COPOLYVIDONE

Copolyvidone, also known as Polyvinylpyrrolidone-Vinyl Acetate Copolymer, is a water-soluble polymer used widely in pharmaceuticals, cosmetics, and industrial applications as a binder, film-former, and stabilizer.
Copolyvidone is particularly valued in tablet formulations for its binding and disintegration properties, improving tablet strength and enhancing drug release.
In cosmetics, Copolyvidone serves as a film-forming agent, providing long-lasting effects in hair care, skincare, and makeup formulations.

CAS Number: 25086-89-9
EC Number: 607-234-3
Molecular Formula: (C6H9NO)x(C4H6O2)y (as a copolymer, it does not have a fixed molecular formula)
Molecular Weight: Variable depending on the copolymer composition

Synonyms: Copolyvidone, Polyvinylpyrrolidone-Vinyl Acetate Copolymer, PVP/VA Copolymer, Polyvinylpyrrolidone Copolymer, Polyvinyl Acetate-PVP Copolymer, Kollidon VA, PVP-VA, Vinylpyrrolidone-Vinyl Acetate Copolymer, Cosmetic-Grade PVP/VA, Binding Agent Copolyvidone, EINECS 607-234-3, C6H9NO-C4H6O2 Copolymer, Film-Forming PVP/VA, Povidone Copolymer, Pharmaceutical PVP/VA, Polyvinyl Acetate with PVP, PVP VA Copolymer, VA-PVP Copolymer, Polyvinylpyrrolidone-Acetate, Water-Soluble PVP/VA, Povidone VA, Cosmetic Binder PVP/VA, Polyvinyl Acetate Complex, Vinyl Acetate-Vinylpyrrolidone Copolymer, Pharmaceutical Binder Copolyvidone

APPLICATIONS

Copolyvidone is widely used in tablet formulations as a binder, where it enhances mechanical strength and ensures uniform drug release.
Copolyvidone is applied in capsule formulations, where it acts as a disintegrant, allowing for controlled and efficient drug release.
Copolyvidone is essential in film coating for tablets, where it provides a protective layer, improving stability and ease of ingestion.

Copolyvidone is found in sustained-release formulations, where it helps control drug dissolution rates, enhancing therapeutic efficacy.
Copolyvidone is included in granulation processes, where it aids in particle binding and improves flow properties of powders.
Copolyvidone is commonly used in dry granulation and direct compression methods, where it enhances compactibility and tablet hardness.

Copolyvidone is incorporated into hair styling products, such as gels and sprays, where it provides long-lasting hold and flexibility.
Copolyvidone is used in hair care formulations as a film-former, offering resistance to humidity and maintaining style durability.
Copolyvidone is a valuable ingredient in hairsprays, where it forms a non-tacky, flexible film that enhances styling control.

Copolyvidone is applied in facial foundations and powders, where it improves adhesion to the skin and prolongs wear time.
Copolyvidone is included in mascaras and eyeliners, where it provides smudge resistance and enhances color adherence.
Copolyvidone is found in lipsticks and lip glosses, where it improves product stability and provides a smooth, even application.

Copolyvidone is used in wound care products and bandages, where it forms a protective film that supports wound healing.
Copolyvidone is applied in transdermal patches, where it acts as a binding agent, ensuring the stable release of active ingredients.
Copolyvidone is a common component in medical adhesives and plasters, where it enhances flexibility and adhesion to the skin.

Copolyvidone is utilized in agricultural formulations, where it acts as a dispersant and stabilizer in pesticide sprays, ensuring even application.
Copolyvidone is essential in industrial coatings and paints, where it enhances adhesion and improves coating durability on various surfaces.
Copolyvidone is used in water treatment products as a binding agent, aiding in the formation of solid tablets or blocks for slow-release treatments.

DESCRIPTION

Copolyvidone is a synthetic copolymer derived from polyvinylpyrrolidone and vinyl acetate, known for its versatility as a binder, film-former, and stabilizer in diverse applications.
Its water-solubility and binding properties make it a popular choice in pharmaceuticals, particularly in tablets and capsules, where it enhances mechanical strength and consistency.
Copolyvidone’s ability to form flexible, durable films makes it ideal for cosmetic and hair care products, where it provides long-lasting hold and improved texture.

Copolyvidone is stable under various pH levels, allowing for effective use across a wide range of formulations.
The copolymer is biodegradable and generally regarded as safe for topical and oral use in regulated concentrations.
Copolyvidone is often preferred in formulations requiring controlled-release or sustained-release of active ingredients, offering flexibility in pharmaceutical and industrial applications.

PROPERTIES

Chemical Formula: (C6H9NO)x(C4H6O2)y (variable as a copolymer)
Molecular Weight: Variable depending on the copolymer composition
Common Name: Copolyvidone (Polyvinylpyrrolidone-Vinyl Acetate Copolymer)
Appearance: White to off-white powder or granules
Density: Approx. 1.1 g/cm³
Boiling Point: Not applicable (decomposes upon heating)
Melting Point: Decomposes before melting
Solubility: Soluble in water and ethanol
Flash Point: Not flammable
Reactivity: Stable under normal conditions; avoid strong oxidizing agents
Chemical Stability: Stable in recommended storage conditions
Storage Temperature: Store in a cool, dry place away from direct sunlight
Vapor Pressure: Low

FIRST AID

Inhalation:
If Copolyvidone dust is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.

Skin Contact:
Wash the affected area with soap and water.
If skin irritation or rash develops, seek medical attention.

Eye Contact:
In case of eye contact, flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.

Ingestion:
If Copolyvidone is ingested, rinse the mouth thoroughly with water.
Do not induce vomiting unless directed by medical personnel.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.

Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.

HANDLING AND STORAGE

Handling:

Personal Protection:
Wear appropriate personal protective equipment (PPE), such as gloves and safety goggles, when handling large quantities of Copolyvidone.
Use in a well-ventilated area to avoid inhalation of dust.

Ventilation:
Ensure adequate ventilation when handling Copolyvidone to control airborne concentrations below occupational exposure limits.

Avoidance:
Avoid direct contact with eyes and prolonged skin contact.
Do not eat, drink, or smoke while handling Copolyvidone.
Wash hands thoroughly after handling.

Spill and Leak Procedures:
Contain spills to prevent further release and minimize exposure.
Sweep up spills carefully to avoid dust generation and dispose of according to local regulations.

Storage:
Store Copolyvidone in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers.
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and moisture.

Handling Cautions:
Avoid inhalation of dust and direct contact with skin and eyes.
Use explosion-proof equipment in areas where dust particles may be present.