PRODUCTS

CROSPOVIDONE

Crospovidone is also used as a fining to extract impurities (via agglomeration followed by filtration).
Crospovidone is used in winemaking.
Using the same principle Crospovidone is used to remove polyphenols in beer production and thus clear beers with stable foam are produced.

CAS Number: 9003-39-8
EC Number: 265-110-5
Chemical Formula: (C6H9NO)n
Molecular Weight: Variable (polymer)

SYNONYMS:
Crospovidone, Crosslinked Polyvinylpyrrolidone, Crosspovidone, PVPP, Insoluble Polyvinylpyrrolidone, Polyvidone, Polyvinylpolypyrrolidone, Kollidon CL, Polyvinylpyrrolidone, PVP, Polyvidone, Povidone, 1-ethenylpyrrolidin-2-one, Polyvinyl polypyrrolidone, crospovidone, crospolividone, E1202, Kollidon CL, Crospovidone, Polyplasdone XL, 1-Ethenyl-2-Pyrrolidinone, Homopolymer, 1-vinyl-2-pyrrolidinone Homopolymer, 2S7830E561, A07BC03, CROSPOVIDONE (EP IMPURITY), CROSPOVIDONE (EP MONOGRAPH), CROSPOVIDONE (II), CROSPOVIDONE (MART.), CROSPOVIDONE (USP-RS), PVP, CROSSLINKED-, crospovidona

Crospovidone (cross linked polyvinyl N-pyrrolidone, or PVP) is a common, FDA-approved inactive ingredient used in the pharmaceutical industry.
Crospovidone is often combined with active ingredients in medications and dietary supplements to allow absorption of the active drug.
Crospovidone is considered a synthetic povidone analog.

Chemically, crospovidone is an inert and insoluble white to light yellow free-flowing powder.
Crospovidone has hygroscopic, or water-attracting properties with excellent swelling characteristics.
Crospovidone is this swelling characteristic that makes it useful as a disintegrant in pharmaceutical dosage forms.

Crospovidone is not absorbed orally.
Oral use of crospovidone is not usually associated with toxicity in normal use as a pharmaceutical excipient.
Pulmonary emboli have been reported in autopsies of intravenous drug abusers who have crushed tablets, such as hydromorphone, for injection.

The long-term effects of crospovidone in the lung are unknown.
Allergic reactions have also been reported with the use of povidone-iodine (Betadine) as a topical antiseptic.
Crospovidone is a crosslinked derivative of PVP that acts as a superdisintegrant in tablets.

Crospovidone facilitates the absorption of fluids into the tablet through capillarity, resulting in rapid and enhanced dissolution of the payload drug.
Crospovidone achieves this through mechanisms such as swelling and wicking.

Crospovidone is an insoluble form of polyvinylpyrrolidone, and its use in the pharmaceutical industry as a tablet excipient (a tablet disintegrant and binder) has been widely documented.
Crospovidone is a highly cross-linked modification of polyvinylpyrrolidone (PVP).

The cross-linked form of Crospovidone is used as a disintegrant (see also excipients) in pharmaceutical tablets.
Crospovidone is a highly cross-linked version of PVP, making it insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force.
This property makes Crospovidone useful as a disintegrant in tablets.

USES and APPLICATIONS of CROSPOVIDONE:
Crospovidone is medically used for the treatment of some intestinal disorders as solubilizing excipients to improve the bioavailability of drugs (such as steroids) and as germicides in wound treatment.
Crospovidone is also commonly used as a clarifier in alcoholic and nonalcoholic beverages.

This property makes Crospovidone useful as a disintegrant in tablets.
Crospovidone can be used as a drug, taken as a tablet or suspension to absorb compounds (so-called endotoxins) that cause diarrhea. (Cf. bone char, charcoal.)

Crospovidone forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.
Crospovidone is used as a stabiliser.

Food Industry: Crospovidone sometimes used as a clarifying agent in beverages like beer and wine.
Cosmetics: Crospovidone is used as a stabilizer, thickener, or binder in various cosmetic formulations.
Chemical Industry: Crospovidone is employed as an adsorbent for purification processes.

-Pharmaceutical Industry:
Crospovidone is used as a superdisintegrant in tablets and capsules to improve dissolution and bioavailability of active pharmaceutical ingredients (APIs).
Crospovidone acts as a binder in oral solid dosage forms.

PROPERTIES OF CROSPOVIDONE:
*Water Absorption:
Crospovidone swells rapidly in water without dissolving.

*Non-Toxic:
Safe for pharmaceutical and food applications.

*Versatility:
Compatible with a wide range of APIs and excipients.

*Particle Size:
Crospovidone can be optimized for specific applications to control disintegration rates.

BENEFITS OF CROSPOVIDONE:
*Crospovidone enhances the dissolution rate of poorly soluble drugs.
*Improves tablet hardness and stability.
*Crospovidone provides uniform disintegration of solid dosage forms for faster drug release.
*Non-reactive and chemically stable under normal storage conditions.

PHYSICAL and CHEMICAL PROPERTIES of CROSPOVIDONE:
Chemical Formula: (C6H9NO)n
Molecular Weight: Variable (polymer)
Appearance: White or off-white, hygroscopic powder
Odor: Odorless
Solubility: Practically insoluble in water,
ethanol, and common solvents,
but swells in water
pH: Neutral to slightly basic
Density: ~1.22 g/cm³
Melting Point: Does not melt; decomposes at high temperatures
Stability: Stable under normal conditions;
sensitive to excessive heat and moisture

Physical state: Powder
Color: Beige
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 5.0 - 8 at 10 g/l at 20 °C

Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: None
Other safety information: No data available

FIRST AID MEASURES of CROSPOVIDONE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of CROSPOVIDONE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of CROSPOVIDONE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CROSPOVIDONE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CROSPOVIDONE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of CROSPOVIDONE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available