chemicals, such as shampoos, shower gels, children's bath cleaner, sensitive skin preparation, etc.
2. This product also used as calcium soap dispersant, sterilization detergent, fiber/ fabric antistatic and softener agent.
3. Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 also finds its application in the rubber industry as gel emulsifier.
4. Cocamidopropylamine Oxide is used as rabbit wool fulling agent and the foaming agent for fire suppression, etc.
5. This product is also the pesticide synergist of glyphosate.
Fengchen Group is a leading China Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 supplier and manufacturer. We specialize in wholesale and bulk amounts, ensuring all our clients have the right China Cocamidopropylamine Oxide (CAO), Cocamidopropyl Amine Oxide CAS 68155-09-9 manufacturer and supplier when they need it.
Cocamidopropylamine Oxide is surfactants commonly used in consumer products such as shampoos, conditioners, detergents, and hard surface cleaners.
Alkyl dimethyl amine oxide (chain lengths C10–C16) is the most commercially used amine oxide.
They are considered a high production volume class of compounds in more than one member country of the Organisation for Economic Co-operation and Development (OECD); with annual production over 26,000, 16,000 and 6,800 metric tons in the US, Europe, and Japan, respectively.
In North America, more than 95% of amine oxides are used in home cleaning products.
They serve as stabilizers, thickeners, emollients, emulsifiers, and conditioners with active concentrations in the range of 0.1–10%.
The remainder (< 5%) is used in personal care, institutional, commercial products[4] and for unique patented uses such as photography.
Almost all amine oxides are prepared by the oxidation of either tertiary aliphatic amines or aromatic N-heterocycles.
Hydrogen peroxide is the most common reagent both industrially and in academia, however peracids are also important.
More specialised oxidising agents can see niche use, for instance Caro's acid or mCPBA.
Spontaneous or catalysed reactions using molecular oxygen are rare.
Certain other reactions will also produce amine oxides, such as the retro-Cope elimination, however they are rarely employed.
Synonims
Amides coco
N-(3-(dimethylamino)propyl)
N-oxide
Coco amides
N-(3-(dimethylamino)propyl)
N-oxide
N-(3-(Dimethylamino)propyl)coco amides-N-oxide
3-(N,N-Dimethylamino)propyl cocoamido amine oxide
3-Cocoamidopropyl dimethylamine oxide
Cocamidopropyldimethylamine oxide
Cocoamido-3-propyldimethylamine oxide
N,N-Dimethyl-N-(3-(coconut oil alkyl)amidopropyl)amine oxide
N,N-Dimethyl-N-(3-cocamidopropyl)amine oxide
N-(3-(Dimethylamino)propyl) coco amides N-oxides
N-(Cocoamidopropyl)-N,N-dimethylamine
N-(3-(dimethylamino)propyl)
N-oxides[ChemIDplus] DEHYTON CAW [Cognis MSDS]
