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CAS NUMBER: 42553-65-1
EC NUMBER: 255-881-6
MOLECULAR FORMULA: C44H64O24
MOLECULAR WEIGHT: 976.96
Crocin has been shown to be an antioxidant, and neural protective agent.
Crocin is the chemical primarily responsible for the color of saffron.
A highly unsaturared diterpene dicarboxylic acid ester found in saffron.
Crocin alleviates some ethanol-induced impairments of learning and prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP), a form of activity-dependent synaptic plasticity that may underly learning and memory.
Crocin effects are specific to the digentiobiose ester; crocetin glucose gentiobiose ester is half as potent, and the diglucose ester has no effect at all.
Crocin is a carotenoid chemical compound that is found in the flowers crocus and gardenia.
Chemically, crocin is the diester formed from the disaccharide gentiobiose and the dicarboxylic acid crocetin.
When isolated as a pure chemical compound, Crocin has a deep red color and forms crystals with a melting point of 186 °C.
When dissolved in water, Crocin forms an orange solution.
The term crocins may also refer to members of a series of related hydrophilic carotenoids that are either monoglycosyl or diglycosyl polyene esters of crocetin.
Crocin underlying saffron's aroma is α-crocin (a carotenoid pigment that may compose more than 10% of dry saffron's mass): trans-crocetin di-(β-D-gentiobiosyl) ester.
Crocin bears the systematic (IUPAC) name 8,8-diapo-8,8-carotenoic acid.
The major active component of saffron is the yellow pigment Crocin containing a gentiobiose (disaccharide) group at each end of the molecule.
The five major biologically active components of saffron, namely the four crocins and crocetin, can be measured with HPLC-UV.
The antioxidant behavior of crocin is related to the sugar moiety in crocin molecule which has a vital role in its chemical reactivity.
Crocin has also been shown to have an antiproliferative action against cancer cells in vitro.
Limited evidence suggests possible antidepressant properties of crocin in humans.
One study reports aphrodisiac properties in male rats at very high doses.
Crocin contains 'Paracetamol' which is a mild analgesic and fever reducer.
Crocin can also be used to treat mild to moderate pain in conditions of headache, toothache, backache, period pain, and muscle pain.
Crocin has less gastric irritating properties compared to other pain killers like aspirin and ibuprofen.
Crocin is the drug of the first choice for reducing fever suitable for all age groups (from children of 2 months to the elderly).
Crocin is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters.
Crocin is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food.
Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol.
Crocin has a role as an antioxidant, a food colouring, a plant metabolite and a histological dye.
Crocin is a diester, a disaccharide derivative and a diterpenoid.
Crocin derives from a beta-D-gentiobiosyl crocetin and a gentiobiose.
Crocin has been investigated for the treatment of Hyperglycemia, Metabolic Syndrome, Hypertriglyceridemia, and Hypercholesterolemia.
Crocin antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro.
Crocin alone did not affect synaptic potentials mediated by non-NMDA or NMDA receptors, however, it specifically antagonizes the inhibitory effect of ethanol on NMDA receptor-mediated responses in hippocampal neurons.
Crocins (crocetin esters) are water-soluble carotenoids that consist of a group of crocetin (8,8′-diapocarotene-8,8′-dioic acid) glycosides.
Crocins contain crocin-1 or α-crocin, crocin-2 (tricrocin), crocin-3, crocin-4, and crocin-5 or dicrocin.
Crocins are highly valued in the food industry and
Crocin Advance tablet is a pain-relieving medicine.
Crocin contains paracetamol as an active ingredient.
Crocin is used for reducing fever and relieving pain including toothache, headache, migraine, muscle ache, period pain, etc.
While taking this medicine you should not take other medicines containing paracetamol.
Do not take more than the recommended dose and keep a gap of a minimum of 4 hours between two consecutive doses.
Crocin is a water-soluble carotenoid pigment of saffron.
Crocin has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer.
Crocin is a carotenoid chemical compound that is present in the flowers crocus and gardenia.
This is the chemical mainly responsible for the color of saffron.
Chemically, the dieter derived from the disaccharide gentiobiose and dicarboxylic acid crocetin is crocin.
Crocin can be administered with another medication alone or in combination.
As recommended by your doctor, you should take Crocin regularly.
Crocin is typically better taken with food, otherwise, your stomach may become disturbed.
Do not take more than prescribed or use Crocin for longer.
Side effects are uncommon if this medication is used properly, but in some individuals, this medicine can cause stomach pain, nausea, and vomiting.
Crocin is commonly used and considered safe, but it is not sufficient for all.
Before taking this drug, let your doctor know if you have problems with your liver or kidneys, or if you are using blood thinners.
The dosage or suitability of this drug can be influenced by it.
Let your doctor know about all the other medicines that you are taking because this medication will affect or be affected by them.
Crocin is a drug that is used for pain relief and fever control.
Crocin is used for the treatment of a variety of disorders, including headache, body ache, toothache, and the common cold.
Crocin functions by blocking the release of certain chemicals that are responsible for pain and fever.
A popular painkiller used for the treatment of aches and pains is Crocin Advance Tablet.
Crocin works by suppressing the brain's chemical messengers that tell us we're in pain.
Crocin is helpful in relieving headaches, migraine, nerve pain, toothache, sore throat, menstrual pain, arthritis, and muscle aches that are caused by pain.
This drug is very commonly used and, if administered at the proper dose, Crocin very seldom causes adverse effects.
To get the most advantage, take it as Crocin is prescribed. Do not take more or longer than required, as this can be hazardous.
In general, for the shortest possible time, you can take the lowest dose that works.
During pregnancy or breastfeeding, it is also the first option for painkillers.
In Fever A high-temperature reduction is also used with the Crocin Advance Tablet (fever).
Crocin operates by blocking the release of some fever-causing chemical messengers.
Crocin can be administered alone or with another drug in combination.
As recommended by your doctor, you should take it regularly.
Crocin is the most widely used over-the-counter (OTC) medication.
Crocin is used for the treatment of fever.
Crocin also provides relief from headache, toothache, backache, nerve pain, musculoskeletal pain, etc. associated with/without fever.
Crocin works by decreasing the intensity of pain signals to the brain.
Crocin also prevents the release of prostaglandins, the chemical that causes pain and an increase in body temperature.
Crocin is safe to use within the recommended dosage.
Crocin can be taken with or without food.
If your doctor has prescribed this medicine, take it for the recommended duration.
Never take more than the prescribed dose, or for a longer duration.
Crocin is a pain-relieving medicine manufactured in India.
The active ingredient present in crocin is paracetamol.
Paracetamol is an analgesic and antipyretic.
Crocin is quickly absorbed from the gastrointestinal tract after oral administration.
Crocin acts by inhibiting the formation of prostaglandins (chemicals) in the body which are accountable for fever and pain.
Crocin has the benefits of relieving mild to moderate pain, including toothache, headache, muscle ache, and menstrual pain.
Crocin is used to reduce fever. Paracetamol in crocin is a good antipyretic agent that prevents the release of pain and fever-causing chemicals (prostaglandins) in the body.
Crocin relieves fever and other symptoms of cold and flu, such as headache, body ache, and sore throat.
Crocin is a natural carotenoid chemical compound that is found in the flowers crocus and gardenia.
Crocin is the diester formed from the disaccharide gentiobiose and the dicarboxylic acid crocetin.
Crocin has a deep red color and forms crystals with a melting point of 186 °C.
When dissolved in water, Crocin forms an orange solution.
Crocin is the chemical ingredient primarily responsible for the color of saffron.
Crocin has also been shown to be a potent antioxidant.
Crocin has also been shown to have an anticarcinogenic action.
Crocin is a natural compound found in gardenia and crocus flowers.
Crocin contains high amounts of antioxidants and has a variety of medicinal uses.
Crocin may be useful in the treatment of mild to moderate depression.
Crocins anticarcinogenic properties make it a promising alternative.
The flowers of Gardenia jasminoids produce stigmas containing crocin.
Crocin also contains saffron collected from the stigmas of Crocus sativas Linnaeus flowers.
The deep reddish-orange hue of this natural compound gives it the color of saffron.
Crocin has been used for centuries both as a natural food colorant and as an ingredient in Oriental medicine.
The use of saffron as a medicine has been documented in ancient literature.
Historically, saffron was a home remedy for ailments such as stomachaches, headaches, and insomnia.
At the beginning of the 21st century, research is being done on cross and saffron, two of the compounds found in saffron.
Studies have shown that crocin works for a variety of medical issues, although as of 2011, saffron has limited medicinal benefits.
Most of the studies are preliminary, but provide a basis for further research.
A 2004 study compared saffron with imipramine in the treatment of mild to moderate depression.
Imipramine is a prescription drug used to treat depression.
The double-blind study showed that saffron containing crocin was as effective as imipramine in treating mild to moderate depression.
Saffron also showed significant benefit over imipramine, as saffron does not cause dry mouth and drowsiness associated with imipramine use.
Crocin is a natural carotenoid compound found in crocus and gardenia flowers.
Crocin is a diester composed of a disaccharide called gentiobiose and a dicarboxylic acid called crocetin.
Crocin is bright red in color and forms crystals that melt at 186 °C.
Crocin forms an orange solution in water.
Crocin is the chemical component that is primarily responsible for the color of saffron.
Crocin has also been shown to be a powerful antioxidant.
Crocin is also known as a-crocin and crocetin.
Crocin is a series of ester glycosides combining water-soluble carotenoids crocetin and different sugars.
Crocin is one of the main active ingredients of saffron, including crocin -1, crocin -2, crocin -3, crocin-4 and crocetin.
Crocin is centrally acting antihypertensive and can prevent atherosclerosis and be of antithrombosis, antiplatelet aggregation, and anti myocardial ischemia.
Crocin has the effect of the anti-inflammation and treatment of soft tissue injury, gall liver protection, anti-tumor and other pharmacological effects.
Crocin is widely used in food, medicine, chemical industry and other industries.
Crocin is used in the treatment of patients with cardiovascular disease and fatty liver.
The traditional medicine believes that the stigma croci can dredge and activate the collaterals, remove blood stasis, eradicate depression and relieve swelling and pain.
Crocin is mainly used for the treatment of anxiety depression, chest distention, irregular menstruation, postpartum haemorrhage and traumatic injury.
Stigma croci are considered to be "the golden plant”.
The main effective components are crocetin and crocin, which has many pharmacological activities, such as being anti-inflammatory and analgesic, antitumor, antidepressant, hypoglycemic and lowering blood pressure.
Because the water solution of stigma croci is bright yellow with sweet smell, it is often used as a food additive and high-grade edible pigment, but also can be used as high dye for silk, cotton and wool products.
Crocin, is a natural carotenoid derived the flowers crocus and gardenia.
Crocin has been shown to be a potent antioxidant.
Crocin has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.
Crocin alleviates some ethanol-induced impairments of learning and prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP), a form of activity-dependent synaptic plasticity that may underly learning and memory.
Crocin effects are specific to the digentiobiose ester; crocetin glucose gentiobiose ester is half as potent, and the diglucose ester has no effect at all.
USES:
-Crocin treats many conditions like temporary pain relief associated with headache, sinus pain, backache, painful menstruation, musculoskeletal pain, sore throat, rheumatic pain, neuralgia, arthritis, osteoarthritis, respiratory tract infections, migraine headache, tennis elbow, and cold and flu.
-Crocin is also used to reduce fever without treating its underlying causes.
-In pediatric patients, Crocin has the benefit of relieving pain associated with an earache, teething, or immunization.
PROPERTIES:
Quality Level: 100
grade: for microscopy
storage temp.: 2-8°C
SMILES string: CC(=CC=CC=C(C)C=CC=C(/C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)C=CC=C(C)C(=C)CO[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O
InChI: 1S/C46H68O23/c1-21(12-8-14-23(3)25(5)18-62-43-40(59)36(55)32(51)28(67-43)19-63-44-38(57)34(53)30(49)26(16-47)65-44)10-6-7-11-22(2)13-9-15-24(4)42(61)69-46-41(60)37(56)33(52)29(68-46)20-64-45-39(58)35(54)31(50)27(17-48)66-45/h6-15,26-41,43-60H,5,16-20H2,1-4H3/b7-6+,12-8+,13-9+,21-10-,22-11+,23-14-,24-15+/t26-,27-,28-,29-,30-,31-,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,43-,44-,45-,46+/m1/s1
InChI key: LUVDBMJRTUBHNX-RSXXRLSLSA-N
STORAGE:
Store in a cool and dry place away from sunlight.
SYNONYM:
Gardenia Yellow
alpha-Crocin
42553-65-1
Crocin I
Crocine
94238-00-3
Crocin 1
Saffron
crocin-1
UNII-877GWI46C2
crocetin di-gentiobiose ester
CHEMBL446785
bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate
CHEBI:79068
Crocetin digentiobiose ester
877GWI46C2
