PRODUCTS

CREMOPHOR EL

CREMOPHOR EL = KOLLIPHOR EL

CAS Number: 61791-12-6
EC Number: 613-210-8
MDL Number: MFCD00130879
Molecular Formula: C5H12O4

Cremophor EL (CrEL, Kolliphor EL), a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol).
Cremophor EL is a pale yellow oily liquid consisting of a mixture of components, primarily polyethylene glycol conjugates.

Cremophor EL is not an inert vehicle, but exerts a range of biological effects, some of which have important clinical implications.
Kolliphor EL, formerly known as Cremophor EL, is the registered trademark of BASF Corp. for its version of polyethoxylated castor oil.

Cremophor EL is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil.
The resulting product is a mixture (CAS number 61791-12-6): the major component is the material in which the hydroxyl groups of the castor oil triglyceride have ethoxylated with ethylene oxide to form polyethylene glycol ethers.

Minor components are the polyethyelene glycol esters of ricinoleic acid, polyethyelene glycols and polyethyelene glycol ethers of glycerol.
Cremophor EL is a synthetic, nonionic surfactant used to stabilize emulsions of nonpolar materials in water.

Cremophor EL is an emulsifier and solubilizer.
Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant.
Cremophor EL (cremophor), a component of the paclitaxel formulation, can potentially reverse P-glycoprotein associated multi drug resistance.

Cremophor EL is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide.
Cremophor EL is a pale yellow oily liquid that is clear at temperatures above 26°C.
Cremophor EL has a faint but characteristic odour.

Cremophor EL is a high grade reagent.
Also known as Polyoxyl 35 castor oil, Cremophor EL is a castor oil. Cremophor EL is available as a powder.
Cremophor EL is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil.

While Cremophor EL is stable under general conditions, Cremophor EL is incompatible with strong oxidizing agents.
Cremophor EL is a non-ionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide in a molar ratio of 1:35.
Cremophor EL is a pale yellow oily liquid that is clear at temperatures above 26 °C.

Cremophor EL has a faint but characteristic odor.
Cremophor EL forms clear solutions in water.
Cremophor EL is also soluble in many organic solvents, e.g. ethyl alcohol, n-propyl alcohol, isopropyl alcohol, ethyl acetate, chloroform, carbon tetrachloride, trichloroethylene, toluene and xylene.

Good compatibility with other ingredients
Cremophor EL is polyoxyethylene glycerol triricinoleate, which also contains a small amount of polyethylene glycol ricinoleate, free ethylene glycol.

Cremophor EL was obtained by reacting 1 mol of glycerol ricinoleate with 35MOL of ethylene oxide.
Cremophor EL is white, off-white or light yellow paste or viscous liquid; Micro special odor.
Cremophor EL is highly soluble in ethanol.

The relative density of Cremophor EL (General 0601) is 1.05~1.06.
The kinematic viscosity of Cremophor EL (General rule 0633 first method) is 570~710/s at 25°C (capillary inner diameter is or suitable capillary inner diameter).

USES and APPLICATIONS of CREMOPHOR EL:
-Used as emulsifier, penetrating agent, antifoaming agent, additive, foaming agent, stabilizer, lubricant, solubilizing agent, levelling agent, antistatic agent, washing agent, dispersing agent, parting agent, degreasing agent, plasticizing agent, thickening agent, viscosity conditioning agent and chemical intermediate in the industry.

-Cremophor EL is a widely used excipient.
-Widely used and fully approved solubilizer
-Cremophor EL has a variety of applications in chemical and biological sectors.

-Cremophor EL finds applications in the organic synthesis of various derivatives.
-Cremophor EL is used as an excipient or additive in drugs.
-Cremophor EL is combines with various chemical solutions such as miconazole, Docetaxel, Sandimmune, propofol, vitamin K, Ixabepilone etc.

-Cremophor EL is suitable for industrial synthesis of products and research applications.
-Cremophor EL is used in lipid-based formulations for drugs and solubilization of cosmetics.
-Cremophor EL is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds.

-Due to Cremophor EL's emulsification functionality, Cremophor EL finds application in biological membrane- based drug transport studies.
-Cremophor EL is a nonionic surfactant widely used in pharmaceutical formulations.

-Cremophor EL (CR) is a solubllizing agent and a modulator of P-glycoprotein (P-gp)-medlated antlcancer multidrug resistance.
-Cremophor EL is a triglyceride fatty acid which has the potential to repel insects and promote plant growth.
-Cremophor EL has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation.

-Cremophor EL has been used as a vehicle for drug/stimulant delivery in cells.
-Cremophor EL (CrEL) (polyoxyethylene glycerol triricinoleate 35) is used as a pharmaceutical vehicle for the formulation of several drugs, including the anticancer agent paclitaxel (Taxolt).

-Cremophor EL is widely employed to improve dissolution and delivery of drugs.
-Cremophor EL (CrEL, Kolliphor EL), a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol).

-Cremophor EL is used in severe anaphylactoid hypersensitivity reactions, hyperlipidaemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy.
-Cremophor EL (CrEL) is a polyoxyethylated castor oil surfactant used to solubilize water-insoluble drugs such as anesthetic, antineoplastic, immunosuppressive and analgesic drugs, vitamins and new synthetic compounds, including potential analgesics.

-Cremophor EL (CrEL) is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol).
-Cremophor EL (CrEL, Kolliphor EL), a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol).

-Cremophor EL is an excipient or additive in drugs.
Therapeutically, modern drugs are rarely given in a pure chemical state, so most active ingredients are combined with excipients or additives such as Cremophor EL.

-Miconazole, anti-fungal; Docetaxel, anti-cancer; Aci-Jel (acetic acid / oxyquinoline / ricinoleic acid - vaginal); Sandimmune (cyclosporine injection, USP); Nelfinavir mesylate, HIV protease inhibitor
-Propofol, intravenous anaesthetic agent, originally presented in Kolliphor EL for trials; now presented in a lipid emulsion
Diazepam injection; superseded by lipid emulsion alternative (Diazemuls); Vitamin K injection; Ixabepilone, anti-cancer

-Cremophor EL's use has been associated with severe anaphylactoid hypersensitivity reactions, hyperlipidemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy.
-Cremophor EL (CrEL) is a formulation vehicle used to improve solubility of various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol).

PHYSICAL and CHEMICAL PROPERTIES of CREMOPHOR EL:
Molecular Weight: 136.15
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 136.07355886
Monoisotopic Mass: 136.07355886
Topological Polar Surface Area: 73.2 Å²

Heavy Atom Count: 9
Formal Charge: 0
Complexity: 35.5
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Appearance Form: liquid
Color: light yellow
Odor: No data available
Odor Threshold: No data available
pH: 6 - 8 at 100 g/l at 20 °C
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available

Flash point: No data available
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: No data available
Vapor density: No data available
Density: 1,050 g/cm3

Relative density: No data available
Water solubility: 100 g/l at 20 °C
Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Decomposition temperature: ca.300 °C -
Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: 700 - 800 mPa.s at 25 °C

Density: 1.4±0.1 g/cm3
Boiling Point: 305.7±32.0 °C at 760 mmHg
Molecular Formula: C4H7Cl2NO2
Molecular Weight: 172.010
Flash Point: 138.7±25.1 °C
Exact Mass: 170.985382
LogP: 0.62
Appearance of Characters: Viscous Liquid | Clear yellow
Vapour Pressure: 0.0±0.6 mmHg at 25°C
Index of Refraction: 1.481

FIRST AID MEASURES of CREMOPHOR EL:
-Description of first-aid measures:
*After inhalation:
Fresh air.

*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.

*After eye contact:
Rinse out with plenty of water.
Remove contact lenses.

*After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.

ACCIDENTAL RELEASE MEASURES of CREMOPHOR EL:
-Environmental precautions:
Do not let product enter drains.

-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of CREMOPHOR EL:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder

*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CREMOPHOR EL:
-Control parameters:
*Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:

*Eye/face protection:
Use Safety glasses

*Skin protection:
not required

*Respiratory protection:
Not required.

-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CREMOPHOR EL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Recommended storage temperature see product label.

-Specific end use(s):
No other specific uses are stipulated.

STABILITY and REACTIVITY of CREMOPHOR EL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .

SYNONYMS:
Cremophor EL
63393-92-0
Fatty acids, castor-oil, esters with ethoxylated glycerol
SCHEMBL830352
Castor Oil Fatty Acids, Ethoxylated Glycerol Esters
oxirane;propane-1,2,3-triol
DTXSID00979565
Propane-1,2,3-triol--oxirane (1/1)
PEG-35 CASTOR OIL
polyoxyethylene castor oil
Polyoxy 35 castor oil
PEG-40 CASTOR OIL
Kolliphor EL
Kolliphor ELP
PEG-36 CASTOR OIL
PEG-50 CASTOR OIL
PEG-60 CASTOR OIL
PEG-10 CASTOR OIL
MFCD00130879
1,3-Dichlor-2-propanylcarbamat
Carbamate de 1,3-dichloro-2-propanyle
2-Propanol, 1,3-dichloro-, carbamate
1,3-dichloropropan-2-yl carbamate
1,3-Dichloro-2-propanyl carbamate
Castor oil ethoxylated
Polyoxyethylene castor oil
cremophor el
castor oil ethoxylated
polyoxyethylene castor oil
Ethoxylated castor oil
PEG Castor oil
Emulsifier EL series
RO 40
RO series
BY series
Cremophor EL series
Castor Oil Ethoxylate
Emulsifier EL